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苏州大学学报（医学版） 2005年第5期25卷 865-867页

作者：姜正南侯建民王蓉芳吴骏张建琴汪毅梁仪江苏大学附属医院心内科江苏镇江212001 江苏大学附属医院科教科江苏镇江212001 江苏大学附属医院中心实验室江苏镇江212001

目的通过观察急性心肌梗死(AMI)患者直接经皮腔内冠状动脉成形术(PTCA)后的心肌肌钙蛋白I(cTnI)的动态变化,以探讨其与AMI溶栓再灌注后cTnI变化的关系。方法12例AMI直接PTCA的患者,系列采集血样,以ELISA法测定cTnI,绘出其释放曲线。选... 详细信息

目的通过观察急性心肌梗死(AMI)患者直接经皮腔内冠状动脉成形术(PTCA)后的心肌肌钙蛋白I(cTnI)的动态变化,以探讨其与AMI溶栓再灌注后cTnI变化的关系。方法12例AMI直接PTCA的患者,系列采集血样,以ELISA法测定cTnI,绘出其释放曲线。选择68例AMI接受溶栓的患者,参照中华心血管病杂志编委会制定的《急性心肌梗死溶栓疗效参考方案》,判定42例再通,26例未通,绘出cTnI释放曲线,比较二者的峰值时间和上升速度,并将溶栓再通组与直接PTCA组相比较。结果①溶栓再通组与溶栓未通组cTnI的释放主要为单峰形式,溶栓再通组的达峰时间明显早于后者,峰值水平及上升速度也明显高于溶栓未通组(P<0.05);②直接PTCA组与溶栓再通组相比,二者达峰时间几乎一致,前者的峰值水平及上升速率略高于后者,但二者无显著性差异(P<0.05)。结论AMI后cTnI的峰值前移可作为AMI后溶栓再灌注的判断标准之一。

关键词：急性心肌梗死直接经皮腔内冠状动脉成形术心肌肌钙蛋白I 溶栓再灌注

蛇毒心脏毒素对荷瘤小鼠的抗肿瘤作用初步研究

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蛇志 1998年第2期10卷 1-4页

作者：梁敏仪陈家坤朱蔚云黄月玲曾军广州医学院广州化学致癌研究所

目的探讨蛇毒心脏毒素（ＣＴＸ）对荷瘤小鼠Ｓ１８０腹水瘤细胞生长抑制的影响。方法小鼠腹腔接种Ｓ１８０活瘤细胞，连续１０ｄ分别腹腔注射ＣＴＸ０．８ｍｇ／ｋｇ、０．４ｍｇ／ｋｇ、０．２ｍｇ／ｋｇ，分析统计荷瘤小鼠的体重变化... 详细信息

目的探讨蛇毒心脏毒素（ＣＴＸ）对荷瘤小鼠Ｓ１８０腹水瘤细胞生长抑制的影响。方法小鼠腹腔接种Ｓ１８０活瘤细胞，连续１０ｄ分别腹腔注射ＣＴＸ０．８ｍｇ／ｋｇ、０．４ｍｇ／ｋｇ、０．２ｍｇ／ｋｇ，分析统计荷瘤小鼠的体重变化和癌细胞死亡率，并用有丝分裂完全阻断法分析体内癌细胞的有丝分裂过程。结果ＣＴＸ各剂量组荷瘤小鼠的体重抑制和癌细胞死亡率均有明显的剂量反应关系，与对照组相比有显著的差异（Ｐ＜０．０１）；镜检发现ＣＴＸ能抑制体内癌细胞的有丝分裂，表现在０．４ｍｇ／ｋｇ和０．８ｍｇ／ｋｇ实验组腹水Ｓ１８０细胞处于有丝分裂前期和中期的细胞数量明显减少，其ＭＩ值分别为０．７１％和０．８０％，比对照组显著减少（Ｐ＜０．００１）。结论ＣＴＸ对Ｓ１８０小鼠体内癌细胞的生长有抑制和杀伤作用，并通过干扰和阻断癌细胞的有丝分裂过程，抑制腹水的生长。

关键词：蛇毒心脏毒素腹水瘤抗肿瘤作用

Sodium hydrosulfide alleviated pulmonary vascular structural remodeling induced by high pulmonary blood flow in rats

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Acta Pharmacologica Sinica 2006年第8期27卷 971-980页

作者： Xiao-hui LI~2 Jun-bao DU~(2,6) Ding-fang BU~3 Xiu-ying TANG~4 Chao-shu TANG~5 ~1Department of Pediatrics,Peking University First Hospital,Key laboratory of Molecular Cardiovascular Diseases,Ministry of Education ~3.laboratory center ~4laboratory of Electron Microscopy,Peking University First Hospital,Beijing 100034,China ~5Department of Physiology,Peking University Health Science center,Beijing 100083,China Department of Pediatrics Peking University First Hospital Key Laboratory of Molecular Cardiovascular Diseases Ministry of Education Beijing China laboratory center Peking University First Hospital Beijing China laboratory of Electron Microscopy Peking University First Hospital Beijing China Department of Physiology Peking University Health Science Center Beijing China

Aim:To explore the possible role of endogenous hydrogen sulfide （H2S）,a novelgasotransmitter,in the pathogenesis of pulmonary vascular structural remodeling（PVSR） induced by high pulmonary blood ***:Thirty-two Sprague-Dawley male rats were randomly divided into sham,shunt,sham+NaHS （a H2Sdonor） and shunt+NaHS *** in shunt and shunt+NaHS groups under-went an abdominal aorta-inferior vena cava shunt,and rats in shunt+NaHS andsham+NaHS groups were intraperitoneally injected with *** was inves-tigated using optical microscope and transmission electron *** H2S was evaluated by sulfide-sensitive *** oxide synthase（NOS）,heme oxygenase （HO-1）,proliferative cell nuclear antigen （PCNA） andextracellular signal-regulated kinase （ERK） activation were analyzed by ***:After 11 weeks of shunting,PVSR developed with a decrease inlung tissue H2S production and an increase in nitric oxide （NO）.However,lungtissue carbon monoxide （CO） did not *** the treatment with NaHS for11 weeks,H2S donor ameliorated PVSR and downregulated PCNA expression andERK activation with an increase in lung tissue CO production and HO-1 proteinexpression but a decrease in NO production,NOS activity and eNOS proteinexpression in shunted ***:H2S exerted a regulatory effect on PVSRinduced by high pulmonary blood ***,H2S down-regulated theERK/MAPK signal pathway,inhibited the NO/NOS pathway and enhanced theCO/HO pathway in rats with high pulmonary blood flow.

关键词： hydrogen sulfide pulmonary hypertension structure remodeling nitric oxide/nitric oxide synthase carbon monoxide/heme oxygenase

Pre-LOI trajectory maneuvers of the CHANG'E-2 libration point mission

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Science China(Information Sciences) 2012年第6期55卷 1249-1258页

作者： WU WeiRen 1,LIU Yong 2,3,LIU Lei 2,3,ZHOU JianLiang 3,TANG GeShi 2,3 & CHEN YongZhi 3 1 Chinese Lunar Exploration and Space Project center,Beijing 100037,China 2 Science and Technology on Aerospace Flight Dynamics laboratory,Beijing 100094,China 3 Beijing Aerospace Control center,Beijing 100094,China Chinese Lunar Exploration and Space Project center Beijing China Science and Technology on Aerospace Flight Dynamics laboratory Beijing China Beijing Aerospace Control center Beijing China

This paper addresses pre-LOI (before Lissajous orbit insertion) trajectory maneuvers for the libration point mission of CHANG'E-2,which is the first Chinese satellite to fly to the Sun-Earth L2 libration point and the first satellite ever to fly to the L2 point from lunar ***,a transfer trajectory for the mission is designed based on InterPlanetary Superhighway theory under the constraint of the remaining propellant,TT&C (telemetry,track and command) and sunlight *** effects of trajectory maneuver errors on the mission are also ***,based on the analysis results,the article investigates the trajectory maneuver schemes for the lunar escape and transfer trajectory maneuvers employing mathematical models and operational *** mission status based on our maneuver schemes is then presented,and the results of control operation and corresponding analysis are provided in ***,the future trajectory maneuver in the Lissajous orbit is *** to the analysis of the CHANG'E-2 TT&C data,the trajectory maneuver schemes proposed in the article work properly and efficiently.

关键词： CHANG’E-2 libration point trajectory maneuver escape trajectory transfer trajectory

Collision dynamics of He@C_(60)+He@C_(60) at low energies

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Science China(Physics,Mechanics & Astronomy) 2008年第7期51卷 765-772页

作者： ZHAO Qiang1,2, ZHANG FengShou1,2,3 & ZHOU HongYu1,2 1 Key laboratory of Beam Technology and Material Modification of Ministry of Education, Institute of Low Energy Nuclear Physics, Beijing Normal University, Beijing 100875, China 2 Beijing Radiation center, Beijing 100875, China 3 center of Theoretical Nuclear Physics, National laboratory of Heavy Ion Accelerator of Lanzhou, Lanzhou 730000, China Key laboratory of Beam Technology and Material Modification of Ministry of Education Institute of Low Energy Nuclear Physics Beijing Normal University Beijing China Beijing Radiation center Beijing China center of Theoretical Nuclear Physics National Laboratory of Heavy Ion Accelerator of Lanzhou Lanzhou China

A semi-empirical molecular dynamics model is developed. The central collisions of C60+C60 and He@C60+He@C60 at different incident energies are investigated based on this model. It is found that the dimer structures have been produced at proper incident energies and these fullerene dimers could be formed by a self-assembly of C60 fullerene and He@C60. The He atom has a significant effect at higher incident energy and this embedded He atom can enhance the stability of the dimer structure.

关键词： C60 He@C60 collision molecular dynamics

A virtual reference satellite differential method for relative correction of satellite ephemeris errors

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Science China(Physics,Mechanics & Astronomy) 2010年第12期53卷 2300-2306页

作者： CAI ChengLin 1,3 , LI XiaoHui 2,3 & WU HaiTao 2,3 1 Gulin University of Electronic Technology, 541004, China 2 National Time Service center, Chinese Academy of Sciences, Lintong 710600, China 3 Key laboratory of Precision Navigation and Timing Technology, National Time Service center, Chinese Academy of Sciences, Lintong 710600, China Gulin University of Electronic Technology Gulin China Key laboratory of Precision Navigation and Timing Technology National Time Service Center Chinese Academy of Sciences Lintong China National Time Service center Chinese Academy of Sciences Lintong China

In order to solve the problems that the novel wide area differential method on the satellite clock and ephemeris relative correction (CERC) in the non-geostationary orbit satellite constellation, a virtual reference satellite (VRS) differential principle using relative correction of satellite ephemeris errors is proposed. It is referred to be as the VRS differential principle, and the elaboration is focused on the construction of pseudo-range errors of VRS. Through qualitative analysis, it can be found that the impact of the satellite’s clock and ephemeris errors on positioning can basically be removed and the users’ positioning errors are near zero. Through simulation analysis of the differential performance, it is verified that the differential method is universal in all kinds of satellite navigation systems with geostationary orbit (GEO) constellation, Medium orbit (MEO) constellation or hybrid orbit constellation, and it has insensitivity to abnormal aspects of a satellite ephemeris and clock. Moreover, the real time positioning accuracy of differential users can be maintained within several decimeters after the pseudo-range measurement noise is effectively weakened or eliminated.

关键词： wide area differential method virtual reference satellite (VRS) satellite ephemeris errors satellite clock errors constellation

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放射治疗相关的器官运动管理指南

中华放射肿瘤学杂志 2024年第3期33卷 189-196页

作者：国家癌症中心/国家肿瘤质控中心陈明不详华南恶性肿瘤防治全国重点实验室广东省鼻咽癌诊治研究重点实验室广东省恶性肿瘤临床医学研究中心中山大学肿瘤防治中心中山大学-国科离子放射治疗前沿技术联合实验室广州510060

肿瘤定位的准确性是实现精准放射治疗的关键。器官运动是肿瘤定位的主要误差来源。不同部位肿瘤的运动类型不同,相应的管理策略也有所差异。本指南系统总结了头颈部、胸部、腹部、盆腔部的常见肿瘤疾病的器官运动来源,以及现行的运动管... 详细信息

肿瘤定位的准确性是实现精准放射治疗的关键。器官运动是肿瘤定位的主要误差来源。不同部位肿瘤的运动类型不同,相应的管理策略也有所差异。本指南系统总结了头颈部、胸部、腹部、盆腔部的常见肿瘤疾病的器官运动来源,以及现行的运动管理方法。针对基于医用电子直线加速器开展的放射治疗,本指南依据肿瘤所处的部位差异,给出了相应的运动管理建议,旨在为已开展或即将开展放射治疗临床实践的单位提供参考的指南依据,以便正确、合理地制订器官运动管理方案,提升放疗实施的准确性,保证治疗疗效。

关键词：放射疗法器官运动管理指南

Relative importance of water, energy, and heterogeneity in determining regional pteridophyte and seed plant richness in China

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Journal of Systematics and Evolution 2011年第2期49卷 95-107页

作者： 1,2,3 Sheng-Bin CHEN § 1 Gao-Ming JIANG 3 Zhi-Yun OUYANG 3 Wei-Hua XU 3 Yi XIAO 1 (State Key laboratory of Vegetation and Environmental Change, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China) 2 (Graduate University of the Chinese Academy of Sciences, Beijing 100049, China) 3 (State Key laboratory of Urban and Regional Ecology, Research center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China) (State Key laboratory of Vegetation and Environmental Change Institute of Botany Chinese Academy of Sciences Beijing 100093 China) (Graduate University of the Chinese Academy of Sciences Beijing 100049 China) (State Key laboratory of Urban and Regional Ecology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China)

Environmental variables, such as ambient energy, water availability, and environmental heterogeneity have been frequently proposed to account for species diversity gradients. How taxon-specific functional traits define large-scale richness gradients is a fundamental issue in understanding spatial patterns of species diversity, but has not been well documented. Using a large dataset on the regional flora from China, we examine the contrast spatial patterns and environmental determinants between pteridophytes and seed plants which differ in dispersal capacity and environmental requirements. Pteridophyte richness shows more pronounced spatial variation and stronger environmental associations than seed plant richness. Water availability generally accounts for more spatial variance in species richness of pteridophytes and seed plants than energy and heterogeneity do, especially for pteridophytes which have high dependence on moist and shady environments. Thus, pteridophyte richness is disproportionally affected by water-related variables; this in turn results in a higher proportion of pteridophytes in regional vascular plant floras (pteridophyte proportion) in wet regions. Most of the variance in seed plant richness, pteridophyte richness, and pteridophyte proportion explained by energy is included in variation that water and heterogeneity account for, indicating the redundancy of energy in the study extent. However, heterogeneity is more important for determining seed plant distributions. Pteridophyte and seed plant richness is strongly correlated, even after the environmental effects have been removed, implying functional linkages between them. Our study highlights the importance of incorporating biological traits of different taxonomic groups into the studies of macroecology and global change biology.

关键词： habitat heterogeneity pteridophytes seed plants species richness water-energy hypothesis.

Dynamic behavior of fragile X full mutations in cultured female fetal fibroblasts

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Acta Pharmacologica Sinica 2004年第7期25卷 127-130页

作者： Yu-jie SUN1,2,Xiao HAN1,3 1laboratory of Functional Genomics at Nanjing Medical University, Nanjing 210029, China 2Division of Molecular Medicine in Beckman Research Institute, Leslie and Susan Gonda (Goldschmied) Diabetes 3 and Genetics Research center, City of Hope National Medical center, Duarte, California laboratory of Functional Genomics at Nanjing Medical University Nanjing 210029

AIM: Toassess mitotic stability ofthe fragile X fullmutations andits relationshipwith DNA methylation. METHODS: The length change of the expanded CGG repeats was examined and correlated it with the methylation status in the DNA samplesisolated fromthe fibroblasts derived from a fragile Xfemale fetus anda fragileX maleadult, respectively. RESULTS: A dramatic instability of the expanded CGG repeats in the female fetal fibroblasts was observed. South- ern blot analysis revealed that the 6.9-kb major expanded band detected in passage 2 was completely replaced by a 7.7-kb band after passage 30. Fibroblast clones derived from the passage 3 displayed an unstable expansion of the CGG repeat during clonal proliferation, while methylation status of the CGG repeat region was maintained. In contrast, in fragile X male fibroblasts the expanded CGG repeats were stable during clonal proliferation. CONCLUSION: The mitotic instability of expanded CGG repeat is not always restricted in early development window as proposed previously and other elements rather than DNA methylation could affect the stability of the expanded CGG repeats in fragile X female fetal fibroblast cells.

关键词： DNA female fetus fibroblasts fragile X syndrome heterozygote human mutation X chromo- some