Overexpression of Hdac6 enhances resistance to virus infection in embryonic stem cells and in mice

作     者：Dekun Wang Qingwen Meng Lihong Huo Meng Yang Lingling Wang Xinyu Chen JianchaoWang Zhiguo Li Xiaoying Ye Na Liu Qiuyan Li Zhen Dai Hongsheng Ouyang Ning Li Jun Zhou Lingyi Chen Lin Liu 

作者机构：State Key Laboratory of Medicinal Chemical Biology Collaborative Innovation Center for Bietherapy Department of Genetics and Cell Biology College of Life Sciences Nankai University Tianjin 300071. China State Key Laboratory of Veterinary Biotechnology Harbin Veter- inary Research Institute Chinese Academy of Agricultural Sci- ences Harbin 150001 China State Key Laboratory for Agrobiotechnology College of Biological Sciences China Agricultural University Beijing 100193 China College of Animal Science and Veterinary Medicine Jilin Univer- sity Changchun 130062 China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2015年第6卷第2期

页      面：152-156页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 090603[农学-临床兽医学] 1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 08[工学] 09[农学] 0906[农学-兽医学] 0703[理学-化学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 

基　　金：We thank Drs. Xiaohong Zhang  Zhonghua Liu  and Wentao Qiao for help and discussion. This work was supported by the Ministry of Agriculture of China Transgenic Special Program (2009ZX08006-010B  2009ZX08006-001B)  the National Basic Research Program (973 Program) (Nos. 2011CBA01002 and 2009CB941000)  the National Science and Technology Major Project of China (2012ZX10001-006)  and the Natural Science Foundation of Tianjin  China (No. 14JCYBJC23600). Dekun Wang  Qingwen Meng  Lihong Huo  Meng Yang  Lingling Wang  Xinyu Chen  Jianchao Wang  Zhiguo Li  Xiaoying Ye  Na Liu  Qiuyan Li  Zhen Dai  Hongsheng Ouyang  Ning Li  Jun Zhou  Lingyi Chen  and Lin Liu declare no conflict of interest. All institutional and national guidelines for the care and use of laboratory animals were followed 

主　　题：Embryonic Stem Embryonic Stem Cell H5N1 Virus Oral Squamous Cell Carcinoma Avian H5N1 Influenza 

摘      要：Dear Editor Histone deacetylase 6 （Hdac6） is a mostly cytoplasmic class II HDAC. Many proteins have been identified as substrates of Hdac6. Among them, the most well characterized sub- strate of Hdac6 is a-tubulin. Through deacetylating acety- lated lysine 40 in a-tubulin, Hdac6 modulates the acetylation of microtubules （Hubbert et al., 2002）.