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The link between intracellular calcium signaling and exosomal PD-L1 in cancer progression and immunotherapy

Genes & Diseases 2024年第1期11卷 321-334页

作者： Md Rakibul Alam Md Mizanur Rahman zhiguo li Department of Toxicology and Cancer Biology College of MedicineUniversity of KentuckyLexingtonKY 40506USA Department of Medicine(Nephrology) Faculty of Medicine and DentistryUniversity of AlbertaEdmontonAlberta T6E2H7Canada

Exosomes are small membrane vesicles containing microRNA,RNA,DNA fragments,and proteins that are transferred from donor cells to recipient *** cells release exo-somes to reprogram the factors associated with the tumor microenvironment(TME)causing tu-mor metastasis and immune *** evidence revealed that cancer cell-derived exosomes carry immune inhibitory molecule program death ligand 1(PD-L1)that binds with re-ceptor program death protein 1(PD-1)and promote tumor progression by escaping immune ***,some FDA-approved monoclonal antibodies are clinicallyused for cancer treatment by blocking PD-1/PD-L1 *** notable treatment outcomes,some pa-tients show poor drug *** PD-L1 plays a vital role in lowering the treatment response,showing resistance to PD-1/PD-L1 blockage therapy through recapitulating the ef-fect of cell surface *** enhance therapeutic response,inhibition of exosomal PD-L1 is *** signaling is the central regulator of tumorigenesis and can regulate exosome biogenesis and secretion by modulating Rab GTPase family and membrane fusion ***-mune checkpoints are also connected with calcium signaling and calcium channel blockers like amlodipine,nifedipine,lercanidipine,diltiazem,and verapamil were also reported to suppress cellular PD-L1 ***,to enhance the PD-1/PD-L1 blockage therapy response,the reduction of exosomal PD-L1 secretion from cancer cells is in our therapeutic *** this review,we proposed a therapeutic strategy by targeting calcium signaling to inhibit the expression of PD-L1-containing exosome levels that could reduce the anti-PD-1/PD-L1 therapy resistance and increase the patient's drug response rate.

关键词： Calcium signaling CD8^(+)T cells Exosomal PD-L1 Exosomes biogenesis Immunosuppression Immunotherapy

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Overexpression of Hdac6 enhances resistance to virus infection in embryonic stem cells and in mice

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Protein & Cell 2015年第2期6卷 152-156页

作者： Dekun Wang Qingwen Meng lihong Huo Meng Yang lingling Wang Xinyu Chen JianchaoWang zhiguo li Xiaoying Ye Na liu Qiuyan li Zhen Dai Hongsheng Ouyang Ning li Jun Zhou lingyi Chen lin liu State Key Laboratory of Medicinal Chemical Biology Collaborative Innovation Center for Bietherapy Department of Genetics and Cell Biology College of Life Sciences Nankai University Tianjin 300071. China State Key Laboratory of Veterinary Biotechnology Harbin Veter- inary Research Institute Chinese Academy of Agricultural Sci- ences Harbin 150001 China State Key Laboratory for Agrobiotechnology College of Biological Sciences China Agricultural University Beijing 100193 China College of Animal Science and Veterinary Medicine Jilin Univer- sity Changchun 130062 China

Dear Editor Histone deacetylase 6 （Hdac6） is a mostly cytoplasmic class II HDAC. Many proteins have been identified as substrates of Hdac6. Among them, the most well characterized sub- strate of Hdac6 is a-tubulin. Through deacetylating acety- lated lysine 40 in a-tubulin, Hdac6 modulates the acetylation of microtubules （Hubbert et al., 2002）.

关键词： Embryonic Stem Embryonic Stem Cell H5N1 Virus Oral Squamous Cell Carcinoma Avian H5N1 Influenza

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