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宽带数字阵列雷达接收通道的优化设计方法研究

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电子科技大学学报 2022年第1期51卷 52-56页

作者：钱璐邹林汪学刚电子科技大学信息与通信工程学院成都611731

宽带数字阵列雷达(WB-DAR)具有模式多变、抗干扰能力强的优势,还兼具高距离分辨力,能够获取未知目标距离像,对目标进行分类和识别。大带宽信号的使用引入了孔径渡越时间的约束,因此,宽带数字阵列雷达需采用基于时延的宽带波束形成方法,... 详细信息

宽带数字阵列雷达(WB-DAR)具有模式多变、抗干扰能力强的优势,还兼具高距离分辨力,能够获取未知目标距离像,对目标进行分类和识别。大带宽信号的使用引入了孔径渡越时间的约束,因此,宽带数字阵列雷达需采用基于时延的宽带波束形成方法,以数字时延补偿方式取代传统窄带相控阵中的移相器来形成波束。该文在宽带数字阵列基础上,针对多级抽取结合可变分数时延滤波器的典型接收通道结构,提出了一种新的接收通道优化设计方法。与原方法相比,在满足同样性能要求的情况下,该方法能够降低抗混叠滤波器和分数时延滤波器的阶数,有效地节约了系统硬件资源。

关键词：多级抽取接收通道分数时延滤波器宽带数字阵列雷达

Sirolimus can promote the disappearance of renal angiomyolipoma associated with tuberous sclerosis complex:a prospective cohort study

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World Journal of Pediatrics 2024年第6期20卷 602-610页

作者： Shuo Dun Yang-Yang wang lin Wan Qiu-Hong wang qian lu Xiao-Yan Yang Qi Zhang Hui-Min Chen lu-Peng Qiu Li-Ping zou Medical School of Chinese PLA Beijing 100853China Department of Pediatrics The First Medical CenterChinese PLA General HospitalBeijing 100853China Center of Epilepsy Beijing Institute for Brain DisordersBeijing 100069China

Background Renal angiomyolipoma(RAML)is the most common kidney lesion in patients with tuberous sclerosis complex(TSC),affecting about 80%of *** is a benign tumor that grows over time,usually bilaterally,and can easily lead to kidney complications such as acute ***,we investigated the efficacy and safety of sirolimus in children with TSC-associated RAML and explored the factors affecting tumor disappearance under sirolimus treatment through subgroup *** A prospective cohort study was *** was initiated at 1 mg/(m^(2)×day),and dose adjustments were made by a 2-week titration period to attain a trough blood concentration of 5-10 ng/*** disappearance of RAML in chil-dren after sirolimus treatment was observed,and Cox regression was used to screen the factors affecting tumor *** One hundred and twenty-six patients who met the criteria were *** 3 months,6 months,12 months,and 24 months of follow-up,tumors disappeared in 18(14.3%),30(23.8%),39(31.0%),and 42(33.3%)children,*** disappeared in 50(39.7%)children by the last visit of each individual,and 30(60%)of them occurred within 6 *** multivariate Cox regression analysis showed that patients with a smaller maximum tumor diameter at baseline had a higher tumor disappearance ***-six(29%)patients had stomatitis during the entire treatment period,and no serious *** Sirolimus could promote the disappearance of TSC-related *** disappearance rate was correlated with the maximum diameter at baseline,and the smaller the tumor was,the higher the disappearance *** is well tolerated in the treatment of RAML associated with TSC.

关键词： Angiomyolipoma mTOR inhibitor Sirolimus Tuberous sclerosis

A self-fused hydrogel for the treatment of glottic insufficiency through outstanding durability,extracellular matrix-inducing bioactivity and function preservation

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Bioactive Materials 2023年第6期24卷 54-68页

作者： Chen-Yu zou Juan-Juan Hu Dan lu qian-Jin Li Yan-lin Jiang Rui wang Hai-Yang wang Xiong-Xin Lei Jesse Li-ling Hui Yang Hui-Qi Xie Laboratory of Stem Cell and Tissue Engineering Orthopedic Research InstituteMed-X Center for MaterialsState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan610041PR China Department of Otolaryngology Head and Neck SurgeryWest China HospitalSichuan UniversityChengduSichuan610041PR China Department of Medical Genetics West China Second HospitalSichuan UniversityChengduSichuan610041PR China

Injection laryngoplasty with biomaterials is an effective technique to treat glottic ***,the inadequate durability,deficient pro-secretion of extracellular matrix(ECM)and poor functional preservation of current biomaterials have yielded an unsatisfactory therapeutic ***,a self-fusing bioactive hydrogel comprising modified carboxymethyl chitosan and sodium alginate is developed through a dual-crosslinking mechanism(photo-triggered and dynamic covalent bonds).Owing to its characteristic networks,the synergistic effect of the hydrogel for vocal folds(VFs)vibration and phonation is adequately ***,owing to its inherent bioactivity of polysaccharides,the hydrogel could significantly enhance the secretion of major components(type I/III collagen and elastin)in the lamina propria of the VFs both in vivo and in *** a rabbit model for glottic insufficiency,the optimized hydrogel(C1A1)has demonstrated a durability far superior to that of the commercially made hyaluronic acid(HA)*** importantly,owing to the ECM-inducing bioactivity,the physiological functions of the VFs treated with the C1A1 hydrogel also outperformed that of the HA Gel,and were similar to those of the normal *** together,through a simple-yet-effective strategy,the novel hydrogel has demonstrated outstanding durability,ECM-inducing bioactivity and physiological function preservation,therefore has an appealing clinical value for treating glottic insufficiency.

关键词： Glottic insufficiency Self-fusion Hydrogel Extracellular matrix Physiological function

Classification and genetic counselling for a novel splicing mutation of the MLH1 intron associated with Lynch syndrome in colorectal cancer

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Gastroenterology Report 2021年第6期9卷 552-559页

作者： ling-ling wang Shuang-Mei zou lin Dong Ming Yang Dan Qi Zhao lu Jia-Nan Chen Shi-Wen Mei Zhi-Xun Zhao Xu Guan Zheng Jiang qian Liu Zheng Liu Xi-Shan wang Department of Colorectal Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China

Background:Lynch-syndrome-associated cancer is caused by germline pathogenic mutations in mismatch repair *** major challenge to Lynch-syndrome screening is the interpretation of variants found by diagnostic *** study aimed to classify the MLH1 c.1989t5G>A mutation,which was previously reported as a variant of uncertain significance,to describe its clinical phenotypes and characteristics,to enable detailed genetic ***:We reviewed the database of patients with Lynch-syndrome gene detection in our hospital.A novel variant of MLH1 c.1989t5G>A identified by next-generation sequencing was further investigated in this *** staining was carried out to assess the expression of MLH1 and PMS2 protein in tumour *** silico analysis by Alamut software was used to predict the MLH1 c.1989t5G>A variant *** transcription-polymerase chain reaction and sequencing of RNA fromwhole bloodwere used to analyse the functional significance of this ***:Among affected family members in the suspected Lynch-syndrome pedigree,the patient suffered from late-stage colorectal cancer but had a good *** found the MLH1 c.1989t5G>A variant,which led to aberrant splicing and loss of MLH1 and PMS2 protein in the nuclei of tumour *** aberrant transcript was detectable and skipping of MLH1 exon 17 in carriers of MLH1 c.1989t5G>A was ***:MLH1 c.1989t5G>A was detected in a cancer family pedigree and identified as a pathological variant in patients with Lynch *** spectrumof Lynch syndrome was enriched through enhanced genetic testing and close surveillancemight help future patients who are suspected of having Lynch syndrome to obtain a definitive early diagnosis.

关键词： Lynch syndrome MLH1 genetic testing colorectal cancer genetic counselling

三毫米波目标RCS测量雷达信号处理机的设计与实现

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电子测量与仪器学报 2009年第11期23卷 48-52页

作者：邹林汪学刚钱璐电子科技大学电子工程系成都610054

毫米波频段目标的雷达截面积(RCS)特性,对于目标识别与分类、飞行器隐身及雷达反隐身等研究工作具有重要意义。实验测量是获得目标RCS特性的有效方法。本文介绍了三毫米波目标RCS测量雷达系统中信号处理机的设计和实现。该信号处理机由... 详细信息

毫米波频段目标的雷达截面积(RCS)特性,对于目标识别与分类、飞行器隐身及雷达反隐身等研究工作具有重要意义。实验测量是获得目标RCS特性的有效方法。本文介绍了三毫米波目标RCS测量雷达系统中信号处理机的设计和实现。该信号处理机由数据采集硬件模块和信号处理软件构成,对实时数据采集后进行离线信号处理。信号处理机对非相参输入信号过采样后完成数字下变频和抽取,将基带数据通过USB总线送入计算机处理,采用傅立叶变换(FFT)实现相参积累,并在积累后通过相对标定来测量目标RCS。理论分析和实测结果表明,可提高接收机灵敏度33dB,对目标RCS测量的相对误差小于5%。

关键词： RCS测量信号处理机 DDC 相参积累误差分析

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LFMCW车载雷达解速度模糊测角新方法

电子科技大学学报 2020年第6期49卷 801-805页

作者：邹林黄述康钱璐汪学刚田晋川电子科技大学信息与通信工程学院成都611731

LFMCW车载雷达采用MIMO虚拟孔径方法提高角度估计性能,通常将MIMO雷达虚拟孔径角度估计和解速度模糊分成两帧信号处理,这样会降低雷达数据率。该文提出一种解速度模糊测角新方法,采用TDM方式发射不同时宽、带宽相同的锯齿波信号。在一... 详细信息

LFMCW车载雷达采用MIMO虚拟孔径方法提高角度估计性能,通常将MIMO雷达虚拟孔径角度估计和解速度模糊分成两帧信号处理,这样会降低雷达数据率。该文提出一种解速度模糊测角新方法,采用TDM方式发射不同时宽、带宽相同的锯齿波信号。在一帧信号内先解速度模糊,再进行相位补偿,最后进行MIMO雷达虚拟孔径角度估计。通过仿真和理论分析,该方法能进行高精度角度估计,减少了信号处理时间,提高了雷达数据率。

关键词：角度估计多输入多输出时分复用技术解速度模糊

实时定量PCR检测细菌中bla_(CTX-M-14)基因

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中国抗生素杂志 2009年第8期34卷 505-508页

作者：王震钱凯吕建新邹立林陈栋孙宝昌温州医学院浙江省医学遗传学重点实验室细胞与分子医学研究所温州325035 温州市疾病预防控制中心温州325000

目的探索实时定量PCR检测临床、环境细菌中blaCTX-M-14基因流行情况。方法将收集的65份标本先用ESBL表型确认试验及其KB琼脂扩散法初筛,然后通过菌落平板计数,实时定量PCR方法测出细菌blaCTX-M-14基因C(t)值,最终计算得到平均每个待测... 详细信息

目的探索实时定量PCR检测临床、环境细菌中blaCTX-M-14基因流行情况。方法将收集的65份标本先用ESBL表型确认试验及其KB琼脂扩散法初筛,然后通过菌落平板计数,实时定量PCR方法测出细菌blaCTX-M-14基因C(t)值,最终计算得到平均每个待测细菌中的blaCTX-M-14基因的单个拷贝数。结果从65份标本中分离得到4株产ESBLs的大肠埃希菌,实时定量PCR检测后得到四株细菌的blaCTX-M-14基因C(t)值依次为11.08,11.63,11.80,13.46,拷贝数分别为6.92×107copies/μl菌液,4.67×107copies/μl菌液,4.22×107copies/μl菌液,1.35×107copies/菌液,即1.05copies/细菌,1.90copies/细菌,2.92copies/细菌,1.10copies/细菌。结论细菌blaCTX-M-14基因拷贝数的高低与细菌多重耐药现象正相关,建立的实时定量PCR检测细菌中blaCTX-M-14基因的方法具有直观,快捷的优点,有助于检测临床及其环境中耐药菌blaCTX-M-14基因流行情况。

关键词：超广谱β-内酰胺酶 CTX—M-14 实时定量PCR

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中国当代儿科杂志 2019年第9期21卷 845-850页

作者：万林杨光邹丽萍王静石秀玉任蔚华卢倩解放军总医院第一医学中心儿内科

目的探讨婴儿痉挛症患儿首次行促肾上腺皮质激素(ACTH)治疗中的相关因素对痉挛控制时间的影响,为临床治疗提供参考依据。方法选择2008年1月至2013年10月收治的72例婴儿痉挛症患儿为研究对象,收集临床资料,选取婴儿痉挛症相关暴露因素,... 详细信息

目的探讨婴儿痉挛症患儿首次行促肾上腺皮质激素(ACTH)治疗中的相关因素对痉挛控制时间的影响,为临床治疗提供参考依据。方法选择2008年1月至2013年10月收治的72例婴儿痉挛症患儿为研究对象,收集临床资料,选取婴儿痉挛症相关暴露因素,以痉挛控制时间分别对各因素进行Cox比例风险回归模型分析,评估各因素对痉挛控制时间的影响。结果有无明确病因(已知病因或不明原因)、治疗前痉挛发作频率、是否联合治疗(ACTH单用或联合硫酸镁)3个因素对婴儿痉挛症患儿的痉挛控制时间具有显著性影响(P < 0.05)。已知病因的婴儿痉挛症患儿痉挛控制时间较短,而治疗前痉挛发作频率较低以及ACTH联合硫酸镁治疗的患儿痉挛控制时间较长(均P < 0.05)。结论对于首诊的婴儿痉挛症患儿,应尽可能明确病因,有助于评估预后;及早应用ACTH联合硫酸镁治疗,可能改善预后。

关键词：婴儿痉挛症促肾上腺皮质激素硫酸镁痉挛控制时间 Cox比例风险回归模型婴儿

伊马替尼治疗95例慢性粒细胞白血病的远期疗效及其影响因素分析

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中华血液学杂志 2008年第1期29卷 18-22页

作者：王国蓉赵耀中钱林生邹德慧李睿秘营昌王建祥邱录贵中国医学科学院、中国协和医科大学血液学研究所、血液病医院实验血液学国家重点实验室

目的分析伊马替尼治疗慢性粒细胞白血病（CML）的疗效和患者生存情况，并初步探讨影响伊马替尼疗效的因素。方法对2002年5月至2006年5月接受伊马替尼治疗的95例CML患者随访至2006年10月31日，分析患者的治疗转归及相关影响因素。结果①... 详细信息

目的分析伊马替尼治疗慢性粒细胞白血病（CML）的疗效和患者生存情况，并初步探讨影响伊马替尼疗效的因素。方法对2002年5月至2006年5月接受伊马替尼治疗的95例CML患者随访至2006年10月31日，分析患者的治疗转归及相关影响因素。结果①慢性期组伊马替尼治疗后12个月95．5％患者获得完全血液学缓解（CHR）；其中遗传学资料完整的52例患者中初治19例，复治33例，初治组治疗后6、12、18、24、30个月的主要细胞遗传学缓解（MCyR）率分别为84．2％、84．2％、89．5％、89．5％和94．7％，复治组分别为36．4％、39．4％、39．4％、39．4％和39．4％，两组比较差异有统计学意义（P〈0．01）；全组患者治疗后12、24、36、50个月预期生存率分别为（98．1±1．9）％、（87．8±7．1）％、（81．9±8．7）％和（81．9±8．7）％。②加速期组伊马替尼治疗后12个月70％患者获得CHR，10％获得MCyR；治疗后12、24和36个月预期生存率分别为（63．0±17．7）％、（15．8±14．3）％和（15．8±14．3）％。③急变期组伊马替尼治疗后6个月57．9％患者获得CHR；治疗后12、24个月预期生存率分别为（40．6±12．3）％和0。④对慢性期组进行COX多因素预后分析显示，伊马替尼治疗前有无其他治疗是影响无进展生存和获得MCyR的独立预后不良因素。结论①伊马替尼作为一线治疗药物用于CML慢性期，对患者生存质量的改善明显优于作为替换治疗药物或用于加速、急变期治疗，因此伊马替尼应明确作为首选的一线治疗药物。②伊马替尼治疗加速期和急变期CML也能获得一定血液学、遗传学疗效，延长患者生存期。

关键词：白血病,髓样,慢性伊马替尼药物疗法治疗结果预后