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Investigation of the Phytoconstituents and Antioxidant Activity of Diospyros malabaricaFruit Extracts

Advances in Bioscience and Biotechnology 2019年第12期10卷 431-454页

作者： Razib Datta Shubhra Shakil Ahmed Polash Tanushree Saha Ashraful Hasan Sharif Hossain zinia islam Satya Ranjan Sarker Department of Biotechnology and Genetic Engineering Jahangirnagar University Dhaka Bangladesh Department of Textile Engineering Dhaka University of Engineering and Technology Gazipur Bangladesh Department of Biochemistry and Molecular Biology Jahangirnagar University Dhaka Bangladesh

Diospyros malabarica (Deshi Gab) belonging to the family “Ebenaceae” grows well in the humid tropical climate of Bangladesh. In order to investigate the phytoconstituents both qualitatively and quantitatively, the seed and flesh extracts of D. malabarica were prepared using two polar solvents (i.e., water and 70% ethanol) and a nonpolar solvent (i.e., hexane). The maximum yield was obtained for aqueous and ethanolic seed extracts indicating that most of the phytoconstituents present in D. malabarica fruit are polar. The qualitative phytochemical analysis of the extracts revealed the presence of diverse amount of phytoconstituents in the extracts. On the other hand, the quantitative phytochemical analysis for phenols, tannins, flavonoids, alkaloids, saponin, proteins, reducing sugar and vitamin C revealed that the maximum amount of phenols, tannins, flavonoids and reducing sugar were present in aqueous seed extract. However, the maximum amount of total protein and vitamin C was found in ethanolic seed extract. D. malabarica seed powder contained more amount of alkaloids (i.e., 13.6%) than that of flesh (i.e., 3.4%). However, the content of saponin was more in flesh extract (0.74%) when compared to that of seed extract (0.42%). In vitro antioxidant properties of the extracts were also investigated by DPPH free radical scavenging assay, FRAP assay and reducing power assay. The highest antioxidant activity was observed for aqueous seed extract followed by the ethanolic seed, ethanolic flesh, and aqueous flesh extracts. The lowest antioxidant activity was obtained for hexane flesh extract. Furthermore, the lowest (i.e., 44.70 μg/ml) as well as the highest (2359.66 μg/ml) IC50 values were obtained for aqueous seed and hexane flesh extracts, respectively.

关键词： Diospyros malabarica Phytochemical Assay Total Phenol Content Total Tannin Content Total Flavonoid Content Antioxidant Activity

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Investigation of the Phytoconstituents and Bioactivity of Various Parts of Wild Type and Cultivated Phyllanthus emblicaL.

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Advances in Bioscience and Biotechnology 2017年第7期8卷 211-227页

作者： Ratna Mondal Shakil Ahmed Polash Tanushree Saha zinia islam Md. Maniruzzaman Sikder Nuhu Alam Md. Sharif Hossain Satya Ranjan Sarker Department of Biotechnology and Genetic Engineering Jahangirnagar University Savar Dhaka Bangladesh Department of Textile Engineering Dhaka University of Engineering and Technology Gazipur Bangladesh Department of Botany Jahangirnagar University Savar Dhaka Bangladesh

Phyllanthus emblica L. belonging to the family Euphorbiaceae is a common medicinal plant in Bangladesh. In order to evaluate the phytoconstituents and bioactivity of various parts of P. emblica, both the wild type (i.e., small) and cultivated (i.e., big) fruits were collected from the local market of Bangladesh and six ethanolic extracts were prepared from various parts of the collected fruits for this current study. A comparative analysis of the phytochemical compositions and various bioactivities especially antibacterial, antifungal, and antioxidant activity of the six ethanolic extracts were accomplished. The qualitative phytochemical analysis of plant extracts revealed the presence of large amounts of proteins, carbohydrates, phenolic compounds, glycosides, alkaloids, coumarins, flavonoids, tannins, saponins and resins etc. The maximum antioxidant activity was observed for wild type P. emblica seed extracts and the minimum activity was observed for cultivated flesh extracts. Moreover, among the samples the wild type P. emblica extracts have excellent amount of total phenol contents and the highest free radical scavenging activity. It is also found that P. emblica samples were active against both gram-positive (i.e., B. subtilis) and gram-negative (i.e., E. coli, and S. typhi) bacteria. The highest antibacterial activity was achieved in the wild type P. emblica seed extracts against both pathogenic (S. typhi) and non-pathogenic bacterial strains (E. coli, and B. subtilis). These samples showed almost no activity against Fusarium sp. fungus.

关键词： Phyllanthus emblica Total Phenol Content Antioxidant Activity Antimicrobial Activity Zone of Inhibition and Antifungal Activity

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Investigation of Ovarian Follicular Waves and Major Hormonal Profile in Red Chittagong Cattle

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Advances in Bioscience and Biotechnology 2020年第2期11卷 7-21页

作者： Saiful islam Md. Ahsanul Kabir Md. Faizul Hossain Miraz Effat Jahan Tamanna Satya Ranjan Sarker zinia islam S. M. Jahangir Hossain Sharif Hossain Gautam Kumar Deb Department of Biotechnology and Genetic Engineering Jahangirnagar University Dhaka Bangladesh Biotechnology Division Bangladesh Livestock Research Institute Savar Dhaka Bangladesh

Red Chittagong Cattle (RCC) is one of the renowned varieties of cattle which is indigenous and most potential type of domestic animal genetic resource in Bangladesh with distinct phenotypic characteristics. Reproductive management might be a process for multiplying this cattle variety. Therefore, the goals of this study were to characterize the follicular waves of RCC and to determine the Progesterone (P4), Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) profile during three consecutive estrus cycle. Follicular wave emergence (Day 0) was identified using trans-vaginal ultrasound technique and follicular growth was then monitored from Day 0 to Day 23 during three consecutive estrus cycle and blood samples were collected. After measuring the growth and diameter of the follicles, hormonal assays of collected blood samples were performed using Enzyme Linked Immunosorbent Assay (ELISA). We found that, both RCC cows and heifers showed two waves inter-ovulatory intervals. The length of inter-ovulatory intervals and the diameter of the ovulatory follicle of RCC cows and heifers were slightly different from each other. The identification of the dominant follicle was confirmed from the start of its deviation from other subordinate follicles till it reached to the maximum diameter and identified as dominant follicle which increases linearly for approximately six days (growing phase). This dominant follicle is remained approximately same size for five days (static phase), and then begins to regress (regressing phase) decreasing the antral diameter. The follicular waves are first detectable as 4 - 5 mm follicles approximately at day 0 and day 10 both for RCC cows and heifers which showed two waves inter-ovulatory intervals. The circulating varied concentrations of LH, FSH and P4 were determined using ELISA in case of both cows and heifers and the concentration curves followed the similar pattern of change during the estrus cycle. Hence, the knowledge about ovaria

关键词： Red Chittagong Cattle Ovarian Follicles Progesterone Follicle Stimulating Hormone Luteinizing Hormone ELISA

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Investigation of the Antimicrobial Activity and in Vivo Cytotoxicity of Diospyros malabarica (Desr.) Kostel. Fruit Extracts

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Natural Science 2021年第8期13卷 331-351页

作者： Razib Datta Shubhra Shakil Ahmed Polash Md. Monir Hossain Amir Hamza Md. Mehedi Hasan Tushar Tanushree Saha Md. Ashraful Hasan Md. Maniruzzaman Sikder Nuhu Alam zinia islam Md. Sharif Hossain Satya Ranjan Sarker Department of Biotechnology and Genetic Engineering Jahangirnagar University Savar Bangladesh Department of Textile Engineering Dhaka University of Engineering and Technology Gazipur Bangladesh Department of Biochemistry and Molecular Biology Jahangirnagar University Savar Bangladesh Department of Botany Jahangirnagar University Savar Bangladesh

Mankind is facing an unprecedented threat of existence due to the antibiotic resistance developed by bacteria. The unripe fruits of Diospyros malabarica (Desr.) Kostel. (family: Ebenaceae) can be considered as one of the natural sources to tackle this issue. The present study is designed to assess the antimicrobial activity of D. malabarica seed and flesh ex-tracts. Herein, D. malabarica extracts were prepared using polar solvents (i.e., water and 70% ethanol) and their antimicrobial activity as well as in vivo toxicity was investigated. Their antibacterial activity was investigated against gram positive (Bacillus subtilis) and gram negative (Escherichia coli DH5α, and Salmonella typhi) bacteria at different time points. All the extracts showed the highest antibacterial activity after 2 hours of incubation. The aqueous seed extract showed the maximum zone of inhibition (i.e., ~13 mm) against Bacillus subtilis with a minimum inhibitory concentration (MIC) value of 2 μg/μl. The an-tibacterial propensity was also confirmed through trypan blue dye exclusion assay, CellToxTM Green assay, and lipid peroxidation (LPO) assay. On the other hand, the etha-nolic seed extract demonstrated higher antifungal activity through inhibition of mycelial growth. All the extracts showed excellent hemocompatibility against both human and rat red blood cells (RBCs). They also did not show any toxicity to rat liver and kidneys. Taken together, this study demonstrates that the aqueous and ethanolic extracts of D. malabarica seed and flesh could be an effective source of natural antimicrobial agents with no cytotox-ic activity.

关键词： Diospyros malabarica (Desr.) Kostel. Antibacterial Activity Trypan Blue Assay Cell ToxTM Green Assay In Vivo Cytotoxicity

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Antibacterial Activities of New Schiff Bases and Intermediate Silyl Compounds Synthesized from 5-Substituted-1,10-phenanthroline- 2,9-dialdehyde

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Advances in Microbiology 2014年第15期4卷 1140-1153页

作者： zinia Jaman Mohammad R. Karim Korsi Dumenyo Aminul H. Mirza Department of Chemistry Tennessee State University Nashville USA Department of Agriculture Tennessee State University Nashville USA Faculty of Science Universiti Brunei Darussalam Bandar Seri Begawan Brunei

Schiff bases are known to possess anticancer, antibacterial, antifungal, antitubercular, anti-inflammatory, antimicrobial and antimalarial properties. In this paper antibacterial studies against variety of plants and human pathogenic bacteria with eight newly synthesized Schiff bases and several intermediate silyl compounds have been reported. The antibacterial activities of the synthesized compounds were primarily determined by paper disc diffusion method. The minimum inhibitory concentration (MIC) of each compound was also determined by tube dilution process. Seven different human pathogenic bacteria and eighteen different plant pathogenic bacteria were used for the antibacterial activity studies. While all synthesized compounds have shown significant antibacterial activity, one intermediate silyl compound has shown remarkably high antibacterial property. 5-substituted derivatives have shown relatively higher activity than non-substituted compounds. Polar substituent which increases hydrophilicity may have a positive impact on the antibacterial property.

关键词： 5-Nitro-1 10-phenanthroline Dialdehyde 5-Bromo-1 Schiff Bases S-Alkyl/Aryldithiocarbazates Thiosemicarbazide

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Synthesis of 5-Substituted 2, 9-Dimethyl-1,10-Phenanthroline Dialdehydes and Their Schiff Bases with Sulfur-Containing Amines

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International Journal of Organic Chemistry 2013年第3期3卷 214-219页

作者： zinia Jaman Mohammad R. Karim Tasneem A. Siddiquee Aminul H. Mirza Mohamad A. Ali Chemistry Faculty of Science University Brunei Darussalam Brunei Darussalam Sudan Department of Chemistry Tennessee State University Nashville USA

Eight new Schiff bases of 5-nitro and 5-bromo-substituted 1,10-phenanthroline-2,9-dicarboxaldehydes with sulfur-containing amines, thiosemicarbazide, S-alkyl/aryl dithiocarbazates and 2-mercaptoaniline have been synthesized and characterized by a variety of spectroscopic methods. The condensation reactions of the dialdehydes with the amines were carried out both in the presence and absence of conc. sulfuric acid. A significant increase in yield of the Schiff bases was observed when the reactions were carried out in the presence of sulfuric acid.

关键词： 5-Nitro-1 10-Phenanthroline Dialdehyde 5-Bromo-1 Schiff Bases S-Alkyl/Aryldithiocarbazates Thiosemicarbazide

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