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Journal of Materials Science & Technology 2023年第3期134卷 142-150页

作者： Yuan Wang Tao Zhang Jianfei Xiao Xiaobao Tian Shaojun Yuan Low-carbon Technology and Chemical Reaction Engineering Lab College of Chemical EngineeringSichuan UniversityChengdu 610065China College of Architecture and Environment Sichuan UniversityChengdu 610065China

Doping is a reasonable solution to improve the electronic structure and surface properties of ***,we propose a rapid and simple methodology,flame synthesis,as an effective preparation strategy for incorporating high-valence metal ions(Ti^(4+),Sn^(4+),and Zr^(4+))into ultrasmall Fe_(2)O_(3)on carbon nanotube support(i.e.,M-FeO-CNT).The resulting materials exhibit not only a boosted Na+adsorption as shown by density functional theory(DFT)calculations,but also display an increased oxygen *** electrochemical activity and charge transfer efficiency of Fe 2 O 3 can be improved by reasonably sub-stituting Fe 3+with Ti^(4+),Sn^(4+),and Zr^(4+).The electrochemical investigation of Ti-doped Fe 2 O 3(Ti-FeO-CNT)electrode demonstrates a splendid specific capacitance of 1.25 F cm^(−2)at 1 mA cm^(−2)in 1 M Na_(2)SO_(4).This is significantly higher as compared to the capacitance of 0.48 F cm^(−2).Flexible solid-state asymmetric su-percapacitor Ti-FeO-CNT//MnO_(2)is verified with operating voltage of 2.0 V and stability over 3000 cycles,and delivers a high energy density of 2.14 mWh cm^(−3)at power density of 25 mW cm−*** flame synthesis is expected to be widely applicable for the preparation of high-valence metal ions doped nanosized Fe_(2)O_(3)functionalized materials,thus opening up new avenues for energy and catalysis research.

关键词： Ultrasmall Fe_(2)O_(3)nanoparticles Doping Flame synthesis Flexible supercapacitor DFT calculations

Understanding the Percolation Effect in Triboelectric Nanogenerator with Conductive Intermediate Layer

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Research 2021年第1期2021卷 452-459页

作者： Binbin Zhang Guo Tian Da Xiong Tao Yang Fengjun Chun Shen Zhong Zhiming Lin Wen Li Weiqing Yang Key Laboratory of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China College of Electronic and Information Engineering Southwest UniversityChongqing 400715China

Introducing the conductive intermediate layer into a triboelectric nanogenerator(TENG)has been proved as an efficient way to enhance the surface charge density that is attributed to the enhancement of the dielectric ***,far too little attention has been paid to the companion percolation,another key element to affect the ***,the TENG with MXeneembedded polyvinylidene fluoride(PVDF)composite film is fabricated,and the dependence of the output capability on the MXene loading is investigated experimentally and ***,the surface charge density mainly depends on the dielectric permittivity at lower MXene loadings,and in contrast,the percolation becomes the degrading factor with the further increase of the conductive *** the balance between the dielectric and percolation properties,the surface charge density of the MXene-modified TENG obtained 350%enhancement compared to that with the pure *** work shed new light on understanding the dielectric and percolation effect in TENG,which renders a universal strategy for the high-performance triboelectronics.

关键词： MXene composite dielectric

Directing the osteoblastic and chondrocytic differentiations of mesenchymal stem cells:matrix *** media

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Regenerative Biomaterials 2017年第5期4卷 269-279页

作者： Jing He Jianglong Guo Bo Jiang Ruijuan Yao Yao Wu Fang Wu National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064P.R.China

While both induction culture media and matrix have been reported to regulate the stem cell fate,little is known about which factor plays a more decisive role in directing the MSC differentiation lineage as well as the underlying *** this aim,we seeded MSCs on HA-collagen and HA-synthetic hydrogel matrixes,which had demonstrated highly different potentials toward osteoblastic and chondrocytic differentiation lineages,respectively,and cultured them with osteogenic,chondrogenic and normal culture media,respectively.A systematic comparison has been carried out on the effects of induction media and matrix on MSC adhesion,cytoskeleton organization,proliferation,and in particular differentiation into the osteoblastic and chondrocytic *** results demonstrated that the matrix selection had a much more profound effect on directing the differentiation lineage than the induction media *** strong modulation effect on the transcription activities might be the critical factor contributing to the above observations in our study,where canonical Wnt-b-Catenin signal pathway was directly involved in the matrix-driven osteoblastic *** findings not only provide a critical insight on natural cellular events leading to the osteoblastic and chondrocytic differentiations,but also have important implications in biomaterial design for tissue engineering applications.

关键词： osteoblastic differentiation chondrocytic differentiation induction media matrix

Investigation of pore structure alteration and permeability enhancement of shale matrix by supercritical water treatment after hydraulic fracturing

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Petroleum 2024年第2期10卷 265-274页

作者： Yili Kang Peisong Li Wangkun Cao Mingjun Chen Lijun You Jiang Liu Zhehan Lai State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500China Institute of Engineering Technology Petro China Coalbed Methane Company LimitedXi'an710082China Chemical and Petroleum Engineering University of CalgaryCalgaryT2N 1N4Canada

Shale gas reservoirs are unconventional tight gas reservoirs,in which horizontal wells and hydraulic fracturing are required to achieve commercial *** fracture networks created by hydraulic fracturing can increase the drainage area extensively to enhance shale gas ***,large volumes of fracturing fluid that is difficult to flow back to the surface and remained in the shale formation,will inevitably lead to damages of the shale formations and limit the effectiveness of *** water(SCW)treatment after hydraulic fracturing is a new method to enhance shale gas recovery by using appropriate heat treatment methods to the specific formation to convert the retained fracturing fluid into a supercritical state(at temperatures in excess of 373.946°C and pressures in excess of 22.064 MPa).An experiment was conducted to simulate the reaction between shale and SCW,and the capacity of SCW treatment to enhance the permeability of the shale was evaluated by measuring the response of the shale porosity and permeability on SCW *** experimental results show that the shale porosity and permeability increase by 213.43%and 2198.37%,*** pore structure alteration and permeability enhancement of the shale matrix were determined by analyzing the changes in pore structure and mineral composition after SCW *** mechanisms that affect pore structure and mineral composition include oxidative catalysis decomposition of organic matters and reducing minerals,acid-catalyzed decomposition of carbonate minerals and feldspar minerals,hydrothermal catalysis induced fracture extension and cementation weakening induced fracture *** treatment converts harm into a benefit by reducing the intrusion of harmful substances into the shale formation,which will broaden the scope and scale of shale formation stimulation.

关键词： Shale gas Formation damage control Formation heat treatment Supercritical water

Control of MSC Differentiation by Tuning the Alkyl Chain Length of Phe- nylboroinc Acid Based Low-molecular-weight Gelators

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Journal of Bionic Engineering 2018年第4期15卷 682-692页

作者： Jing He Yalong Hu Fang Wu Bin He Wenxia Gao National Engineering Research Centre for Biomaterials Sichuan University Chengdu 610064 China College of Chemistry and Materials Engineering Wenzhou University Wenzhou 325027 China

The physical environment plays a critical role in modulating stem cell differentiation into specific lineages. In this study, we designed and synthesized a series of low-molecular-weight gels （LMWGs） with different moduli based on phenylboronic acid derivatives. The moduli of the LMWGs were readily tuned by varying the alkyl chain without any chemical crosslinker. The cell responses to the gels were evaluated with mesenchymal stem cell （MSCs）, in respect of cell morphology, proliferation and differentiation. The prepared gels were non-toxic to MSCs, suggesting good biocompatibility. The hydrogel stiffness exerted a striking modulation effect on MSC fate decisions, where MSCs were inclined to differentiate into osteoblasts in stiff LMWGs and into chondrocytes in soft LMWGs. The pivotal elastic modulus of the LMWGs to drive MSC differentiation into osteoblastic lineage and chondrocytic lineage were approximately 20 kPa - 40 kPa and 1 kPa - 10 kPa, respectively. Overall, our results demonstrated that the modification ofhydrogel stiffness via tuning the alkyl chain was a simple but effective approach to regulate MSC differentiation into specific lineage, which might have important implications in the design of LMWGs for tissue engineering applications.

关键词： low-molecular-weight gels phenylboronic acid alkyl chain mesenchymal stem cell osteoblast differentiation chondrocytic differentiation

Design, synthesis and SAR study of novel sulfonylurea derivatives containing arylpyrimidine moieties as potential anti-phytopathogenic fungal agents

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Chinese Chemical Letters 2019年第12期30卷 2160-2162页

作者： Wei Chen Yuxin Li Yunyun Zhou Yi Ma Zhengming Li School of Life Science and Engineering Southwest Jiaotong UniversityChengdu 610031China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200433China

Acetohydroxyacid synthase(AHAS) was considered as a promising target for antifungal ***,three series of novel sulfonylureas(SUs) 9-11 containing aromatic-substituted pyrimidines were designed and synthesized according to pharmacophore-combination and bioisosterism *** in vitro fungicidal activities against ten phytopathogenic fungi indicated that most of the title compounds exhibited broad-spectrum and excellent fungicidal *** on the preliminary fungicidal activities,a CoMFA model was constructed and the 3 D-QSAR analysis indicated that either a bulky group around the 5-position of the pyrimidine ring or electropositive group around the 2-position of the benzene ring would be favour to fungicidal *** order to study interaction mechanism,10 k was automatically docked into yeast AHAS and it further indicated that bearing bulky groups-aryl at the pyrimidine ring was critical to enhance antifungal *** revealed that the antifungal activity of derivatives 9-11 probably results from the inhibition of fungal ***,the present results strongly showed that SUs should be considered as lead compounds or model molecules to develop novel antiphyt o pathogenic fungal agents.

关键词： Sulfonylurea Phytopathogenic fungi Antifungal activity Substituted pyrimidine 3D-QASR

Role of exosomes in the pathogenesis of inflammation in Parkinson’s disease

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Neural Regeneration Research 2022年第9期17卷 1898-1906页

作者： Ke-Lu Li Hong-Yan Huang Hui Ren Xing-Long Yang Department of Geriatric Neurology First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan ProvinceChina Department of Neurology West China HospitalSichuan UniversityChengduSichuan ProvinceChina

Inflammatory responses,including glial cell activation and peripheral immune cell infiltration,are involved in the pathogenesis of Parkinson’s disease(PD).These inflammatory responses appear to be closely related to the release of extracellular vesicles,such as ***,the relationships among different forms of glial cell activation,synuclein dysregulation,mitochondrial dysfunction,and exosomes are *** review discusses the multiple roles played by exosomes in PD-associated inflammation and concludes that exosomes can transport toxicα-synuclein oligomers to immature neurons and into the extracellular environment,inducing the oligomerization ofα-synuclein in normal ***α-synuclein causes microglia and astrocytes to activate and secrete *** cell-derived exosomes participate in communications between glial cells and neurons,triggering anti-stress and anti-inflammatory responses,in addition to axon *** production and release of mitochondrial vesicles and exosomes establish a new mechanism for linking mitochondrial dysfunction to systemic inflammation associated with *** the relevance of exosomes as mediators of neuron-glia communication in neuroinflammation and neuropathogenesis,new targeted treatment strategies are currently being developed that use these types of extracellular vesicles as drug ***-mediated inflammation may be a promising target for intervention in PD patients.

关键词： astrocytes exosomes inflammation microglia mitochondria neurodegeneration neuroglia neuron-glia communication Parkinson’s disease synucleins

Resisting Protein but Promoting Cell Adhesion by Choline Phosphate:A Comparative Study with Phosphorylcholine

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Journal of Bioresources and Bioproducts 2018年第1期3卷 3-8页

作者： Fuhui Huang Chunmei Ding Jianshu Li College of Polymer Science and Engineering Sichuan UniversityChengdu610065China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu610065China.

Zwitterionic materials are now widely used to fabricate various functionalized surfaces for biomedical applications due to their excellent non-fouling ***,a newly-discovered zwitterionic material,choline phosphate(CP),was reported to be cell-adhesive,which makes it different from traditional non-fouling zwitterionic materials such as sulfobetaine,carboxybetaine and phosphorylcholine(PC).To further investigate the properties of CP,a comparative study was conducted and the widely-reported zwitterionic PC was employed as a control which has the same chemical component but opposite orientation of charged groups with *** this purpose,CP and PC-functionalized surfaces were prepared by surface-initiated atom transfer radical polymerization(Si-ATRP),and their non-fouling properties were probed by protein adsorption and eukaryotic cell adhesion *** showed that CP-functionalized surfaces exhibited almost equivalent amounts of adsorbed proteins to that of PC,but they were more beneficial to cells initial adhesion and further spreading in serum-free medium,indicating that CP had a promising prospect of application in tissue engineering.

关键词： Zwitterionic Choline phosphate Phosphorylcholine ATRP Non-fouling properties

Linked brain connectivity patterns with psychopathological and cognitive phenotypes in drug-naive first-episode schizophrenia

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Psychoradiology 2022年第2期2卷 43-53页

作者： Hui Sun Wenjing Zhang Hengyi Cao Huaiqiang Sun Jing Dai Siyi Li Jiaxin Zeng XiaWei Biqiu Tang Qiyong Gong Su Lui Huaxi MR Research Center(HMRRC) Department of RadiologyWest China Hospital of Sichuan University610041 ChengduChina Center for Psychiatric Neuroscience Feinstein Institute for Medical Research11030 ManhassetNYUSA Division of Psychiatry Research Zucker Hillside Hospital11004 Glen OaksNYUSA Department of Psychoradiology Chengdu Mental Health Center610031 ChengduChina

Background Schizophrenia is considered to be a disorder of dysconnectivity characterized by abnormal functional integration between distinct brain *** brain connection abnormalities were found to be correlated with various clinical manifestations,but whether a common deficit in functional connectivity(FC)in relation to both clinical symptoms and cognitive impairments could present in first-episode patients who have never received any medication remains *** To find a core deficit in the brain connectome that is related to both psychopathological and cognitive *** A total of 75 patients with first-episode schizophrenia and 51 healthy control participants underwent scanning of the brain and clinical ratings of behaviors.A principal component analysis was performed on the clinical ratings of symptom and *** correlation analyses were conducted between the main psychopathological components and resting-state FC that were found abnormal in schizophrenia *** Using the principal component analysis,the first principal component(PC1)explained 37%of the total variance of seven clinical *** ratings of GAF and BACS contributed negatively to PC1,while those of PANSS,HAMD,and HAMA contributed *** FCs positively correlated with PC1 mainly included connections related to the insula,precuneus gyrus,and some frontal brain *** negatively correlated with PC1 mainly included connections between the left middle cingulate cortex and superior and middle occipital *** In conclusion,we found a linked pattern of FC associated with both psychopathological and cognitive manifestations in drug-na¨ıve first-episode schizophrenia characterized as the dysconnection related to the frontal and visual cortex,which may represent a core deficit of brain FC in patients with schizophrenia.

关键词： schizophrenia untreated functional connectome principal correlation analysis psychopathology

On 3D face reconstruction via cascaded regression in shape space

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Frontiers of Information Technology & Electronic Engineering 2017年第12期18卷 1978-1990页

作者： Feng LIU Dan ZENG Jing LI Qi-jun ZHAO College of Computer Science Sichuan University Chengdu 610065 China

Cascaded regression has been recently applied to reconstruct 3D faces from single 2D images directly in shape space, and has achieved state-of-the-art performance. We investigate thoroughly such cascaded regression based 3D face reconstruction approaches from four perspectives that are not well been studied：（1） the impact of the number of 2D landmarks; （2） the impact of the number of 3D vertices; （3） the way of using standalone automated landmark detection methods; （4） the convergence property. To answer these questions, a simplified cascaded regression based 3D face reconstruction method is devised. This can be integrated with standalone automated landmark detection methods and reconstruct 3D face shapes that have the same pose and expression as the input face images, rather than normalized pose and expression. An effective training method is also proposed by disturbing the automatically detected landmarks. Comprehensive evaluation experiments have been carried out to compare to other 3D face reconstruction methods. The results not only deepen the understanding of cascaded regression based 3D face reconstruction approaches, but also prove the effectiveness of the proposed method.

关键词： 3D face reconstruction Cascaded regressor Shape space Real-time