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Effects of coffee and caffeine on bladder dysfunction in streptozotocininduced diabetic rats

Acta Pharmacologica Sinica 2006年第8期27卷 1037-1043页

作者： Chao-ran YI~(2,5) Zhong-qing WEI~2 Xiang-lei DENG~4 Ze-yu SUN~2 Xing-rong LI~4 Cheng-gong TIAN~3 ~2department of Urology,~3department of Endocrinology,the Affiliated Drum Tower Hospital,nanjing university Medical School,nanjing 210008,china ~4department of biochemisto,and molecular biology,medieal college of southeast university,nanjing 210009,china department of Urology the Affiliated Drum Tower Hospital Nanjing University Medical School Nanjing China department of Biochemistry and molecular biology Medical College of Southeast University Nanjing China department of Endocrinology the Affiliated Drum Tower Hospital Nanjing University Medical School Nanjing China

Aim:To explore the effects and mechanisms of caffeine and coffee on bladderdysfunction in streptozotocin-induced diabetic ***:Sprague-Dawleymale rats were divided randomly into 4 groups:control,diabetes mellitus(DM),DM with coffee treatment,and DM with caffeine *** diabetic rat wasinduced by intraperitoneal injection of streptozotocin(60 mg/kg).After 7 weeks oftreatment with coffee and caffeine,cystometrogram,contractile responses to elec-trical field stimulation(EFS)and acetylcholine(ACh),and cyclic AMP(cAMP)concentration of the bladder body and base were ***:The bladderweight,volume threshold for micturition and post-void residual volume(PVR)inthe diabetic rats were significantly higher compared to those in the control *** or caffeine treatment significantly reduced the bladder weight,bladdercapacity and PVR in the diabetic *** caused significant decreases in cAMPconcentration of the bladder and coffee and caffeine caused upregulation of cAMPcontent in the diabetic *** addition,coffee and caffeine tended to normal-ize the altered detrusor contractile responses to EFS and ACh in the diabetic ***:These results indicate that caffeine and coffee may have beneficialeffects on bladder dysfunction in the early stage of diabetes by increasing cAMPcontent in the lower urinary tract,recovering the micturition reflex and improvingthe detrusor contractility.

关键词： caffeine diabetic mellitus bladder urodynamics muscle contraction cyclic AMP

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Heat Shock Protein 90 Indirectly Regulates ERK Activity by Affecting Raf Protein Metabolism

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Acta Biochimica et Biophysica Sinica 2005年第7期37卷 501-505页

作者： Fei DOU Liu-Di YUAN Jing-Jing ZHU department of Genetics and Development biology,southeast university Medical School,nanjing 210009,china department of Genetics and Development biology Southeast University Medical SchoolNanjing 210009 China

Extracellular signal-regulated protein kinase (ERK) has been implicated in the pathogenesis ofseveral nerve system *** more and more kinases have been discovered to be the client proteins ofthe molecular chaperone Hsp90,the use of Hsp90 inhibitors to reduce abnormal kinase activity is a newtreatment strategy for nerve system *** study investigated the regulation of the ERK pathway *** showed that Hsp90 inhibitors reduce ERK phosphorylation without affecting the total ERKprotein *** investigation showed that Raf,the UPstream kinase in the Ras-Raf-MEK-ERK pathway,forms a complex with Hsp90 and *** cells with Hsp90 inhibitors facilitates Raf degradation,thereby down-regulating the activity of ERK.

关键词： molecular chaperone phosphorylation Hsp90 extracellular signal-regulated protein kinase (ERK) Raf tau

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Efficient method of cycle slips detection for dual-frequency GPS data

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中国有色金属学会会刊：英文版 2005年第S1期15卷 22-24页

作者： YU Guo-rong (Survey department of Transportation college, southeast university, nanjing 210096, china) Survey department of Transportation college Southeast University Nanjing 210096 China

An algorithm has been developed from various exiting techniques, that provides fully automatic cycle-slip detection at the data preprocessing stage. This algorithm, called pair linear combination, operates on undifferenced or double-differenced, dual frequency carrier phase data, and requires the sampling interval is short. Test results carried out in a variety of situations including static and kinematic modes, short and long baseline situation, and low and high data rates were presented.

关键词： cycle slips geometry free phase pair linear combination

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Cross-linked Polyethylenimine as Potential DNA Vector for Gene Delivery with High Efficiency and Low Cytotoxicity

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Acta Biochimica et Biophysica Sinica 2006年第11期38卷 780-787页

作者： Wei DONG~(1,2) Guang-Hui JIN~1 Shu-Feng LI~(1,3) Qi-Ming SUN~1 Ding-Yuan MA~1 Zi-Chun HUA~1 1 State Key Laboratory of Pharmaceutical Biotechnology,college of Life Science,nanjing university,nanjing 210093,china 2 School of Chemical Engineering nanjing university of Science and Technology,nanjing 210094,china 3 college of Basic Medical Science,southeast university,nanjing 210009,china State Key Laboratory of Pharmaceutical Biotechnology College of Life Science Nanjing UniversityNanjing 210093 China School of Chemical Engineering Nanjing University of Science and TechnologyNanjing 210094 China college of Basic Medical Science Southeast UniversityNanjing 210009 China

Polyethylenimine (PEI) has been known as an efficient gene carrier with the highest cationiccharge *** transfection efficiency of PEI,along with its cytotoxicity,strongly depends on itsmolecular *** enhance its gene delivery efficiency and minimize cytotoxicity,we have synthesizedsmall cross-linked PEI with biodegradable linkages and evaluated their transfection efficiencies in *** study,branched PEI with a molecular weight of 800 Da was cross-linked by small diacrylate[1,4-butanediol diacrylate or ethyleneglycol dimethacrylate (EGDMA)] for 2-6 *** efficiencies of thecross-linked PEI in in vitro transfection of plasmid DNA containing enhanced green fluorescent protein(EGFP) reporter gene were assessed in melanoma B 16F10 cell line and other cell *** cytometrywas used to quantify the cellular entry efficiency of plasmid and the transgene expression *** of the cross-linked PEI in these cells were evaluated by MTT ***-PEI 800-4h,atypical cross-linked PEI reported here,mediated a more efficient expression of reporter gene than thecommercially available 25-kDa branched PEI control,and resulted in a 9-fold increase in gene deliveryin B16F10 cells and a 16-fold increase in 293T cells,while no cytotoxicity was found at the optimizedcondition for gene ***,the transfection activity of polyplexes was preserved in thepresence of serum proteins.

关键词： polyethylenimine gene delivery cytotoxicity B16F10 293T cell line

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Maschke-type theorem and Morita context over weak Hopf algebras

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Science china Mathematics 2006年第5期49卷 587-598页

作者： ZHANG Liangyun college of Science, nanjing Agricultural university, nanjing 210095, china department of Mathematics, nanjing university, nanjing 210008, china college of Science Nanjing Agricultural University Nanjing China department of Mathematics Nanjing University Nanjing China

This paper gives a Maschke-type theorem over semisimple weak Hopf algebras,extends the well-known Maschke-type theorem given by Cohen and Fishman and constructs a Morita context over weak Hopf algebras.

关键词： weak Hopf algebra, smash product, Maschke-type theorem, Morita context.

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Integrated intelligent control analysis on semi-active structures by using magnetorheological dampers

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Science china(Technological Sciences) 2008年第12期51卷 2270-2284页

作者： XU ZhaoDong1 & GUO YingQing2 1Civil Engineering college, southeast university, nanjing 210096, china 2 Automation college, southeast university, nanjing 210096, china Civil Engineering college Southeast University Nanjing China Automation college Southeast University Nanjing China

The control strategy is very important for semiactive control or active control systems. An integrated intelligent control strategy for building structures incorpo rated with magnetorheological (MR) dampers subjected to earthquake excitation is proposed. In this strategy, the time-delay problem is solved by a neural network and the control currents of the MR dampers are determined quickly by a fuzzy controller. Through a numerical example of a three-storey structure with one MR damper installed in the first floor, the seismic responses of the uncontrolled, the intelligently controlled, the passiveon controlled, and the passive-off controlled structures under different earthquake excitations are analyzed. Based on the numerical results, it can be found that the time domain and the frequency domain responses are reduced effectively when the MR damper is added in the structure, and the integrated intelligent control strategy has a better earthquake mitigation effect.

关键词： magnetorheological damper semi-active control intelligent

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Modal parameter identification under non-stationary ambient excitation based on continuous time AR Model

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Science china(Technological Sciences) 2009年第10期52卷 3180-3187页

作者： DU XiuLi1,2 & WANG FengQuan1 1 college of Civil Engineering, southeast university, nanjing 210096, china 2 School of Mathematical Sciences, nanjing Normal university, nanjing 210097, china college of Civil Engineering Southeast University Nanjing China School of Mathematical Sciences Nanjing Normal University Nanjing China

A new time-domain modal identification method of linear time-invariant system driven by the non-stationary Gaussian random excitation is introduced based on the continuous time AR model. The method can identify physical parameters of the system from response data. In order to identify the parameters of the system, the structural dynamic equation is first transformed into the continuous time AR model, and subsequently written into the forms of observation equation and state equation which is just a stochastic differential equation. Secondly, under the assumption that the uniformly modulated function is approximately equal to a constant matrix in a very short time period, the uniformly modulated function is identified piecewise. Then, we present the exact maximum likelihood estimators of parameters by virtue of the Girsanov theorem. Finally, the modal parameters are identified by eigenanalysis. Numerical results show that the method we introduce here not only has high precision and robustness, but also has very high computing efficiency. Therefore, it is suitable for real-time modal identification.

关键词： modal identification uniformly modulated function CAR model exact maximum likelihood estimator

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Calculation method of quantum efficiency to TiO_2 nanocrystal photocatalysis reaction

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Journal of Environmental Sciences 2002年第1期14卷 70-75页

作者： XIE Yi bing, YUAN Chun wei (National Laboratory of molecular & Biomolecular Electronics, southeast university, nanjing 210096, china.) southeast university National Laboratory of Molecular & Biomolecular Electronics Nanjing 210096

The quantum yield is an important factor to evaluate the efficiency of photoreactor. This article gives an overall calculation method of the quantum efficiency( Φ ) and the apparent quantum efficiency( Φ a) to the TiO 2/UV photocatalysis system. Furthermore, for the immobility system (IS), the formulation of the faction of light absorbed by the TiO 2 thin film is proposed so as to calculate the quantum efficiency by using the measured value and theoretic calculated value of transmissivity (T). For the suspension system(SS), due to the difficulty to obtain the absorption coefficient ( α ) of TiO 2 particulates, the quantum efficiency is calculated by means of the relative photonic efficiency ( ζ r) and the standard quantum yield ( Φ standard ).

关键词： photodegradation reaction quantum efficiency apparent quantum efficiency photonic efficiency relative photonic efficiency absorption coefficient

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molecular group dynamics study on slip flow of thin fluid film based on the Hamaker hypotheses

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Science china(Technological Sciences) 2010年第7期53卷 1833-1838页

作者： ZHOU JianFeng, SHAO ChunLei & GU BoQin college of Mechanical and Power Engineering, nanjing university of Technology, nanjing 210009, china college of Mechanical and Power Engineering Nanjing University of Technology Nanjing China

The thin fluid film was assumed to consist of a number of spherical fluid molecular groups and the attractive forces of molecular group pairs were calculated by the derived equation according to the three Hamaker homogeneous material hypotheses. Regarding each molecular group as a dynamics individual, the simulation method for the shearing motion of multilayer fluid molecular groups, which was initiated by two moving walls, was proposed based on the Verlet velocity iterative algorithm. The simulations reveal that the velocities of fluid molecular groups change about their respective mean velocities within a narrow range in steady state. It is also found that the velocity slips occur at the wall boundary and in a certain number of fluid film layers close to the wall. Because the dimension of molecular group and the number of group layers are not restricted, the hypothetical thickness of fluid film model can be enlarged from nanometer to micron by using the proposed simulation method.

关键词： Hamaker hypotheses molecular group velocity slip Lennard-Jones potential

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Dynamic damage and stress-strain relations of ultra-high performance cementitious composites subjected to repeated impact

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Science china(Technological Sciences) 2010年第6期53卷 1520-1525页

作者： LAI JianZhong1 & SUN Wei2 1 department of Materials Science and Engineering,nanjing university of Science and Technology,nanjing 210094,china 2 college of Materials Science and Engineering,southeast university,nanjing 211189,china department of Materials Science and Engineering Nanjing University of Science and Technology Nanjing China college of Materials Science and Engineering Southeast University Nanjing China

Ultra-high performance cementitious composites (UHPCC) were prepared by replacing 60% of cement with ultra-fine industrial waste *** dynamic damage and compressive stress-strain relations of UHPCC were studied using split Hopkinson pressure bar (SHPB).The damage of UHPCC subjected to repeated impact was measured by the ultrasonic pulse velocity *** show that the dynamic damage of UHPCC increases linearly with impact times and the abilities of repeated impact resistance of UHPCC are improved with increasing fiber volume *** stress waves on impact were recorded and the average stress,strain and strain rate of UHPCC were calculated based on the wave propagation *** effects of strain rate,fibers volume fraction and impact times on the stress-strain relations of UHPCC were *** show that the peak stress and elastic modulus decrease while the strain rate and peak strain increase gradually with increasing impact times.

关键词： ultra-high performance cementitious composites (UHPCC) split Hopkinson pressure bar (SHPB) repeated impact damage stress-strain

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