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Vanadium-dependent activation of glucose transport in adipocytes by catecholamines is not mediated via adrenoceptor stimulation or monoamine oxidase activity

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World Journal of Diabetes 2020年第12期11卷 622-643页

作者： Jessica Fontaine Geneviève Tavernier Nathalie Morin Christian Carpéné Institut des Maladies Métaboliques et Cardiovasculaires Institut National de la Santéet de la Recherche MédicaleINSERM UMR1048UniversitéPaul Sabatier Toulouse IIIToulouse 31432France INSERM UMR 1139 Facultéde Pharmacie Universitéde ParisParis 75006France

BACKGROUND Benzylamine and methylamine activate glucose uptake in *** tyramine,this effect has even been extended to *** To investigate the effects of catecholamines and other amines on glucose *** A screening compared 25 biogenic amines on 2-deoxyglucose(2-DG)uptake activation in rat *** approaches and transgenic mouse models were then used to decipher the mode of action of several *** In rat adipocytes,insulin stimulation of 2-DG uptake was reproduced with catecholamines.100μmol/L or 1 mmol/L adrenaline,noradrenaline,dopamine and deoxyepinephrine,maximally activated hexose transport only when sodium orthovanadate was added at 100μmol/*** activation was similar to that already reported for benzylamine,methylamine and tyramine,well-recognized substrates of semicarbazide-sensitive amine oxidase(SSAO)and monoamine oxidase(MAO).Several,but not all,tested agonists ofβ-adrenoreceptors(β-ARs)also activated glucose transport whileα-AR agonists were *** of blockade byα-andβ-AR antagonists indicated that catecholamine-induced 2-DG uptake was not mediated by AR *** from mice lackingβ1-,β2-andβ3-ARs(triple KO)also responded to millimolar doses of adrenaline or noradrenaline by activating hexose transport in the presence of 100μmol/L *** MAO blocker pargyline,and SSAO inhibitors did not block the effects of adrenaline or noradrenaline plus vanadate,which were blunted by *** Catecholamines exert unexpected insulin-like actions in adipocytes when combined with *** limiting insulin resistance by activating glucose consumption at least in fat stores,we propose that catecholamine derivatives combined with vanadium can generate novel complexes that may have low toxicity and promising anti-diabetic properties.

关键词： Adipocyte Amine oxidases Insulin Diabetes Vanadium Obesity

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