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复旦学报（医学版） 2004年第5期31卷 505-508页

作者：王旭朱越蜂顾湘杰陈飞雁黄加张何勇上海复旦大学附属华山医院骨科上海200040 华东医院骨科上海200040

目的　调查跖骨下籽骨变异种类与发生率。方法　随机抽取我院自 2 0 0 1年 8月 19日至 2 0 0 2年 8月18日所拍摄的 4 38足部正、斜位X线片 ,观察并记录籽骨形态的变化。结果　籽骨异常 39足。其中籽骨缺如 7足 ,占 17.95 % (胫腓侧全部... 详细信息

目的　调查跖骨下籽骨变异种类与发生率。方法　随机抽取我院自 2 0 0 1年 8月 19日至 2 0 0 2年 8月18日所拍摄的 4 38足部正、斜位X线片 ,观察并记录籽骨形态的变化。结果　籽骨异常 39足。其中籽骨缺如 7足 ,占 17.95 % (胫腓侧全部缺如 4足 ,单纯胫侧缺如 3足 )。双分籽骨 31足 ,占 79.4 8%。纵裂 1足 ,余为横裂。胫腓侧籽骨均为双分籽骨 1足 ,占 2 .5 6 % ,单纯腓侧籽骨双分 2足 ,占 5 .13% ,单纯胫侧双分籽骨 2 7足 ,占 74 .36 %。三分籽骨 1足 ,占 2 .5 6 % ,单纯胫侧籽骨发育不良 1足 ,占 2 .5 6 %。结论　正常情况下 ,跖骨头下籽骨存在一定比例的形态学变化 ,对于籽骨功能紊乱要全面检查分析、仔细鉴别。

关键词：跖骨骨形态骨头单纯斜位正常异种情况目的拍摄

明尼苏达心力衰竭生活质量调查表适用性的评价

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上海医学 2004年第4期27卷 222-225页

作者：奚悦文范维琥复旦大学附属华山医院心内科上海200040

目的　旨在建立一个有效、敏感 ,适合于中国慢性充血性心力衰竭 (CHF)患者的生活质量调查表。方法　将英文的明尼苏达心力衰竭生活质量调查表 (LiHFe)翻译为中文。入选稳定型CHF患者 2 2例 ,在入选时及 2周后分别填写中文版LiHFe ,进行... 详细信息

目的　旨在建立一个有效、敏感 ,适合于中国慢性充血性心力衰竭 (CHF)患者的生活质量调查表。方法　将英文的明尼苏达心力衰竭生活质量调查表 (LiHFe)翻译为中文。入选稳定型CHF患者 2 2例 ,在入选时及 2周后分别填写中文版LiHFe ,进行调查表的信度检测 (包括内在一致性及重测信度 )。入选的不稳定型CHF患者 4 0例 ,分别于入选时及治疗 1个月稳定后填写LiHFe ,进行调查表反应性检测。对全部病例的基线资料进行调查表的效度检测。结果　①调查表的信度好 ,各项目除经济限制外 ,内在一致性均很好 ,Cronbach’sα值均 >0 .75 ;重测信度好 ,稳定型CHF患者 (2 0例 )前后 2周的LiHFe各计分值变化很小 (平均差异为 - 0 .4 0～0 .85 ,P值均 >0 .0 5 )。②调查表的反应性良好 ,不稳定型CHF患者 (35例 )经 1个月治疗稳定后 ,前后LiHFe各计分值有显著变化 (平均差异为 0 .71～ 8.88,P值均 <0 .0 1)。③调查表的结构效度很好 ,所有 6 2例CHF患者基线时LiHFe各计分与纽约心功能分级间高度相关 (r =0 .6 4～ 0 .70 ,P值均 <0 .0 0 1)。结论　中文版LiHFe是一个有效、敏感 ,且适合于中国慢性CHF患者的生活质量调查表。

关键词：明尼苏达心力衰竭生活质量调查表适用性评价慢性充血性心力衰竭

百草枯增加小鼠黑质细胞caspase-3 mRNA的表达及其酶活性

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复旦学报（医学版） 2004年第5期31卷 462-465页

作者：丁正同任惠民蒋雨平复旦大学附属华山医院神经科上海200040

目的　探讨百草枯对C5 7bl/ 6小鼠黑质细胞caspase 3mRNA的表达及其活性的影响。方法　应用RT-PCR技术检测C5 7bl/ 6小鼠暴露于百草枯不同时间后黑质细胞中caspase 3mRNA表达的变化 ,并采用比色法测定相应时间点黑质细胞的caspase 3酶... 详细信息

目的　探讨百草枯对C5 7bl/ 6小鼠黑质细胞caspase 3mRNA的表达及其活性的影响。方法　应用RT-PCR技术检测C5 7bl/ 6小鼠暴露于百草枯不同时间后黑质细胞中caspase 3mRNA表达的变化 ,并采用比色法测定相应时间点黑质细胞的caspase 3酶的活性。结果　C5 7bl/ 6小鼠暴露于百草枯后黑质细胞中caspase 3mRNA的表达明显增加 ,caspase 3酶的活性也相应地增加 ,这种增加与黑质细胞的凋亡相一致。结论　百草枯可诱导C5 7bl/ 6小鼠黑质细胞表达caspase 3mRNA ,增加caspase 3酶的活性。

关键词：黑质细胞 caspase-3 小鼠表达百草枯 RNA 凋亡酶活性 RT-PCR技术变化

Inhibition of epidermal growth factor receptor expression by RNA interference in A549 cells

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Acta Pharmacologica Sinica 2004年第1期 63-69页

作者： Min ZHANG, Xin ZHANG, Chun-xue BAI, Jie CHEN, MinQ WEILung Department of Zhong Shan hospital, fudan university, shanghai 200032, china Department of Medicine, university of Queensland, Brisbane Qld 4032, Australia

AIM: To investigate the biological features of A549 cells in which epidermal growth factor (EGF) receptors expression were suppressed by RNA interference (RNAi). METHODS: A549 cells were transfected using short small interfering RNAs (siRNAs) formulated with Lipofectamine 2000. The EGF receptor numbers were determined by Western blotting and flowcytometry. The antiproliferative effects of sequence specific double stranded RNA (dsRNA) were assessed using cell count, colony assay and scratch assay. The chemosensitivity of transfected cells to cisplatin was measured by MTT. RESULTS: Sequence specific dsRNA-EGFR down-regulated EGF receptor expression dramatically. Compared with the control group, dsRNA-EGFR reduced the cell number by 85.0 %, decreased the colonies by 63.3 %, inhibited the migration by 87.2 %, and increased the sensitivity of A549 to

关键词： epidermal growth factor receptor RNA interference double-stranded RNA small interfering RNA non-small-cell lung carcinoma

罂粟碱灌洗液能改善异种移植肝早期再灌注障碍

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复旦学报（医学版） 2002年第2期29卷 135-137,F003页

作者：孙鹏蔡端张群华芮晓晖复旦大学附属华山医院普外科上海200040

目的　研究豚鼠至大鼠异种肝移植动物模型中移植肝再灌注障碍的原因和改善的方法。方法　采用Kamada方法建立异种肝移植动物模型 ,分为生理盐水灌洗组 (NS组 )和罂粟碱灌洗组 (PP组 ) ,检测受体门静脉直径、血流速度和血流量 ,并对移植... 详细信息

目的　研究豚鼠至大鼠异种肝移植动物模型中移植肝再灌注障碍的原因和改善的方法。方法　采用Kamada方法建立异种肝移植动物模型 ,分为生理盐水灌洗组 (NS组 )和罂粟碱灌洗组 (PP组 ) ,检测受体门静脉直径、血流速度和血流量 ,并对移植肝行组织学检查。结果　NS组门静脉血流量为 ( 0 .3 2± 0 .0 6)mL s,PP组为( 0 .5 3± 0 .0 9)mL s,PP组门静脉压力差为NS组的 1.85倍。两组移植肝有相似的组织学变化 ,表现为肝细胞水样变性 ,中央静脉和小叶间静脉扩张淤血 ,但肝小叶结构存在。两组受体大鼠存活时间无显著性差别 (P >0 .0 5 )。结论　在该模型中 ,移植肝早期再灌注障碍由门静脉系统血管痉挛引起 ,可用罂粟碱灌洗液缓解 ,后期的再灌注障碍由超急性排斥反应 (HAR)引起。

关键词：肝移植罂粟碱超急性排斥反应再灌注障碍异种移植灌洗液

Ankle fusion with a retrograde locked intramedullary nail for sequela of lower extremity compartment syndrome

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中华创伤杂志(英文版) 2012年第3期15卷 140-144页

作者： WANG Xu,MA Xin,ZHANG Chao,HUANG Jia-zhang,GU Xiang-jie JIANG Jian-yuan Department of Orthopaedics,huashan hospital,fudan university,shanghai 200040,china Department of Orthopaedics Huashan Hospital Fudan University Shanghai 200040 China

Objective:To assess the value of ankle fusion with a retrograde locked intramedullary nail in the treatment of sequela of lower extremity compartment syndrome. Methods:Thirty-five cases of equinus deformity following tibiofibular compartment syndrome treated by means of ankle fusion with a retrograde locked intramedullary nail from January 2001 to December 2010 were retrospectively *** complications,the time needed for bony fusion of the ankle joint assessed by anteroposterior and lateral X-ray photographs as well as patients’ subjective evaluation were recorded and analysed. Results:Among the 35 patients,15 had previously undergone surgical treatment twice on the same limb,13 had thrice and 7 had to be operated on four times before ankle *** anterior midpoint approach to the ankle joint was adopted in 29 cases,while anterior midpoint approach plus a small incision on the posterior ankle joint was made in 17 cases,whereas lateral approach in 6 *** joint fusion was performed on 4 *** follow-up period ranged 6-124 months,averaged 40.6 *** grafting was not performed in this *** tibial shaft fracture occurred in one patient and was healed after conservative *** dehiscence located at previous Achilles tendon incision was found in two patients. As a result,one received an intramedullary nail emplacement at calcaneoplantar part while the wound at anterosuperior part of the other one was healed by dressing *** patients failed to bony union 5 months postoperatively,in which one healed 10 weeks after retrieval of proximal tibial nail and another by iliac *** necrosis of the toe due to blood supply dysfunction was not found in this *** the patients were satisfied with the ankle joint function *** time for bony union on X-rays was 9.8 weeks on *** for one patient who demanded removal of intramedullary nail,all the intramedullary nails were not retrieved at

关键词： Ankle Compartment syndromes Lower extremity Bone nails

Quantitative evaluation of contrast-enhanced ultrasonography in the diagnosis of chronic ischemic renal disease in a dog model

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Quantitative evaluation of contrast-enhanced ultrasonography...

Pravastatin activates platelet nitric oxide synthase (NOS) in patients with type 2 diabetes mellitus and NOS activation is accompanied by serine phosphorylation

第二届长三角超声医学论坛暨2009年浙江省超声医学学术年会

作者： Department of Ultrasound,huashan hospital,fudan university,shanghai 200040,china Yi DONG Department of Diagnostic Ultrasound,Zhongshan hospital,fudan university,shanghai 200032,china Wen-ping WANG Hong DING Jia-ying CAO Pei-li FAN Xi-yuan LIN

Objective Chronic ischemic renal disease(CIRD) is very common in clinical medicine,which is very complicated in its pathological *** of perfusion is an early event in the course of renal dysfunction and usually preced...

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中华医学杂志(英文版) 2005年第19期000卷 72-75页

作者： YAO Kang, XU Biao, Gao Ling and GE Jun-bo shanghai Institute of Cardiovascular Disease, Zhongshan hospital, fudan university, shanghai 200032, china Department of Cardiovascular Disease,Gulou hospital,Nanjing university,Nanjing210008,china shanghai Institute of Cardiovascular Disease Zhongshan Hospital Fudan University Shanghai 200032 China Department of Cardiovascular Disease Gulou Hospital Nanjing University Nanjing 210008 China

Statins cause reductions in myocardial infarction and also morbidity and mortality of type 2 diabetes related to atheromatous disease and its thrombotic complications beyond those predicted by reductions in low density lipoprotein cholesterol (LDL).~ 1,2 It has been suggested that the protective mechanism(s) may relate to improved endothelial function and/or antithrombotic effects, but the mechanism is not clear.

关键词： platelet · HMG-CoA reductase inhibitors · type 2 diabetes mellitus · nitric oxide synthase

Preventive treatments for recurrence after curative resection of hepatocellular carcinoma-A literature review of randomized control trials

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World Journal of Gastroenterology 2003年第4期9卷 635-640页

作者： Hui-Chuan Sun Zhao-You Tang Liver Cancer Institute and Zhong Shan hospital,fudan university,shanghai 200032,china Associate Professor of Surgery Liver Cancer Institute and Zhong Shan Hospital Fudan University 136 Yi Xue Yuan Road Shanghai 200032 China. sunhc@***

To review the inhibitory effect of preventive approaches on recurrence after operation in patients with hepatocellular carcinoma (HCC), we summarized all available publications. reporting randomized control trial indexed in PubMed. The treatment approaches presented above included preoperative transcatheter arterial chemoembolization (TACE),post-operative TACE, systemic or locoregional chemotherapy,immunotherapy, Interferons and acyclic retinoic acid Although no standard treatment has been established,several approaches presented promising results, which were both effective and tolerable in post-operative patients. Preoperative TACE was not effective on prolonging survivals,while post-operative TACE was shown with both diseasefree survival and overall survival benefits in some papers,however, it was also questioned by others. Systemic chemotherapy was generally not effective on prolonging survival but also poorly tolerated for its significant *** immunotherapy using LAK cells was proved to be beneficial to patients' survival in a recent paper. Interferon and Interferon β can inhibit recurrence in HCC patients with HCV infection background, though the mechanism is not fully understood. Acyclic retinoic acid was shown to decrease multi-centric recurrence after operation, which was reported by only one group. In conclusion, several adjuvant approaches have been studied for their efficacy on recurrence in HCC patients in randomized control trials; however, multi-centric randomized control trial is still needed for further evaluation on their efficacy and systemic or local toxicities;in addition, new adjuvant treatment should be investigated to provide more effective and tolerable methods for the patients with HCC after operation.

关键词：预防性治疗肝细胞癌肿瘤切除术复发随机对照研究肝动脉化疗栓塞术