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Electrical property of 8-mol% yttria-stabilized zirconia electrolyte by spark-plasma sintering

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Science china(Technological Sciences) 2004年第5期47卷 569-576页

作者： JIAN Jiawen1,2, CHANG Aimin3, YANG Bangchao2 & ZHANG Yikang4 1. The school of Information Science Engineering, ningbo university, ningbo 315211, china 2. The school of Microelectronics and Solid-state Electronics, university of Electronic Science and Tech-nology of china, Chengdu 610054, china 3. The Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830022, china 4. Hongtak (Chengdu) Electronic Co., Ltd, Chengdu 610041, china Correspondence should be addressed to Jian Jiawen 1. The school of Information Science Engineering Ningbo University 315211 Ningbo China 2. The school of Microelectronics and Solid-state Electronics University of Electronic Science and Technology of China 610054 Chengdu China 3. The Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences 830022 Urumqi China 4. Hongtak (Chengdu) Electronic Co. Ltd 610041 Chengdu China

Spark-plasma sintering (SPS) process was used to sinter ZrO2 (8Y) powders, and a relative density of 99% has been reached at a low temperature (1350°C) and short dwelling time (10 min) compared to the conventional sintered identical samples (1450°C 4 h)(CS). By the X-ray diffraction (XRD) patterns, the microstructure of the SPS pellet and CS pellet are both indexed by the cubic unit cell (Fm3m). The finer crystallite size (D111) of the SPS pellet is 154 nm and D111 of the CS pellet is more than 1 μm. The AC impedance spectroscopy shows that the ionic conductivity of SPS pellet is different from that of CS pellet. The activation energy for the SPS ceramics, estimated from the slope in the range of 400–800°C, was 91 kJ mol?1, which is in good agreement with CS pellet (96 kJ mol?1), indicating that the conduction mechanism in SPS ceramics is similar to that in CS ceramics.

关键词： yttria-stabilized zirconia electrolyte, spark-plasma sintering, AC impedance.

Genistein stimulates osteoblastic differentiation via p38 MAPK-Cbfa1 pathway in bone marrow culture

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Acta Pharmacologica Sinica 2007年第10期28卷 1597-1602页

作者： Qing-chuan LIAO~2,Zhou-sheng XIAO~(4,5),Yan-fang QIN~3,Hong-hao ZHOU~4~2 affiliated Children's hospital,Nanjing Medical university,Nanjing 210008,china,~3 Department of Pathology,school of Medicine,Jinanuniversity,Guangzhou 510632,china ~4 Institute of Clinical Pharmacology,Central South university,Changsha 410078,china ated Childrenos hospital Nanjing Medical University Nanjing 210008 China. xiaozs64@***.

Aim:To test the hypothesis that genistein stimulates the osteoblastic differentia-tion through the p38 mitogen activated protein kinase (MAPK)-core-binding fac-tor 1 (Cbfa1) ***:The activation of p38 MAPK was detected byWestern *** phosphatase (ALP) activity and calcium depositionwere assessed for osteoblastic differentiation of bone marrow-derived mesenchy-mal stem cell (BMSC) *** expression of Cbfa1 was analyzed at both themRNA and protein *** activity of Cbfa1 was detected by electrophoreticmobility shift *** sialoprotein (BSP),ALP,osteocalcin (OC),andosteopontin (OPN) gene transcription were also evaluated by either RT-PCR orNorthern ***:Genistein (0.01-1 μmol/L) dose dependently led tothe rapid and sustained activation of the p38 MAPK pathway in mouse *** with genistein (1 μmol/L) resulted in increased ALP activityand calcium deposition of BMSC cultures as a function of *** alsoenhanced Cbfa1 DNA binding activity and promoted the expressions of Cbfa1itself as well as several Cbfa1-regulated genes,including ALP,BSP,OC,and *** treatment with p38 MAPK inhibitor (SB203580) diminished thegenistein-induced osteoblastic maturation and p38 MAPK-Cbfa1 activation inmouse BMSC ***:These results indicated that genistein couldstimulate the osteoblastic differentiation of BMSC cultures through the p38MAPK-Cbfa1 pathway.

关键词： bone marrow-derived mesenchymal stem cells core-binding factor 1 osteoblastic differentiation genistein mitogen-activated protein kinase

A novel mutation—L539fs/47 of hERG in a Chinese long QT syndrome family

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Journal of Pharmaceutical Analysis 2010年第3期22卷 188-191页

作者： Jiang-Fang Lian,Xiao-Yan Huang,Wei-Feng Xu,Xi Yang,Ying Wang,Di Li,Jian-Qing Zhou Li Huili hospital,Medical school of ningbo university,ningbo 315041,china Li Huili hospital Medical School of Ningbo University Ningbo 315041 China

Objective To identify the mutation of human ether-a-go-go-related gene(hERG)and analyze the clinical characteristics of a Chinese family with long ST syndrome(LQTS).Methods The electrocardiogram and DNA samples were obtained from a Chinese LQTS family of 26 *** was performed with polymorphic short tandem repeat(STR)markers at the known LQT1,LQT2,and LQT3 *** analysis was used to find aberrant *** mutation was confirmed by cloning and *** Three gene carriers were linked to chromosome 7q35-36,where the potassium channel gene hERG was encoded.A 19-base pair deletion was *** mutation was located at nucleotide position 1 619-1 637 between transmembrane domains S4 and ***,A1692G polymorphism was found both in the normal control and *** A novel 19 bp deletion mutation of hERG is identified in a Chinese *** gene carriers are demonstrated to be typical LQT2 ECG phenotype.

关键词： long QT syndrome human ether-a-go-go-related gene(hERG) potassium channel mutation

基于天牛须BP神经网络的船舶电动舵机自抗扰控制

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计算机应用与软件 2024年第3期41卷 81-86页

作者：孙宏林李宁博张均东大连海事大学轮机工程学院辽宁大连116026

将自抗扰控制器(ADRC)引入到智能船舵机控制优化问题中,同时将神经网络嵌入到自抗扰控制,针对电动舵机快响应、非线性的特点提出一种神经网络自抗扰控制。将天牛须搜索(BAS)寻优能力强的特性与BP神经网络中的权值与阈值寻优过程相结合,... 详细信息

将自抗扰控制器(ADRC)引入到智能船舵机控制优化问题中,同时将神经网络嵌入到自抗扰控制,针对电动舵机快响应、非线性的特点提出一种神经网络自抗扰控制。将天牛须搜索(BAS)寻优能力强的特性与BP神经网络中的权值与阈值寻优过程相结合,建天牛须BP神经网络自抗扰控制器,弥补了BP神经网络训练时间较长、收敛速度较慢的问题。以船舶电动舵机系统作为被控对象在该控制器下的舵机系统的控制性能得到了提升,控制精度高无超调同时具有良好的鲁棒性,同时建立的BAS-BP神经网络自抗扰控制器对于实际应用具有指导意义。

关键词：天牛须搜索算法 BP神经网络电动舵机天牛须BP神经网络自抗扰控制

Alterations in circadian rhythms of melaton in and cortisol in patients with bronchial asthma

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Acta Pharmacologica Sinica 2004年第5期25卷 109-114页

作者： Guang-he FEI2,3, Rong-yu LIU3,4, Zhi-hong ZHANG3, Jiang-ning ZHOU2,32school of Life Science, university of Science and Technology of china, Hefei 230026, china 3Pulmonary Department, First affiliated hospital, Anhui Medical university, Hefei 230022, china school of Life Science University of Science and Technology of China Hefei 230026 China

AIM: To investigate the possible relationships between alterations in circadian rhythm of melatonin, cortisol andbronchial asthma. METHODS: Salivary melatonin and cortisol were measured simultaneously by radioimmunoas-say in 10 mild intermittent or persistent patients, 11 moderate-to-severe persistent asthma patients, and 15 controlsubjects. Twelve salivary samples were collected in a series during a 24-h period in each subject. RESULTS: Theresults showed overall lower levels of salivary melatonin in asthma patients compared with control subject(P4-h mean level of salivary cortisol was greatly lower and the acrophase was markedly delayedin patients with mild intermittent or persistent asthma (P<0.01) and moderate-to-severe persistent asthma (P<0.05, P<0.01) compared with control subject. CONCLUSION: Disordered circadian rhythms of salivary melato-nin and cortisol were found in asthma patients, which may be involved in the pathogenesis of bronchial asthma.

关键词： melatonin asthma circadian rhythm glucocorticoids human saliva

地缘政治风险对中国农产品期货收益率的影响研究:基于TVP-VAR-SV模型的分析

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湖北工程学院学报 2024年第1期44卷 76-88,96页

作者：郭鹏王宁博河南工业大学经济贸易学院河南郑州450001

本文使用TVP-VAR-SV模型,探讨中美地缘政治风险对中国农产品期货收益率的时变影响。研究结果表明:在短期内,地缘政治风险对农产品期货收益率的影响较为明显,而在中长期内,农产品期货收益率波动相对较小。不同农产品期货对地缘政治风险... 详细信息

本文使用TVP-VAR-SV模型,探讨中美地缘政治风险对中国农产品期货收益率的时变影响。研究结果表明:在短期内,地缘政治风险对农产品期货收益率的影响较为明显,而在中长期内,农产品期货收益率波动相对较小。不同农产品期货对地缘政治风险冲击反应不同,大豆、豆粕收益率受到地缘政治风险冲击波动最激烈,其他六种农产品期货则呈现出周期性特点。克里米亚事件、中美贸易摩擦和全球新冠疫情,三个不同时期的极端事件对农产品期货市场具有负向影响,不同期货品种受到的冲击存在异质性与滞后性。

关键词：地缘政治风险农产品期货收益率 TVP-VAR-SV模型

Arch structure effect of the coal gangue flow of the fully mechanized caving in special thick coal seam and its impact on the loss of top coal

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International Journal of Mining Science and Technology 2016年第4期26卷 593-599页

作者： Zhang ningbo Liu Changyou State Key Laboratory of Coal Resources and Mine Safety China University of Mining and Technology school of Mines Key Laboratory of Deep Coal Resource MiningMinistry of Education of ChinaChina University of Mining and Technology

Based on the characteristics of the top coal thickness of the fully mechanized caving in special thick coal seam,the long distance of coal gangue caving,as well as the different sizes of the coal gangue broken fragment dimension and spatial variation of drop flow,this paper uses laboratory dispersion simulation experiment and theoretical analysis to study the arch structure effect and its influence rule on the top coal loss in the process of coal gangue *** shows that in the process of coal gangue flow,arch structure can be formed in three types:the lower arch structure,middle arch structure,and upper arch ***,the arch structure has the characteristics of dynamic random arch,the formation probability of dynamic random arch with different layers is not the same,dynamic random arch caused the reduction of the top coal fluency;analyzing the dynamic random arch formation mechanism,influencing factors,and the conditions of instability;the formation probability of the lower arch structure is the highest,the whole coal arch and the coal gangue arch structure has the greatest impact on top coal ***,to prevent or reduce the formation of lower whole coal arch structure,the lower coal gangue arch structure and the middle whole coal arch structure is the key to reduce the top coal *** research conclusion provides theoretical basis for the further improvement of the top coal recovery rate of the fully mechanized caving in extra thick coal seam.

关键词： Extra thick coal seam Coalgangue flow Top coalloss Dynamic random arch effect

Effect of Porphyromonas gingivalis PrtC on cytokine expression in ECV304 endothelial cells and its level in subgingival plaques from patients with chronic periodontitis

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Acta Pharmacologica Sinica 2007年第7期28卷 1015-1023页

作者： Yan-min WU~2,Li-li CHEN~(2,6),Jie YAN~(3,6),Chun-yan ZHUANG~4,Zhi-yuan GU~5~2 Department of Stomatology,the Second affiliated hospital,College of Medicine,Zhejiang university,Hangzhou 310009,china ~3 Depart-ment of Medical Microbiology and Parasitology,College of Medicine,Zhejiang university,Hangzhou 310006,china ~4 Department ofStomatology,the affiliated hospital of the school of Medicine,ningbo university,ningbo 315020,china ~5 Department of Oral andMaxillofacial Surgery,the affiliated hospital of Stomatology,College of Medicine,Zhejiang university,Hangzhou 310006,china Department of Stomatology the Second Affiliated Hospital College ofMedicine Zhejiang University Hangzhou 310009 China. yanchen_5657@***.

Aim:To investigate the effect of the collagenase gene (prtC) product ofPorphyromonas gingivalis on inducing host cells to secrete inflammatorycytokines,and to discuss the correlation between the PrtC level in subgingivalplaque samples and clinical ***:A prokaryotic expression sys-tem pET32a-prtC-Escheria coli BL21 DE3 was *** and im-munoreactivity of the recombinant PrtC protein (rPrtC) was identified by *** was applied to detect interleukin (IL)-1α,IL-8,and TNF-α levelsin supernatants from rPrtC-induced human umbilical vein endothelial cells (HUVEC)originated ECV304 *** parameters recorded at baseline and after treat-ment included bleeding on probing (BOP),probing depth (PD),and attachmentloss (AL).ELISA was established to measure the PrtC level in 196 subgingivalplaque samples from 49 patients with chronic ***:After co-incubation with 1 μg/mL rPrtC for 24 h and with 5 or 10 μg/mL rPrtC for 12 h,thelevels of IL-1α,IL-8,and TNF-α secreted by the ECV304 cells increased signifi-candy (P6 mm PDsites was higher than that in the BOP-negative or the ≤2 mm AL or ≤6 mm PD sites(P6 mm PD sites,the PrtC levels changed insignifi-cantly (P>0.05).Conclusion:rPrtC is able to directly induce host cells to synthe-size and secrete IL-1α,IL-8,and TNF-α.The PrtC level in subgingival samples iscorrelated with BOP,AL,and PD.

关键词： Porphyromonas gingivalis collagenase cloning cytokine ELISA

含油污泥热解残渣制备渗水砖的重金属和多环芳烃浸出特性

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化工进展 2024年第9期43卷 5226-5233页

作者：全翠高宁博张广涛索浩杰西安交通大学能源与动力工程学院陕西西安710049 陕西威环能科技有限公司陕西西安710086

热解残渣作为含油污泥热解的伴生物,存量日益增多,严重威胁生态环境。含油污泥热解残渣的成分与黏土矿物类似,为此,利用热解残渣代替黏土制备渗水砖,探究制备过程中残渣添加量、加水量和挤压应力对渗水砖抗压强度和透水性能的影响以及... 详细信息

热解残渣作为含油污泥热解的伴生物,存量日益增多,严重威胁生态环境。含油污泥热解残渣的成分与黏土矿物类似,为此,利用热解残渣代替黏土制备渗水砖,探究制备过程中残渣添加量、加水量和挤压应力对渗水砖抗压强度和透水性能的影响以及对渗水砖浸出液中重金属和多环芳烃(PAHs)浓度的影响。分析结果表明,残渣添加量、加水量和挤压应力对渗水砖的抗压强度和透水性能有较大影响,当残渣添加量为15%、加水量为13%(以上均为质量分数)、挤压应力为30MPa时,渗水砖的物理性能最佳。此时,抗压强度为32.20MPa,达到Cc30等级标准;透水系数为1.80×10^(-2)cm/s,高于《透水砖》(JC/T 945—2005)中所规定的1.00×10^(-2)cm/s。重金属和PAHs浸出实验结果表明,渗水砖浸出液中检出的金属包括Cr、Pb、Cu、Ni和Zn,且Cr、Cu和Zn的浓度均低于《地表水环境质量标准》(GB 3838—2002)中所规定的Ⅱ类标准限值和《地下水质量标准》(GB/T 14848—2017)中所规定的Ⅲ类标准限值。残渣添加量、加水量和挤压应力对浸出液中Ni的影响较大,而对Cr的影响较小。渗水砖浸出液中主要检测出萘、苊、二氢苊、芴和菲这5种PAHs,总浓度范围为218.43~408.34μg/L。其中,苊是浸出液中的主要成分,其相对质量分布比例为59.80%~77.55%。本研究可为含油污泥热解残渣的无害化处理和资源化利用提供科学依据。

关键词：油泥热解残渣渗水砖浸出液重金属浸出资源化