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Nowcasting and Forecasting Seasonal Influenza Epidemics—China,2022-2023

China CDC weekly 2023年第49期5卷 1100-1106,I0003-I0005页

作者： Zhanwei Du Zengyang Shao Xiao Zhang Ruohan Chen Tianmu Chen Yuan Bai Lin Wang Eric H.Y.Lau Benjamin J.Cowling WHO Collaborating Center for Infectious Disease Epidemiology and Control School of Public HealthLKS Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Laboratory of Data Discovery for Health Limited Hong Kong Science and Technology ParkHong Kong Special Administrative RegionChina State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics School of Public HealthXiamen UniversityXiamen CityFujian ProvinceChina Department of Genetics University of CambridgeCambridgeUK Institute for Health Transformation&School of Health&Social Development Deakin UniversityMelbourneAustralia

Background:Seasonal influenza resurged in China in February 2023,causing a large number of *** influenza epidemics occurred across China during the coronavirus disease 2019(COVID-19)pandemic,the relaxation of COVID-19 containment measures in December 2022 may have contributed to the spread of acute respiratory infections in winter 2022/***:Using a mathematical model incorporating influenza activity as measured by influenza-like illness(ILI)data for northern and southern regions of China,we reconstructed the seasonal influenza incidence from October 2015 to September 2019 before the COVID-19 *** this trained model,we predicted influenza activities in northern and southern China from March to September ***:We estimated the effective reproduction number Re as 1.08[95%confidence interval(CI):0.51,1.65]in northern China and 1.10(95%CI:0.55,1.67)in southern China at the start of the 2022-2023 influenza *** estimated the infection attack rate of this influenza wave as 18.51%(95%CI:0.00%,37.78%)in northern China and 28.30%(95%CI:14.77%,41.82%)in southern ***:The 2023 spring wave of seasonal influenza in China spread until July 2023 and infected a substantial number of people.

关键词： winter relaxation measures

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Epidemic Surveillance of Influenza Infections:A Network-Free Strategy—hong kong Special Administrative Region,China,2008–2011

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China CDC weekly 2022年第46期4卷 1025-1031,I0002-I0005页

作者： Zhanwei Du Qi Tan Yuan Bai Lin Wang Benjamin J.Cowling Petter Holme WHO Collaborating Centre for Infectious Disease Epidemiology and Control School of Public HealthLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina Laboratory of Data Discovery for Health Limited(D24H) Hong Kong Science and Technology ParkHong Kong SARChina Department of Genetics University of CambridgeCambridgeUK Department of Computer Science Aalto UniversityEspooFinland

Introduction:The ease of coronavirus disease 2019(COVID-19)non-pharmacological interventions and the increased susceptibility during the past COVID-19 pandemic could be a precursor for the resurgence of influenza,potentially leading to a severe outbreak in the winter of 2022 and future *** recent increased availability of data on Electronic Health Records(EHR)in public health systems,offers new opportunities to monitor individuals to mitigate ***:We introduced a new methodology to rank individuals for surveillance in temporal networks,which was more practical than the static *** targeting previously infected nodes,this method used readily available EHR data instead of the contactnetwork ***:We validated this method qualitatively in a real-world cohort study and evaluated our approach quantitatively by comparing it to other surveillance methods on three temporal and empirical *** found that,despite not explicitly exploiting the contacts’network structure,it remained the best or close to the best *** related the performance of the method to the public health goals,the reproduction number of the disease,and the underlying temporal-network structure(e.g.,burstiness).Discussion:The proposed strategy of using historical records for sentinel surveillance selection can be taken as a practical and robust alternative without the knowledge of individual contact behaviors for public health policymakers.

关键词： network policy networks

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“Slow walk”mimetic tensile loading maintains human meniscus tissue resident progenitor cells homeostasis in photocrosslinked gelatin hydrogel

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Bioactive Materials 2023年第7期25卷 256-272页

作者： Jing Sun Yau Tsz Chan Ki Wai Kevin Ho Li Zhang Liming Bian Rocky S.Tuan Yangzi Jiang Institute for Tissue Engineering and Regenerative Medicine School of Biomedical SciencesFaculty of MedicineThe Chinese University of Hong KongShatinHong Kong Special Administrative Region of China School of Biomedical Sciences Faculty of MedicineThe Chinese University of Hong KongShatinHong Kong Special Administrative Region of China Department of Orthopaedics&Traumatology Faculty of MedicineThe Chinese University of Hong KongAnd Prince of Wales HospitalShatinHong Kong Special Administrative Region of China Department of Mechanical and Automation Engineering Faculty of EngineeringThe Chinese University of Hong KongShatinHong Kong Special Administrative Region of China Department of Biomedical Engineering Faculty of EngineeringThe Chinese University of Hong KongShatinHong Kong Special Administrative Region of China Center for Neuromusculoskeletal Restorative Medicine Hong Kong Special Administrative Region of China

Meniscus,the cushion in knee joint,is a load-bearing tissue that transfers mechanical forces to extracellular matrix(ECM)and tissue resident *** mechanoresponse of human tissue resident stem/progenitor cells in meniscus(hMeSPCs)is significant to tissue homeostasis and regeneration but is not well *** study reports that a mild cyclic tensile loading regimen of~1800 loads/day on hMeSPCs seeded in 3-dimensional(3D)photocrosslinked gelatin methacryloyl(GelMA)hydrogel is critical in maintaining cellular ***,a“slow walk”biomimetic cyclic loading regimen(10%tensile strain,0.5 Hz,1 h/day,up to 15 days)is applied to hMeSPCs encapsulated in GelMA hydrogel with a magnetic force-controlled loading *** loading significantly increases cell differentiation and fibrocartilage-like ECM deposition without affecting cell *** analysis reveals 332 mechanoresponsive genes,clustered into cell senescence,mechanical sensitivity,and ECM dynamics,associated with interleukins,integrins,and collagens/matrix metalloproteinase *** cell-GelMA constructs show active ECM remodeling,traced using a green fluorescence tagged(GFT)-GelMA *** enhances nascent pericellular matrix production by the encapsulated hMeSPCs,which gradually compensates for the hydrogel loss in the *** findings demonstrate the strong tissue-forming ability of hMeSPCs,and the importance of mechanical factors in maintaining meniscus homeostasis.

关键词： Human meniscus progenitor cells 3D cell-based constructs Biomimetic cyclic loading GelMA hydrogel Extracellular matrix

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Artesunate suppresses Th17 response via inhibiting IRF4-mediated glycolysis and ameliorates Sjogren's syndrome

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Signal Transduction and Targeted Therapy 2022年第9期7卷 3210-3212页

作者： Fan Xiao Ke Rui Man Han Liyun Zou Enyu Huang Jie Tian Lijun Zhang Quan Jiang Yuzhang Wu Liwei Lu Department of Pathology and Shenzhen Institute of research and innovation Shenzhen HospitalThe University of Hong Kong Chongqing International Institute for Immunology Hong KongChina Department of Laboratory Medicine Affliated Hospital andInstitute of Medical ImmunologyJiangsu UniversityZhenjiangChina Division of Rheumatology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBejjingChina Institute of ImmunologyArmy Medical UniversityChongqingChina

Dear Editor,Primary Sjogren's syndrome(pSS)is an autoimmune disease characterized by dry eyes and dry mouth caused by glandular inflammation in salivary glands(SG)and lacrimal ***,pSS patients are suffering from a lack of effective *** studies have revealed dysregulated immune responses during pSS development,in which Th17 cells are considered as the key driver in disease initiation and perpetuation.

关键词： Th17 Sjogren inhibiting

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