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Effect of Down-regulation of MMP-2 by Quercetin on the Migration and Invasion of Uterine Fibroids Cells through the cAMP Signaling Pathway

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Chinese Journal of Biomedical Engineering 2024年第2期33卷 54-61页

作者： LIN Shu-ping zou xiao-fen Longyan First Affiliated Hospital of Fujian Medical University

Objective: To investigate the effect of down-regulation of matrix metalloproteinase-2(MMP-2) by down-regulating the cyclic adenosine monophosphate(cAMP) signaling pathway on the migration and invasion of uterine fibroids ***: A total of 65 female SD rats were randomly divided into five groups after being adaptively fed for 7 d. Except for the blank group, the remaining four groups of rats were injected with 0.05 mg/(100 g·d) estradiol benzoate and 0.5 mg/(100g·d) progesterone into the muscle to establish a uterine fibroids rat model. After successful modeling, the blank group and model group were given 200 mg/(kg·d) physiological saline by gavage,the low-dose group was given 100 mg/(kg·d) mifepristone by gavage, the medium-dose group was given 200 mg/(kg·d) mifepristone by gavage, and the high-dose group was given 300 mg/(kg·d) mifepristone by gavage. After continuous gavage treatment for 21 d,serum and uterine tissues were collected from rats to observe and compare the expression levels of MMP-2 mRNA, TIMP-2 mRNA, estradiol(E2), cAMP signaling pathway related proteins, and the migration and invasive ability of uterine fibroids cells in the five groups of rats. Results: The expression levels of MMP-2 mRNA and E2in the high-dose group were lower than those in the low-dose group and the medium-dose group, and the expression level of TIMP-2 mRNA was higher than that in the low-dose group and the medium-dose group(P<0.05). The number of cell migration in a single visual field of rats in the high-dose group was lower than that in the low-dose group and the medium-dose group(P<0.05). The number of cell invasion in a single visual field of rats in the high-dose group was lower than that in the low-dose group and the medium-dose group(P<0.05). The mRNA expression levels of cAMP, PDE and PK in the high-dose group were higher than those in the low-dose group, and the mRNA expression levels of AC in the high-dose group were lower than those in the low-dose group(P<0.

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碳复合磷酸铁锂中总磷含量测定方法研究

实验室检测

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实验室检测 2024年第5期2卷 14-17页

作者：邹小芬福建紫金矿冶测试技术有限公司龙岩364204

目的本文旨在研究直接除碳重量法测定碳复合磷酸铁锂中总磷含量。方法采用高氯酸分解试样并同时除去样品中的碳后,在酸性介质中,正磷酸根与喹钼柠酮沉淀剂反应生成黄色磷钼酸喹啉沉淀,经过滤、洗涤、干燥、称量,即可求出磷含量。结果高... 详细信息

目的本文旨在研究直接除碳重量法测定碳复合磷酸铁锂中总磷含量。方法采用高氯酸分解试样并同时除去样品中的碳后,在酸性介质中,正磷酸根与喹钼柠酮沉淀剂反应生成黄色磷钼酸喹啉沉淀,经过滤、洗涤、干燥、称量,即可求出磷含量。结果高氯酸消解除碳,样品消解完全且清亮,减少了过滤除碳步骤,通过优化条件试验、对该方法进行了精密度和准确度试验,其相对标准偏差(Relative Standard Deviation,RSD)小于0.2%,加标回收率为98.4%~101.1%。该方法最大的优点在于碳在消解过程中直接除去,消除了碳包裹对磷测定的影响,不需要过滤除碳,缩短了操作流程,分析时间短,高含量磷用经典重量法测定,其精密度和准确度高,能为生产提供快速准确的结果。结论本法适用于快速准确测定碳复合磷酸铁锂中总磷含量的。

关键词：高氯酸磷酸铁锂总磷

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An Efficient Multi-objective Approach Based on Golden Jackal Search for Dynamic Economic Emission Dispatch

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Journal of Bionic Engineering 2024年第3期21卷 1541-1566页

作者： Keyu Zhong fen xiao Xieping Gao Key Laboratory of Computing and Stochastic Mathematics of Ministry of Education Hunan Normal UniversityChangsha410081China School of Mathematics and Statistics Hunan Normal UniversityChangsha410081China School of Computer Science Xiangtan UniversityXiangtan411105China Hunan Provincial Key Laboratory of Intelligent Computing and Language Information Processing Hunan Normal UniversityChangsha410081China

Dynamic Economic Emission Dispatch(DEED)aims to optimize control over fuel cost and pollution emission,two conflicting objectives,by scheduling the output power of various units at specific *** many methods well-performed on the DEED problem,most of them fail to achieve expected results in practice due to a lack of effective trade-off mechanisms between the convergence and diversity of non-dominated optimal dispatching *** address this issue,a new multi-objective solver called Multi-Objective Golden Jackal Optimization(MOGJO)algorithm is proposed to cope with the DEED *** proposed algorithm first stores non-dominated optimal solutions found so far into an ***,it chooses the best dispatching solution from the archive as the leader through a selection mechanism designed based on elite selection strategy and Euclidean distance index *** mechanism can guide the algorithm to search for better dispatching solutions in the direction of reducing fuel costs and pollutant ***,the basic golden jackal optimization algorithm has the drawback of insufficient search,which hinders its ability to effectively discover more Pareto *** this end,a non-linear control parameter based on the cosine function is introduced to enhance global exploration of the dispatching space,thus improving the efficiency of finding the optimal dispatching *** proposed MOGJO is evaluated on the latest CEC benchmark test functions,and its superiority over the state-of-the-art multi-objective optimizers is highlighted by performance ***,empirical results on 5-unit,10-unit,IEEE 30-bus,and 30-unit systems show that the MOGJO can provide competitive compromise scheduling solutions compared to published DEED ***,in the analysis of the Pareto dominance relationship and the Euclidean distance index,the optimal dispatching solutions provided by MOGJO are the closest to the ideal solutions for minimizing fuel costs

关键词： Dynamic economic emission dispatch Multi-objective optimization Golden jackal Euclidean distance index

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APFA:Ameliorated Pathfinder Algorithm for Engineering Applications

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Journal of Bionic Engineering 2024年第3期21卷 1592-1616页

Pathfinder algorithm(PFA)is a swarm intelligent optimization algorithm inspired by the collective activity behavior of swarm animals,imitating the leader in the population to guide followers in finding the best food *** algorithm has the characteristics of a simple structure and high ***,PFA faces challenges such as insufficient population diversity and susceptibility to local optima due to its inability to effectively balance the exploration and exploitation *** paper proposes an Ameliorated Pathfinder Algorithm called APFA to solve complex engineering optimization ***,a guidance mechanism based on multiple elite individuals is presented to enhance the global search capability of the ***,to improve the exploration efficiency of the algorithm,the Logistic chaos mapping is introduced to help the algorithm find more high-quality potential solutions while avoiding the worst ***,a comprehensive following strategy is designed to avoid the algorithm falling into local optima and further improve the convergence *** three strategies achieve an effective balance between exploration and exploitation overall,thus improving the optimization performance of the *** performance evaluation,APFA is validated by the CEC2022 benchmark test set and five engineering optimization problems,and compared with the state-of-the-art metaheuristic *** numerical experimental results demonstrated the superiority of APFA.

关键词： Pathfinder algorithm Swarm intelligent Metaheuristic Engineering problems

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Area Operators on Bergman Spaces

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Acta Mathematica Sinica,English Series 2024年第5期40卷 1161-1176页

作者： xiao fen LV Jordi PAU Mao Fa WANG Department of Mathematics Huzhou UniversityHuzhou 313000P.R.China Departament de Matemàtiques i Informàtica Universitat de Barcelona08007 BarcelonaCataloniaSpain School of Mathematics and Statistics Wuhan UniversityWuhan 430072P.R.China

We completely characterize the boundedness of area operators from the Bergman spaces A_(α)^(p)(Bn)to the Lebesgue spaces L^(q)(S_(n))for all 0 详细信息

We completely characterize the boundedness of area operators from the Bergman spaces A_(α)^(p)(Bn)to the Lebesgue spaces L^(q)(S_(n))for all 0

关键词： Area operator Bergman space tent space area formula

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Severe liver injury and clinical characteristics of occupational exposure to 2-amino-5-chloro-N,3-dimethylbenzamide: A case series

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 186-194页

作者： Meng-xiao feng Hua zou Yuan-Qiang Lu Department of Emergency Medicine The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Key Laboratory for Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province Hangzhou 310003China Occupational Health and Radiation Protection Institute Zhejiang Provincial Center for Disease Control and PreventionHangzhou 310051China

Background:The 2-amino-5-chloro-N,3-dimethylbenzamide is a key intermediate in the synthesis of pesticides and ***,no literature currently exists on 2-amino-5-chloro-N,3-dimethylbenzamide poisoning in *** study aimed to reveal the health hazard of this chemical for humans and summarize the clinical characteristics of patients with occupational 2-amino-5-chloro-N,3-dimethylbenzamide ***:This observational study included four patients with 2-amino-5-chloro-N,3-dimethylbenzamide poisoning from June 2022 to July *** entire course of the incidents was described in *** 2-amino-5-chloro-N,3-dimethylbenzamide concentrations were detected by a mass ***-toxylin and eosin staining was performed to assess liver injury,and immunofluorescence was used to evaluate hepatic ***:The 2-amino-5-chloro-N,3-dimethylbenzamide powder(99%purity)entered the human body mainly via the skin and respiratory tract due to poor personal protective *** typical course of 2-amino-5-chloro-N,3-dimethylbenzamide poisoning was divided into latency,rash,fever,organic dam-age,and recovery phases in accordance with the clinical *** and fever may be the important premonitory symptoms for further organ *** chemical was detected in the blood of all patients and caused multiple organ injuries,predominantly liver injury,including kidney,myocardium,and *** patients recovered smoothly after comprehensive treatments,including artificial liver therapy,continuous renal replacement therapy,glucocorticoids,and other symptomatic and supportive *** patient survived by liver *** postoperative pathological findings of the removed liver showed acute liver failure,and immunofluorescence staining confirmed the abundance of mitophagy in residual ***:This study is the first to elaborate the clinical characteristics of patients with 2-amino-5-chloro-N,

关键词： 2-amino-5-chloro-N,3-dimethylbenzamide Poisoning Clinical characteristics Liver injury

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Impact of nutritional support on immunity,nutrition,inflammation,and outcomes in elderly gastric cancer patients after surgery

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2175-2182页

作者： xiao-Wan Chen xiao-Chun Guo fen Cheng Department of Gastrointestinal Surgery Hubei Cancer HospitalWuhan 430079Hubei ProvinceChina Department of Gastroenterology The First People’s Hospital of Jiangxia DistrictWuhan 430200Hubei ProvinceChina

BACKGROUND Postoperative rehabilitation of elderly patients with gastric cancer has always been the focus of clinical *** the intervention by a full-course nutritional support team can have a positive impact on the postoperative immune function,nutritional status,inflammatory response,and clinical outcomes of this special population has not yet been fully *** To evaluate the impact of full-course nutritional support on postoperative comprehensive symptoms in elderly patients with gastric *** This is a retrospective study,including 60 elderly gastric cancer patients aged 70 years and above,divided into a nutritional support group and a control *** nutritional support group received full postoperative nutritional support,including individualized meal formulation,and intravenous and parenteral nutrition supplementation,and was regularly evaluated and adjusted by a professional nutrition *** control group received routine postoperative *** After intervention,the proportion of CD4+lymphocytes(25.3%±3.1%vs 21.8%±2.9%,P<0.05)and the level of immunoglobulin G(12.5 G/L±2.3 G/L vs 10.2 G/L±1.8 G/L,P<0.01)were significantly higher in the nutritional support group than in the control group;the changes in body weight(-0.5 kg±0.8 kg vs-1.8 kg±0.9 kg,P<0.05)and body mass index(-0.2±0.3 vs-0.7±0.4,P<0.05)were less significant in the nutritional support group than in the control group;and the level of C-reactive protein(1.2 mg/L±0.4 mg/L vs 2.5 mg/L±0.6 mg/L,P<0.01)and WBC count(7.2×10^(9)/L±1.5×10^(9)/L vs 9.8×10^(9)/L±2.0×10^(9)/L,P<0.01)were significantly lower in the nutritional support group than in the control *** addition,patients in the nutritional support group had a shorter hospital stay(10.3 d±2.1 d vs 14.8 d±3.6 d,P<0.05)and lower incidence of infection(15%vs 35%,P<0.05)in those of the control *** The intervention by the nutritional support team has a positive impact on postoperative immune function,

关键词： Elderly gastric cancer Postoperative Nutritional support Immune function Inflammatory response Clinical outcome

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Pressure-induced emission(PIE)in halide perovskites toward promising applications in scintillators and solid-state lighting

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Aggregate 2024年第1期5卷 9-15页

作者： Wenya Zhao Guanjun xiao Bo zou State Key Laboratory of Superhard Materials College of PhysicsJilin UniversityChangchunChina

High-pressure chemistry has provided a huge boost to the development of scientific ***-induced emission(PIE)in halide perovskites is gradually showing its unique charm in both pressure sensing and optoelectronic device ***,the PIE retention of halide perovskites under ambient conditions is of great commercial ***,we mainly focus on the potential applications of PIE and PIE retention in metal halide perovskites for scintillators and solid-state *** on the performance requirements of scintillator and single-component white light-emitting diodes(WLEDs),the significance of PIE and PIE retention is critically clarified,aiming to design and synthesize materials used for high-performance optoelectronic *** perspective not only demonstrates promising applications of PIE in the fields of scintillators and WLEDs,but also provides potential applications in display imaging and anti-counterfeiting of PIE ***,solving the scientific disputes that exist under ambient conditions is also simply discussed as an outlook by introducing high-pressure dimension to produce PIE.

关键词： halide perovskites high pressure light-emitting diode pressure-induced emission scintillators solidstate lighting

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Plutonium utilization in a small modular molten-salt reactor based on a batch fuel reprocessing scheme

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Nuclear Science and Techniques 2024年第4期35卷 15-28页

作者： Xue-Chao Zhao Rui Yan Gui-feng Zhu Ya-fen Liu Jian Guo Xiang-Zhou Cai Yang zou Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China CAS Innovative Academies in TMSR Energy System Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China

A molten salt reactor(MSR)has outstanding features considering the application of thorium fuel,inherent safety,sustainability,and resistance to ***,fissile material^(233)U is significantly rare at the current stage,thus it is difficult for MSR to achieve a pure thorium-uranium fuel ***,using plutonium or enriched uranium as the initial fuel for MSR is more *** this study,we aim to verify the feasibility of a small modular MSR that utilizes plutonium as the starting fuel(SM-MSR-Pu),and highlight its advantages and ***,the structural design and fuel management scheme of the SM-MSR-Pu were ***,the neutronic characteristics,such as the graphite-irradiation lifetime,burn-up performance,and coefficient of temperature reactivity were calculated to analyze the physical characteristics of the *** results indicate that plutonium is a feasible and advantageous starting fuel for a SM-MSR;however,there are certain shortcomings that need to be *** a 250 MWth SM-MSR-Pu,approximately 288.64 kg^(233)U of plutonium with a purity of greater than 90% is produced while 978.00 kg is burned every ten *** temperature reactivity coefficient decreases from -4.0 to -6.5 pcm K^(-1) over the 50-year operating time,which ensures a long-term safe ***,the amount of plutonium and accumulation of minor actinides(MAs)would increase as the burn-up time increases,and the annual production and purity of^(233)U will *** achieve an optimal burn-up performance,setting the entire operation time to 30 years is ***,more than 3600 kg of plutonium eventually accumulate in the *** research is required to effectively utilize this accumulated plutonium.

关键词： Molten salt fuel Plutonium utilization ^(233)U TRUs mole fraction Temperature feedback coefficient

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Impacts of Water-Sediment Regulation Scheme on Chromophoric Dissolved Organic Matter in the Lower Yellow River

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Journal of Ocean University of China 2024年第2期23卷 455-466页

作者： LIU xiao JIANG Xueyan LIU Qian SUI Juanjuan zou Li Key Laboratory of Marine Chemistry Theory and Technology of Ministry of Education Ocean University of ChinaQingdao 266100China College of Chemistry and Chemical Engineering Ocean University of ChinaQingdao 266100China School of Earth Sciences University of BristolBristolBS81RJUK North China Sea Environmental Monitoring Center State Oceanic AdministrationQingdao 266033China Key Laboratory of Ecological Prewarning Protection and Restoration of Bohai SeaMinistry of Natural ResourcesQingdao 266033China Key Laboratory of Marine Environment and Ecology of Ministry of Education Ocean University of ChinaQingdao 266100China College of Environmental Science and Engineering Ocean University of ChinaQingdao 266100China

As a river with more than 3000 reservoirs in its watershed,the Yellow River has been affected by dams not only on the sediment load,but also on the water ***-sediment regulation scheme(WSRS),which has been carried out annually in the Yellow River since 2002,is a typical human activity affecting river water *** dissolved organic matter(CDOM)in river is susceptible to changes in ecological and environmental conditions as well as human ***,we report variations in dissolved organic carbon concentrations,compositions and sources of CDOM in time series samples in the lower Yellow River during *** addition,a parallel factor fluorescence analysis(PARAFAC)method is applied to identify different fluorescent components in water samples during WRSR,showing four major components including tryptophan-like component(C1),microbial humic-like component(C2),terrestrial humic-like component(C3)and tyrosine-like component(C4).In general,C1 increased after water regulation,while C2 and C3 increased after sediment regulation,indicating that the water and sediment released by the dam have different effects on CDOM *** the impacts of the dam,source of CDOM in the lower Yellow River is mainly autochthonous related to microbial activities,and is regulated by the terrestrial input during WSRS *** resuspension inhibits microbial activities and reduces the production of autochthonous ***,human activities especially WSRS,as exemplified here,significantly alter the quality and quantity of CDOM in the lower Yellow River,affecting CDOM dynamics and biogeochemical processes in the estuarine environment.

关键词： chromophoric dissolved organic matter(CDOM) water-sediment regulation scheme(WSRS) Yellow River optical properties

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