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Presence of a long nuclear-localization signal sequence in homeodomain transcription factor Nkx 1.2

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Journal of Oceanology and Limnology 2024年第2期42卷 620-626页

作者： Xinyi LI Lihui CHEN Xinyuan WANG Chen SUN guangdong JI Guobin HU Zhenhui LIU College of Marine Life Science and institute of Evolution&Marine Biodiversity Ocean University of ChinaQingdao 266003China Laoshan Laboratory Qingdao 266237China

Homeodomains,a 60-amino acid sequence encoded by 180 nucleotides,are highly conserved DNA-binding motifs that are present in a variety of transcription factors in species ranging from yeast to *** NKX proteins belong to the homeodomain(HD)-containing transcription factor *** play vital roles in the regulation of ***1-2 is one member of the NKX *** present,information about its nuclear localization signal(NLS)sequence is *** studied the NLS sequence of zebrafish Nkx1.2 by introducing sequence changes such as deletion,mutation,and truncation,and identified an NLS motif(QNRRTKWKKQ)that is localized at the C-terminus of the ***,the deletion of two amino acid residues(RR)in this NLS motif prevents Nkx1.2 from entering the nucleus,indicating that the two amino acids are essential for Nkx1.2 nuclear ***,the NLS motif alone is unable to target cytoplasmic protein glutathione S-transferase(GST)to the *** intact homeodomain is necessary for mediating the complete nuclear transport of cytoplasmic *** most nuclear import proteins with short NLS sequences,a long NLS is present in zebrafish *** also demonstrated that the sequences of homeodomain of NKX1.2 are well conserved among different *** study is informative to verify the function of the NKX1.2 protein.

关键词： NKX1.2 NKX protein homeodomain nuclear localization signal(NLS) nuclear transport

Characteristics of the Lower Yellow River channel shrinkage and its discriminant parameters

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Science china(Technological Sciences) 2010年第5期53卷 1374-1386页

作者： HU ChunHong1 & ZHANG GuoGang2 1 china institute of Water Resources and Hydropower Research,Beijing 100038,china 2.guangdong Electric Power Design institute,guangzhou 510663,china 1. china institute of Water Resources and Hydropower Research Beijing 100038 China2. Guangdong Electric Power Design Institute Guangzhou 510663 China

This paper analyzes the changing trends of the Lower Yellow River(LYR) transverse profile parameters and their aberrance points by the time series analysis *** results show that there has been a trend of changes in the LYR channel transverse profile parameters since the *** main river channel has a tendency of shrinkage year by year and the trend will be continued in the *** main features of the LYR channel shrinkage are remarkable reductions of bankfull dis-charges and bankfull areas,corresponding decreases of bankfull widths,average bankfull water depths and maximal bankfull water depths,as well as increases of bankfull water levels and width-depth ratios *** discriminant parameters for threshold of the LYR main channel shrinkage were put *** indicates that the LYR main channel began to shrink in the 1970s and has entered into a serious phase of channel shrinkage since the *** incompatible index of discharged water-sediment processes of the Sanmenxia Reservoir was introduced,which revealed that there was a trend of increasing in the incompatibility between water flow and sediment *** relations between the LYR main channel shrinkage parameters and discharged water-sediment processes of the Sanmenxia Reservoir were founded,which indicate that the LYR main channel shrinkage can be mitigated and improved through the regulation of discharged water-sediment processes of the reservoir,especially through the regulation of water-sediment incompatible *** LYR channel for water and sediment transportation can be restored and maintained.

关键词： Lower Yellow River time series analysis main river channel shrinkage discriminant parameters of channel shrinkage water-sediment incompatible index

Effects of cyclooxygenase 2 inhibitors on biological traits of nasopharyngeal carcinoma cells

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Acta Pharmacologica Sinica 2004年第7期25卷 97-103页

作者： Pei-yi CHEN1, Qi-cai LONG2 institute of ClinicalPharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, guangzhou 510080, china1 Now in Inspection, Evaluation and Certification Committee fordrug, guangdong Province Drug Administration, guangzhou510080, china. institute of Clinical Pharmacology School of Pharmaceutical Sciences Sun Yat-sen University Guangzhou 510080 Chin

AIM: To investigate effects of cyclooxygenase 2 (COX-2) inhibitors on nasopharyngeal carcinoma (NPC) cells and on angiogenesis in vitro. METHODS: Human NPC cell lines (CNE1, CNE2 and SUNE) were treated with nimesulide or celecoxib. MTT assay and colony formation assay were performed to observe antiproliferation activity of COX-2 inhibitors to NPC cell lines. Cell cycle arrest and apoptosis of NPC cell strains were tested by flow cytometry assay, microscopic morphology observation, and DNA fragmentation assay. The effect of COX- 2 inhibitor on angiogenesis was tested by chick chorioallantoic membrane (CAM) model. RESULTS: Nimesulide (Nim) and celecoxib (Cel) could antiproliferate NPC cell lines with IC50 182 μmol/LNim-SUNE, 78 μmol/LNim-CNE1, 175 μmol/LNim-CNE2, 7.2 μmol/LCel-SUNE, 8.1 μmol/LCel-CNE1, and 7.6 μmol/LCel-CNE2. The antiproliferation presented dose- dependent (Nim5-400 μmol/L, Cel 0.5-80μmol/L) and time-dependent manner (Nim IC50 562 μmol/L24 , 316 μmol/L48 , h h 50.1 μmol/L240 ). Nim and Cel arrested SUNE and CNE1 cell cycle at phase G2/M (cell aggregation rate 28.9 %- h 45.1 %Nim 25-200μmol-12 h-SUNE , 18.9%-26.2 %Nim 25-200μmol-24 h-SUNE ,28.8 %-35.6%Nim 25-200 μmol-48 h-SUNE ,30.4 %-16.4%Cel 25-100μmol-12 h-SUNE , 21.2 %-19.7 %Cel 25-100 μmol-24 h-SUNE, 31.1 %-19.9 %Cel 25-100 μmol-24 h-SUNE, 20.5 %-34.1 %Nim25-200 μmol-12 h-CNE1, 25.2 %- 26.9 %Nim 25-200 μmol-24 h-CNE1 , 11.5 %-7.1 %Nim 25-200 μmol-48 h-CNE1). Apoptosis shape and apoptosis strap displayed in NPC cells after treatment with Nim and Cel. Nim had a feature of anti-angiogenesis on CAM model. CONCLUSION: Nim and Cel could suppress proliferation of squamous epithelium NPC cell (SUNE, CNE1 and CNE2) through blocking cell cycle and inducing cell apoptosis. Nim could apparently suppress CAM angiogenesis induced by

关键词： cyclooxygenase inhibitors nimesulide celecoxib nasopharyngeal neoplasms apoptosis cell cycle angiogenesis inhibitors

Hybrid Modified Rubber Powder and Its Application in Cement Mortar

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Journal of Wuhan University of Technology(Materials Science) 2010年第6期25卷 1033-1037页

作者：于利刚刘岚 Department of Materials Science and Engineering South China University of Technology guangdong Building Materials institute

This research focused on using the waste rubber powder as a kind of regenerate resources to improve the mechanical properties of cement *** two kinds of hybrid modified rubber powder TRP and ATRP were prepared by sol-gel method and then used in cement *** structures and properties of them were *** is shown that the nano Si-O-Si network is generated in TRP and ATRP networks and the hydrophilic group is grafted on the surface of *** mechanical properties of rubber-treated mortar（RTM） were tested and the microstructures of them were also *** to the mortars with unmodified rubber powders（RP）,NaOH treated rubber powder（SRP） and coupling agent treated rubber powder（CRP）,the RTM with ATRP has the highest compressive strength and flexural *** stress-strain curves shown that the peak of stress of RTM with ATRP is increased and indicated the higher compression deformation and *** is found that the interfacial adhesion between the ATRP and cement mortar is increased distinctly by SEM,which results in enhanced ductility and mechanical properties of RTM with ATRP.

关键词： rubber powder cement mortar hybrid modified mechanical properties interface adhesion

THE　INFLUENCE　OF　THE　SECONDARY　NORMAL　STRESS　DIFFERENCE　OF　VISCOELASTIC　FLUID　ON　ECCENTRIC　CAPSULE　FLOW

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Journal of Hydrodynamics 1995年第1期7卷 85-91页

作者： Pan Da-lin(guangdong institute of of Technology,guangzhou 510090, P. R. china) guangdong Inst of Technology Guangzhou China

A rheological analysis of the flow of a very long, denser-than-liquid carrier, cylindrical capsule in a horizontal pipeline is presented. The analysis indicate that secondary normal stress difference of viscoelastic fluid may balance with the force caused by the difference of densities and stabilize the POsition of capsule in pipeline.

关键词： capsule flow normal stress viscoelastic fluid.

Autophagy receptor ZmNBR1 promotes the autophagic degradation of ZmBRI1a and enhances drought tolerance in maize

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Journal of Integrative Plant Biology 2024年第6期66卷 1068-1086页

作者： Yang Xiang guangdong Li Qian Li Yingxue Niu Yitian Pan Yuan Cheng Xiangli Bian Chongyang Zhao Yuanhong Wang Aying Zhang College of Life Sciences Nanjing Agricultural UniversityNanjing210095 China State Key Laboratory of Crop Genetics&Germplasm Enhancement and Utilization Nanjing Agricultural UniversityNanjing210095 China Sanya institute of Nanjing Agricultural University Nanjing Agricultural UniversitySanya572025 China

Drought stress is a crucial environmental factor that limits plant growth,development,and *** of misfolded proteins can help alleviate the damage caused in plants experiencing ***,the mechanism of autophagy-mediated drought tolerance in plants remains largely ***,we cloned the gene for a maize(Zea mays)selective autophagy receptor,NEXT TO BRCA1GENE 1(ZmNBR1),and identified its role in the response to drought *** observed that drought stress increased the accumulation of *** sequencing and reverse transcriptionquantitative polymerase chain reaction showed that ZmNBR1 is markedly induced by drought ***1 overexpression enhanced drought tolerance,while its knockdown reduced drought tolerance in *** results established that ZmNBR1 mediates the increase in autophagosomes and autophagic activity under drought ***1 also affects the expression of genes related to autophagy under drought ***,we determined that BRASSINOSTEROID INSENSITIVE1A(ZmBRI1a),a brassinosteroid receptor of the BRI1-like family,interacts with *** analysis showed that ZmBRI1a negatively regulates drought tolerance in maize,and genetic analysis indicated that ZmNBR1 acts upstream of ZmBRI1a in regulating drought ***,ZmNBR1facilitates the autophagic degradation of ZmBRI1a under drought *** together,our results reveal that ZmNBR1 regulates the expression of autophagy-related genes,thereby increasing autophagic activity and promoting the autophagic degradation of ZmBRI1a under drought stress,thus enhancing drought tolerance in *** findings provide new insights into the autophagy degradation of brassinosteroid signaling components by the autophagy receptor NBR1 under drought stress.

关键词： autophagy receptor drought tolerance Zea mays ZmBRI1a ZmNBR1

林克明旧居修缮与活化利用,广州,广东,中国

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世界建筑 2024年第8期 64-69页

作者： guangdong Architectural Design and Research institute Group Co.,Ltd. Architectural Design and Research institute of South china University of Technology 广东省建筑设计研究院集团股份有限公司华南理工大学建筑设计研究院有限公司

街区断点更新林克明旧居(简称旧居)1935年由中国第一代著名建筑师林克明设计建造。旧居所在的越秀北路原为民国初年广州城墙拆除后的城基路,城外即东濠涌,前后高差达8m。林克明巧妙地利用地形组织功能与空间,并采用摩登建筑理念,使建筑... 详细信息

街区断点更新林克明旧居(简称旧居)1935年由中国第一代著名建筑师林克明设计建造。旧居所在的越秀北路原为民国初年广州城墙拆除后的城基路,城外即东濠涌,前后高差达8m。林克明巧妙地利用地形组织功能与空间,并采用摩登建筑理念,使建筑形体呈现出迷人的风采。

关键词：建筑形体建筑理念活化利用功能与空间著名建筑师林克明修缮城墙

The Research of controlling Inclusions in Middle and High Carbon Steel During TSCR

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Journal of Iron and Steel Research International 2011年第S2期18卷 365-370页

作者： LI Lie-jun1, GAO Ji-xiang1,2 (1. School of Mechanical and Automotive Engineering, South china University of Technology, guangzhou 510640, guangdong, china 2. CSP applying technology institute, GISE, guangzhou 510730, guangdong,china) S china Univ Technol Sch Mech & Automot Engn Guangzhou 510640 Guangdong Peoples R China GISE CSP Applying Technol Inst Guangzhou 510730 Guangdong Peoples R China

Based on the characteristics of Thin slab casting and rolling (TSCR) process,using test methods such as SEM,EDS and measuring content of inclusions, the influencing factor of controlling inclusions during producing middle and high carbon steel was studied. The technologies of electric furnace smelting, LF refining and controlling inclusions of tundish were proposed. The inclusions control level of middle and high carbon steel in which the carbon content is 0.3-1.0%, The level reached and even exceeded the level of like product producing with conventional process at home and abroad.

关键词： thin slab casting and rolling (TSCR) middle and high carbon steel inclusions

Extension theory and its application

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Chinese Science Bulletin 1999年第17期44卷 1538-1548页

作者： CAI WenResearch institute of Matter-Element Analysis , guangdong University of Technology , guangzhou 510090, china Research institute of Matter-Element Analysis Guangdong University of Technology Guangzhou China

The article Extension Set and Non-compatible Problems was published in 1983. It proclaimed the birth of extension theory. Its objects of study are contradictory problems in the realistic world; its theoretical pillars are matter element theory and extension set theory. Its basic methods are extension methods. Its practical methods are extension engineering methods,

关键词： extension theory matter element extension set.