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Finding the semantic similarity in single-particle diffraction images using self-supervised contrastive projection learning

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npj Computational Materials 2023年第1期9卷 2118-2126页

作者： Julian zimmermann Fabien Beguet Daniel Guthruf bruno Langbehn Daniela Rupp ETH Zürich ZürichSwitzerland Technische Universität Berlin BerlinGermany Max-Born-Institut BerlinGermany

Single-shot coherent diffraction imaging of isolated nanosized particles has seen remarkable success in recent years,yielding in-situ measurements with ultra-high spatial and temporal *** progress of high-repetition-rate sources for intense X-ray pulses has further enabled recording datasets containing millions of diffraction images,which are needed for the structure determination of specimens with greater structural variety and dynamic *** size of the datasets,however,represents a monumental problem for their ***,we present an automatized approach for finding semantic similarities in coherent diffraction images without relying on human expert *** introducing the concept of projection learning,we extend self-supervised contrastive learning to the context of coherent diffraction imaging and achieve a dimensionality reduction producing semantically meaningful embeddings that align with physical *** method yields substantial improvements compared to previous approaches,paving the way toward real-time and large-scale analysis of coherent diffraction experiments at X-ray free-electron lasers.

关键词： projection coherent similarity

Publisher Correction: Finding the semantic similarity in single-particle diffraction images using self-supervised contrastive projection learning

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npj Computational Materials 2023年第1期9卷 1732-1733页

作者： Julian zimmermann Fabien Beguet Daniel Guthruf bruno Langbehn Daniela Rupp ETH Zürich Zürich Switzerland Max-Born-Institut Berlin Germany Technische Universität Berlin Berlin Germany

Correction to:npj Computational Materials https://***/10.1038/s41524-023-00966-0,published online 16 February 2023 The original version of this Article contained several typographical errors in both the PDF and the HTML *** the first paragraph of‘Introduction’,the sentence‘(The phrase was coined by Nobel laureate Francis Crick in his book What Mad Pursuit:A personal view of scientific discovery)’duplicated reference *** sentence and brackets have been removed in the corrected version.

关键词： semantic similarity projection

Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump

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World Journal of Gastroenterology 2008年第1期14卷 38-45页

作者： Yvonne Meier Tina Zodan Carmen Lang Roland zimmermann Gerd A Kullak-Ublick Peter J Meier bruno Stieger Christiane Pauli-Magnus Division of Clinical Pharmacology and Toxicology Department of Internal Medicine University Hospital Zurich Zurich Switzerland Department of Gynecology and Obstetrics University Hospital Zurich Zurich Switzerland Division of Clinical Pharmacology and Toxicology Department of Internal Medicine University Hospital Zurich Zurich Switzerland Clinical Trial Unit University Hospital Basel Basel Switzerland

AIM： To study the association of three common ABCB11 and ABCC2 polymorphisms （ABCB11： 1331T〉C→V444A; ABCC2： 3563T〉A → V1188E and 4544G 〉A → C1515Y） with intrahepatic cholestasis of pregnancy （ICP） and contraceptive-induced cholestasis （CIC）. METHODS： ABCB11 and ABCC2 genotyping data were available from four CIC patients and from 42 and 33 ICP patients, respectively. Allele-frequencies of the studied polymorphisms were compared with those in healthy pregnant controls and Caucasian individuals. Furthermore, serum bile acid levels were correlated with the presence or absence of the 1331 C allele. RESULTS： The ABCB11 1331T〉C polymorphism was significantly more frequent in cholestatic patients than in pregnant controls： C allele 76.2% （CI, 58.0-94.4） vs 51.3% （CI 35.8-66.7）, respectively （P = 0.0007）; and CC allele 57.1% （CI 36.0-78.3） vs 20% （CI 7.6-32.4）, respectively （P = 0.0065）. All four CIC patients were homozygous carriers of the C allele. In contrast, none of the studied ABCC2 polymorphism was overrepresented in ICP or CIC patients. Higher serum bile acid levels were found in carriers of the 1331CC genotype compared to carriers of the TT genotype. CONCLUSION： Our data support a role for the ABCB11 1331T〉C polymorphism as a susceptibility factor for the development of estrogen-induced cholestasis, whereas no such association was found for ABCC2. Serum bile acid and 7-glutamyl transferase levels might help to distinguish ABCB4- and ABCB11-related forms of ICP and CIC.

关键词： Cholestasis of pregnancy Contraceptive-induced cholestasis Bile salt export pump Multidrugresistance associated protein 2 Pharmacogenetics

Systematic Review on Ground-Based Cloud Tracking Methods for Photovoltaics Nowcasting

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American Journal of Climate Change 2024年第3期13卷 452-476页

作者： Juliana Marian Arrais Allan Cerentini bruno Juncklaus Martins Thiago zimmermann Loureiro Chaves Sylvio Luiz Mantelli Neto Aldo von Wangenheim PPGCC-INE UFSC Federal University of Santa Catarina Florianpolis Brazil INPE Brazilian National Institute for Space Research So Paulo Brazil

Renewable energies are highly dependent on local weather conditions, with photovoltaic energy being particularly affected by intermittent clouds. Anticipating the impact of cloud shadows on power plants is crucial, as clouds can cause partial shading, excessive irradiation, and operational issues. This study focuses on analyzing cloud tracking methods for short-term forecasts, aiming to mitigate such impacts. We conducted a systematic literature review, highlighting the most significant articles on cloud tracking from ground-based observations. We explore both traditional image processing techniques and advances in deep learning models. Additionally, we discuss current challenges and future research directions in this rapidly evolving field, aiming to provide a comprehensive overview of the state of the art and identify opportunities for significant advancements in the next generation of cloud tracking systems based on computer vision and deep learning.

关键词： Nowcasting Photovoltaic Image Processing

Quantitative analysis of RNA levels from single hepatocytes in vivo: combined use of real-time RT-PCR and laser microdissection

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中国病理生理杂志 2007年第11期23卷 2285-2288页

作者： SHI Xin Jǒg Kleeff ZHU Zhao - wen bruno Schmied TANG Wen - hao Arthur zimmermann Markus W. Bǔchle Helmut Friess Department of General Surgery University of Heidelberg Im Neuenheimer Feld 110 D- 69120 Heidelberg Germany Department of General Surgery Zhongda Hospital Southeast University Nanjing 210009 China Institute of Pathology University of Bern Inselspital CH - 3010 Bern Switzerland

AIM: The manner in which a cell responds to and influences its environment is ultimately determined by the genes that are expressed. To better understand cellular functions, the isolation of single cells and subsequent quantification of the expressed genes is essential. METHODS: Normal liver tissue was obtained from operation, snap-frozen in liquid nitrogen and sectioned in crystat. Individual hepatocytes were microdissected. RNA was extracted, then reverse transcribed and amplified using real-time quantitative polymerase chain reaction (PCR). RESULTS: Single hepatocytes were dissected by laser beam and catapulted to the microcentrifuge cap which was put above the slide. In this way, cells were collected, RNA was extracted, reverse transcribed to cDNA and used for analysis of RNA expression by real-time quantitative PCR. The amplification results showed that quantitation of the RNA inside the cell was compatible with the number of cells. CONCLUSION: The expression of RNA in single cells can be quantitated successfully by using laser microdissection and real-time PCR. These techniques provide an opportunity to monitor in vivo gene expression levels in single hepatocytes.

关键词： RNA 肝细胞实时RT-PCR 激光显微切割数量性状