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Journal of Geographical Sciences 2006年第3期16卷 371-374页

作者： YAO Tandong ZHU Liping TAN Ge Institute of Tibetan Plateau Research CAS Beijing 100085 China

The Tibetan Plateau （TP） plays a unique role in Earth System Sciences. It represents a key area to understand not only basic geodynamic processes linked with the formation and uplift of mountains and plateaus, but also the interaction between plateau uplift and environmental changes. Over the last 50 million years the formation of the TP has considerably influenced the global climate and monsoon system. Moreover, the TP proves to be extremely sensitive to present-day global change phenomena. Based upon the foundation of the new Institute of Tibetan Plateau Research （1TP） by the Chinese Academy of Sciences （CAS） and through the Memorandum signed by the CAS and dfg （Deutschen Forschungsgemeinschaft）, both CAS and dfg provide opportunities to intensify TP research and to develop coordinated research programs. ＂The Tibetan Plateau - Geodynamics and Environmental Evolution＂ consisting of one big projects funded by CAS and five projects funded by dfg that cover the pre- and early-collision history of the TP, the Palaeogene/Neogene uplift and climatic dynamics as well as the Late Quaternary and recent environmental and climatic changes on the TP. The projects are linked through several levels of interactions.

关键词： Tibetan Plateau Sino-Germany cooperation geodynamics environmental evolution

Cellular models of stress resistance may pave ways to fight neurodegenerative diseases

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Neural Regeneration Research 2025年第9期20卷 2579-2580页

作者： Thu Nguyen Minh Pham Christian Behl Institute of Pathobiochemistry University Medical Center of the Johannes Gutenberg UniversityMainzGermany

Alzheimer's disease(AD),the most common form of neurodegeneration,is characterized by selective neuronal vulnerability and brain regionselective neuron *** entorhinal cortex and hippoc,ampal CA1 projection neurons are at greater risk in AD whereas other regions display resistance to ***,the cerebellum,a phylogenetically very old region,is affected only very late in the disease progression.

关键词： cortex resistance Alzheimer

Cryptic exon inclusion in TDP-43 proteinopathies:opportunities and challenges

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Neural Regeneration Research 2025年第7期20卷 2003-2004页

作者： Lorena Decker Sonja Menge Axel Freischmidt Department of Neurology Ulm UniversityUlmGermany

TDP-43 proteinopathies and cryptic exons:Transactive response DNA binding protein of 43 kDa(TDP-43)is a ubiquitously expressed RNA/DNA binding protein crucial for coding and non-coding RNA metabolism including transcription,splicing,transport,translation,and ***-43 shuttles between the nucleus and cytoplasm,but is predominantly localized in the *** diseases(NDs)may be accompanied by nuclear loss and possible cytoplasmic accumulation and aggregation of TDP-43 in vulnerable neurons and *** neuropathology is the hallmark of most individuals suffering from amyotrophic lateral sclerosis(ALS),frontotemporal dementia(FTD)with TDP-43-immunoreactive pathology(FTD-TDP),limbic-predominant age-related TDP-43 encephalopathy(LATE)and Perry syndrome,but also coexists with the primary pathology in subsets of patients suffering from other NDs,such as Alzheimer’s disease,Lewy body dementias,or Huntington’s *** in the gene encoding TDP-43(TARDBP)are the cause of ALS and/or FTD in some rare cases substantiating the importance of this protein in aging *** is still controversial if loss of nuclear,or increased cytoplasmic and/or aggregating TDP-43 is more harmful to neurons(Nag and Schneider,2023).Recently,the role of nuclear TDP-43 in repressing the inclusion of intronic sequences,named cryptic exons(CEs),into mature mRNAs gained much attention.

关键词： Huntington metabolism TDP

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira S.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Translocator protein and neurodegeneration: insights from Alzheimer’s disease

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Neural Regeneration Research 2025年第4期20卷 1090-1091页

作者： Arpit Kumar Pradhan Rainer Rupprecht Gerhard Rammes Klinik für Anaesthesiologie und Intensivmedizin der Technischen Universität München Klinikum rechts der IsarMunichGermany Graduate School of Systemic Neurosciences Ludwig-Maximilians-Universität MünchenMartinsriedGermany Department of Psychiatry and Psychotherapy University RegensburgRegensburgGermany

The 18 kDa translocator protein(TSPO)located on the outer mitochondrial membrane regulates several key cellular processes including mitochondrial homeostasis,cholesterol transport,apoptosis,cell proliferation,and maintenance of mitochondrial health(Rupprecht et al.,2022,2023).TSPO is expressed in both peripheral organs and the central nervous system,with a more pronounced expression in tissues that produce *** main reason why TSPO has garnered so much attention is because it plays a key role in neurosteroidogenesis by transferring cholesterol from the outer to the inner mitochondrial membrane,which is the rate-limiting step in neurosteroid synthesis.A cholesterol-recognizing amino acid consensus domain has been identified in the cytosolic C terminus of the TSPO protein by both in vitro and site-directed mutagenesis experiments(Li et al.,2001).However,the role of TSPO in the process of neurosteroid synthesis has been challenged by several studies,particularly TSPO knockout models,which suggest that TSPO removal does not affect the phenotype or the system’s viability(Tu et al.,2014).However,ligands targeting TSPO have been shown to enhance levels of neurosteroids which suggests that neurosteroidogenesis is one of the major functional roles mediated by the TSPO protein.

关键词： cholesterol organs

High-temperature-tolerant flexible supercapacitors: Gel polymer electrolytes and electrode materials

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Journal of Energy Chemistry 2025年第1期100卷 426-457页

作者： Chong Peng Xinyi Huang Mingwei Zhao Shuling Liao Quanhong Yang Nianjun Yang Siyu Yu School of Chemistry & Chemical Engineering Southwest University Nanoyang Group Tianjin Key Laboratory of Advanced Carbon and Electrochemical Energy Storage School of Chemical Engineering and Technology and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin University Department of Chemistry & IMO-IMOMEC Hasselt University

The development of flexible supercapacitors(FSCs) capable of operating at high temperatures is crucial for expanding the application areas and operating conditions of supercapacitors. Gel polymer electrolytes and electrode materials stand as two key components that significantly impact the efficacy of hightemperature-tolerant FSCs(HT-FSCs). They should not only exhibit high electrochemical performance and excellent flexibility, but also withstand intense thermal stress. Considerable efforts have been devoted to enhancing their thermal stability while maintaining high electrochemical and mechanical performance. In this review, the fundamentals of HT-FSCs are outlined. A comprehensive overview of state-of-the-art progress and achievements in HT-FSCs, with a focus on thermally stable gel polymer electrolytes and electrode materials is provided. Finally, challenges and future perspectives regarding HT-FSCs are discussed, alongside strategies for elevating operational temperatures and *** review offers both theoretical foundations and practical guidelines for designing and manufacturing HT-FSCs, further promoting their widespread adoption across diverse fields.

关键词： Flexible supercapacitors High-temperature tolerance Gel polymer electrolytes Electrode materials

Spatial Variability of Soil Properties and Rice Yield Along Two Catenas in Southeast China

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Pedosphere 2008年第4期18卷 409-420页

作者： B. RTH B. LENNARTZ Institute for Land Use University of Rostock Justus-von-Liebig-Weg 6 18059 Rostock (Germany).

In the light of an increasing demand for staple food, especially rice, in southeast China, investigations on the specific site potential expressed as the relationship between soil and crop yield parameters gain increasing importance. Soil texture and several soil chemical parameters as well as plant properties such as crop height, biomass and grain yield were investigated along two terraced catenas with contrasting soil textures cropped with wet rice. We were aiming at identifying correlative relationships between soil and crop properties. Data were analyzed both statistically and geostatistically on the basis of semivariograms. Statistical analysis indicated a significant influence of the relief position on the spatial distribution of soil texture, total carbon and total nitrogen contents. Significant correlations were found for the catena located in a sandstone area (Catena A) between rice yield and silt as well as total nitrogen content. Corresponding relationships were not detectable for paddy fields that developed from Quaternary clays (Catena B). As suggested by the nugget to sill ratio, spatial variability of soil texture, total carbon and nitrogen was mainly controlled by intrinsic factors, which might be attributed to the erosional transport of fine soil constituents, indicating the importance of the relief position and slope in soil development even in landscapes that are terraced. The crop parameters exhibited short ranges of influence and about one third of their variability was unexplained. Comparable ranges of selected crop and soil parameters, found only for Catena A, are indicative of close spatial interactions between rice yield and soil features. Our findings show that especially in sandstone-dominated areas, a site-specific management can contribute to an environmentally safe rice production increase.

关键词： rice productivity semivariogram analysis soil properties spatial data

Anisotropy of Soil Hydraulic Properties Along Arable Slopes

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Pedosphere 2008年第3期18卷 353-362页

作者： JING Yuan-Shu ZHANG Bin A. THIMM H. ZEPP Institute of Soil Science Chinese Academy of Sciences Nanjing 210008 （China） Geographical Institute Ruhr-University Bochum D-44780 Bochum （Germany）

The spatial variations of the soil hydraulic properties were mainly considered in vertical direction. The objectives of this study were to measure water-retention curves, θ（ψ）, and unsaturated hydraulic conductivity functions, K（ψ）, of the soils sampled at different slope positions in three directions, namely, in vertical direction, along the slope and along the contour, and to determine the effects of sampling direction and slope position of two soil catenas. At the upper slope positions, the surface soils （0-10 cm） sampled in the vertical direction had a lower soil water content, 0, at a certain soil water potential （-1 500 kPa 〈 ψ 〈 -10 kPa） and had the greatest unsaturated hydraulic conductivity, K, at ψ 〉 -10 kPa. At the lower slope positions, K at ψ〉 -10 kPa was smaller in the vertical direction than in the direction along the slope. The deep soils （100 110 cm） had similar soil hydraulic properties in all the three directions. The anisotropic variations of the hydraulic properties of the surface soils were ascribed to the effects of natural wetting and drying cycles on the structural heterogeneity. These results suggested that the anisotropy of soil hydraulic properties might be significant in influencing soil water movement along the slope and need to be considered in modeling.

关键词： slope hydrology spatial variation unsaturated hydraulic conductivity water-retention curve

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al Kabbani Christoph Köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-KO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

An Alternative Approach for the Determination of Soil Water Mobility

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Pedosphere 2008年第3期18卷 328-334页

作者： M.P.C.ENGLER R.CICHOTA Q.DE JONG VAN LIER E.M.BLOEM G.SPAROVEK E.SCHNUG University of Sao Paulo C.P.9Piracicaba(SP) 13418-900(Brazil) Institute of Natural Resources Massey UniversityP.O.Box 11 222Palmerston North(New Zealand) University of Sao Paulo C.P.9Piracicaba(SP) 13418-900(Brazil)Institute of Natural ResourcesMassey UniversityP.O.Box 11 222Palmerston North(New Zealand) Institute for Crop and Soil Science (JKI) Federal Research Centre for Cultivated PlantsBundesallee 50D-38116 Braunschweig(Germany)

A new laboratory method was proposed to establish an easily performed standard for the determination of mobile soil water close to real conditions during the infiltration and redistribution of water in a soil. It consisted of applying a water volume with a tracer ion on top of an undisturbed ring sample on a pressure plate under a known suction or pressure head. Afterwards, soil water mobility was determined by analyzing the tracer-ion concentration in the soil sample. Soil water mobility showed to be a function of the applied water volume. No relation between soil water mobility and applied pressure head could be established with data from the present cxperiment. A simple one- or two-parameter equation can be fitted to the experimental data to parameterize soil water mobility as a function of applied solute volume. Sandy soils showed higher mobility than loamy＂ soils at low values of applied solute volumes, and both sandy and loamy soils showed an almost complete mobility at high applied solute volumes.

关键词： laboratory method mobile-immobile water pressure head soil texture