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Population pharmacokinetics of valproate in Chinese children with epilepsy

Acta Pharmacologica Sinica 2007年第10期28卷 1677-1684页

作者： De-chun JIANG~(2.3),Li WANG~4,Yu-qin WANG~(2.6),Lin LI~3,Wei LU~5,Xiang-rong BAI~2.2.department of Pharmacy,xuan-wu hospital of capital medical university,Beijing {2. ~4 department of Pediatrics,Peking universityFirst hospital,Beijing 100034,china ~3.department of pharmacology,xuan-wu hospital of capital medical university,education ministry keylaboratory for neurodegenerative diseases,Beijing {2. ~5 School of Pharmaceutical Science,Peking university,Beijing 100083,china department of Pharmacy Xuan-wu Hospital of Capital Medical University Beijing China department of pharmacology Xuan-wu Hospital of Capital Medical University Education Ministry Key Laboratory for Neurodegenerative Diseases Beijing China department of Pediatrics Peking University First Hospital Beijing China School of Pharmaceutical Science Peking University Beijing China

Aim:The aim of the present study is to establish a population pharmacokinetic（PPK） model of valproate （VPA） in Chinese epileptic children to promote thereasonable use of anti-epileptic ***:Sparse data of VPA serumconcentrations from 417 epileptic children were *** patients weredivided into 2.groups:the PPK model group （n=317） and the PPK valid group（n=100）.The PPK parameter values of VPA were calculated by NONMEM soft-ware using the data of the PPK model group.A basic model and a final modelwere set *** validate the 2.models,the concentrations of PPK valid groupwere predicted by each model,*** mean prediction error （MPE）,mean squared prediction error （MSPE）,root mean squared prediction error（RMSPE）,weight residues （WRES）,and the 95% confidence intervals （95%CI） were also ***,the values between the 2.models were ***:The PPK of VPA was determined by a 1-compartment model with afirst-order absorption *** basic model was:Ka=3.09 (h-1),V/F=2..4（L）,CL/F=0.2.6 （L/h）.The final model was:Ka=0.2.1+2.2.·（1-HS）(h-1),V/F=2.88+0.157·WT （L）,CL/F=0.1060.98·CO+0.0157·AGE （L/h）.For thebasic model,the MPE,MSPE,RMSPE,WRES,and the 95% CI were-2..53（-30.36,-16.70）,372..96 （2.72.72.4585.2.）,39.62.（34.34,44.90）,and-0.06 （-0.14,0.02.,*** the final model,the MPE,MSPE,RMSPE,WRES,and the95% CI were-1.16 （-4.85,2.53）,1002.83 （1050.64,1143.61）,2..04 （2..12.2..96）,and0.08 （-0.04,0.2.）,*** final model was more optimal than the ***:The PPK model of VPA in Chinese epileptic children wassuccessfully *** will be valuable to facilitate individualized dosageregimens.

关键词： population pharmacokinetics valproic acid epilepsy children Bayesian method NONMEM software individualized dosage regimens

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Morroniside prevents peroxide-induced apoptosis by induction of endogenous glutathione in human neuroblastoma cells

Morroniside prevents peroxide-induced apoptosis by induction...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Wen WANG~1,Wen-Ting HUANG~2.Lin Li~(1,3),Hou-Xi AI~1,Fang-Ling SUN~2.Ci LIU~1.Yi AN~2.1 department of pharmacology,{2.,Key Laboratory for neurodegenerative diseases of ministry of education,Beijing 100053.china 2.chool of Life Science and Technology,Beijing Institute of Technology,Beijing 100081,china

(1) Morroniside belongs to an extensive group of natural iridorid *** the present study,using human neuroblastoma SH-SY5Y cells,we have investigated the protective effects of this compound on modifications in endogenous reduced glutathione(GSH),intracellular oxygen species(ROS) and apoptotic death on HO-mediated cytoxicity. (2. Incubation of cells with morroniside led to a significant dose-dependent elevation of cellular GSH accompanied by a marked protection against H2.2.mediated *** at 1-100μmol/L inhibited the formation of ROS and the activation of caspase-3 and 9,and the upregulation of Bcl-2.whereas no significant change occurred in Bax levels.(3) Our results indicated that the anti-oxidative and anti-apoptotic properties render this natural compound potentially protective against HO-induced cytotoxicity.(4) This study suggested that intracellular GSH appeared to be an important factor in morroniside-mediated cytoprotection against HO-toxicity in SH-SY5Y cells.

关键词： morroniside antioxidant apoptosis human neuroblastoma cell iridorid glycoside neurodegenerative disorders cornus officinalis

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Abnormal white matter microstructure in Parkinson's disease revealed by diffusion tensor imaging A non-randomized concurrent control observation

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Neural Regeneration Research 2010年第2期5卷 98-101页

作者： Jiangtao Liu Kuncheng Li Jinglin Zhang Xiaoli wu Biao Chen department of Radiology Xuanwu Hospital Capital Medical University Beijing 100053 China Key Laboratory of ministry of education on {2. diseases Xuanwu Hospital Capital Medical University Beijing 100053 China

BACKGROUND： Imaging has been used to determine gray matter volume and metabolism in subjects with depressed Parkinson＇s disease （DPD）. OBJECTIVE： To reveal abnormalities in orbitofrontal white matter and the anterior cingulate bundle in depressed and non-depressed Parkinson＇s disease （NDPD） patients using diffusion tensor imaging. DESIGN, TIME AND SETTING： A non-randomized, concurrent, control, neuroimaging study was performed at the Laboratory of neurodegenerative diseases and Center of Neuroimage, {2.wu hospital of capital medical university from July 2.08 to January 2.09. PARTICIPANTS： A total of 30 Parkinson＇s disease patients, including 14 males and 16 females, were included in the present study. All patients met Brain Bank criteria for idiopathic Parkinson＇s disease formulated by the United Kingdom Parkinson＇s Disease Society. Patients, who underwent previous head surgery, exhibited abnormal density on T2.weighted images, or Mini-Mental State Examination scores 〈 corresponding education level, were excluded from the study. METHODS： All 35 patients underwent MRI scans, including traditional T2.weighted and DTI scans. The patients were assigned to DPD （n = 16） and NDPD （n = 14） groups according to the Diagnostic and Statistical Manual of Mental Disorders-IV （DSM-IV） criteria. The fractional anisotropy values of regions of interest were compared between the NDPD and DPD groups. MAIN OUTCOME MEASURES： Abnormalities in the orbitofrontal white matter and anterior cingulate bundle. RESULTS： Compared with the NDPD group, the DPD group exhibited significantly lower fractional anisotropy values in orbitofrontal white matter and anterior cingulate bundle （P 〈 0.05）. CONCLUSION： Microstructure abnormalities existed in the orbitofrontal and anterior cingulate regions in DPD patients. This is the first report of abnormalities in the orbitofrontal white matter region in DPD patients.

关键词： Parkinson's disease depression diffusion tensor imaging fractional anisotropy

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Seropositivity rates of water channel protein 4 antibodies compared between a cell-based immunofluorescence assay and an enzyme-linked immunosorbent assay in neuromyelitis optica patients

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Neural Regeneration Research 2011年第32期6卷 2490-2494页

作者： Xiaoli wu Zhangyuan Liao Jing Ye Huiqing Dong ChaodongWang Piu Chan department of Neurology and Key Laboratory ministry of {2. on neurodegenerative diseases Xuanwu Hospital of Capital MedicalUniversity Beijing 100053 China department of Neurology Xuanwu Hospital of Capital Medical University Beijing 100053 China

A total of 66 samples （from 2. cases with neuromyelitis optica, 2. cases with multiple sclerosis, aa 13 cases with optic neuritis） were tested for aquaporin-4 antibody by a cell-based immunofluorescence assay and an enzyme-linked immunosorbent assay. The sensitivities and specificities of the two assays were similar. We further analyzed an additional 68 patients and 93 healthy controls using the enzyme-linked immunosorbent assay. A Kappa test showed good consistency between the two methods in terms of detection of anti-aquaporin-4 antibody in the se of neuromyelitis optica patients. No significant correlations were identified with onset age or disea duration, suggesting that aquaporin-4 antibody is a good marker for neuromyelitis optica. The enzyme-linked immunosorbent assay can be used for quantifying aquaporin-4 antibody concentrations and may be useful to dynamically monitor changes in the levels of aquaporin-4 antibody during disease duration.

关键词： neuromyelitis optica cell-based immunofluorescence assay anti-aquaporin 4 antibody enzyme-linked immunosorbent assay long and extended spinal cord lesions neural regeneration

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Tetrahydroxystilbene glucoside protects against sodium azide-induced mitochondrial dysfunction in human neuroblastoma cells

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Chinese Herbal Medicines 2021年第2期13卷 255-260页

作者： Ru-yi Zhang Xu Zhang Lan Zhang Yan-chuan wu Xue-jing Sun Lin Li department of Pharmacy Xuanwu Hospital of Capital Medical UniversityBeijing Engineering Research Centre for Nerve System DrugsBeijing Institute for Brain DisordersKey Laboratory for Neurodegenerative Diseases of Ministry of EducationBeijing 100053China department of Central Laboratory Xuanwu Hospital of Capital Medical UniversityBeijing 100053China department of Haematology Xuanwu Hospital of Capital Medical UniversityBeijing 100053China

Objective:Mitochondrial dysfunction is evident in the early stage of Alzheimer's disease(AD).Therefore development of drugs that protect mitochondrial function is a promising strategy for *** present work was to investigate the effects of 2.3,5,4'-Tetrahydroxystilbene-2.O-β-d-glucosides(TSG) on a mitochondrial dysfunction cell model induced by sodium azide and elucidate the underlying ***:Mitochondrial membrane potential(MMP) was detected by a fluorescence *** adenosine triphosphate(ATP) level was measured using a firefly luciferase-based *** oxygen species(ROS) was detected using dichlorofluorescin diacetate(DCFH-DA).The expression levels of Bcl-2.and Bax were measured by Western blotting *** cytometry was utilized to measure ***:Pretreatment of TSG(2.-2.0 μmol/L) for 2. h significantly elevated MMP and ATP content,reduced ROS level and Bax/Bcl-2.ratio,and inhibited apoptosis in SH-SY5 Y cells exposed to sodium ***:These results suggest that TSG protects SH-SY5 Y cells against sodium azide-induced mitochondrial dysfunction and *** findings are helpful to understand the protective effect of TSG on mitochondria,which are involved in the early stage of AD.

关键词： Alzheimer’s disease mitochondria tetrahydroxystilbene glucoside sodium azide

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Effects of tetrahydroxystilbene glucoside in Parkinson′s disease mice model induced by MPTP

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中国药理学与毒理学杂志 2015年第S1期29卷 45-45页

作者： Ru-yi ZHANG Li ZHANG Yan-chuan wu Lin LI department of pharmacology Xuanwu HospitalCapital Medical UniversityBeijing Geriatric Medical Research CenterKey Laboratory for Neurodegenerative Diseases of Ministry of Education department of Central Lab Xuanwu HospitalCapital Medical University

OBJECTIVE To observe effects of tetrahydroxystilbene glucoside(TSG)on behavior,content of dopamine and its metabolites in striatum of Parkinson′s disease(PD)model mice induced by 1-methyl-4-phenyl-1,2.3,6-tetrahydropyridine(MPTP)*** Mice were randomly divided into control group,model group,TSG low dose(60mg·kg-1)and high dose(12.mg·kg-1)*** behavior changes of mice were observed by pole test,rotarod test and spontaneous movement *** tyrosine hydroxylase(TH)positive cells were detected by immunohistochemical *** content of dopamine(DA)and its metabolites in striatum were determined by *** MPTP model mice showed behavior *** number of TH positive neurons in substantia nigra,the content of dopamine and its metabolites in striatum in model mice decreased significantly compared with control *** ameliorated mice behavior,increased the number of TH positive neurons in the substantia nigra about 18.8%,and elevated the content of dopamine in striatum about 34.5% compared with model *** TSG protected dopaminergic neurons against MPTP-induced damage,and may become a candidate drug for prevention and treatment of Parkinson′s disease.

关键词： tetrahydroxystilbene glucoside 1-methyl-4-phenyl-1

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Recommendations for the diagnosis and treatment of paroxysmal kinesigemc dyskinesia: an expert consensus in china

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Translational Neurodegeneration 2021年第1期10卷 67-76页

作者： Li Cao Xiaojun Huang Ning Wang Zhiying wu Cheng Zhang Weihong Gu Shuyan Cong Jianhua Ma Ling Wei Yanchun Deng Qi Fang Qi Niu Jin Wang Zhaoxia Wang You Yin Jinyong Tian Shufen Tian Hongyan Bi Hong Jiang Xiaorong Liu Yang Lu Meizhen Sun Jianjun wu Erhe Xu Tao Chen Tao Chen Xu Chen Wei Li Shujian Li Qinghua Li Xiaonan Song Ying Tang Ping Yang Yun Yang Min Zhang Xiong Zhang Yuhu Zhang Ruxu Zhang Yi Ouyang Jintai Yu Quanzhong Hu Qing Ke Yuanrong Yao Zhe Zhao Xiuhe Zhao Guohua Zhao Furu Liang Nan Cheng Jianhong Han Rong Peng Shengdi Chen Beisha Tang department of Neurology Ruijin Hospital Shanghai Jiao Tong University School of MedicineShanghaiChina department of Neurology The Sixth People's Hospital Shanghai Jiaotong UniversityShanghaiChina department of Neurology and Institute of Neurology The First Affiliated HospitalFujian Medical University/Fujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouChina department of Neurology and Research Center of Neurology The Second Affiliated Hospital/Key Laboratory of Medical Neurobiology of Zhejiang ProvinceZhejiang University School of MedicineHangzhouChina department of Neurology The First Affiliated HospitalSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases/National Key Clinical Department and Key Discipline of NeurologyGuangzhouChina department of Neurology China-Japan Friendship HospitalMovement Disorder and Neurogenetics Research CenterBeijingChina department of Neurology Shengjing Hospital of China Medical UniversityShenyangChina department of Neurology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiChina department of Neurology The First Affiliated Hospital of Anhui Medical UniversityCollaborative Innovation Center for Neuropsychiatric Disorders and Mental HealthAnhui Medical University/Anhui Province Key Laboratory of Cognition and Neuropsychiatry DisordersHefeiChina department of Neurology Xijing HospitalFourth Military Medical UniversityXi'anChina department of Neurology The First Affiliated Hospital of Soochow UniversitySuzhouChina department of Neurology The First Affiliated Hospital of Nanjing Medical UniversityNanjingChina department of Neurology The First Affiliated Hospital of Guangxi Medical UniversityNanningChina department of Neurology Peking University First HospitalBeijingChina department of Neurology Changzheng Hospitalthe PLA Naval Medical UniversityShanghaiChina department of Neurology and department of Emergency Guizhou Provincial People's Hospital

Paroxysmal dyskinesias are a group of neurological diseases characterized by intermittent episodes of involuntary movements with different *** kinesigenic dyskinesia(PKD)is the most common type of paroxysmal dyskinesia and can be divided into primary and secondary types based on the ***,PKD is characterized by recurrent and transient attacks of involuntary movements precipitated by a sudden voluntary *** major cause of primary PKD is genetic abnormalities,and the inheritance pattern of PKD is mainly autosomal-dominant with incomplete *** proline-rich transmembrane protein 2.PRRT2.was the first identified causative gene of PKD,accounting for the majority of PKD cases *** increasing number of studies has revealed the clinical and genetic characteristics,as well as the underlying mechanisms of *** seeking the views of domestic experts,we propose an expert consensus regarding the diagnosis and treatment of PKD to help establish standardized clinical evaluation and therapies for *** this consensus,we review the clinical manifestations,etiology,clinical diagnostic criteria and therapeutic recommendations for PKD,and results of genetic analyses in PKD patients performed in domestic hospitals.

关键词： Paroxysmal kinesigenic dyskinesia Diagnosis and treatment Expert consensus china

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Perspectives on a collaborative Canada-china research program on diagnostic biomarkers for pre-dementia stages of Alzheimer’s disease

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Journal of Translational Neuroscience 2017年第3期2卷 1-6页

作者： Serge Gauthier Jianping Jia Sylvie Belleville Simon Cloutier Dessa Sadovnick Colleen Guimond Laura Robb Mario Masellis Guy A Rouleau Liyong wu Pedro Rosa-Neto McGill Center for Studies in Aging Douglas Mental Health Research Institute Montreal H4H IR3 Canada Innovation Center for Neurological Disorders Department of Neurology Xuanwu Hospital Capital Medical University Beijing 100053 China Beijing Key Laboratory of Geriatric Cognitive Disorders Beijing 100053 China Clinical Center for neurodegenerative Disease and Memory Impairment Capital Medical University Beijing 100053 China Center of Alzheimer's Disease Beijing Institute for Brain Disorders Beijing 100053 China Key Laboratory of neurodegenerative diseases Ministry of Education Beijing 100053 China National Clinical Research Center for Geriatric Disorders Beijing 100053 China Institut Universitaire de Gériatrie de Montréal Montréal H3W IW5 Canada department of medical Genetics University of British Columbia Vancouver V6T IZ4 Canada Division of Neurology Department of Medical Genetics University of British Columbia Vancouver V6T IZ4 Canada Division of Neurology/department of Medicine Sunnybrook Health Sciences Centre University of Toronto Toronto M5S 3H7 Canada Hurvitz Brain Sciences Research Program Sunnybrook Research Institute Toronto M4N 3M5 Canada Montreal Neurological Institute Montréal H3A 2B4 Canada department of Neurology Xuanwu Hospital Capital Medical University Beijing 100053 China

As biomarkers are important in the early diagnosis ofAlzheimer’s disease （AD）, the frst collab-orative work of recruiting early-onset familial AD （EO-FAD） families in Canada and china was initiated in 2.12. The registration networks have collected hundreds of pedigrees, for which genetic screening, neuropsycholog-ical tests and amyloid and tau imaging was used to study diagnostic biomarkers for preclinical and mild cognitive impairment （MCI） stages of AD. Besides identifying ped-igrees with novel mutations in presenilins （PSENs）/amy-loid precursor protein （APP）, the program has benefted training of Chinese research fellows, AD clinical trials forprevention,the ethical concernsfor clinical fndings, and other collaborative projects with Chinese investiga-tors. Further research of the collaborative program may facilitate the testing and clinical use of novel treatments for EOFAD and late onset AD and contribute to dementia prevention strategies in Canada and china.

关键词： registration network early-onset fa-milial Alzheimer’s disease (EOFAD) mutation neuro-psychological testing

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Biomarkers of aging

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Science china(Life Sciences) 2023年第5期66卷 893-1066页

作者： Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang xuan Wang Yaning Wang Yuhan Wang Rimo wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu Aging Biomarker Consortium(ABC) Beijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Aging Biology Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Clinic Center of Human Gene Research Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Clinical Research Center of Metabolic and Cardiovascular Disease Huazhong University of Science and TechnologyWuhan 430022China Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging Huazhong University of Science and TechnologyWuhan 430022China Stem Cell Translational Research Center Tongji HospitalTongji University School of MedicineShanghai 200065China department of Nuclear Medicine Daping HospitalThird Military Medical UniversityChongqing 400042China CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Shanghai Key Laboratory of Maternal Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchShanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China The department of Endovascular Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Regenerative Medicine of ministry of education Institute of Ageing and Regenerative MedicineJ

Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological *** a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly *** immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this ***,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory *** fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant.

关键词： aging senescence biomarker clock

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An Investigation on the Clinical Features and Rest-state Functional MRI ( fMRI) Changes of Olfactory Dysfunction in Alzheimer's Disease

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神经药理学报 2018年第2期 52-53页

作者： LIAN Teng-hong LI Shao-wu WANG Rui-dan YU Shu-yang ZUO Li-jun YU Qiu-jin GUO Peng LIU Li YI Yang JIN Cao PU Ying-shan LI Li-xia 张巍 department of Geriatrics Beijing Tiantan HospitalCapital Medical University Beijing Neurosurgical Institute Capital Medical University department of Neurology Beijing Tiantan HospitalCapital Medical University china National Clinical Research Center for Neurological diseases Beijing Institute for Brain Disorders Key Laboratory for neurodegenerative Disorders of the ministry of {2.

Objective:To explore the changes of clinical features and rest-state functional MRI(fM RI) changes of olfactory dysfunction in patients with Alzheimer’s disease( AD). Methods:Total 31 AD patients were consecutively recruited from the department of Geriatrics,Beijing Tiantan hospital,{2. medical university from April 2.16 to November 2.16. Argentina Hyposmia Rating Scale( AHRS) were used for screening olfaction. Olfactory function test was tested with Sniffin’ Sticks which consisted of three tests:odor threshold( THR),odor discrimination( DIS),odor identification( ID) and TDI score were obtained by summing up the score of THR,DIS and ID. AD patients were divided into olfactory dysfunction( AD-OD) group and non-olfactory dysfunction( AD-NOD) group according to the hyposmia standard adjusted for age and gender in Sniffin’ Sticks test. Demographic information of participants was recorded. Cognitive abilities were evaluated by a series of neuropsychological scales. The fM RI based on blood oxygen level dependent( BOLD) was performed at resting state;the differences of amplitude of low frequency fluctuation( ALFF) and regional homogeneity( ReH o) were statistically analyzed. Results:(1)Of 31 AD patients,there were 14 cases(45.1%) in AD patients with olfactory disorder( AD-OD) group and 17(54.8%) cases in AD patients without olfactory disorder( AD-NOD) group. There were 10 cases( 32.2.) were self-reported olfactory dysfunction. The median TDI score was( 2..38±7.72. in AD patients,with median THR score( 4.55±2.31),median DIS( 8.97±3.07) score and median ID score( 8.86±3.69). In AD-OD group,the scores of TDI,THR,DIS and ID were all significantly lower than in AD-NOD group(P2.The median AHRS score is( 2..81±2.44) in AD patients. AHRS score of AD-OD group is significantly lower than in AD-NOD group( P<0.05).(3)There is a large positive correlation between AHRS score and TDI score( r=0.648,P<0.001).(4)There is no difference between AD-OD group and ADNOD group in gen

关键词： AD DIS THR NOD Changes of Olfactory Dysfunction in Alzheimer’s Disease

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