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International Journal of Digital Earth 2022年第1期15卷 397-415页

作者： zimu li Qingliang Wu College of Engineering and Technology Southwest UniversityChongqingPeople's Republic of China College of Computer and Information Science College of Software Southwest UniversityChongqingPeople's Republic of China

In this paper,the crack process of the A74 iceberg is carefully monitored in different aspects by using synthetic aperture radar(SAR)***,a offset tracking strategy is designed to retrieve the temporal evolution of the glacier velocity ***,a signal coherence factor(SCF)is proposed to analyze the interferometric *** resulting SCF maps can present a more distinct rupture pattern than the SAR magnitude images,which enables the development of rift to be tracked more ***,a new approach is proposed to explore the temporal change of the ice *** this approach is based on interferometric phase signals,it is more sensitive than the offset tracking ***,the abnormal variation signals associated with the rupture process can be discovered from the experimental results in an earlier *** results also show that the area with abnormal signals is almost identical to the region of the calved ice,which demonstrates that the scale of the iceberg might be predicted at least two months before the rupture ***,such a consistent pattern may indicate a total alteration of ice characteristics,implying that the complete separation between A74 and BIS is inevitable.

关键词： Offset tracking InSAR change detection glacier velocity field iceberg rupture

Investigation on Precooling Effects of 4 K Stirling-Type Pulse Tube Cryocoolers

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Journal of Thermal Science 2019年第4期28卷 714-726页

作者： CAO Qiang li zimu LUAN Mingkai SUN Zheng TANG Xiao li Peng JIANG Zhenhua WEI li Institute of Refrigeration and Cryogenics School of Mechanical EngineeringTongji UniversityShanghai 201804China Shanghai Key Laboratory of Vehicle Aerodynamics and Vehicle Thermal Management Systems Tongji UniversityShanghai 201804China Shanghai Institute of Technical Physics Chinese Academy of SciencesShanghai 200083China Department of Electrical Engineering School of Electronics and Information EngineeringTongji UniversityShanghai 201804China

Stirling-type pulse tube cryocoolers(SPTCs)working at liquid-helium temperatures are appealing in space applications because of their promising advantages such as high reliability,compactness,*** efforts have been put in to develop SPTCs operating at liquid-helium temperatures especially with helium-4 as the working *** structure is essential to reach such low ***,both the regenerator of the last section and the pulse tube together with the phase shifter are precooled by its upper stage or by external cold source to a low temperature of around 20 ***,the precooling effects on the regenerator and the pulse tube are synthetic in previous studies,and their independent effects have not been studied *** this manuscript,the precooling effects on the regenerator and on the pulse tube together with the phase shifter are tested independently on a unique-designed precooled *** tested precooling temperature is between 13.3 K and 22 K,and the no-load refrigeration temperature gets down to 3.6 *** analyses and numerical calculations have been carried *** is found that the influence on the regenerator is remarkable,which is different from previous *** is also found that the precooling effects on the pulse tube are relatively weak because of the large pressure-induced enthalpy flow of a real gas working at the temperatures near to the critical ***,the phase shifting capacity is analyzed with two cases and with both helium-4 and helium-3 as working fluids,and it keeps quite constant after optimizing the frequency and the precooling temperature for each *** investigation on these independent effects will provide valid reference on the precooling mechanism study of SPTCs working down to liquid-helium temperatures.

关键词： stirling-type pulse tube cryocooler precooling effects liquid-helium temperatures

Insight into the relationship between microorganism communities and flavor quality of Chinese dry-cured boneless ham with different quality grades

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Food Bioscience 2022年第6期50卷 1890-1901页

作者： zimu li Ying Wang Daodong Pan Fang Geng Changyu Zhou Jinxuan Cao Key Laboratory of Animal Protein Food Processing Technology of Zhejiang Province College of Food&Pharmaceutical SciencesNingbo UniversityNingbo315211China School of Food and Health Beijing Technology and Business University (BTBU)BeijingBeijing100048PR China Meat Processing Key Laboratory of Sichuan Province School of Food and Biological EngineeringChengdu UniversityNo.2025 Chengluo AvenueChengdu610106China

Microorganisms played a key role in developing the flavor quality,while few studies focused on the relationship between microbial diversity and flavor quality of dry-cured boneless *** explore the relationship,sensory evaluation,lipases,microorganism communities,free fatty acids and volatile compounds were investigated in dry-cured boneless ham with different quality grades(NS,WS and GS groups);the correlation between cored microbes and crucial volatiles was further evaluated by metabolic network *** group showed the highest scores in aroma and overall acceptance among three *** highest values of phospholipase activities(7.88 U*g−1 protein)were shown in GS group,while the lowest values of TBARS(0.93 mg/kg)were observed in GS among three ***-throughput sequencing revealed that fungi showed the most various among three groups;Xerochrysium,Aspergillus,Penicillium and Debaryomyces were the most genera in ***-GC-MS revealed that GS showed higher contents and numbers in volatiles than other groups;aldehydes and furans were intensely response to the variations of volatiles among these *** pathway further revealed that several key species derived from Penicillium and Aspergillus accelerated the formation of volatiles byβ-lipoxidation and Strecker *** results indicated that molds could be the major contributors in developing and differentiating the flavor quality of Chinese dry-cured boneless ham.

关键词： Dry-cured boneless ham Microbial communities Volatile compounds lipid oxidation Metabolic network

Formation of coke in thermal cracking of jet fuel under supercritical conditions

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Frontiers of Chemical Science and Engineering 2008年第1期2卷 17-21页

作者： Yuhong ZHU Caixiang YU zimu li Zhentao MI Xiangwen ZHANG Key Laboratory of Green Chemical Technology School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China

Continuous-flow reactor experiments were carried out to study coke formation from thermal crack-ing of home-made jet fuel RP-3 under supercritical *** mechanism and precursor of coke forming were *** starting cracking temperature of RP-3 fuel was determined to be 471.8uC by differential scan-ning calorimetry(DSC).Temperature-programmed oxidation and scanning electron microscopy(SEM)characterizations of the stressed tubes showed that there are three different coke species including chemisorbed carbon,amorphous carbon and filamentous coke in the solid *** than 90%of coke deposits are carried away by the supercritical fluid,which has strong capabilities of extraction for coke deposits and their *** were 17.1 wt-%of iron and 11.1 wt-%of chromium found on the coke surface detected by energy dispersive spectroscopy(EDS)which suggests carbure-tion on ***-3 fuel and its cracking liquids were analyzed by GC-MS,which showed that the content of alkyl benzene and alkyl naphthalene increased evidently in cracking liquids.

关键词： coke jet fuel thermal cracking supercritical extraction

Multifunctional biodegradable nanoplatform based on oxaliplatin prodrug cross-linked mesoporous polydopamine for enhancing cancer synergetic therapy

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Chinese Chemical Letters 2024年第1期35卷 379-384页

作者： Ping Sun zimu li Dan Zhang Wenfeng Zeng Yi Zheng lin Mei Hongzhong Chen Nansha Gao Xiaowei Zeng School of Pharmaceutical Sciences(Shenzhen) Sun Yat-sen UniversityShenzhen 518107China Central Laboratory University of Chinese Academy of Sciences-Shenzhen HospitalShenzhen 518106China Tianjin Key Laboratory of Biomedical Materials Key Laboratory of Biomaterials and Nanotechnology for Cancer ImmunotherapyInstitute of Biomedical EngineeringChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300192China

Due to the limitations of conventional chemotherapy including side effects,poor prognosis,and drug resistance,there is an urgent need for the development of a novel multi-functional combined therapy ***-modified oxaliplatin prodrug(OXA-DA)was successfully synthesized in this study to ameliorate the organ distribution of oxaliplatin for improving the drug efficacy and reducing toxic side effects,and OXA-DA was applied to develop a porous oxaliplatin cross-linked polydopamine nanoparticle for loading siPD-L1 to construct multifunctional *** multifunctional nanoplatform was modified with poly(2-ethyl-2-oxazoline)(PEOz),which occurred charge reversal in the tumor microenvironment,and exerted the lysosomal escape effect in tumor cells to improve the bioavailability of small interfering RNA targeting programmed cell death-ligand 1(siPD-L1).The pH-responsive charge reversal,photothermal,biodegradation,lysosomal escape ability,PD-L1 protein degradation,toxicity properties and multiple antitumor effects were comprehensively evaluated in vitro and in vivo *** findings indicated that OXA-DA-siPD-L1@PDA-PEOz excellently induced tumor cell necrosis and apoptosis as a result of the synergistic effect of chemo-photothermal therapy,and upregulated CD8+T cells produced interferon-γ(IFN-γ)to further attack the tumor *** conclusion,the novel nanoplatform-mediated chemo/photothermal/immunotherapy has promising clinical applications in the treatment of malignant tumors.

关键词： Oxaliplatin prodrug Mesoporous polydopamine Charge reversal Synergetic therapy Cancer nanotechnology

Polyphenol-based hydrogels: Pyramid evolution from crosslinked structures to biomedical applications and the reverse design

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Bioactive Materials 2022年第11期7卷 49-70页

作者： zimu li Zhidong Chen Hongzhong Chen Kebing Chen Wei Tao Xiao-kun Ouyang lin Mei Xiaowei Zeng Institute of Pharmaceutics School of Pharmaceutical Sciences(Shenzhen)Sun Yat-sen UniversityShenzhen518107China Department of Spine Surgery Center for Orthopaedic SurgeryThe Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhou510655China Center for Nanomedicine Brigham and Women’s HospitalHarvard Medical SchoolBostonMA02115United States School of Food and Pharmacy Zhejiang Ocean UniversityZhoushan316022China

As a kind of nature-derived bioactive materials, polyphenol-based hydrogels possess many unique and outstanding properties such as adhesion, toughness, and self-healing due to their specific crosslinking structures, which have been widely used in biomedical fields including wound healing, antitumor, treatment of motor system injury, digestive system disease, oculopathy, and bioelectronics. In this review, starting with the classi-fication of common polyphenol-based hydrogels, the pyramid evolution process of polyphenol-based hydrogels from crosslinking structures to derived properties and then to biomedical applications is elaborated, as well as the efficient reverse design considerations of polyphenol-based hydrogel systems are proposed. Finally, the existing problems and development prospects of these hydrogel materials are discussed. It is hoped that the unique perspective of the review can promote further innovation and breakthroughs of polyphenol-based hydrogels in the future.

关键词： Biomaterials Adhesive hydrogels Polyphenol Disease treatment Reverse design

Rapidly separating dissolving microneedles with sustained-release colchicine and stabilized uricase for simplified long-term gout management

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Acta Pharmaceutica Sinica B 2023年第8期13卷 3454-3470页

作者： Yao Yang zimu li Ping Huang Jiachan lin Jinyuan li Kexin Shi Jiahui lin Jingwen Hu Zhuoxian Zhao Yongkang Yu Hongzhong Chen Xiaowei Zeng lin Mei Institute of Pharmaceutics School of Pharmaceutical Sciences(Shenzhen)Sun Yat-sen UniversityShenzhen 518107China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yatsen University Cancer CenterGuangzhou 510060China Tianjin Key Laboratory of Biomedical Materials Key Laboratory of Biomaterials and Nanotechnology for Cancer ImmunotherapyInstitute of Biomedical EngineeringChinese Academy of Medical SciencesPeking Union Medical CollegeTianjin300192China

Despite growing prevalence and incidence,the management of gout remains *** intermittent nature of the gout makes the long-term urate-lowering therapy(ULT)particularly important for gout ***,patients are reluctant to take medication day after day to manage incurable occasional gout flares,and suffer from possible long-term ***,a safe and easy-tooperate drug delivery system with simple preparation for the long-term management of gout is very ***,a chitosan-containing sustained-release microneedle system co-loaded with colchicine and uricase liposomes were fabricated to achieve this *** microneedle system was confirmed to successfully deliver the drug to the skin and maintain a one-week drug ***,its powerful therapeutic potency to manage gout was investigated in both acute gouty and chronic gouty ***,the drug co-delivery system could help avoid long-term daily oral colchicine,a drug with a narrow therapeutic *** system also avoids mass injection of uricase by improving its stability,enhancing the clinical application value of *** general,this two-drug system reduces the dosage of uricase and colchicine and improves the patient’s compliance,which has a strong clinical translation.

关键词： Microneedles Colchicine Sustained-release Uricase liposome Transdermal administration Gout management Long-term urate-lowering therapy

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岩浆岩中磷灰石的地球化学特征及应用

岩石学报 2025年第1期41卷 321-338页

作者：李子木令狐苗苗孙金凤孙之晗周宝全杨进辉中国科学院大学地球与行星科学学院北京100049 中国科学院大学北京燕山地球关键带国家野外科学观测研究站北京101408 中国科学院地质与地球物理研究所岩石圈演化与环境演变全国重点实验室北京100029

不同类型的岩浆岩可能来源于不同源区,经历复杂的岩浆演化过程,导致岩浆成分、温度和压力等条件发生变化。磷灰石在岩浆岩中广泛发育,可以形成于不同的岩浆环境。作为富含多种地球化学指示元素(如稀土元素、锶、锰及多种挥发分),并且对... 详细信息

不同类型的岩浆岩可能来源于不同源区,经历复杂的岩浆演化过程,导致岩浆成分、温度和压力等条件发生变化。磷灰石在岩浆岩中广泛发育,可以形成于不同的岩浆环境。作为富含多种地球化学指示元素(如稀土元素、锶、锰及多种挥发分),并且对寄主岩浆环境的变化十分敏感的副矿物,近年来被广泛应用于岩浆岩和矿床成因等研究中。了解不同类型岩石中磷灰石的矿物学和地球化学特征,是深入开展相关研究的基础。本文对GEOROC数据库及其他文献报道的岩浆岩中磷灰石稀土元素数据进行了汇总整理和归纳分析,获得了不同类型岩石中磷灰石的矿物学和稀土元素组成特征。结合多元统计分析方法,深入分析不同类型岩浆岩和花岗岩中磷灰石的稀土元素变化规律。计算结果显示,不同类型岩石中磷灰石的La元素、Eu/Eu*和Yb含量之间存在明显差异,推断综合利用La含量与(Eu/Eu^(*))/Yb值特征可以有效区分形成于不同岩浆岩的磷灰石。本文的研究表明,磷灰石在示踪岩浆源区和岩石成因方面具有独特优势,综合运用磷灰石产状、共生矿物组合、微量元素及同位素组成等分析可以为岩浆岩成因研究提供全面信息。

关键词：岩浆岩花岗岩磷灰石地球化学稀土元素岩石成因

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IPv6地址配置和网络迁移的简化技术

华中科技大学学报（自然科学版） 2016年第11期44卷 87-91页

作者：李子木傅怡琦郝辉清华大学信息化技术中心北京100084

提出一种通过名字-地址映射关系简化IPv6地址配置和网络迁移的方法.利用IPv6本地链路地址可以在邻居节点间直接通信的特性,将根设备上定义的名字-地址映射信息通过专用控制协议在全网范围内进行涟漪式传递,使得网络设备上须要配置传统12... 详细信息

提出一种通过名字-地址映射关系简化IPv6地址配置和网络迁移的方法.利用IPv6本地链路地址可以在邻居节点间直接通信的特性,将根设备上定义的名字-地址映射信息通过专用控制协议在全网范围内进行涟漪式传递,使得网络设备上须要配置传统128位IPv6地址的地方可以通过配置名字来替代,降低了IPv6地址配置的复杂性,同时大幅简化了网络迁移的难度.结果表明:本方法不仅可以极大减少IPv6地址配置和网络迁移的工作量,而且可以有效提高效率,降低误操作风险.

关键词： IPv6协议本地链路网络迁移地址配置映射

北京典型汇水区域雨水径流温度特征及影响因素分析

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环境工程技术学报 2024年第1期14卷 345-354页

作者：李子牧李俊奇李璟李小静北京建筑大学城市雨水系统与水环境教育部重点实验室北京节能减排与城乡可持续发展省部共建协同创新中心

城市化发展导致不透水地表面积率大幅攀升,由此带来的一系列问题逐渐受到人们关注,夏季城市汇水区域地表产生高温径流后汇入下游受纳水体所造成的雨水径流热污染,对水生态、水环境造成不良影响的风险尤为突出。选取北京市典型汇水区域,... 详细信息

城市化发展导致不透水地表面积率大幅攀升,由此带来的一系列问题逐渐受到人们关注,夏季城市汇水区域地表产生高温径流后汇入下游受纳水体所造成的雨水径流热污染,对水生态、水环境造成不良影响的风险尤为突出。选取北京市典型汇水区域,对2021—2022年多场降雨径流出流温度进行监测与分析,并对气象因素、下垫面温度及管道内径流热量等数据进行同步采集,运用皮尔逊相关系数法分析其影响因素。结果表明:研究区域夏季降雨常出现雨水径流温度升高现象,降水量小于12.5mm、降雨历时短于250 min的降雨场次更易于升温,升温幅度最高可达4.1℃;径流温度升高往往出现在径流过程初期,温度达峰平均时间为38 min;径流是否升温与降雨强度峰值位置之间没有明显关系;气温、不透水地表初始时刻温度、降雨历时及降水量是雨水径流温度的极显著影响因素(P<0.01);降雨期间气温、降雨历时、不透水地表初始时刻温度和管道内壁温度4个指标,可以基本解释研究区域96.7%的径流温度输出情况。

关键词：雨水径流监测径流温度相关性分析多元线性回归