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FOREWORD

中国病毒学：英文版 2008年第2期23卷 I0001-I0002页

作者： Bin He, PhD. department of Microbiology and Immunology College of Medicine The university of illinois at Chicago Chicago, il 60612, usa

Herpesviruses are large double-stranded DNA viruses which cause a variety of diseases ranging from genital sores,retinitis,cancers,and encephalitis. Notably,herpesviruses are opportunistic agents in the context HIV in... 详细信息

关键词：疱疹病毒 DNA 临床分析生殖器疱疹诊断方法

Expression Analysis of MicroRNAs in Cotton

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棉花学报 2008年第S1期20卷 63-页

作者： PAN Xiao-ping1,ZHANG Bao-hong2(1.department of Chemistry,Western illinois university,Macomb,il 61455,usa 2.department of Biology,East Carolina university,Greenville,NC 27858,usa) department of Chemistry Western Illinois UniversityMacombIL 61455USA department of Biology East Carolina UniversityGreenvilleNC 27858USA

MicroRNAs are a class of newly identified non-protein-coding small *** posttranscriptionally regulates the expression of more than 30% of genes,which control many biological

关键词： microRNAs

Comparisons of Graph-structure Clustering Methods for Gene Expression Data

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Acta Biochimica et Biophysica Sinica 2006年第6期38卷 379-384页

作者： Zhuo FANG~1,Lei LIU~(2,4),Jiong YANG~3,Qing-Ming LUO~(1*),and Yi-Xue LI~(2*) ~1 Hubei Bioinformatics and Molecular Imaging Key Laboratory,College of Life Science and Technology, Huazhong university of Science and Technology,Wuhan 430074,China ~2 Shanghai Center for Bioinformatics Technology,Shanghai 200235,China ~3 department of EECS,Case Western Reserve university,Cleveland 44106,usa ~4 W.M.Keck Center for Comparative and Functional Genomics,university of illinois at Urbana-Champaign,Urbana 61801,usa HubeiBioinformaticsandMolecularImagingKeyLaboratory CollegeofLifeScienceandTechnologyHuazhongUniversityofScienceandTechnologyWuhan430074China ShanghaiCenterforBioinformaticsTechnology Shanghai200235China W.M

Although many numerical clustering algorithms have been applied to gene expression dataanalysis,the essential step is still biological interpretation by manual *** correlation betweengenetic co-regulation and affiliation to a common biological process is what biologists ***,weintroduce some clustering algorithms that are based on graph structure constituted by biological *** applying a widely used dataset,we compared the result clusters of two of these algorithms in terms ofthe homogeneity of clusters and coherence of annotation and matching *** results show that theclusters of knowledge-guided analysis are the kernel parts of the clusters of Gene Ontology (GO)-Clustersoftware,which contains the genes that are most expression correlative and most consistent with ***,knowledge-guided analysis seems much more applicable than GO-Cluster in a largerdataset.

关键词： clustering expression pattern biological function

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紫露草微核对环境污染物的监测法

山东海洋学院学报 1981年第2期11卷 65-73页

作者：马德修美国西伊里诺州立大学生物学系及环境管理研究所

紫露草微核监测法是业已证实为监测环境污染物最有效的一种技术。这个监测法可以在现场测试空气中气体污染物或放射线,又可测定食品中或药物中有毒或有破坏性的液体或水溶性固体物质。如果要测试气体污染物或放射线时,应将紫露草含有花... 详细信息

紫露草微核监测法是业已证实为监测环境污染物最有效的一种技术。这个监测法可以在现场测试空气中气体污染物或放射线,又可测定食品中或药物中有毒或有破坏性的液体或水溶性固体物质。如果要测试气体污染物或放射线时,应将紫露草含有花粉母细胞的花序的枝条放在污染环境的现场或是在密封的处理箱中;如果要测液体之类的污染物时,应使花枝由茎吸收污染物而转运到花粉母细胞中。如此,那些在早期减数分裂过程中所引起的染色体断裂部分,将在四分体时期变成微核。显微镜玻片可用醋酸洋红染色法制成。从大量的四分体中所得到的微核频率,可用作染色体损伤程度的指标,此监测法可直接显示出真核生物的生殖细胞染色体损伤的程度。监测的结果可以在二十四至四十八小时之内分析出来。这个监测法可算是目前最简便、最有效的监测系统。

关键词：紫露草微核监测法大气污染无性繁殖

Functional deprivation promotes amyloid plaque formation in the olfactory bulb and piriform cortex in a transgenic mouse model of Alzheimer’s disease

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Functional deprivation promotes amyloid plaque formation in ...

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Kun XIONG~1,Xue-Mei ZHANG~2,Yan CAI~1,Jia-Chun FENG~2,Ju-Fang HUANG~1,Xue-Gang LUO~1,Huai-Bin CAI~3,Xiao-Xin YAN~(4,*) 1 department of Anatomy and Neurobiology,Central South university Xiangya Medical School,Changsha,410013, China 2 department of Neurology,The First Hospital of Jilin university,Changchun,130021,China 3 Laboratory of Neurogenetics,National Institute on Aging,National Institutes of Health,Bethesda,Maryland,usa, 20892 4 departments of Anatomy,Southern illinois university School of Medicine,Carbondale,illinois 62901,usa

＜正＞Cerebral hypometabolism is closely associated with the development of Alzheimer’s disease（AD） according to imaging ***,brain or neuronal activity might play a role in AD etiology based on many epidemiological studies suggesting that cognitive and physical activities appear to delay the onset of *** transgenic mouse models of AD, certain stimulative experimental paradigms,such as physical,cognitive or environment enrichment,are found to lower centralβ-amyloid peptide（Aβ） levels,ameliorate plaque development and improve cognitive ***,it is of particular interest to investigate if and how physiological neuronal activity might affect the process of plaque formation in anatomically defined brain area or *** recently identified a clear inverse correlation between endogenous neuronal metabolism and BACE1 expression at the olfactory glomeruli,the first synaptic relay of the olfactory pathway （Yan et al.,2007）.Biochemical analysis in that study confirmed elevated BACE1 protein levels,activity and products including APP C-terminal fragments and Aβ40 in the deprived relative to the non-deprived *** Tg2576 mice as an experimental model,the present study characterized a promotive effect of functional deprivation on amyloid pathology in the olfactory *** naris-occlusion in young transgenic mice caused BACE1 elevation in neuronal terminals in the deprived relative to the non-deprived bulb and transneuronally in the piriform cortex as *** unilateral narisocclusion resulted in increased BACE1 labeling in association with amyloid plaques first in the piriform cortex（at～9 month-old） then within the bulb mostly over the granule cell and subependymal layers on the deprived relative to the nondeprived side（from 12 to 24 month-old）.Double immunofluorescence detected a complete overlap of Aβdeposits with dystrophic axonal neurites that co-expressed BACE1,β-amyloid precursor protein and presenilin-1,forming compact-like

关键词： hypometabolism secretase amyloidogenesis neuroplasticity axonopathy

来源： cnki会议评论

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厌气流化床生物污泥消化处理

中国给水排水 1987年第3期 17-23页

作者：黄汝常 BillT.Ray 黄耀江美国密苏里大学美国南伊利诺大学北京中国科学院建筑设计院

为研究厌气流化床处理二次污泥的技术可行性,分别用1,2.5,5和10天的水力停留时间(HRT)进行试验。同时,也研究了运行温度(15、25和35℃)和初始污泥溶解性(溶解COD与总COD比值)对消化器性能的影响。试验表明,要达到合适的处理程度(40％... 详细信息

为研究厌气流化床处理二次污泥的技术可行性,分别用1,2.5,5和10天的水力停留时间(HRT)进行试验。同时,也研究了运行温度(15、25和35℃)和初始污泥溶解性(溶解COD与总COD比值)对消化器性能的影响。试验表明,要达到合适的处理程度(40％以上挥发性固体去除率),在35℃,如二次污泥用17.5meq/L氢氧化钠预水解,则HRT为1—2天;若不经预水解,则需10天。在25℃,污泥预水解,HRT只需2.5天。然而,当温度下降至15℃.即使污泥预水解,HRT长达10天,也不能获得理想的处理效果。同样,也观察到,流化床对冲击负荷的适应性.大大优于常规悬浮生长消化器。

关键词：水力停留时间溶解性去除率 VS 污泥消化氢氧化钠剂量 HRT 预水解挥发性固体氢氧化物用药量沸腾床反应器流化床反应器污泥处理生物污泥

Desiccation tolerance in bryophytes： the rehydration proteomes of Bryum argenteum provide insights into the resuscitation mechanism

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Journal of Arid Land 2018年第1期10卷 152-167页

作者： GAO Bei ZHANG Daoyuan LI Xiaoshuang YANG Honglan LIANG Yuqing CHEN Moxian ZHANG Yuanming ZHANG Jianhua Andrew WOOD Key Laboratory of Biogeography and Bioresource in Arid Land Xinjiang Institute of Ecology and GeographyChinese Academy of SciencesUrumqi 830011China School of Life sciences and State Key Laboratory of Agrobiotechnology The Chinese University of Hong KongHong KongChina department of Biology Faculty of ScienceHong Kong Baptist UniversityHong KongChina department of Plant Biology Southern Illinois University-CarbondaleCarbondaleIL 62901-6509USA

Bryum argenteum Hedw. is a desiccation tolerant bryophyte and belongs to one of the most important components of the biological soil crusts （BSCs） found in the deserts of Central Asia. Limited information is available on rehydration-responsive proteins in desiccation tolerant plants. As a complement to our previous research analyzing the rehydration transcriptome, we present a parallel quantitative proteomic effort to study rehydration-responsive proteins. Bryophyte gametophores were desiccated （Dry） and rehydrated for 2 h （R2） and 24 h （R24）. Proteins from Dry, R2 and R24 gametophores were labeled by isobaric tags for relative and absolute quantitation （iTRAQ） to determine the relative abundance of rehydration-responsive proteins. A total of 5503 non-redundant protein sequences were identified and 4772 （86.7%） protein sequences were annotated using Gene Ontology （GO） terms and Pfam classifications. Upon rehydration 239 proteins were elevated and 461 proteins were reduced as compared to the desiccated protein sample. Differentially up-regulated proteins were classified into a number of categories including reactive oxygen species scavenging enzymes, detoxifying enzymes, Late Embryogenesis Abundant （LEA） proteins, heat shock proteins, proteasome components and proteases, and photosynthesis and translation related proteins. Furthermore, the results of the correlation between transcriptome and proteome revealed the discordant changes in the expression between protein and mRNA.

关键词： desiccation tolerance B*Tum Physcomitrellapatens proteome iTRAQ rehydration