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Role of gut microbiota in Crohn’s disease pathogenesis:Insights from fecal microbiota transplantation in mouse model

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World Journal of Gastroenterology 2024年第31期30卷 3689-3704页

作者： Qiang Wu Lian-Wen Yuan Li-Chao yang Ya-Wei Zhang Heng-Chang yao Liang-Xin Peng Bao-Jia yao Zhi-Xian Jiang Geriatric Surgery of Department of General Surgery The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

BACKGROUND Inflammatory bowel disease,particularly Crohn’s disease(CD),has been associated with alterations in mesenteric adipose tissue(MAT)and the phenomenon termed“creeping fat”.Histopathological evaluations showed that MAT and intestinal tissues were significantly altered in patients with CD,with these tissues characterized by inflammation and *** To evaluate the complex interplay among MAT,creeping fat,inflammation,and gut microbiota in *** Intestinal tissue and MAT were collected from 12 patients with *** manifestations and protein expression levels were analyzed to determine lesion *** samples were collected from five recently treated CD patients and five control subjects and transplanted into *** intestinal and mesenteric lesions in these mice,as well as their systemic inflammatory status,were assessed and compared in mice transplanted with fecal samples from CD patients and control *** Pathological examination of MAT showed significant differences between CDaffected and unaffected colons,including significant differences in gut microbiota *** microbiota transplantation(FMT)from clinically healthy donors into mice with 2,4,6-trinitrobenzene sulfonic acid(TNBS)-induced CD ameliorated CD symptoms,whereas FMT from CD patients into these mice exacerbated CD ***,FMT influenced intestinal permeability,barrier function,and levels of proinflammatory factors and ***,FMT from CD patients intensified fibrotic changes in the colon tissues of mice with TNBS-induced *** Gut microbiota play a critical role in the histopathology of *** MAT and creeping fat may therefore have potential in the treatment of patients with CD.

关键词： Mesenteric adipose tissue Crohn’s disease Fecal microbiota transplantation Intestinal fibrosis Intestinal barrier

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Enhancement of catalytic activity for hydrogenation of nitroaromatic by anionic metal-organic framework

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Chinese Chemical Letters 2024年第3期35卷 144-148页

作者： Qi Wu Anyang Li Ruibo He Yaxi Wu Lei Hou Guoping yang Wenyan Zhang yao-Yu Wang Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education College of Chemistry&Materials ScienceNorthwest UniversityXi'an 710127China

Nitroaromatic hydrogenation catalysis without precious metals remains a longstanding *** rate of electron transfer is the crucial factor affecting hydrogenation ***,an ionic Cd-based metal-organic framework(I-Cd-MOF)exhibiting a unique structure with one-dimensional(1D)opening nanochannels and good electron transfer ability was synthesized for catalyzing hydrogenation of 4-nitrophenol(4-NP).The catalytic activity of the unique I-Cd-MOF without noble metals is detected,which is higher than most reported noble metal ***,the reaction rate of I-Cd-MOF(4.28 min^(-1))is about 47.6 times higher than that of the Cd-based neutral MOF(N-Cd-MOF)with the similar crystalline *** chromatograph mass spectrometer(LC-MS)and theoretical results demonstrate that 4-NP and five intermediates are stabilized in the channels of I-Cd-MOF,which increases the possibility of contact with H^*and H_(2)g enerated at the Cd *** I-Cd-MOF was extended to other nitroaromatic hydrogenation catalysis,which still displays excellent *** importantly,the I-MOF@Filter membrane was successfully constructed for continuous hydrogenation catalytic reactions,which maintains a high catalytic performance after 7 cycles of recycling without *** work fills in the application of the I-MOFs in hydrogenation catalytic reactions and provides an effective way for the rapid and green degradation of nitroaromatic compounds.

关键词： Anions Metal-organic frameworks Catalysis Electron transfer Hydrogen production

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The Relationship Between the Atmospheric Environment and Road Traffic Fatalities — Shandong Province, China, 2012–2021

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China CDC weekly 2024年第13期6卷 267-271页

作者： Tao Wang Jie Chu Zhiying yao Li yang Zilong Lu Ge Tian Xiaolei Guo Cunxian Jia Department of Epidemiology School of Public HealthCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department for Chronic and Non-Communicable Disease Control and Prevention Shandong Center for Disease Control and PreventionJinanShandong ProvinceChina

Introduction:This study aims to analyze the potential impact of the meteorological environment and air pollutants on road traffic ***:Road traffic fatality data in Shandong Province from 2012 to 2021 were obtained from the Population Death Information Registration Management *** and air pollutant data for the same period were collected from the *** Oceanic and Atmospheric Administration and the Ecological Environment Monitoring Center of Shandong Province,***’s correlation and ridge regression were used to analyze the impact of the meteorological environment and air pollutants on road traffic ***:From 2012 to 2021,there were 163,863 road traffic fatality *** results of the ridge regression analysis showed that the daily average temperature was negatively correlated with total fatalities and passengers and positively correlated with pedestrians,nonmotorized drivers,and motorized *** daily minimum temperature was negatively correlated with total fatalities and positively correlated with motorized *** daily maximum temperature was positively correlated with both pedestrian and nonmotorized *** daily accumulated precipitation was negatively correlated with *** duration was positively correlated with both nonmotorized and motorized *** particulate matter(PM_(10))and nitrogen dioxide(NO_(2))were positively correlated with total fatalities,pedestrians,and nonmotorized *** dioxide(SO_(2))was positively correlated with total fatalities but negatively correlated with nonmotorized drivers,passengers,and motorized ***:Atmospheric factors associated with the occurrence of road traffic fatalities include air temperature,daily accumulated precipitation,sunshine duration,and air pollutants such as PM_(10),NO_(2),and SO_(2).

关键词： Ecological dioxide sunshine

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Anti-inflammatory germacrane-type sesquiterpene lactones from Vernonia sylvatica

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Chinese Journal of Natural Medicines 2024年第6期22卷 568-576页

作者： WANG Min LI Han HU Bintao TANG Chunping XU Hui KE Changqiang XIE zuoquan YE yang yao Sheng State Key Laboratory of Drug Research&Natural Products Research Center Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China School of Life Science and Technology Shanghai Tech UniversityShanghai 201210China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Zhongshan Institute for Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of SciencesZhongshan 528400China

Nine new germacranolides,sylvaticalides A−H(1-9),and three known analogues(10-12)were isolated from the aeri-al part of Vernonia *** structures were established using comprehensive spectroscopic analysis,including high-resolution electrospray ionization mass spectroscopy(HR-ESI-MS)and 1D and 2D nuclear magnetic resonance(NMR)*** absolute configurations were determined by X-ray diffraction *** anti-inflammatory activities of all isolated compounds were as-sessed by evaluating their inhibitory effects on the nuclear factor kappa B(NF-κB)pathway,which was activated by lipopolysacchar-ide(LPS)-stimulated human THP1-Dual cells,and the interferon-stimulated gene(ISG)pathway,activated by STING agonist MSA-2 in the same cell *** 1,2 and 6 showed inhibitory effects on the NF-κB and ISG signaling pathways,with IC_(50)values ranging from 4.12 to 10.57μmol·L^(−1).

关键词： Vernonia sylvatica Germacrane-type sesquiterpene lactone Sylvaticalides A−H Anti-inflammatory NF-κB path-way ISG pathway

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Cuproptosis mediates copper-induced testicular spermatogenic cell death

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Asian Journal of Andrology 2024年第3期26卷 295-301页

作者： Jing-Yi Zhang Xu-Jun Yu Jun-Jun Li yao Xiao Guang-Sen Li Fang yang Liang Dong Chengdu University of Traditional Chinese Medicine Chengdu 611137China Chengdu Fifth People’s Hospital The Fifth People’s Hospital of Chengdu University of Traditional Chinese MedicineChengdu 611130China TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072China Department of Surgery The Reproductive and Women-Children HospitalChengdu University of Traditional Chinese MedicineChengdu 610041China

Cuproptosis,a novel mechanism of programmed cell death,has not been fully explored in the context of spermatogenic *** investigated the potential involvement of cuproptosis in spermatogenic cell death using a mouse model of copper *** male Institute of Cancer Research(ICR)mice were randomly divided into four groups that received daily oral gavage withsodium chloride(control)or copper sulfate(CuSO_(4))at 50 mg kg^(−1),100 mg kg^(−1),or 200 mg kg^(−1),for 42 consecutive *** to copper overload exhibited a disruption in copper ***,significant upregulated expression of keycuproptosis factors was accompanied by a significant rise in the rates of testicular tissue cell *** revealed the presence of ferredoxin 1(Fdx1)in Sertoli cells,Leydig cells,and spermatogenic cells at various stages oftesticular development,and the Fdx1-positive staining area was significantly increased in copper-overloaded *** and decreased adenosine triphosphate levels were also observed,further implicating mitochondrial damage *** analyses revealed pathological lesions and blood−testis barrier destruction in the testicular tissue,accompaniedby decreased sperm concentration and motility,in copper-overloaded *** summary,our results indicate that copper-overloadedmice exhibit copper homeostasis disorder in the testicular tissue and that cuproptosis participates in spermatogenic cell *** findings provide novel insights into the pathogenic mechanisms underlying spermatogenic cell death and provide initialexperimental evidence for the occurrence of cuproptosis in the testis.

关键词： blood−testis barrier cuproptosis ferredoxin 1 spermatogenic cell death

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Integrated modelling of vacuum flashover development:Above-surface processes and breakdown threshold analyses

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High Voltage 2024年第3期9卷 614-625页

作者： Guangyu Sun Yitong yao Xiong yang Baohong Guo Shu Zhang Chao Wang Ruhui Lian Baipeng Song Haibao Mu Guanjun Zhang State Key Laboratory of Electrical Insulation and Power Equipment Xi'an Jiaotong UniversitySchool of Electrical EngineeringXi'anShaanxiChina

The flashover in vacuum is a rapid interfacial discharge across the insulator surface when subjected to high applied *** a theoretical model covering above-surface processes is *** model calculates the flashover threshold in vacuum,with revised secondary electron emission avalanche theory and improved desorbed neutral transport *** model serves as the first part of an integrated flashover model,aiming for consistent treatment of both above-surface and subsurface processes during the entire flashover *** flashover threshold is obtained by combining the desorbed neutral pressure at given applied voltage and the gas breakdown criterion dictated by the Paschen's *** analytical formula for threshold estimation containing physical parameters,and a simplified formula consisting of empirical coefficients are introduced,catering for both conceptual understanding and practical *** derived formulae are validated by experimental data for a variety of insulator *** theory generalisation for non-uniform electric field distribution is further discussed.

关键词： flash breakdown vacuum

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Hydrogen spillover bridged dual nano-islands triggered by built-in electric field for efficient and robust alkaline hydrogen evolution at ampere-level current density

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Nano Research 2024年第6期17卷 5050-5060页

作者： Kecheng Tong Liangliang Xu Hanxu yao Xingkun Wang Canhui Zhang Fan yang Lei Chu Jinwoo Lee Heqing Jiang Minghua Huang School of Materials Science and Engineering Ocean University of ChinaQingdao 266100China Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and Technology(KAIST)291Daejeon 34141Republic of Korea Qingdao New Energy Shandong Laboratory Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China University of Chinese Academy of Sciences Beijing 100049China

Employing the alkaline water electrolysis system to generate hydrogen holds great prospects but still poses significant challenges,particularly for the construction of hydrogen evolution reaction(HER)catalysts operating at ampere-level current ***,the unique Ru and RuP_(2)dual nano-islands are deliberately implanted on N-doped carbon substrate(denoted as Ru-RuP_(2)/NC),in which a built-in electric field(BEF)is spontaneously generated between Ru-RuP_(2)dual nano-islands driven by their work function *** and theoretical results unveil that such constructed BEF could serve as the driving force for triggering fast hydrogen spillover process on bridged Ru-RuP_(2)dual nano-islands,which could invalidate the inhibitory effect of high hydrogen coverage at ampere-level current density,and synchronously speed up the water dissociation on Ru nano-islands and hydrogen adsorption/desorption on RuP_(2)nano-islands through hydrogen spillover *** a result,the Ru-RuP_(2)/NC affords an ultra-low overpotential of 218 mV to achieve 1.0 A·cm^(−2)along with the superior stability over 1000 h,holding the great promising prospect in practical applications at ampere-level current *** importantly,this work is the first to advance the scientific understanding of the relationship between the constructed BEF and hydrogen spillover process,which could be enlightening for the rational design of the cost-effective alkaline HER catalysts at ampere-level current density.

关键词： built-in electric field hydrogen spillover dual nano-islands ampere-level current density alkaline hydrogen evolution

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Variant PRC1 subunit RYBP/YAF2 forms condensate with RING1B and promotes H2AK119ub deposition

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Science China(Life Sciences) 2024年第9期67卷 2036-2038页

作者： Yanjiang Liu Gongcheng Hu Shengxiong yang Chenghong Yan Juehan Wang Guangjin Pan Hongjie yao State Key Laboratory of Respiratory Disease Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou510530China Department of Basic Research Guangzhou National LaboratoryGuangzhou 510005China CAS Key Laboratory of Regenerative Biology Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China University of Chinese Academy of Sciences Beijing 100049China

Dear Editor,Polycomb group(Pc G)proteins represent important roles in repressing gene expression throughout *** Polycomb repressive complexes(PRCs)have been subdivided into two central protein complexes,PRC1 and ***1 catalyzes H2AK119ub and PRC2catalyzes H3K27me1/2/3(Fursova et al.,2019).PRC1 is further categorized as CBX-containing canonical PRC1(c PRC1)and RYBP/YAF2-containing variant PRC1(v PRC1)(Blackledge and Klose,2021).

关键词： PRC1 RING1 RYBP

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Ce-and La-doped polymetallic layered double hydroxides for enhanced oxygen evolution reaction performance at high current density

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Science China Chemistry 2024年第8期67卷 2586-2598页

作者： Rinel R.Kimaka P. Ping Wang Miao He Senyao Meng Jiasai yao Huawei Li Cheng yang Zhenxing Li State Key Laboratory of Heavy Oil Processing College of New Energy and MaterialsChina University of Petroleum(Beijing)Beijing 102249China

Polymetallic layered double hydroxides are promising cost-effective catalysts for the oxygen evolution reaction(OER) due to their versatile anionic and cationic tunability. Nevertheless, several challenges persist, notably, issues related to low electrical conductivity, poor catalytic activity, and stability, especially at high current density. Herein, we report the design of Ce-and Ladoped Co Ni Fe-layered double hydroxide(Ce La Co Ni Fe-LDH) nanosheets through a facile and scalable in situ self-assembly strategy that displays enhanced OER activity. Experimental and theoretical investigations provide insights into the impact of Ceand La-doping by comparing Ce Co Ni Fe-LDH, La Co Ni Fe-LDH, and pristine Co Ni Fe-LDH, all synthesized using the same methodology. These results reveal that doping Ce^(3+)and La^(3+)into Co Ni Fe-LDH substantially improves its electronic structure,resulting in enhanced conductivity, more oxygen vacancies(Vo), electron interaction, and active site formation. Consequently,significantly reduced overpotentials of 175, 314, and 424 m V at 10, 100, and 500 m A cm^(-2), respectively, and a highly stable current density of 120 h in 1 M KOH were achieved. Notably, these performance metrics surpass those of unmodified LDHs and are competitive with many lanthanide-doped transition metal-based LDH electrocatalysts, as well as noble metal catalysts like ruthenium catalysts. This work represents a pioneering effort in doping Ce^(3+)and La^(3+)ions into a functional Co Ni Fe-based electrocatalyst, offering inspiring OER performance and scalability potential.

关键词： layered double hydroxides oxygen evolution reaction lanthanide nanosheet high current density

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Single-cell profiling of the pig cecum at various developmental stages

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Zoological Research 2024年第1期45卷 55-68页

作者： Yan-Yuan Xiao Qing Zhang Fei Huang Lin Rao Tian-Xiong yao Si-Yu yang Lei Xie Xiao-Xiao Zou Li-Ping Cai Jia-Wen yang Bin yang Lu-Sheng Huang National Key Laboratory for Swine Genetic Improvement and Germplasm Innovation Ministry of Science and Technology of ChinaJiangxi Agricultural UniversityNanchangJiangxi 330045China

The gastrointestinal tract is essential for food digestion,nutrient absorption,waste elimination,and microbial ***-cell transcriptome profiling of the intestinal tract has greatly enriched our understanding of cellular diversity,functional heterogeneity,and their importance in intestinal tract development and *** such profiling has been extensively conducted in humans and mice,the single-cell gene expression landscape of the pig cecum remains ***,single-cell RNA sequencing was performed on 45572 cells obtained from seven cecal samples in pigs at four different developmental stages(days(D)30,42,150,and 730).Analysis revealed 12 major cell types and 38 subtypes,as well as their distinctive genes,transcription factors,and regulons,many of which were conserved in *** increase in the relative proportions of CD8^(+)T and Granzyme A(low expression)natural killer T cells(GZMA^(low)NKT)cells and a decrease in the relative proportions of epithelial stem cells,Tregs,RHEX^(+)T cells,and plasmacytoid dendritic cells(pDCs)were noted across the developmental ***,the post-weaning period exhibited an up-regulation in mitochondrial genes,COX2 and ND2,as well as genes involved in immune activation in multiple cell ***-cell crosstalk analysis indicated that IBP6^(+)fibroblasts were the main signal senders at D30,whereas IBP6^(−)fibroblasts assumed this role at the other *** cells established interactions with epithelial cells and IBP6^(+)fibroblasts in the D730 cecum through mediation of GZMA-F2RL1/F2RL2 *** study provides valuable insights into cellular heterogeneity and function in the pig cecum at different development stages.

关键词： Single-cell RNA-seq Cecum Bama Xiang pigs Various developmental stages Cellular heterogeneity

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