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Indirect comparison of efficacy and safety of chiglitazar and thiazolidinedione in patients with type 2 diabetes:A meta-analysis

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World Journal of Diabetes 2023年第10期14卷 1573-1584页

作者： Chu lin zong-lin li Xiao-ling Cai Sui-Yuan Hu Fang Lv Wen-Jia Yang li-Nong Ji Department of Endocrinology and Metabolism Peking University People's HospitalBeijing 100044China

BACKGROUND Chiglitazar is an emerging pan-agonist of all peroxisome proliferator activated receptors(PPAR)-α,δandγ,and has therapeutic potential for type 2 diabetes(T2D).However,to date,no clinical studies or meta-analyses have compared the efficacy and safety of chiglitazar and traditional PPAR-γagonist thiazolidinediones(TZDs).A meta-analysis concerning this topic is therefore required.AIM To compare the efficacy and safety of chiglitazar and TZD in patients with T2D.METHODS PubMed,Medline,Embase,the Cochrane Central Register of Controlled Trials,Reference Citation Analysis and Clinicaltrial.gov websites were searched from August 1994 to March 2022.Randomized controlled trials(RCTs)of chiglitazar or TZD vs placebo in patients with T2D were included.Indirect comparisons and sensitivity analyses were implemented to evaluate multiple efficacy and safety endpoints of interest.RESULTS We included 93 RCTs that compared TZD with placebo and one that compared chiglitazar with placebo.For efficacy endpoints,the augmented dose of chiglitazar resulted in greater reductions in hemoglobin(Hb)A1c[weighted mean difference(WMD)=-0.15%,95%confidence interval(CI):-0.27 to-0.04%],triglycerides(WMD=-0.17 mmol/L,95%CI:-0.24 to-0.11 mmol/L)and alanine aminotransferase(WMD=-5.25 U/L,95%CI:-8.50 to-1.99 U/L),and a greater increase in homeostasis model assessment-β(HOMA-β)(WMD=17.75,95%CI:10.73-24.77)when compared with TZD treatment.For safety endpoints,the risks of hypoglycemia,edema,bone fractures,upper respiratory tract infection,urinary tract infection,and weight gain were all comparable between the augmented dose of chiglitazar and TZD.In patients with baseline HbA1c≥8.5%,body mass index≥30 kg/m^(2)or diabetes durationlitazar compared with TZD.CONCLUSION Augmented dose of chiglitazar,a pan-activator of PPARs,may serve as an antidiabetic agent with preferable glycemic and lipid control,betterβ-cell function preserving capacity,and d

关键词： Chiglitazar Thiazolidinedione Glycemic control β-cell function Drug safety

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Multiple myeloma presenting with amyloid arthropathy as the first manifestation:Two case reports

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World Journal of Clinical Cases 2022年第35期10卷 13028-13037页

作者： Chuan He Xue-Ping Ge Xiao-Hui Zhang Ping Chen Bing-zong li Department of Haematology The Second Affiliated Hospital of Soochow UniversitySuzhou 215004Jiangsu ProvinceChina

BACKGROUND Multiple myeloma(MM)can be accompanied by amyloidosis,which occurs in a small number of patients and is characterized by deposition of light chains in the joints,leading to multiple myeloma-associated amyloid arthropathy(MAA).As a rare complication of MM,clinical manifestations of MAA are often similar to those of rheumatoid arthritis,and the two are easily confused.CASE SUMMARY In recent years,our center treated two patients of MM with amyloid arthropathy as the first manifestation,both of whom presented with polyarthritis.After treatment for MM,both patients achieved complete remission.However,subsequently,the two patients underwent hip arthroplasty for femoral neck fractures.Congo red staining and immunofluorescence of the joint tissues confirmed MAA after surgery.Eventually,one of the patients died of MM recurrence,while the other survived.CONCLUSION MAA should be regarded as an initial symptom of MM and should be taken seriously.

关键词： Amyloidosis Polyarthritis Monoclonal gammopathies Immunoglobulin light chain amyloidosis Multiple myeloma Case report

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基于恒流源特性的电场感应取能电源研究

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通信电源技术 2024年第10期41卷 115-117,235页

作者：王新涛郑强牟磊李宗赵建坤青岛电气工程安装有限公司山东青岛266000 国网山东省电力公司青岛供电公司山东青岛266002 内蒙古电力科学研究院内蒙古呼和浩特510500

在线监测装置是保证高压线路安全稳定运行的重要组成部分,但受限于户外的运行环境,该装置缺乏稳定的供电电源。文章提出一种基于恒流源特性的电场感应取能电源,通过换能器有效放大高压导线与大地之间的恒定位移电流,可满足高压架空输电... 详细信息

在线监测装置是保证高压线路安全稳定运行的重要组成部分,但受限于户外的运行环境,该装置缺乏稳定的供电电源。文章提出一种基于恒流源特性的电场感应取能电源,通过换能器有效放大高压导线与大地之间的恒定位移电流,可满足高压架空输电线路低功率传感器的功率需求。首先,建立基于恒流源特性的电场感应取能电源的电路模型,分析其关键影响因素;其次,针对影响因素进行理论和仿真分析,以优化参数配置;最后,将该取能电源应用于一种隔离开关触头温度在线测量和无线传输装置,分析其应用效果。本研究为在线监测装置的户外供电提供了一种新的方式。

关键词：电场感应换能器位移电流低功率传感器

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Probabilistic seismic inversion based on physics-guided deep mixture density network

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Petroleum Science 2024年第3期21卷 1611-1631页

作者： Qian-Hao Sun Zhao-Yun zong Xin li National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China) Laoshan Laboratory CNOOC Research Institute Ltd.

Deterministic inversion based on deep learning has been widely utilized in model parameters estimation.Constrained by logging data, seismic data, wavelet and modeling operator, deterministic inversion based on deep learning can establish nonlinear relationships between seismic data and model parameters.However, seismic data lacks low-frequency and contains noise, which increases the non-uniqueness of the solutions. The conventional inversion method based on deep learning can only establish the deterministic relationship between seismic data and parameters, and cannot quantify the uncertainty of inversion. In order to quickly quantify the uncertainty, a physics-guided deep mixture density network(PG-DMDN) is established by combining the mixture density network(MDN) with the deep neural network(DNN). Compared with Bayesian neural network(BNN) and network dropout, PG-DMDN has lower computing cost and shorter training time. A low-frequency model is introduced in the training process of the network to help the network learn the nonlinear relationship between narrowband seismic data and low-frequency impedance. In addition, the block constraints are added to the PG-DMDN framework to improve the horizontal continuity of the inversion results. To illustrate the benefits of proposed method, the PG-DMDN is compared with existing semi-supervised inversion method. Four synthetic data examples of Marmousi II model are utilized to quantify the influence of forward modeling part, low-frequency model, noise and the pseudo-wells number on inversion results, and prove the feasibility and stability of the proposed method. In addition, the robustness and generality of the proposed method are verified by the field seismic data.

关键词： Deep learning Probabilistic inversion Physics-guided Deep mixture density network

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基于CRISPR/Cas13a系统建立大口黑鲈弹状病毒检测方法

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水生生物学报 2024年第2期48卷 283-291页

作者：张敏琳黄枫淇左小玲梁建韬梁凯珊单金红李宗烊喻婕罗丽媛禤梓杰赵会宏王庆华南农业大学海洋学院广州510642 华南农业大学粤港海洋生物资源保护与开发联合实验室广州510642

为了建立一种灵敏度高、特异性强并且适合现场诊断的大口黑鲈弹状病毒(Micropterus salmoides rhabdovirus,MSRV)检测方法,研究基于CRISPR-Cas13a系统并结合多酶恒温核酸快速扩增(MIRA)技术建立了一种MSRV的检测方法。实验对MSRV序列进... 详细信息

为了建立一种灵敏度高、特异性强并且适合现场诊断的大口黑鲈弹状病毒(Micropterus salmoides rhabdovirus,MSRV)检测方法,研究基于CRISPR-Cas13a系统并结合多酶恒温核酸快速扩增(MIRA)技术建立了一种MSRV的检测方法。实验对MSRV序列进行多重序列比对分析后,针对MSRV衣壳蛋白(CP)基因的特异性区域设计两个靶点,并通过体外转录成特异性的crRNA,同时设计合成MIRA引物序列实现目标序列的等温扩增,最后结合Cas13a蛋白、crRNA、恒温扩增体系构建检测体系,并从高效crRNA的选择、反应温度、ssRNA报告探针浓度和Cas13a与crRNA的浓度比四个方面优化了反应体系,并采用最优检测体系对大口黑鲈样本进行检测验证。结果显示,在20μL检测体系中加入200 nmol/L Cas13a、100 nmol/L crRNA1、100 nmol/L crRNA2及500 nmol/L ssRNA报告探针,在37℃的情况下能够获得最佳的检测效果。并且该检测体系可以检测到102 fM的MSRV病毒,具有良好的特异性和灵敏性,此外检测结果可直接通过紫外灯照射直接观察。研究基于CRISPR/Cas13a系统结合等温扩增MIRA技术建立的MSRV检测方法,可在室温下且不需要昂贵的仪器进行MSRV病毒检测,检测结果可以肉眼直接观察,能在多种场合下使用,研究结果为检测MSRV提供了有效方法。

关键词：大口黑鲈弹状病毒 CRISPR-Cas13a MIRA 大口黑鲈

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大断面一次成巷爆破数值模拟及试验研究

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工程爆破 2024年第2期30卷 66-72页

作者：马东尤元元胡世超宫国慧高常胜李宗武吴东海左进京鞍钢集团矿业弓长岭有限公司辽宁鞍山114046 中国矿业大学(北京)力学与建筑工程学院北京100083 北京科技大学土木与资源工程学院北京100083

为有效解决大断面掘进爆破作业中存在的技术难题,在大断面巷道中采用孔间多时序一次成巷爆破技术。利用LS-DYNA有限元数值模拟软件,通过改变大断面巷道炮孔掏槽方式、孔间起爆时差,进行数值模拟计算。在此基础上确定了掏槽方式、炮孔布... 详细信息

为有效解决大断面掘进爆破作业中存在的技术难题,在大断面巷道中采用孔间多时序一次成巷爆破技术。利用LS-DYNA有限元数值模拟软件,通过改变大断面巷道炮孔掏槽方式、孔间起爆时差,进行数值模拟计算。在此基础上确定了掏槽方式、炮孔布置方式等关键爆破技术参数,并进行了现场试验及应用。结果表明:与分步开挖相比,采用孔间多时序全断面一次掘进成巷爆破技术后,巷道成型效果好、炮孔利用率提高18%。改进后的爆破方案有效地解决了大断面分步开挖中面临的问题,对地下矿大断面掘进爆破巷道成型及控制具有一定的参考价值。

关键词：弓长岭铁矿大断面一次成巷孔间多时序炮孔利用率数值模拟

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5G高铁专网覆盖综合解决方案研究和应用

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电信工程技术与标准化 2024年第1期37卷 87-92页

作者：李宗恒邹文杰方子贤何志丰中国移动通信集团广东有限公司广州分公司广州510335

5G高铁覆盖面临着资源占时短、瞬时容量高、车体损耗大、移动速度快、基站交替快和远近兼顾难等多重挑战。本文针对5G高铁专网的覆盖方案、容量方案、公专网频率协同方案、主设备与天线选型方案、优化创新方案五大关键点开展了对比论证... 详细信息

5G高铁覆盖面临着资源占时短、瞬时容量高、车体损耗大、移动速度快、基站交替快和远近兼顾难等多重挑战。本文针对5G高铁专网的覆盖方案、容量方案、公专网频率协同方案、主设备与天线选型方案、优化创新方案五大关键点开展了对比论证和深入研究,并应用于某高铁规划建设优化实践中,提升了高铁客户的感知,满足了“5G高铁上车”过渡期的高铁场景5G覆盖需求,为后续高铁覆盖项目的应用推广提供了重要的参考。

关键词：无线通信技术 5G网络 5G高铁专网

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Development and validation of a new prognostic model for patients with acute-on-chronic liver failure in intensive care unit

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World Journal of Gastroenterology 2024年第20期30卷 2657-2676页

作者： zong-Yi Zhu Xiu-Hong Huang Hui-Qing Jiang li liu Department of Gastroenterology The Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Department of Gastroenterology Weixian People's HospitalXingtai 054700Hebei ProvinceChina

BACKGROUND Cirrhotic patients with acute-on-chronic liver failure(ACLF)in the intensive care unit(ICU)have a poor but variable prognoses.Accurate prognosis evaluation can guide the rational management of patients with ACLF.However,existing prognostic scores for ACLF in the ICU environment lack sufficient accuracy.AIM To develop a new prognostic model for patients with ACLF in ICU.METHODS Data from 938 ACLF patients in the Medical Information Mart for Intensive Care(MIMIC)database were used to develop a new prognostic model(MIMIC ACLF)for ACLF.Discrimination,calibration and clinical utility of MIMIC ACLF were assessed by area under receiver operating characteristic curve(AUROC),calibration curve and decision curve analysis(DCA),respectively.MIMIC ACLF was then externally validated in a multiple-center cohort,the Electronic Intensive Care Collaborative Research Database and a single-center cohort from the Second Hospital of Hebei Medical University in China.RESULTS The MIMIC ACLF score was determined using nine variables:ln(age)×2.2+ln(white blood cell count)×0.22-ln(mean arterial pressure)×2.7+respiratory failure×0.6+renal failure×0.51+cerebral failure×0.31+ln(total bilirubin)×0.44+ln(internationalized normal ratio)×0.59+ln(serum potassium)×0.59.In MIMIC cohort,the AUROC(0.81/0.79)for MIMIC ACLF for 28/90-day ACLF mortality were significantly greater than those of Chronic liver Failure Consortium ACLF(0.76/0.74),Model for End-stage liver Disease(MELD;0.73/0.71)and MELD-Na(0.72/0.70)(all Plity.The superior predictive accuracy and clinical utility of MIMIC ACLF were validated in the external cohorts.CONCLUSION We developed and validated a new prognostic model with satisfactory accuracy for cirrhotic patients with ACLF hospitalized in

关键词： Acute-on-chronic liver failure Cirrhosis Risk stratification Prognosis Model Scores

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关于母线保护二次屏柜更换的流程及注意事项

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农村电气化 2024年第6期 34-37页

作者：徐龙江李宏臣李宗陈春龙刘延庆文宏成国网山东省电力公司青岛供电公司山东青岛266002

文章对母线保护二次屏柜更换的流程及注意事项进行了梳理,包括从母线保护改造前的现场勘查、旧屏检查、新屏接线、保护调试、送电测方向5个方面阐述了各流程中应该遵循的步骤以及注意事项,对于工作中容易出现的错误项、遗漏项进行了总结... 详细信息

文章对母线保护二次屏柜更换的流程及注意事项进行了梳理,包括从母线保护改造前的现场勘查、旧屏检查、新屏接线、保护调试、送电测方向5个方面阐述了各流程中应该遵循的步骤以及注意事项,对于工作中容易出现的错误项、遗漏项进行了总结,帮助继电保护人员提高母线保护改造的规范性和可靠性,进一步提升母线保护改造工作的效率。

关键词：母线保护二次屏柜改造方案

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Comparative identification of Ca～(2+) channel expression in INS-1 and rat pancreatic β cells

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World Journal of Gastroenterology 2009年第24期15卷 3046-3050页

作者： Fei li zong-Ming Zhang Department of General Surgery Digestive Medical Center The First Affiliated Hospital Medical School Tsinghua University Beijing 100016 China

AIM:To identify and compare the profile of Ca2+ channel subunit expression in INS-1 and rat pancreatic β cells. METHODS:The rat insulin-secreting INS-1 cell line was cultured in RPMI-1640 with Wistar rats employed as islet donors.Ca2+ channel subunit expression in INS-1 and isolated rat β cells were examined by reverse transcription polymerase chain reaction (RT-PCR).Absolute real-time quantitative PCR was performed in a Bio-Rad iQ5 Gradient Real Time PCR system and the data analyzed using an iQ5 system to identify the expression level of the Ca 2+ channel subunits. RESULTS:In INS-1 cells,the L-type Ca 2+ channel 1C subunit had the highest expression level and the TPRM2 subunit had the second highest expression. In rat β cells,the TPRC4 β subunit expression was dominant and the expression of the L-type 1C subunit exceeded the 1D subunit expression about two-fold. This result agreed with other studies,confirming the important role of the L-type 1C subunit in insulinsecreting cells,and suggested that non-voltageoperated Ca 2+ channels may have an important role in biphasic insulin secretion. CONCLUSION:Twelve major Ca 2+ channel subunit types were identified in INS-1 and rat β cells and significant differences were observed in the expression of certain subunits between these cells.

关键词： L型钙通道胰腺细胞 INS 大鼠比较鉴别 Ca 逆转录聚合酶链反应胰岛素分泌

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