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Motor neuron replacement therapy for amyotrophic lateral sclerosis

Neural Regeneration Research 2022年第8期17卷 1633-1639页

作者： Bochao Liu Mo Li Lingyan Zhang Zhiguo Chen Paul Lu Cell Therapy Center Beijing Institute of GeriatricsXuanwu HospitalCapital Medical UniversityNational Clinical Research Center for Geriatric Diseasesand Key Laboratory of Neurodegenerative DiseasesMinistry of EducationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Center of Parkinson’s Disease Beijing Institute for Brain DisordersBeijingChina iXCells Biotechnologies USA Inc.San DiegoCAUSA Amogene Biotech XiamenFujian ProvinceChina Veterans Administration San Diego Healthcare System San DiegoCAUSA Department of Neurosciences University of California-San DiegoLa JollaCAUSA

Amyotrophic lateral sclerosis is a motor neuron degenerative disease that is also known as Lou Gehrig’s disease in the United States,Charcot’s disease in France,and motor neuron disease in the *** loss of motor neurons causes muscle wasting,paralysis,and eventually death,which is commonly related to respiratory failure,within 3-5 years after onset of the *** there are a limited number of drugs approved for amyotrophic lateral sclerosis,they have had little success at treating the associated symptoms,and they cannot reverse the course of motor neuron ***,there is still a lack of effective treatment for this debilitating neurodegenerative *** cell therapy for amyotrophic lateral sclerosis is a very attractive strategy for both basic and clinical researchers,particularly as transplanted stem cells and stem cell-derived neural progenitor/precursor cells can protect endogenous motor neurons and directly replace the lost or dying motor *** cell therapies may also be able to re-establish the motor control of voluntary ***,we review the recent progress in the use of neural stem cells and neural progenitor cells for the treatment of amyotrophic lateral *** focus on MN progenitor cells derived from fetal central nervous system tissue,embryonic stem cells,and induced pluripotent stem *** our recent studies,we found that transplanted human induced pluripotent stem cell-derived motor neuron progenitors survive well,differentiate into motor neurons,and extend axons into the host white matter,not only in the rostrocaudal direction,but also along motor axon tracts towards the ventral roots in the immunodeficient rat spinal ***,the significant motor axonal extension after neural progenitor cell transplantation in amyotrophic lateral sclerosis models demonstrates that motor neuron replacement therapy could be a promising therapeutic strategy for amyotrophic lateral sclerosis,particularly as a variety

关键词： amyotrophic lateral sclerosis motor neuron replacement neural progenitor cells neural stem cells stem cells

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Lysine deficiency impaired growth performance and immune response and aggravated inflammatory response of the skin,spleen and head kidney in grown-up grass carp (Ctenopharyngodon idella)

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Animal Nutrition 2021年第2期7卷 556-568页

作者： Yangyang Hu Lin Feng Weidan Jiang Pei Wu Yang Liu Shengyao Kuang Ling Tang Xiaoqiu Zhou Animal Nutrition Institute Sichuan Agricultural UniversityChengduChina Fish Nutrition and Safety Production University Key Laboratory of Sichuan ProvinceSichuan Agricultural UniversityChengduChina Key Laboratory of Animal Disease-resistant Nutrition Sichuan ProvinceChina Key Laboratory of Animal Disease-resistant Nutrition Ministry of EducationChina Key Laboratory of Animal Disease-resistant Nutrition and Feed Ministry of Agriculture and Rural AffairsChina Animal Nutrition Institute Sichuan Academy of Animal ScienceChengduChina

This dissertation was primarily focused on the immune response,inflammatory response and molecular mechanisms in the skin,head kidney and spleen of grown-up grass carp(Ctenopharyngodon idella).Six iso-nitrogen diets differing in lysine concentrations(5.6,8.5,11.6,14.4,17.5 and 20.7 g/kg)were fed to 540 grass carp(164.85±0.79 g)for 60 *** that,grass carp were challenged by Aeromonas hydrophila for 6 *** study revealed that lysine deficiency(1)suppressed the growth performa,nce of the fish and decreased their ability to resist skin lesion morbidity,(2)impaired the immune organ s immune response by decreasing the gene expressions of mucin,liver-expressed antimicrobial peptide(LEAP)-2B,β-defensin-1 and LEAP-2A and the production of antibacterial compounds of grown-up grass carp,and(3)aggravated the inflammatory response of immune organs in the fish by increasing the gene expressions of pro-inflammatory cytokines(interferon y2[IFN-γ2],tumor necrosis factorα[TNF-α],interleukin[IL]-15,IL-17D,IL-12p40,IL-6 and IL-8)and down-regulating anti-inflammatory cytokines(IL-11,transforming growth factorβ1[TGF-β1],IL-10 and IL-4/13A),which were tightly correlated with signal transducer and activator of transcription(STAT)1 and STAT3 signaling pathway,*** different phenomenon in the skin,spleen and head kidney of fish may be correlated with the difference in gene *** addition,using quadratic regression analysis of percent weight gain(PWG),skin lesion morbidity,and the lysozyme activities in the spleen and head kidney,the dietary lysine requirements for grown-up grass carp were estimated to be 13.58,13.51,14.56 and 14.18 g/kg,respectively.

关键词： Lysine deficiency Grass carp(Ctenopharyngodon idella) Immune function Head kidney Spleen Skin

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Hierarchically nitrogen-doped mesoporous carbon nanospheres with dual ion adsorption capability for superior rate and ultra-stable zinc ion hybrid supercapacitors

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Science China Materials 2022年第9期65卷 2401-2411页

作者： Zhongyou Peng Junxi Guo Qichang He Shulong Li Licheng Tan Yiwang Chen College of Chemistry and Chemical Engineering/Institute of Polymers and Energy Chemistry(IPEC) Nanchang UniversityNanchang 330031China Institute of Advanced Scientific Research(iASR)/Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education Jiangxi Normal UniversityNanchang 330022China School of Future Technology Nanchang UniversityNanchang 330031China

Although significant progress has been achieved in developing high energy aqueous zinc ion hybrid supercapacitors(ZHSCs),the sluggish diffusion of zinc ion(Zn^(2+))and unsatisfactory cathodes still hinder their energy density and cycling life *** work demonstrates the use of nitrogen-doped mesoporous carbon nanospheres(NMCSs)with appropriately hierarchical pore distribution and enhanced zinc ion storage capability for efficient Zn^(2+)*** asprepared aqueous ZHSC delivers a significant specific capacity of 157.8 mA h g^(-1),a maximum energy density of 126.2 W h kg^(-1) at 0.2 A g^(-1),and an ultra-high power density of 39.9 kW kg^(-1) with a quick charge time of 5.5 ***,the ZHSC demonstrates an ultra-long cycling life span of 50,000 cycles with an exciting capacity retention of 96.2%.More interestingly,a new type of planar ZHSC is fabricated with outstanding low-temperature electrochemical performance,landmark volumetric energy density of 31.6 mW h cm^(-3),and excellent serial and parallel *** investigation verifies that the superior electrochemical capability is due to the synergistic effect of cation and anion adsorption,as well as the reversible chemical adsorption of *** work provides not only an innovative strategy to construct and develop novel high-performance ZHSCs,but also a deeper understanding of the electrochemical characteristics of ZHSCs.

关键词： mesoporous carbon nanospheres nitrogen doping dual ion adsorption anti-freezing electrolyte zinc ion hybrid supercapacitors

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High-definition colorful perovskite narrowband photodetector array enabled by laser-direct-writing

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Nano Research 2022年第6期15卷 5476-5482页

作者： Xiaobao Xu Yuhang Dong Yuanzhou Zhang Zeyao Han Jiaxin Liu Dejian Yu Yi Wei Yousheng Zou Bo Huang Jun Chen Haibo Zeng Key Laboratory of Advanced Display Materials and Devices Ministry of Industry and Information TechnologyInstitute of Optoelectronics&NanomaterialsCollege of Material Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China

Narrowband photodetectors as specific spectral sensing pixels have drawn intense attention in multispectral detection due to their distinct characteristic of filter-free spectrum discrimination,in which the emerging halide lead perovskites witness a booming development in their performance and wavelength-selectivity from blue to near-infrared ***,the challenge in integrating perovskite narrowband photodetectors on one chip imposes an impediment on practical *** this work,the combination of laser-direct-writing and ion exchange is proposed as an efficient way to fabricate high-definition colorful sensing array with perovskite narrowband photodetector unit as *** laser irradiation,the photolysis of halocarbon solvent(CHCl_(3),CH_(3)CH_(2)I,etc)releases the halide ions,which brings the ion exchange and gives rise to slow-varying bandgap in single perovskite photoactive *** ion exchange can be controlled via laser irradiation time and focus point,thus enabling precisely engineerable *** optimizing the process,it is successfully applied to develop patterned perovskite narrow blue and green photodetectors array with a high-definition of~53 *** believe this result will make a great step forward to integrate multifunctional perovskite devices on one chip,which will pave the way for perovskite optoelectronic device to the commercial application.

关键词： photodetector narrowband imaging array laser-direct-writing perovskite

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钴钒水滑石纳米片用于电催化尿素氧化（英文）

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物理化学学报 2023年第2期39卷 7-13页

作者：刘瑶钰王宇辰刘碧莹 Mahmoud Amer 严凯中山大学环境科学与工程学院 Mechanical Engineering Department Faculty of Engineering Alexandria University

电解水是一种常用的制氢方法,但高能耗的阳极析氧反应(OER)阻碍了其应用。尿素氧化反应(UOR)具有较低的热力学电势,是最有前景的OER替代反应之一。过渡金属基水滑石具有独特的层状结构和层间阴离子可交换等优点,被认为是性能优异的UOR... 详细信息

电解水是一种常用的制氢方法,但高能耗的阳极析氧反应(OER)阻碍了其应用。尿素氧化反应(UOR)具有较低的热力学电势,是最有前景的OER替代反应之一。过渡金属基水滑石具有独特的层状结构和层间阴离子可交换等优点,被认为是性能优异的UOR催化剂,然而目前大多数研究主要聚焦于后过渡金属元素。该研究通过一步法制备了具有前/后过渡金属的CoV-LDHs纳米片。与相同方法制备的Co(OH)2相比,CoV-LDHs纳米片具有以下优点:1)纳米片结构有利于暴露更多的活性位点。2) V的引入增强了CoV-LDHs的亲水性,提高了其本征电催化动力学。3) Co (3d74s2)和V(3d34s2)之间的d-电子补偿效应有利于促进尿素的吸附。因此,CoV-LDHs仅需要1.52V(***)就可以达到10mA·cm-2的电流密度,比Co(OH)2低了70 mV,同时CoV-LDHs较低的塔菲尔斜率表明了其较快的反应动力学。此外,CoV-LDHs在连续反应10 h后,驱动电位几乎没有增加,表明其具有良好的稳定性。该研究结果不仅证明了前/后过渡金属之间的d-电子补偿效应可以提高UOR催化性能,还为设计高效的UOR催化剂提供了可行的途径。

关键词：尿素氧化水滑石纳米片 d-电子补偿润湿性

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绿肥粉垄耦合对稻田耕层土壤团粒结构特征的影响

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南方农业学报 2020年第11期51卷 2653-2664页

作者：郑佳舜胡钧铭韦燕燕李婷婷苏世鸣韦翔华何铁光夏旭广西农业科学院农业资源与环境研究所南宁530007 广西大学农学院南宁530004 中国农业科学院农业环境与可持续发展研究所北京100081

[目的]研究稻田生态系统耕层优化对双季稻田耕层土壤团粒结构特征的影响,为探明和评估绿肥粉垄耦合土壤物理结构特征及稻田土壤逆境调控提供理论依据。[方法]2017—2018年在广西农业科学院试验田(南宁)开展为期4个稻季的定位试验,早稻... 详细信息

[目的]研究稻田生态系统耕层优化对双季稻田耕层土壤团粒结构特征的影响,为探明和评估绿肥粉垄耦合土壤物理结构特征及稻田土壤逆境调控提供理论依据。[方法]2017—2018年在广西农业科学院试验田(南宁)开展为期4个稻季的定位试验,早稻采用粉垄耕作(F)和常规耕作(C)2种方式,以不施肥(N)为对照,设置常规施用化肥(N0)、同等肥力条件下单倍绿肥配施化肥(N1)和双倍绿肥配施化肥(N2),共设8个处理(CN、CN0、CN1、CN2、FN、FN0、FN1、FN2),晚稻实行常规施用化肥免耕。采用粒度分析仪测定0~15、15~30和30~45 cm耕层黏粒、粉粒、砂粒的土壤粒径含量;采用湿筛法测定0~15 cm层土壤水稳性团聚体含量,计算土壤水稳性团聚体凝聚力的关键指标,即平均重量直径(MWD)和几何平均直径(GMD);采用电子显微镜扫描团聚体超微观形态结构;采用土壤紧实度仪测定不同耕层土壤紧实度。[结果]FN1处理提高了0~15和30~45 cm土壤黏粒含量,其中早稻分别增加0.75%和2.10%,晚稻分别增加0.67%和0.09%;FN2提高了除晚稻30~45 cm以外的其他耕层土壤粉粒含量。绿肥粉垄耦合能提高稻田土壤团聚体的凝聚效果。同一季稻田粉垄耕作土壤MWD和GWD均低于常规耕作,其中早稻和晚稻粉垄耕作土壤MWD较常规耕作分别降低0.19~0.96和0.47~0.72 mm,GMD较常规耕作分别降低0.36~1.52和0.79~1.15 mm。绿肥用量的增加有效提高了土壤MWD和GMD,其中FN1和FN2早稻处理下分别提高0.75和1.06 mm,晚稻分别提高0.21和0.31 mm。FN1处理提高土壤持水性和通气性,有效促进了土壤团聚体的形成。粉垄耕作下土壤微观结构呈孔隙多而偏小,空洞少而偏大的特征。晚稻FN1处理的土壤微团聚体和大团聚体含量最高,分别占8.60%和29.09%,免耕晚稻的土壤微团聚体和大团聚体含量较粉垄早稻有所提升,FN1处理增加了3.88%和1.34%,FN2处理增加了12.04%和9.01%。粉垄耕作下早、晚稻不同土层土壤紧实度均低于常规耕作,免耕晚稻的土壤紧实度高于免耕早稻。与常规耕作相比,FN1早稻土壤紧实度从土层自上而下分别降低8.90、22.73和55.15 kPa,晚稻分别降低1.20、28.84和53.93 kPa,FN2早稻分别降低5.80、25.37和66.00 kPa,晚稻分别降低6.80、36.97和50.33 kPa。[结论]绿肥还田对粉垄耕作稻田土壤微形态结构特征产生重要影响,绿肥粉垄耦合有助于集约化水稻抗逆栽培、实现减肥增效。

关键词：绿肥还田粉垄耕作稻田土壤土壤团聚体微观结构

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固定化离子液体高效催化废弃食用油合成生物柴油（英文）

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过程工程学报 2018年第S1期18卷 129-137页

作者：晏冬霞石春艳吕兴梅辛加余王公应中国科学院成都有机化学研究所催化与环境工程研究中心中国科学院过程工程研究所离子液体清洁过程北京市重点实验室中国科学院大学化工学院

采用溶胶-凝胶技术和浸渍法制备了固定化1-（4-丁基磺酸）-3-甲基咪唑硫酸氢盐（[（n-Bu-SO3H）MIm][HSO4]）离子液体（IL）,得到了一种适用于游离脂肪酸和甲醇酯化反应的不溶性IL催化体系,对合成的催化剂进行了表征,并对其活性进行了... 详细信息

采用溶胶-凝胶技术和浸渍法制备了固定化1-（4-丁基磺酸）-3-甲基咪唑硫酸氢盐（[（n-Bu-SO3H）MIm][HSO4]）离子液体（IL）,得到了一种适用于游离脂肪酸和甲醇酯化反应的不溶性IL催化体系,对合成的催化剂进行了表征,并对其活性进行了系统评价.结果表明,离子液体成功负载于载体上,该固定化Br?nsted性离子液体在油酸和甲醇酯化反应中具有非常好的催化活性,在最佳反应条件下,油酸的转化率高达98.4%.该催化剂用于催化高游离脂肪酸含量的废弃食用油酯化时,经后续碱催化酯交换反应,可获得收率高达94.7%的生物柴油.

关键词：生物柴油废弃食用油离子液体溶胶-凝胶技术浸渍法

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A strong Lewis acid imparts high ionic conductivity and interfacial stability to polymer composite electrolytes towards all-solid-state Li-metal batteries

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Science China Materials 2022年第8期65卷 2179-2188页

作者： Litong Wang Yunlei Zhong Zhaorui Wen Chaowei Li Jingxin Zhao Mingzheng Ge Pengfei Zhou Yanyan Zhang Yuxin Tang Guo Hong Institute of Applied Physics and Materials Engineering University of MacaoAvenida da UniversidadeTaipaMacao SAR 999078China College of Chemical Engineering Fuzhou UniversityFuzhou 350116China Department of Physics and Chemistry Faculty of Science and TechnologyUniversity of MacaoAvenida da UniversidadeTaipaMacao SAR 999078China School of Textile and Clothing Nantong UniversityNantong 226019China

The development of high-performance solid polymer electrolytes is crucial for producing all-solid-state lithium metal batteries with high safety and high energy ***,the low ionic conductivity of solid polymer electrolytes and their unstable electrolyte/electrode interfaces have hindered their widespread *** address these critical challenges,a strong Lewis acid(aluminum fluoride(AIF_(3)))with dual functionality is introduced into poly(ethylene oxide)(PEO)-based polymer *** AlF;facilitates the dissociation of lithium salt,increasing the iontransfer efficiency due to the Lewis acid-base interaction;further the in-situ formation of lithium fluoride-rich interfacial layer is promoted,which suppresses the uneven lithium deposition and continuous undesired reactions between the Li metal and PEO *** from our rational design,the symmetric Li/Li battery with the modified electrolyte exhibits much longer cycling stability(over 3600 h)than that of the pure PEO/lithium bis(trifluoromethanesulfonyl)imide(LiTFSI)electrolyte(550 h).Furthermore,the all-solid-state LiFeP04 full cell with the composite electrolyte displays a much higher Coulombic efficiency(98.4%after 150 cycles)than that of the electrolyte without the AlF;additive(63.3%after 150 cycles)at a large voltage window of 2.4-4.2 V,demonstrating the improved interface and cycling stability of solid polymer lithium metal batteries.

关键词： all-solid-state battery composite electrolyte interfaces Li-ion conductivity polyethylene oxide

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Ketogenic diet alleviates colitis by reduction of colonic group 3 innate lymphoid cells through altering gut microbiome

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Signal Transduction and Targeted Therapy 2021年第5期6卷 1573-1584页

作者： Cheng Kong Xuebing Yan Yongqiang Liu Linsheng Huang Yefei Zhu Jide He Renyuan Gao Matthew F.Kalady Ajay Goel Huanlong Qin Yanlei Ma Department of Gastrointestinal Surgery Shanghai Tenth People's HospitalTongji UniversityShanghaiChina Research Institute of Intestinal Diseases Tongji University School of MedicineShanghaiChina Department of Cancer Biology Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Oncology Affiliated Hospital of Yangzhou UniversityYangzhou UniversityYangzhouChina sDepartment of Coloreaal Surgery Digestive Disease and Surgery InstituteCleveland ClinicClevelandOHUSA Department of Molecular Diagnostics and Experimental Therapeutics Beckman Research Institute of City of Hope Comprehensive Cancer CenterDuarteCAUSA Department of Oncology Shanghai Medical CollegeFudan UniversityShanghaiChina Department of Colorectal Surgery Fudan University Shanghai Cancer CenterShanghaiChina

Accumulating evidence suggests that ketogenic diets(KDs)mediate the rise of circulating ketone bodies and exert a potential antiinflammatory effect;however,the consequences of this unique diet on colitis remain *** performed a series of systematic studies using a dextran sulfate sodium(DSS)animal model of inflammatory *** were fed with a KD,low-carbohydrate diet(LCD),or normal diet(ND).Germ-free mice were utilized in validation *** tissues were analyzed by transcriptome sequencing,RT2 profiler PCR array,histopathology,and *** samples were analyzed by metabolic assay *** samples were analyzed by 16S rRNA gene sequencing,liquid chromatography-mass spectrometry and gas chromatography-mass *** observed that KD alleviated colitis by altering the gut microbiota and metabolites in a manner distinct from *** diet experiments confirmed the unique impact of KD relative to LCD with a reproducible increase in Akkermansia,whereas the opposite was observed for Escherichia/*** colitis induction,the KD protected intestinal barrier function,and reduced the production of R0Ryt+CD3_group 3 innate lymphoid cells(ILC3s)and related inflammatory cytokines(IL-17a,IL-18,IL-22,Ccl4).Finally,fecal microbiota transplantation into germ-free mice revealed that the KD-mediated colitis inhibition and ILC3 regulation were dependent on the modification of gut *** together,our study presents a global view of microbiome-metabolomics changes that occur during KD colitis treatment,and identifies the regulation of gut microbiome and ILC3s as novel targets involving in IBD dietary therapy.

关键词： colitis lymphoid consequences

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Enhanced mechanical properties of lamellar Cu/Al composites processed via high-temperature accumulative roll bonding

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Transactions of Nonferrous Metals Society of China 2019年第8期29卷 1621-1630页

作者： Lin WANG Qing-lin DU Chang LI Xiao-hui CUI Xing ZHAO Hai-liang YU State Key Laboratory of High Performance Complex Manufacturing Central South University Changsha 410083 China College of Mechanical and Electrical Engineering Central South University Changsha 410083 China Light Alloys Research Institute Central South University Changsha 410083 China

Cu/Al multilayers were produced by high-temperature accumulative roll bonding(ARB)methods up to three *** achieve a high bonding strength,prior to ARB processing,the Cu and Al sheets were heated to 350,400,450 and 500 ℃,*** mechanical properties were evaluated by tensile *** microstructure was examined by optical microscopy and scanning electron microscopy equipped with energy dispersive *** ultimate tensile stress,the grain size and the thickness of diffusion layer of lamellar composites increase with rolling *** the rolling temperature is 400 ℃,the laminates show the highest ductility,but the yield stress is the *** the rolling temperature further increases,both the yield stress and the ultimate tensile stress increase and the ductility decreases *** mechanical properties of lamellar composites processed by low and high temperature ARB are determined by grain size and the thickness of diffusion layer,respectively.

关键词： diffusion layer Cu/Al multilayers accumulative roll bonding rolling temperature intermetallics mechanical properties

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