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The role of nitric oxide in the dorsomedial periaqueductal gray(dmPAG)column in cardiovascular responses in urethane-anesthetized male rats

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Animal Models and Experimental Medicine 2022年第6期5卷 557-564页

作者： Mohammad Najaftomaraei Atiyeh Ghorbani Alireza Rahimi Reza Mohebbati Sogol Sherkat Mohammad Naser Shafei Department of Physiology Faculty of MedicineMashhad University of Medical SciencesMashhadIran Material Science and Metallurgy Engineering Islamic Azad University-Karaj BranchKarajIran Department of Physiology Faculty of MedicineGonabad University of Medical SciencesGonabadIran Applied Biomedical Research Center Mashhad University of Medical SciencesMashhadIran Department of Physiology School of MedicineSabzevar University of Medical SciencesSabzevarIran Division of Neurocognitive Sciences Psychiatry and Behavioral Sciences Research CenterMashhad University of Medical SciencesMashhadIran

Background:The dorsomedial periaqueductal gray(dmPAG)is a mesencephalic area and has numerous functions including cardiovascular *** nitric oxide(NO)is present in the dmPAG,here we investigate,the probable cardiovascular effect of NO in the ***:Five groups(n=6 for each group)were used as follows:(1)control;(2)L-NAME(N^(G)-nitro-L-arginine methyl ester,a NO synthase inhibitor,90 nmol);(3)Larginine(L-Arg,a precursor for NO,60 nmol);(4)Sodium nitroprusside(SNP,a NO donor,27 nmol);and(5)L-Arg+*** cardiovascular parameters were recorded by a Power Lab device after cannulation of the femoral *** were injected using a stereotaxic *** changes(Δ)in systolic blood pressure(SBP),mean arterial pressure(MAP),and heart rate(HR)were calculated at different times and compared to the control ***:Microinjection of L-NAME significantly increased ΔSBP,ΔMAP,and ΔHR more than saline(from p<0.05 to p<0.001).L-Arg only significantly increased ΔHR(p<0.05).In the L-Arg+L-NAME group,the above parameters also significantly increased(from p<0.01 to p<0.05)but not as significantly as with L-NAME *** of SNP significantly decreased ΔSBP and ΔMAP more than in the control and L-NAME groups(from p<0.01 to p<0.001),but ΔHR did not change ***:The results indicated that NO in dmPAG has an inhibitory effect on cardiovascular responses in anesthetized rats.

关键词： blood pressure dorsomedial periaqueductal gray L-arginine L-NAME nitric oxide

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Can Social Media be Used to Control Academic Stress?An Application of the Theory of Planned Behavior

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International Journal of Mental Health Promotion 2022年第1期24卷 25-38页

作者： Maliheh Shadi Nooshin Peyman Ali Taghipour Alireza Jafari Hadi Tehrani Department of Health Education&Health Promotion School of HealthStudent Research CommitteeMashhad University of Medical SciencesMashhad13131-99137Iran Health Education&Health Promotion Social Determinants of Health Research CenterMashhad University of Medical SciencesMashhad13131-99137Iran Epidemiology Social Determinants of Health Research CenterMashhad University of Medical SciencesMashhad13131-99137Iran Social Determinants of Health Research Center Gonabad University of Medical SciencesGonabadIran

The present study was conducted aiming at investigating the effect of social media-based intervention according to the Theory of Planned Behavior(TPB)to control the academic stress of the *** study comes in two descriptive and quasi-experimental sections in the Academic Year *** order to determine the effect of planned behavioral constructs on stress levels,the descriptive study was conducted on 320 *** quasiexperimental study was organized to determine the effect of a social media-based educational intervention on the TPB on 180 *** collection was conducted through questionnaires of personal information,Gadzella’s Student-Life Stress Inventory,and researcher-made questionnaire based on the TPB,with a confirmed validity and *** predicted 15.1%of the variance of academic stress among students and the perceived behavioral control construct had the most significant effect(p<0.001).The mean score of knowledge and subject norms in the experimental group was significantly increased during the study(p<0.05).The social media intervention could reduce the students’academic stress to some extent and lead to the student’s subject norms development.

关键词： Academic stress social media students

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Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model

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World Journal of Gastrointestinal Oncology 2022年第1期14卷 242-252页

作者： Fereshteh Asgharzadeh Alex Tarnava Asma Mostafapour Majid Khazaei Tyler W LeBaron Department of Physiology Faculty of MedicineMashhad University of Medical SciencesMashhad ***Iran Drink HRW New WestminsterBC V3j0b6 Canada Department of Medical Genetics and Molecular Medicine Faculty of MedicineMashhad University of Medical SciencesMashhad ***Iran Centre of Experimental Medicine Institute for Heart Research Slovak Academy of SciencesBratislava 984104Slovakia Department of Kinesiology and Outdoor Recreation Southern Utah UniversityUT 84720United States Biological Research Molecular Hydrogen InstituteUT 84721United States Department of Physical Science Southern Utah UniversityUT 84720United States

BACKGROUND Colorectal cancer(CRC)is the third leading cause of cancer-related deaths in the *** removal remains the preferred frontline treatment;however,effective non-surgical interventions remain a high priority.5-fluorouracil(5-FU)is a widely used chemotherapy agent,and molecular hydrogen(H2)has been recognized for its antioxidant and anti-inflammatory effects,with research also suggesting its potential anti-tumor ***,H2 dissolved in water[hydrogen-rich water(HRW)],with or without 5-FU,may present itself as a novel therapeutic for *** To investigate the effects of HRW,with or without 5-FU,as a novel therapeutic for *** CRC was induced in the left flank of inbred Balb/c mice.A total of 24 mice bearing tumors were randomly divided into four groups(n=6 per group)and treated as follows:(1)Control group;(2)5-FU group that received intraperitoneal injection of 5-FU(5 mg/kg)every other day;(3)H2 group that received HRW,created and delivered via dissolving the H2-generating tablet in the animals’drinking water,with 200μL also delivered by oral gavage;and(4)The combination group,H2(administered in same way as for group three)combined with 5-FU administered same way as group *** Administration of HRW+5-FU significantly improved tumor weight,tumor size,collagen content and fibrosis as compared to the CRC control ***,HRW attenuated oxidative stress(OS)and potentiated antioxidant activity(AA),whereas 5-FU treatment exacerbated OS and blunted *** combination of HRW+5-FU significantly reduced tumor weight and size,as well as reduced collagen deposition and the degree of fibrosis,while further increasing OS and decreasing AA compared to administration of 5-FU *** Administration of HRW,with or without 5-FU,may serve as a therapeutic for treating CRC.

关键词： Colorectal cancer Molecular hydrogen 5-fluorouracil Oxidative stress Antioxidants Inflammation

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ARIMA models forecasting the SARS-COV-2 in the Islamic Republic of Iran

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Asian Pacific Journal of Tropical Medicine 2020年第11期13卷 521-524页

作者： Nayereh Esmaeilzadeh Mohammadtaghi Shakeri Mostafa Esmaeilzadeh Vahid Rahmanian Department of Epidemiology School of HealthMashhad University of Medical SciencesMashhadIran Department of Biostatistics School of HealthMashhad University of Medical SciencesMashhadIran Department of Mechanical Engineering Mashhad BranchAzad UniversityMashhadIran Zoonoses Research Center Jahrom University of Medical SciencesJahromIran

Currently,the COVID-19 epidemic has spread to more than 210 countries,with 3272202 confirmed cases and 230104 deaths globally as of 3rd May *** is found as the hotspot region of COVID-19 in the Eastern Mediterranean w... 详细信息

关键词： forecasting globally Eastern

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Excess mortality in Northeast Iran caused by COVID-19:Neglect of offset community transformations of health

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Asian Pacific Journal of Tropical Medicine 2023年第6期16卷 261-267页

作者： Nayereh Esmaeilzadeh Seyed Javad Hoseini Majid Jafari Nejad-Bajestani Mohammadtaghi Shakeri Zahra Izadi Mood Hamidreza Hoseinzadeh Mohammad Hasan Derakhshan Dooghaee Department of Epidemiology School of HealthMashhad University of Medical SciencesMashhadIran Department of Medical Biotechnology and Nanotechnology Faculty of MedicineMashhad University of Medical SciencesMashhadIran Department of Persian Medicine School of Persian and Complementary MedicineMashhad University of Medical SciencesMashhadIran Department of Biostatistics School of HealthMashhad University of Medical SciencesMashhadIran Health Deputy Mashhad University of Medical SciencesMashhadIran

Objective:To make evidence-based decisions based on broad mortality trends for Razavi Khorasan province,***:In order to determine the baseline number of deaths,we used univariate time series analyses for monthly data from the monthly vital statistics reports(From April 2015 to March 2022).For excess mortalities,these baselines were subtracted from reported deaths with a 95%prediction *** compare time and causes,a P-score was ***:From March 2020 to March 2022,there were 61949 registered deaths,and the estimated deaths with a 95%confidence interval(CI)were 43246.16(35718.28,50774.05).So,in 2020-2021 and 2021-2022,the death counts were 35.15%and 51.33%higher than projected.A total of 18666 cardiovascular diseases were reported and a total of 15704.46(12006.95,19401.96)was *** P-score for this duration was 14.49%and 23.23%higher than *** and parasitic diseases plus COVID-19 were 16633 and estimated to be 1044.87(456.77,1632.96).A total of 4420 diseases of the respiratory system were reported,and 4564.94 deaths were predicted(2277.43,6852.43).In the first year of the pandemic,the P-score dropped to-35.28%and in the second year,it jumped sharply to 22.38%.Conclusions:Excess mortality,along with cause-specific mortality,can be helpful for monitoring trends and developing public health policies at the local,national,and international levels.

关键词： Mortality COVID-19 Health Systems Plans Prediction Cardiovascular deaths

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Chinese Journal of Traumatology 2021年第2期24卷 115-119页

作者： Khalil Kimiafar Maryam Farrokhi Fereshte Manouchehri Monazah Majid Khadem-Rezaiyan Masoumeh Sarbaz Department of Medical Records and Health Information Technology School of Paramedical SciencesMashhad University of Medical SciencesMashhadIran Department of Medical Informatics Faculty of MedicineMashhad University of Medical SciencesMashhadIran Department of Community Medicine and Public Health School of MedicineMashhad University of Medical SciencesMashhadIran

Purpose:Trauma has been called the neglected disease of modern *** to WHO,fall is the second major cause of trauma or deaths resulting from unintentional *** aim of this study was to investigate the different types of fall according to International Statistical Classification of Diseases and Related Health Problems 10th Revision(ICD-10)in hospitalized patients visiting specialized accident and trauma hospitals of Mashhad,***:This was a cross sectional retrospective study performed between March 20,2013 and March 20,*** research population consisted of all medical records of patients for fall injuries in three specialized accident and trauma ***-10 was adopted to categorize all types of falls(w00-w19).The results obtained were analyzed by SPSS ***:Altogether 7,448 cases were *** codes w18(fall on same level)and w09(fall involving playground equipment)with the frequencies of 1,856 and 1,303,respectively in both genders had the maximum number of *** maximum percentage of mortality has been related to“fall on and from ladder”,“fall from cliff”and“fall on same level involving ice and snow”.Conclusion:As falls can cause irrecoverable injuries including mortality of people,thus health authorities and policymakers should take preventive measures given the causes of falls and the root of this type of injuries,so that the costs resulting from this cause and its injuries can be reduced.

关键词： Inpatient Fall Trauma

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Zataria multiflora and its constituent,carvacrol,counteract sepsis-induced aortic and cardiac toxicity in rat:Involvement of nitric oxide and oxidative stress

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Animal Models and Experimental Medicine 2023年第3期6卷 221-229页

作者： Mahmoud Hosseini Zohreh Arab Farimah Beheshti Akbar Anaeigoudari Farzaneh Shakeri Arezoo Rajabian Psychiatry and Behavioral Sciences Research Center Mashhad University of Medical SciencesMashhadIran Applied Biomedical Research Center Mashhad University of Medical SciencesMashhadIran Neuroscience Research Center Torbat Heydariyeh University of Medical SciencesTorbat HeydariyehIran Department of Physiology School of Paramedical SciencesTorbat Heydariyeh University of Medical SciencesTorbat HeydariyehIran Department of Physiology School of MedicineJiroft University of Medical SciencesJiroftIran Natural Products and Medicinal Plants Research Center North Khorasan University of Medical SciencesBojnurdIran Department of Physiology and Pharmacology School of MedicineNorth Khorasan University of Medical SciencesBojnurdIran Department of Internal Medicine Faculty of MedicineMashhad University of Medical SciencesMashhadIran

Background:Zataria multiflora and carvacrol showed various pharmacological prop-erties including anti-inflammatory and anti-oxidant ***,up to now no studies have explored its potential benefits in ameliorating sepsis-induced aortic and cardiac ***,this study aimed to investigate the effects of *** and carvacrol on nitric oxide(NO)and oxidative stress indicators in lipopolysaccharide(LPS)-induced aortic and cardiac ***:Adult male Wistar rats were assigned to:Control,lipopolysaccharide(LPS)(1 mg/kg,intraperitoneal(i.p.)),and *** hydro-ethanolic extract(ZME,50–200 mg/kg,oral)-and carvacrol(25–100 mg/kg,oral)-treated *** was in-jected daily for 14 *** with ZME and carvacrol started 3 days before LPS administration and treatment continued during LPS *** the end of the study,the levels of malondialdehyde(MDA),NO,thiols,and antioxidant enzymes were ***:Our findings showed a significant reduction in the levels of superoxide dis-mutase(SOD),catalase(CAT),and thiols in the LPS group,which were restored by ZME and ***,ZME and carvacrol decreased MDA and NO in car-diac and aortic tissues of LPS-injected ***:The results suggest protective effects of ZME and carvacrol on LPS-induced cardiovascular injury via improved redox hemostasis and attenuated NO ***,additional studies are needed to elucidate the effects of ZME and its constituents on inflammatory responses mediated by LPS.

关键词： carvacrol lipopolysaccharide nitric oxide oxidative injury sepsis Z.multiflora

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High-risk spatiotemporal patterns of cutaneous leishmaniasis:a nationwide study in Iran from 2011 to 2020

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Infectious Diseases of Poverty 2023年第3期12卷 93-93页

作者： Neda Firouraghi Robert Bergquist Munazza Fatima Alireza Mohammadi Davidson H.Hamer Mohammad Reza Shirzadi Behzad Kiani Department of Medical Informatics School of MedicineMashhad University of Medical SciencesMashhadIran Ingerod BrastadSweden Formerly with the UNICEF/UNDP/World Bank/WHO Special Program for Research and Training in Tropical Diseases World Health OrganizationGenevaSwitzerland Department of Geography The Islamia University of BahawalpurBahawalpurPunjabPakistan Department of Geography and Urban Planning Faculty of Social SciencesUniversity of Mohaghegh ArdabiliArdabilIran Department of Global Health Boston University School of Public HealthBostonMAUSA Section of Infectious Diseases Department of MedicineBoston University School of MedicineBostonMAUSA Center for Disease Control and Prevention(CDC) Iran Ministry of Health&Medical EducationTehranIran Centre de Recherche en SantéPublique Universitéde Montréal7101Avenue du ParcMontréalCanada

Background Cutaneous leishmaniasis(CL)is a wide-reaching infection of major public health *** is one of the six most endemic countries in the *** study aims to provide a spatiotemporal visualization of CL cases in Iran at the county level from 2011 to 2020,detecting high-risk zones,while also noting the movement of high-risk *** On the basis of clinical observations and parasitological tests,data of 154,378 diagnosed patients were obtained from the Iran Ministry of Health and Medical *** spatial scan statistics,we investigated the disease’s purely temporal,purely spatial,spatial variation in temporal trends and spatiotemporal *** P=0.05 level,the null hypothesis was rejected in every *** In general,the number of new CL cases decreased over the course of the 9-year research *** 2011 to 2020,a regular seasonal pattern,with peaks in the fall and troughs in the spring,was *** period of September–February of 2014–2015 was found to hold the highest risk in terms of CL incidence rate in the whole country[relative risk(RR)=2.24,P<0.001)].In terms of location,six signifcant high-risk CL clusters covering 40.6%of the total area of the country were observed,with the RR ranging from 1.87 to *** addition,spatial variation in the temporal trend analysis found 11 clusters as potential high-risk areas that highlighted certain regions with an increasing ***,fve space-time clusters were *** geographical displacement and spread of the disease followed a moving pattern over the 9-year study period afecting many regions of the *** Our study has revealed signifcant regional,temporal,and spatiotemporal patterns of CL distribution in *** the years,there have been multiple shifts in spatiotemporal clusters,encompassing many diferent parts of the country from 2011 to *** results reveal the formation of clusters across counties that cover certain parts of provinces

关键词： Cutaneous leishmaniasis Spatial epidemiology Geographical Information Systems Spatiotemporal analysis SaTScan Spatial scan statistics Neglected tropical diseases Spatiotemporal clustering Iran

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