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Journal of Earth Science 2013年第3期24卷 410-427页

作者： Constantin Athanassas Ioannis Fountoulis Laboratory of Archaeometry Institute of Materials Science N.C.S.R.'Demokritos' Department of Dynamic Tectonic and Applied Geology Faculty of Geology and Geoenvironment National and Kapodistrian University of Athens

This project studies marine terraces in western Messenia, southwestern Peloponnese, greece, to propose a model of neotectonic configuration and paleogeographic evolution of western Messenia during the Quaternary. GIS analysis of topographic data and geological mapping revealed flanks of raised terraces created on Quaternary marine deposits. Luminescence ages of sediments from the three westernmost marine terraces tend to be consistent OIS-5, OIS-7 and OIS-9, respectively, thus agreeing with the three latest warm stages of the Pleistocene. Moreover, the type and the extent of deformation of the dated marine terraces allowed us to reflect on the neotectonic configuration of western Messenia as well as to conclude that progressive differential uplift over the last 300 ka has induced a dome-like structure to the upper crust of western Messenia.

关键词： Quaternary Southwest greece neotectonics sea-level change marine terrace lumines- cence dating tectonic uplift.

Bimatoprost/timolol fixed combination(BTFC) in patients with primary open angle glaucoma or ocular hypertension in greece

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International Journal of Ophthalmology(English edition) 2016年第1期9卷 69-75页

作者： Tryfon G.Rotsos Vasso G.Kliafa Kevin J.Asher Dimitrios Papaconstantinou 1st Department of Ophthalmology University of Athens Department of Regulatory Affairs Nexus Medicals S.A. Department of Regional Scientific Services Allergan Holdings Limited

AIM：To evaluate the efficacy and tolerability of the fixed combination of bimatoprost 0.03%and timolol 0.5%（BTFC）in patients in greece with primary open angle glaucoma（POAG）or ocular hypertension（OHT）whose previous therapy provided insufficient lowering of intraocular pressure（IOP）.·METHODS：A multicenter,prospective,open-label,non-interventional,observational study of the use of BTFC in clinical practice was conducted at 41 sites in *** primary endpoint was the reduction in IOP from baseline at study end,approximately 12wk after initiation of BTFC therapy.·RESULTS：A total of 785 eligible patients were enrolled in the study and 97.6%completed the *** mean±SD IOP reduction from baseline at 12wk after initiation of BTFC was 6.3±2.8 mm Hg（=764;〈0.001）.In patients（=680）who replaced their previous IOP-lowering monotherapy（a single drug,or a fixed combination of 2drugs in a single ophthalmic drop）with once-daily BTFC,the mean±SD IOP reduction from baseline at 12wk was 6.2±2.8 mm Hg（〈0.001）.IOP was reduced from baseline in 99.2%of patients,and 58.0%of patients reached or exceeded their target *** mean IOP reductions were observed regardless of the previous *** was well tolerated,with 96.0%of patients who completed the study rating the tolerability of BTFC as＂good＂or＂very good.＂Adverse events were reported in 8.3%of patients;only 0.6%of patients discontinued the study due to adverse events.·C ONCLUSION：In clinical practice in greece,BTFC is well tolerated and effectively lower the IOP in patients with POAG or OHT who requires additional IOP lowering on their previous therapy.

关键词： fixed combination glaucoma intraocularpressure ocular hypertension primary open angle glaucoma prostaglandin prostamide timolol

Crohn’s disease incidence evolution in North-western greece is not associated with alteration of NOD2/CARD15 variants

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World Journal of Gastroenterology 2007年第38期13卷 5116-5120页

作者： Michael Economou Grigoris Filis Zoi Tsianou John Alamanos Antonios Kogevinas Kostas Masalas Anna Petrou Epameinondas V Tsianos 1st Department of Internal Medicine and Hepato- gastroenterology Unit University of Ioannina School of Medicine Ioannina Greece Department of Hygiene and Epidemiology University of Ioannina School of Medicine Ioannina Greece

AIM: To assess the trends in the incidence of inflammatory bowel disease (IBD) over 23 years in the same area and to identify genetic factors related to incidence evolution. METHODS: Patients with IBD arising from North- western greece were systematically recorded through the 1983-2005 period. Trends in disease incidence and genetic patterns related to CARD15 variants were documented and correlated. RESULTS: A total of 447 patients with IBD were recorded (23.5% Crohn’s disease, 72.7% Ulcerative colitis and 3.8% indeterminate colitis). Mean annual incidence rates of CD and UC were 0.9/100 000 (95% CI 0.1-1.7) and 2.7/100 000 (95% CI 1.7-4.1) inhabitants, respectively. There was a statistically significant increase of CD incidence (P greece has risen disproportionately to that of UC in the 21st century. This is not related to alterations of genetic background though.

关键词： Inflammatory bowel disease Crohn's disease Epidemiology CARD15

Homogenised Monthly and Daily Temperature and Precipitation Time Series in China and greece since 1960

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Advances in Atmospheric Sciences 2023年第7期40卷 1326-1336页

作者： Athanassios A.ARGIRIOU Zhen LI Vasileios ARMAOS Anna MAMARA Yingling SHI Zhongwei YAN Laboratory of Atmospheric Physics Department of PhysicsUniversity of PatrasRio 26504Greece Key Laboratory of Regional Climate-Environment in Temperate East Asia Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Hellenic National Meteorological Service Athens 16777Greece Longyang District Meteorological Service Baoshan 678007China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

In this paper,we describe and analyze two datasets entitled“Homogenised monthly and daily temperature and precipitation time series in China during 1960–2021”and“Homogenised monthly and daily temperature and precipitation time series in greece during 1960–2010”.These datasets provide the homogenised monthly and daily mean(TG),minimum(TN),and maximum(TX)temperature and precipitation(RR)records since 1960 at 366 stations in China and 56stations in *** datasets are available at the Science Data Bank repository and can be downloaded from https://***/10.57760/sciencedb.01731 and https://***/10.57760/*** China,the regional mean annual TG,TX,TN,and RR series during 1960–2021 showed significant warming or increasing trends of 0.27℃(10 yr)^(-1),0.22℃(10 yr)^(-1),0.35℃(10 yr)^(-1),and 6.81 mm(10 yr)-1,*** of the seasonal series revealed trends significant at the 0.05level,except for the spring,summer,and autumn RR *** greece,there were increasing trends of 0.09℃(10 yr)-1,0.08℃(10 yr)^(-1),and 0.11℃(10 yr)^(-1)for the annual TG,TX,and TN series,respectively,while a decreasing trend of–23.35 mm(10 yr)^(-1)was present for *** seasonal trends showed a significant warming rate for summer,but no significant changes were noted for spring(except for TN),autumn,and *** RR,only the winter time series displayed a statistically significant and robust trend[–15.82 mm(10 yr)^(-1)].The final homogenised temperature and precipitation time series for both China and greece provide a better representation of the large-scale pattern of climate change over the past decades and provide a quality information source for climatological analyses.

关键词： daily and monthly temperature precipitation homogenisation climate time series greece China

Seasonal variation in the biochemical composition,condition index,and meat yield of the non-indigenous pearl oyster Pinctada imbricata radiata(Leach,1814)from the West of the Aegean Sea,greece

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Aquaculture and Fisheries 2023年第4期8卷 451-456页

作者： John A.Theodorou Maria Makri Xanthi Douvi Alexis Ramfos Efthimios Spinos Department of Animal Production Fisheries&AquacultureUniversity of PatrasMesolongi30200Greece Fisheries Department of Directorate of Agricultural Economy Region of Western GreecePatras26443Greece

The average values of the seasonal flesh biochemical composition(%)of the pearl oyster Pinctada imbricata radiata originated form 2 sampling sites,the gulfs of Evoikos(E)and Saronikos(S)in the Western Aegean Sea,showed that is rich in proteins(64.00±1.86-(E),64.67±2.95-(S))with low fat content(10.96±1.04-(E),11.86±1.13-(S))and carbohydrates(13.29±2.48-(E),9.94±4.32(S)).The condition index ranged from 26.16%±5.04 in the autumn in(E),to 44.73%±7.50 in the summer in(S).The meat yield varied from 20.49%±3.20%in the summer in(E)to 30.73%±3.47%in the summer in(S).Both results demonstrate the high nutritional profile of the pearl oyster,supporting its suitability as a potential new Mediterranean seafood source for human consumption.

关键词： Pearl oyster Condition index Meat yield Biochemical composition Aegean

Recurrence Behaviors of Earthquakes along the Kefallinia Transform Fault, Ionian Sea, greece

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Earthquake Research in China 2007年第4期21卷 409-419页

作者： Qi Cheng Athanassios Ganas Huang Fuqiong Chen Yong George Drakatos Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China Institute of Geodynamics National Observatory of Athens ll810 Athens Greece Institute of Earthquake Science CEA Beijing 100036 China

We examined the whole strong earthquake recurrence behaviors of two fault zones along the Kefallinia Transform, Ionian Sea, greece, using seismological data and statistical methods. Our data include 29 events with M 〉 5.5 for the period 1636 - 2003. We found different recurrence behaviors for the Kefallinia Fault Zone （clustering and time-predictable recurrence behaviors） and the Letkada Fault Zone （near random and non-slip-predictable or non-time-predictable recurrence nature）. The different modes may be attributed to：（a） segment interaction along-strike （Kefallinia） by static triggering and （b） the influence of fault systems to the north and east on the recurrence on Lefkada. Within the active periods, earthquake recurrence intervals are distributed in a more dispersed fashion, and can be fitted well by a Weibull distribution. In contrast, the distribution of the quiet periods is relatively less dispersed and difficult to describe by suitable probability functions.

关键词： Historical earthquake Active fault zone Earthquake recurrence Probability distribution greece

Enhancement of endogenous midbrain neurogenesis by microneurotrophin BNN-20 after neural progenitor grafting in a mouse model of nigral degeneration

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Neural Regeneration Research 2024年第6期19卷 1318-1324页

作者： Theodora Mourtzi Nasia Antoniou Christina Dimitriou Panagiotis Gkaravelas Georgia Athanasopoulou Panagiota Nti Kostantzo Olga Stathi Efthymia Theodorou Maria Anesti Rebecca Matsas Fevronia Angelatou Georgia Kouroupi Ilias Kazanis Laboratory of Developmental Biology Department of BiologyUniversity of PatrasPatrasGreece Laboratory of Cellular and Molecular Neurobiology-Stem Cells Hellenic Pasteur InstituteAthensGreece Department of Physiology School of MedicineUniversity of PatrasPatrasGreece

We have previously shown the neuroprotective and pro-neurogenic activity of microneurotrophin BNN-20 in the substantia nigra of the“weaver”mouse,a model of progressive nigrostriatal ***,we extended our investigation in two clinically-relevant ***,we assessed the effects of BNN-20 on human induced pluripotent stem cell-derived neural progenitor cells and neurons derived from healthy and parkinsonian ***,we assessed if BNN-20 can boost the outcome of mouse neural progenitor cell intranigral transplantations in weaver mice,at late stages of *** found that BNN-20 has limited direct effects on cultured human induced pluripotent stem cell-derived neural progenitor cells,marginally enhancing their differentiation towards neurons and partially reversing the pathological phenotype of dopaminergic neurons generated from parkinsonian *** agreement,we found no effects of BNN-20 on the mouse neural progenitor cells grafted in the substantia nigra of weaver ***,the graft strongly induced an endogenous neurogenic response throughout the midbrain,which was significantly enhanced by the administration of microneurotrophin *** results provide straightforward evidence of the existence of an endogenous midbrain neurogenic system that can be specifically strengthened by ***,the lack of major similar activity on cultured human induced pluripotent stem cell-derived neural progenitors and their progeny reveals the in vivo specificity of the aforementioned pro-neurogenic effect.

关键词： adult neurogenesis BNN-20 brain-derived neurotrophic factor cell replacement induced pluripotent stem cells(iPSCs) neurotrophic factors Parkinson's disease substantia

Studies of polyol production by the yeast Yarrowia lipolytica growing on crude glycerol under stressful conditions

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Carbon Resources Conversion 2024年第3期7卷 17-31,F0004页

作者： Eleni-Stavroula Vastaroucha Nikolaos G.Stoforos George Aggelis Seraphim Papanikolaou Department of Food Science and Human Nutrition Agricultural University of Athens75 Iera Odos11855AthensGreece Unit of Microbiology Department of BiologyUniversity of Patras26504 Rio PatrasGreece

Crude glycerol,the principal by-product of biodiesel production process,was employed as substrate by three wild-type Yarrowia lipolytica strains(ACA-YC 5030,LMBF 20 and NRRL Y-323).Stressful conditions(low pH value=2.0±0.3,low incubation temperature T=20±1℃,non-aseptic conditions)were ***-esting production of yeast biomass and polyols(***,mannitol and arabitol)was noted at pH=2.0±0.3 and T=20±1℃.Strains failed to produce significant quantities of cellular lipid,while variable quantities of intra-cellular polysaccharides were *** under previously pasteurized media supported significant biomass and polyols production for most of the tested strains,while only one strain(NRRL Y-323),managed to produce polyols at media that were not previously thermally treated at *** production of mannitol was favored at low initial glycerol(Glol0)concentrations,whereas higher Glol0 quantities favored the biosynthesis of *** the strain NRRL Y-323,highly aerated/agitated bioreactor trials showed different physiological profiles as compared to the respective flask ***,in flask experiments with the strain NRRL Y-323 at high Glol0 amounts(≈140 g/L)at low medium pH(=2.0±0.3),a significant production of polyols(=84.2 g/L)with the corresponding remarkable conversion yield on glycerol consumed=62%w/w was *** application:Renewable and biodegradable fuels,such as biodiesel,are safer and environmentally friendlier than the conventional petroleum *** is a cost-effective substrate obtained as the main side-product from biodiesel production process and is currently being employed in the realm of Industrial Microbi-ology and Biotechnology to produce metabolic products with added *** research focuses on using glycerol as a starting substrate for biotechnological conversions aiming at producing,amongst other compounds,polyols,microbial biomass,citric acid,*** selected strains of the Generall

关键词： Biomass Glycerol Polyols Yarrowia lipolytica

Recent advances in the production of single cell protein from renewable resources and applications

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Carbon Resources Conversion 2024年第2期7卷 38-49页

作者： Danai Ioanna Koukoumaki Erminta Tsouko Seraphim Papanikolaou Zacharias Ioannou Panagiota Diamantopoulou Dimitris Sarris Laboratory of Physico-Chemical and Biotechnological Valorization of Food By-Products Department of Food Science&NutritionSchool of EnvironmentUniversity of the AegeanLeoforos Dimokratias 66Myrina 81400LemnosGreece Department of Food Science and Human Nutrition Agricultural University of Athens75Iera Odos11855 AthensGreece Laboratory of Edible Fungi Institute of Technology of Agricultural ProductsHellenic Agricultural Organization-Dimitra1Sof.Venizelou14123 LykovrysiGreece

Single Cell Protein(SCP)refers to dry cells of microorganisms,and it constitutes a highly promising and alternative protein source for multiple *** presents a rich nutritional profile containing valuable amino acids and fatty acids,nucleic acids,minerals,and several *** businesses worldwide have introduced SCP into their production cycles,hence expanding the scope of its application in value added market chains such as the edible food *** is produced by a plethora of microorganisms,including fungi,yeasts,bacteria,and algae while many of them are Generally Recognized as Safe(GRAS).Selected microbial strains present satisfying growth capability with high yields when cultivated in renewable ***,production rates and process sustainability could be enhanced via the valorization of industrial and agricultural wastes as the nutrient sources,combined with optimization of process parameters,i.e fermentation mode and feeding strategy,pH,temperature,C/N ratio,agitation rate and oxygen *** review addresses the latest developments made towards the SCP production,highlighting efficient microbial SCP producers,and production systems that valorize solid and liquid streams from several agricultural *** applications,challenges in sensorial-,and safety-aspects as well as consumers perception issues of SCP incorporation into food-related matrices are also discussed.

关键词： Alternative protein Sustainability Sensorial aspects Safety Food and feed Packaging applications

Modular supervisory control for multi-floor manufacturing processes

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Control Theory and Technology 2023年第2期21卷 148-160页

作者： Fotis N.Koumboulis Dimitrios G.Fragkoulis Aristides A.Michos Department of Digital Industry Technologies School of ScienceNational and Kapodistrian University of AthensEuripus Campus3400 Psahna EuboeaGreece Core Department National and Kapodistrian University of AthensEuripus Campus3400 Psahna EuboeaGreece

Due to space availability limitations and high land costs,there is an increasing development of multi-floor manufacturing(MFM)systems in urban and industrial *** problem of coordination in a multi-floor manufacturing process,in the Ramadge Wonham framework,is *** manufacturing chain of each floor and the elevator system are modeled in the form of finite deterministic *** models of the multi-floor manufacturing process are parametric with respect to the number of floors and the number of manufacturing machines on each *** coordination desired performance is formulated in the form of desired regular languages in analytic *** languages are realized by appropriate supervisors in the form of finite deterministic *** models of the supervisors are also parametric with respect to the number of floors and the number of manufacturing machines on each *** total control of the coordination of the multi-floor manufacturing process is accomplished via a modular supervisory control *** complexity of the supervisors as well as the complexity of the total modular supervisory architecture are determined in analytic forms with respect to the number of floors and the number of manufacturing machines on each *** special case of a two floor manufacturing process is presented as an illustrative example.

关键词： Manufacturing processes Discrete event systems Supervisory control Industry 4.0