Motor neuron replacement therapy for amyotrophic lateral sclerosis

作     者：Bochao Liu Mo Li Lingyan Zhang Zhiguo Chen Paul Lu Bochao Liu;Mo Li;Lingyan Zhang;Zhiguo Chen;Paul Lu

作者机构：Cell Therapy CenterBeijing Institute of GeriatricsXuanwu HospitalCapital Medical UniversityNational Clinical Research Center for Geriatric Diseasesand Key Laboratory of Neurodegenerative DiseasesMinistry of EducationBeijingChina Center of Neural Injury and RepairBeijing Institute for Brain DisordersBeijingChina Center of Parkinson’s DiseaseBeijing Institute for Brain DisordersBeijingChina iXCells Biotechnologies USAInc.San DiegoCAUSA Amogene BiotechXiamenFujian ProvinceChina Veterans Administration San Diego Healthcare SystemSan DiegoCAUSA Department of NeurosciencesUniversity of California-San DiegoLa JollaCAUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第8期

页      面：1633-1639页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the Stem Cell and Translation National Key Project(No.2016YFA0101403,to ZC) the National Natural Science Foundation of China(Nos.81973351,81661130160,81422014,81561138004,all to ZC) the Beijing Municipal Natural Science Foundation(No.5142005,to ZC) Beijing Talents Foundation(No.2017000021223TD03,to ZC) the Support Project of High-level Teachers in Beijing Municipal Universities in the Period of 13th Five-Year Plan(No.CIT&TCD20180333,to ZC) the Beijing Medical System High Level Talent Award(No.2015-3-063,to ZC) Beijing Municipal Health Commission Fund(No.PXM2020_026283_000005) Beijing One Hundred,Thousand,and Ten Thousand Talents Fund(No.2018A03,to ZC) the Royal Society-Newton Advanced Fellowship(No.NA150482,to ZC) the USA Veterans Administration(No.I01 RX002264-01A2,to PL) 

主　　题：amyotrophic lateral sclerosis motor neuron replacement neural progenitor cells neural stem cells stem cells 

摘      要：Amyotrophic lateral sclerosis is a motor neuron degenerative disease that is also known as Lou Gehrig’s disease in the United States,Charcot’s disease in France,and motor neuron disease in the *** loss of motor neurons causes muscle wasting,paralysis,and eventually death,which is commonly related to respiratory failure,within 3-5 years after onset of the *** there are a limited number of drugs approved for amyotrophic lateral sclerosis,they have had little success at treating the associated symptoms,and they cannot reverse the course of motor neuron ***,there is still a lack of effective treatment for this debilitating neurodegenerative *** cell therapy for amyotrophic lateral sclerosis is a very attractive strategy for both basic and clinical researchers,particularly as transplanted stem cells and stem cell-derived neural progenitor/precursor cells can protect endogenous motor neurons and directly replace the lost or dying motor *** cell therapies may also be able to re-establish the motor control of voluntary ***,we review the recent progress in the use of neural stem cells and neural progenitor cells for the treatment of amyotrophic lateral *** focus on MN progenitor cells derived from fetal central nervous system tissue,embryonic stem cells,and induced pluripotent stem *** our recent studies,we found that transplanted human induced pluripotent stem cell-derived motor neuron progenitors survive well,differentiate into motor neurons,and extend axons into the host white matter,not only in the rostrocaudal direction,but also along motor axon tracts towards the ventral roots in the immunodeficient rat spinal ***,the significant motor axonal extension after neural progenitor cell transplantation in amyotrophic lateral sclerosis models demonstrates that motor neuron replacement therapy could be a promising therapeutic strategy for amyotrophic lateral sclerosis,particularly as a variety