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超快声波脉冲的受控发射:走向超高时空分辨成像的新路径

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光学学报 2024年

作者：崔乾楠张何许文雄徐春祥东南大学电子科学与工程学院

超快激光脉冲实现超高时间分辨成像的能力令人期待，但光波的本质限制了其空间分辨和穿透力。超快激光脉冲与固体薄膜相互作用所发射出的超快声波脉冲，兼具超短脉宽、纳米波长和高穿透深度的物理优势，是一种综合性能优异的超快光谱成... 详细信息

超快激光脉冲实现超高时间分辨成像的能力令人期待，但光波的本质限制了其空间分辨和穿透力。超快激光脉冲与固体薄膜相互作用所发射出的超快声波脉冲，兼具超短脉宽、纳米波长和高穿透深度的物理优势，是一种综合性能优异的超快光谱成像工具。新兴的二维异质结构超快声波脉冲发射源，有望解决超快声波脉冲的高效、可控发射难题，不仅可为现有许多重要微纳器件、芯片的超高分辨成像及无损评测提供支撑，而且可为功能界面多物理场耦合超快动力学研究与应用带来机会，必将有力助推半导体科学与超快光谱学的协同深入发展。文章将重点介绍二维半导体材料体系中超快声波脉冲的光致发射与测控研究进展，并展望超快声波脉冲如何助推未来前沿超快光物理研究与应用。

关键词：超快激光脉冲超快声波脉冲二维表界面超高分辨

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二维半导体的相干声学声子研究进展

发光学报 2024年第8期45卷 1232-1246页

作者：许文雄张何崔乾楠徐春祥东南大学生物科学与医学工程学院数字医学工程全国重点实验室江苏南京210096 东南大学电子科学与工程学院江苏南京210096

飞秒脉冲激光激发固体薄膜材料产生的相干声学声子可以快速无损获取发光材料与器件结构特性,对于光电器件功能界面的无损检测及成像具有重要意义。相较于热弹性机制的传统金属薄膜光声换能器,二维半导体材料具备宽谱吸收、表面原子级平... 详细信息

飞秒脉冲激光激发固体薄膜材料产生的相干声学声子可以快速无损获取发光材料与器件结构特性,对于光电器件功能界面的无损检测及成像具有重要意义。相较于热弹性机制的传统金属薄膜光声换能器,二维半导体材料具备宽谱吸收、表面原子级平整、层数易控等优良特性。飞秒激光激发二维半导体能原位产生相干声学声子振荡,为进一步发射超快声波脉冲获取界面信息创造了条件,广泛适用于无损评测发光器件的缺陷分布、力学性能和界面品质。本文主要介绍二维半导体中相干声学声子的研究进展,并讨论利用超快光声转换的高穿透深度、高时空分辨测量技术重大的科学意义与社会价值。

关键词：二维半导体异质界面相干声学声子

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限域空间反应合成氧化铁纳米颗粒

Science China Materials 2024年第8期67卷 2447-2461页

作者：赵一帆吴临远李艳毛宇顾宁 Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Sciences and Medical EngineeringSoutheast UniversityNanjing 210096China Nanjing Key Laboratory for Cardiovascular Information and Health Engineering Medicine Institute of Clinical MedicineNanjing Drum Tower HospitalMedical SchoolNanjing UniversityNanjing 210093China

氧化铁纳米颗粒(IONPs)在生物医学领域具有广阔的应用前景.以共沉淀法、热分解法、溶胶-凝胶法与水热法为代表的传统方法,在控制IONPs合成反应过程的物质交换存在一定局限性,或影响产物纯度及功能性.在限域空间内进行的合成反应,有望为I... 详细信息

氧化铁纳米颗粒(IONPs)在生物医学领域具有广阔的应用前景.以共沉淀法、热分解法、溶胶-凝胶法与水热法为代表的传统方法,在控制IONPs合成反应过程的物质交换存在一定局限性,或影响产物纯度及功能性.在限域空间内进行的合成反应,有望为IONPs合成过程精准控制以及产物性能提升提供有效的解决方案.限域空间合成方法与细胞利用纳米反应器精确控制系列化学反应的生物合成过程类似.本文聚焦于IONPs的限域空间合成,综述了目前实验室构建限域空间反应器制备IONPs的策略,旨在加深对纳米反应器在合成IONPs过程中所发挥作用的理解并推进其应用,进而推动开发具有更优异生物相容性和诊疗效应的IONPs.

关键词：纳米反应器物质交换氧化铁纳米颗粒热分解法生物合成过程产物纯度产物性能空间合成

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应对老龄化所致慢病的智能生物材料

中国科学：技术科学 2024年第8期54卷 1519-1532页

作者：袁月辉黎谨周亚鸣朱雪菲邵小东方伦刘一杨金娟王乐禹李永生吴水林蔡平强胡本慧顾宁南京医科大学生物医学工程与信息学院南京211166 南京大学医学院附属鼓楼医院南京210008 南京医科大学第四临床医学院南京210029 南京大学医学院南京210093 广州医科大学基础医学院广州511436 华东理工大学材料科学与工程学院上海200237 北京大学材料科学与工程学院北京100871

人口老龄化进程的不断加速直接导致骨质疏松和心血管疾病等慢性病高发,对以组织修复材料为核心的临床治疗方法提出了巨大挑战.本综述通过回顾生物材料的发展历程,总结归纳了各阶段生物材料的优劣势,同时详细论述了老龄化病损组织修复所... 详细信息

人口老龄化进程的不断加速直接导致骨质疏松和心血管疾病等慢性病高发,对以组织修复材料为核心的临床治疗方法提出了巨大挑战.本综述通过回顾生物材料的发展历程,总结归纳了各阶段生物材料的优劣势,同时详细论述了老龄化病损组织修复所面临的组织功能和微环境稳态难以维持的难题,最后基于此探讨如何结合人工智能、材料生物学、影像组学等新兴技术,研发能感知生理病理微环境,适时响应和主动调控生物学效应,并全周期适配病损组织修复进程的新一代“自适应”智能生物材料.

关键词：老龄化疾病材料生物学智能生物材料组织修复

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限域空间反应合成氧化铁纳米颗粒（英文）

Science China Materials 2024年

作者：赵一帆吴临远李艳毛宇顾宁 Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Sciences and Medical Engineering Southeast University Nanjing Key Laboratory for Cardiovascular Information and Health Engineering Medicine Institute of Clinical Medicine Nanjing Drum Tower HospitalMedical School Nanjing University

氧化铁纳米颗粒(IONPs)在生物医学领域具有广阔的应用前景.以共沉淀法、热分解法、溶胶-凝胶法与水热法为代表的传统方法,在控制IONPs合成反应过程的物质交换存在一定局限性,或影响产物纯度及功能性.在限域空间内进行的合成反应,有望为I...

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Adaptive iron-based magnetic nanomaterials of high performance for biomedical applications

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Nano Research 2022年第1期15卷 1-17页

作者： Ning Gu Zuoheng Zhang Yan Li State Key Laboratory of Bioelectronics Jiangsu Key Laboratory for Biomaterials and DevicesSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Collaborative Innovation Center of Suzhou Nano-Science and Technology Suzhou Key Laboratory of Biomaterials and TechnologiesSuzhou 215123China School of Biomedical Engineering and Informatics Nanjing Medical UniversityNanjing 211166China

With unique physicochemical properties and biological effects,magnetic nanomaterials(MNMs)play a crucial role in the biomedical *** particular,magnetic iron oxide nanoparticles(MIONPs)are approved by the United States Food and Drug Administration(FDA)for clinical applications at present due to their low toxicity,biocompatibility,and *** the unarguable effectiveness,massive space for improving such materials'performance still needs to be ***,many efforts have been devoted to improving the preparation methods based on the materials'***,researchers have *** the performance of magnetic nanoparticles(MNPs)by changing their sizes,morphologies,compositions;or *** as-synthesized MNPs in an orderly arrangement to meet various clinical *** rise of cloud computing and artificial intelligence techniques provides novel ways for fast material characterization,automated data analysis,and mechanism *** this review,we summarized the studies that focused on the preparation routes and performance regulations of high-quality MNPs,and their special properties applied in biomedical detection,diagnosis,and *** the same time,the *** of MNMs was also discussed.

关键词： magnetic nanomaterials high performance performance regulation controllable assembly biomedical applications

Drug delivery system based on nanobubbles

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Interdisciplinary Materials 2022年第4期1卷 471-494页

作者： Juan Jin Li Yang Feng Chen Ning Gu School of Biomedical Engineering and Informatics Nanjing Medical UniversityNanjingP.R.China State Key Laboratory of Bioelectronics Jiangsu Key Laboratory for Biomaterials and DevicesSchool of Biological Sciences and Medical EngineeringSoutheast UniversityNanjingP.R.China

Ultrasound(US)medical technology is widely used due to its advantages of safety,speed,and low *** the rapid development of biomedical nanotechnology,micro/nanobubbles,as US contrast agents,are not only valuable in US imaging diagnosis but also show broad application prospects in drug ***(NBs)have more advantages as drug delivery systems(DDSs)due to their smaller size and longer circulation time compared with *** this review,the fundamentals of NBs,including classification,stability mechanism,and preparation methods are ***,the strategies of a DDS based on NBs,including direct delivery,codelivery,target delivery,and stimuli-responsive delivery are reviewed and *** three main applications of NBs-based DDSs,namely tumor theranostics,brain drug delivery,and vascular disease theranostics were *** challenges and future directions of the NBs-based DDSs are also considered and discussed.

关键词： drug delivery system nanobubbles theranostics ultrasound

Novel magnetic silk fibroin scaffolds with delayed degradation for potential long-distance vascular repair

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Bioactive Materials 2022年第1期7卷 126-143页

作者： Xin Liu Yuxiang Sun Bo Chen Yan Li Peng Zhu Peng Wang Sen Yan Yao Li Fang Yang Ning Gu State Key Laboratory of Bioelectronics Jiangsu Key Laboratory for Biomaterials and DevicesSchool of Biological Science&Medical EngineeringSoutheast UniversityNanjing210096PR China Materials Science and Devices Institute Suzhou University of Science and Technology1 Kerui RoadSuzhou215009PR China State Key Laboratory of Quality Research in Chinese Medicines Macao Institute for Applied Research in Medicine and HealthMacao University of Science and TechnologyMacao999078PR China College of Social Sciences University of GlasgowGlasgowG128QQUnited Kingdom

Although with the good biological properties,silk fibroin(SF)is immensely restrained in long-distance vascular defect repair due to its relatively fast degradation and inferior mechanical *** is necessary to construct a multifunctional composite scaffold based on *** this study,a novel magnetic SF scaffold(MSFCs)was prepared by an improved infiltration *** with SF scaffold(SFC),MSFCs were found to have better crystallinity,magnetocaloric properties,and mechanical strength,which was ascribed to the rational introduction of iron-based magnetic nanoparticles(MNPs).Moreover,in vivo and in vitro experiments demonstrated that the degradation of MSFCs was significantly *** mechanism of delayed degradation was correlated with the dual effect that was the newly formed hydrogen bonds between SFC and MNPs and the complexing to tyrosine(Try)to inhibit hydrolase by internal iron ***,theβ-crystallization of protein in MSFCs was increased with the rise of iron concentration,proving the beneficial effect after MNPS ***,although macrophages could phagocytose the released MNPs,it did not affect their function,and even a reasonable level might cause some cytokines to be ***,in vitro and in vivo studies demonstrated that MSFCs showed excellent biocompatibility and the growth promotion effect on CD34-labeled vascular endothelial cells(VECs).In conclusion,we confirm that the doping of MNPs can significantly reduce the degradation of SFC and thus provide an innovative perspective of multifunctional biocomposites for tissue engineering.

关键词： Silk fibroin scaffold Iron based magnetic nanoparticles Composite scaffold Extended degradation Vascular tissue engineering

High-performance self-powered ultraviolet to near-infrared photodetector based on WS_(2)/InSe van der Waals heterostructure

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Nano Research 2023年第5期16卷 7851-7857页

作者： Jinping Chen Zhen Zhang Yi Ma Jiying Feng Xiaoyu Xie Xiaoxuan Wang Aoqun Jian Yuanzheng Li Zhuxin Li Heng Guo Yizhi Zhu Qiannan Cui Zengliang Shi Chunxiang Xu State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Micro Nano System Research Center Key Laboratory of Advanced Transducers and Intelligent Control System of the Ministry of Education&College of Information Engineering and ComputerTaiyuan University of TechnologyTaiyuan 030024China Key Laboratory of UV-Emitting Materials and Technology of Ministry of Education Northeast Normal UniversityChangchun 130024China

van der Waals heterostructures(vdWHs)based on two-dimensional(2D)materials without the crystal lattice matching constraint have great potential for high-performance optoelectronic ***,a WS_(2)/InSe vdWH photodiode is proposed and fabricated by precisely stacking InSe and WS_(2)flakes through an all-dry transfer *** WS_(2)/InSe vdWH forms an n–n heterojunction with strong built-in electric field due to their intrinsic n-type semiconductor characteristics and energy-band alignments with a large Fermi level offset between WS_(2)and *** a result,the device displays excellent photovoltaic behavior with a large open voltage of 0.47 V and a short-circuit current of 11.7 nA under 520 nm light ***,a fast rising/decay time of 63/76μs,a large light on/off ratio of 105,a responsivity of 61 mA/W,a high detectivity of 2.5×10^(11) Jones,and a broadband photoresponse ranging from ultraviolet to near-infrared(325–980 nm)are achieved at zero *** study provides a strategy for developing high-performance self-powered broadband photodetectors based on 2D materials.

关键词： two-dimensional materials van der Waals heterostructure self-powered photodetector photocurrent