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Food Science and Human Wellness 2024年

作者： Yueying Han Ziye zhang zihao Li Zhenxing Li Hong Lin State Key Laboratory of Marine Food Processing & Safety Control， College of Food Science and Engineering， Ocean University of China

Polyphenol is a kind of natural active substance with immunoregulatory activity. In this study， the immunoregulatory activities of Sargassum carpophyllum polyphenol (SCP) on the allergic reactions induced by shrimp tropomyosin were investigated. As the results， the SCP performed high hyaluronidase inhibition ability， which even greater than sodium chromoglycate (an anti-allergic medicine). SCP was able to affect the allergic reactions of RAW 264.7 macrophage cells via regulating the NF-κB， JNK1/2， Erk1/2 and p38 MAPK cellular signaling pathways， weakened the degranulation degree and secretion of IL-4， TNF-α and histamine， and promoted the secretion of IL-10 from RBL-2H3 mast cells. In BALB/c mouse model assay， after gavage of SCP， the mouse allergic symptoms got significantly alleviated， the cytokine (IL-4， IL-10 and IFN-γ) secretion of mouse spleen lymphocytes were significantly declined and the allergic lung damage was relieved， which indicated SCP performed strong both in vitro and in vivo anti-allergic functions. Therefore， SCP could serve as candidate anti-allergic bioactive substances for shrimp induced allergy via immunoregulation.

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Coupling of Adhesion and Anti‑Freezing Properties in Hydrogel Electrolytes for Low‑Temperature Aqueous‑Based Hybrid Capacitors

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Nano-Micro Letters 2024年第2期16卷 15-31页

作者： Jingya Nan Yue Sun Fusheng Yang Yijing zhang Yuxi Li zihao Wang Chuchu Wang Dingkun Wang Fuxiang Chu Chunpeng Wang Tianyu Zhu Jianchun Jiang Institute of Chemical Industry of Forest Products Chinese Academy of ForestryKey Laboratory of Biomass Energy and MaterialJiangsu ProvinceNanjing 210042JiangsuPeople’s Republic of China Co‑Innovation Center of Efficient Processing and Utilization of Forest Resources Nanjing Forestry UniversityNanjing 210037JiangsuPeople’s Republic of China Energy Technologies Area Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Department of Materials Science and Engineering Clemson UniversityClemsonSC 29634USA

Solid-state zinc-ion capacitors are emerging as promising candidates for large-scale energy storage owing to improved safety,mechanical and thermal stability and easy-to-direct *** electrolytes are appealing solid-state electrolytes because of eco-friendliness,high conductivity and intrinsic ***,the electrolyte/electrode interfacial contact and anti-freezing properties of current hydrogel electrolytes are still challenging for practical applications of zinc-ion ***,we report a class of hydrogel electrolytes that couple high interfacial adhesion and anti-freezing *** synergy of tough hydrogel matrix and chemical anchorage enables a well-adhered interface between hydrogel electrolyte and ***,the cooperative solvation of ZnCl2 and LiCl hybrid salts renders the hydrogel electrolyte high ionic conductivity and mechanical elasticity simultaneously at low *** significantly,the Zn||carbon nanotubes hybrid capacitor based on this hydrogel electrolyte exhibits low-temperature capacitive performance,delivering high-energy density of 39 Wh kg^(-1)at-60°C with capacity retention of 98.7%over 10,000 *** the benefits of the well-adhered electrolyte/electrode interface and the anti-freezing hydrogel electrolyte,the Zn/Li hybrid capacitor is able to accommodate dynamic deformations and function well under 1000 tension cycles even at-60°*** work provides a powerful strategy for enabling stable operation of low-temperature zinc-ion capacitors.

关键词： Interfacial adhesion Anti-freezing Hydrogel electrolytes Low-temperature hybrid capacitors Dynamic deformati

Organic-inorganic hybrid piezotronic bipolar junction transistor for pressure sensing

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Microsystems & Nanoengineering 2024年第3期10卷 229-244页

作者： Emad Iranmanesh zihao Liang Weiwei Li Congwei Liao Shunyu Jin Chuan Liu Kai Wang Shengdong zhang Charalampos Doumanidis Gehan A.J.Amaratunga Hang Zhou Guangdong Provincial Key Laboratory of In-Memory Computing Chips School of Electronic and Computer EngineeringPeking University Shenzhen Graduate SchoolShenzhen 518055P.R.China School of Mechanical Engineering Guangdong Technion-Israel Institute of TechnologyShantou 515063P.R.China State Key Laboratory of Microelectronics Device and Integrated Technology Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029P.R.China Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 23000PR China School of Electronics and Information Technology Sun Yat-sen UniversityNo.132 East Waihuan RoadGuangzhou 510006P.R.China Department of Mechanical Aerospaceand Biomedical EngineeringUniversity of South AlabamaShelby Hall3128MobileAL 36688USA Electrical Engineering Division Department of EngineeringUniversity of Cambridge9 JJ Thomson AvenueCambridge CB30FAUnited Kingdom Zhejiang University International CampusHainingChina

With the rapid development of the Internet of Things(IoTs),wearable sensors are playing an increasingly important role in daily monitoring of personal health and *** signal-to-noise-ratio has become the most critical performance factor to *** enhance it,on the one hand,good sensing materials/devices have been employed;on the other hand,signal amplification and noise reduction circuits have been ***,most of these devices and circuits work in an active sampling mode,requiring frequent data acquisition and hence,entailing high-power *** this scenario,a flexible and wearable event-triggered sensor with embedded signal amplification without an external power supply is of great ***,we report a flexible two-terminal piezotronic n-p-n bipolar junction transistor(PBJT)that acts as an autonomous and highly sensitive,current-and/or voltage-mediated pressure *** PBJT is formed by two back-to-back piezotronic diodes which are defined as emitter-base and collectorbase *** force exertion on the emitter side,as a result of the piezoelectric effect,the emitter-base diode is forward biased while the collector-base diode is reverse *** to the inherent BJT amplification effect,the PBJT achieves record-high sensitivities of 139.7 kPa^(-1)(current-based)and 88.66 kPa^(-1)(voltage-based)in sensing *** PBJT also has a fast response time of<110 ms under exertion of dynamic stimuli ranging from a flying butterfly to a gentle finger ***,the PBJT advances the state of the art not only in terms of sensitivity but also in regard to being self-driven and autonomous,making it promising for pressure sensing and other IoT applications.

关键词： bipolar transistor IoT

BMP7 expression in mammalian cortical radial glial cells increases the length of the neurogenic period

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Protein & Cell 2024年第1期15卷 21-35页

作者： Zhenmeiyu Li Guoping Liu Lin Yang Mengge Sun Zhuangzhi zhang Zhejun Xu Yanjing Gao Xin Jiang zihao Su Xiaosu Li Zhengang Yang State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain Scienceand Department of NeurologyZhongshan HospitalFudan UniversityShanghai 200433China

The seat of human intelligence is the human cerebral cortex,which is responsible for our exceptional cognitive *** principles that lead to the development of the large-sized human cerebral cortex will shed light on what makes the human brain and species so *** remarkable increase in the number of human cortical pyramidal neurons and the size of the human cerebral cortex is mainly because human cortical radial glial cells,primary neural stem cells in the cortex,generate cortical pyramidal neurons for more than 130 days,whereas the same process takes only about 7 days in *** molecular mechanisms underlying this difference are largely ***,we found that bone morphogenic protein 7(BMP7)is expressed by increasing the number of corti-cal radial glial cells during mammalian evolution(mouse,ferret,monkey,and human).BMP7 expression in cortical radial glial cells promotes neurogenesis,inhibits gliogenesis,and thereby increases the length of the neurogenic period,whereas Sonic Hedgehog(SHH)signaling promotes cortical *** demonstrate that BMP7 sign-aling and SHH signaling mutually inhibit each other through regulation of GLI3 repressor *** propose that BMP7 drives the evolutionary expansion of the mammalian cortex by increasing the length of the neurogenic period.

关键词： radial glia cortical neurogenesis cortical gliogenesis cortical evolution BMP7 SHH

非法拘禁罪结果加重犯的认定规则——以介入被害人因素为切入

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法学 2020年第11期 139-150页

作者：张子豪武汉大学法学院

在非法拘禁过程中,对被害人的重伤或死亡结果,是由被害人创设的物理性危险直接现实化的,应否肯定行为人构成非法拘禁罪的结果加重犯,取决于如何理解《刑法》第238条第2款前半部分规定的“致人重伤”“致人死亡”的内涵。一律否定该种情... 详细信息

在非法拘禁过程中,对被害人的重伤或死亡结果,是由被害人创设的物理性危险直接现实化的,应否肯定行为人构成非法拘禁罪的结果加重犯,取决于如何理解《刑法》第238条第2款前半部分规定的“致人重伤”“致人死亡”的内涵。一律否定该种情形下构成非法拘禁罪的结果加重犯的可能性,难以满足立法者充分保护被害法益的意图。如果一律肯定该种情形下可以构成非法拘禁罪的结果加重犯,则不但过度扩张结果加重犯的处罚范围,且同自我答责原理存在内在冲突。为了协调法益保护原则和自我负责原则的冲突,原则上应当认为,只有被害人的自损行为不能被视为自我负责之行为时,才可以将被害人介入行为引起的加重结果,评价为非法拘禁罪的结果加重犯。

关键词：非法拘禁结果加重犯被害人介入自我答责

血清sLOX-1、ESM-1对急性缺血性脑卒中患者rt-PA静脉溶栓后发生出血转化的预测价值

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检验医学与临床 2024年第3期21卷 333-337页

作者：赵浩王敏博张子豪陕西省宝鸡市人民医院神经内科陕西宝鸡721000 陕西省宝鸡市岐山县医院神经内科陕西宝鸡722400

目的探讨血清可溶性凝集素样氧化型低密度脂蛋白受体-1(sLOX-1)、内皮细胞特异性分子-1(ESM-1)对急性缺血性脑卒中(AIS)患者重组组织型纤溶酶原激活剂(rt-PA)静脉溶栓治疗后发生出血转化(HT)的预测价值。方法选择2020年1月至2022年6月... 详细信息

目的探讨血清可溶性凝集素样氧化型低密度脂蛋白受体-1(sLOX-1)、内皮细胞特异性分子-1(ESM-1)对急性缺血性脑卒中(AIS)患者重组组织型纤溶酶原激活剂(rt-PA)静脉溶栓治疗后发生出血转化(HT)的预测价值。方法选择2020年1月至2022年6月在宝鸡市人民医院接受rt-PA静脉溶栓治疗的AIS患者320例为研究对象,根据治疗后头颅CT复查结果分为HT组和非HT组,采用酶联免疫吸附试验检测两组患者的血清sLOX-1、ESM-1水平,并进行比较;采多因素Logistic回归分析rt-PA静脉溶栓后发生HT的影响因素;采用受试者工作特征(ROC)曲线分析血清sLOX-1、ESM-1对rt-PA静脉溶栓后发生HT的预测价值。结果治疗36 h后,47例患者发生HT(HT组),HT发生率为14.69%(47/320),剩余273例未发生HT患者为非HT组。HT组年龄、合并高血压患者占比、入院时NIHSS评分、治疗前血清sLOX-1和ESM-1水平高于非HT组(P13.04分、血清sLOX-1>0.92 ng/mL、血清ESM-1>1.24μg/mL是AIS患者静脉溶栓后发生HT的独立危险因素(P<0.05)。治疗前血清sLOX-1、ESM-1单独及联合检测预测rt-PA静脉溶栓后发生HT的曲线下面积(AUC)分别为0.797、0.775和0.840。结论血清sLOX-1、ESM-1是AIS患者rt-PA静脉溶栓后发生HT的影响因素,二者联合检测对其具有较高的预测价值。

关键词：可溶性凝集素样氧化型低密度脂蛋白受体-1 内皮细胞特异性分子-1 急性缺血性脑卒中重组组织型纤溶酶原激活剂静脉溶栓出血转化预测价值

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单级直齿轮副的共存吸引子特性研究

振动与冲击 2023年第23期42卷 1-7页

作者：金花张子豪吕小红兰州交通大学机电工程学院兰州730070

考虑单级直齿轮副,构建Poincaré映射。应用初值胞映射法、延拓打靶法以及数值仿真求解并追踪系统的共存吸引子及其演化,计算Jacobi矩阵的特征值,根据Floquet理论确定周期吸引子的稳定性与分岔类型,应用胞映射法计算吸引域,研究共存吸... 详细信息

考虑单级直齿轮副,构建Poincaré映射。应用初值胞映射法、延拓打靶法以及数值仿真求解并追踪系统的共存吸引子及其演化,计算Jacobi矩阵的特征值,根据Floquet理论确定周期吸引子的稳定性与分岔类型,应用胞映射法计算吸引域,研究共存吸引子的分岔特征,揭示系统在极小参数区间存在的容易隐藏的吸引子信息以及鞍结型擦边分岔和混沌激变等不连续分岔行为。在一定参数条件下,单级直齿轮副存在大量的多吸引子共存现象以及周期倍化和鞍结分岔;由于非光滑因素的影响,擦边诱导的鞍结分岔引起系统终态的跳跃和迟滞。研究结果可为直齿轮副动力学行为的评价以及系统参数设计与优化提供指导。

关键词：齿轮共存吸引子稳定性分岔激变

基于VFF-RLS的力传感器的动态特性研究

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华南理工大学学报（自然科学版） 2023年第5期51卷 86-94页

作者：姚斌张子豪代煜张建勋南开大学人工智能学院/机器人与信息自动化研究所天津300350

在科学实验与工业生产中,力传感器动态特性会直接影响传感器的精度,因此研究力传感器动态特性具有重要意义。针对应用于手术机器人的应变式力传感器动态特性难以满足精度要求的问题,文中研究了基于最小二乘参数辨识方法在力传感器振动... 详细信息

在科学实验与工业生产中,力传感器动态特性会直接影响传感器的精度,因此研究力传感器动态特性具有重要意义。针对应用于手术机器人的应变式力传感器动态特性难以满足精度要求的问题,文中研究了基于最小二乘参数辨识方法在力传感器振动结构中的应用。由于递推最小二乘(RLS)对于二阶振动系统模型辨识难以同时保证快速性和抗干扰性,文中提出了一种基于可变遗忘因子的递推最小二乘参数辨识方法。首先,通过建立随机振动系统模型,对系统的输入/输出特性进行仿真与分析,确定了遗忘因子函数中的参数,仿真结果表明,文中提出的方法在保持更快收敛速度的同时,使参数辨识误差和收敛预测误差相比于RLS有明显的降低,相比于最小二乘有良好的时变性;然后,在阶跃测试标定法基础上对微创外科手术机器人力传感器的动态参数进行辨识,获得该传感器系统的结构动态特性,即固有频率和阻尼比。实验结果表明,文中提出的方法有较好的收敛性和稳定性,有效地提高了辨识精度。

关键词：遗忘因子振动结构动态性能标定递推最小二乘参数辨识

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坚定理想信念实现伟大梦想

贵州社会科学 2019年第11期 4-7页

作者：张国安张紫豪贵州大学

共同的理想信念是中国特色社会主义制度的显著优势,研究理想信念的本质特征、优越性和实现方式,对于坚定“四个自信”,克服各种困难,实现中华民族伟大复兴中国梦具有重要的理论价值和现实意义。世界有三大类型理想信念,分别为虚妄邪恶... 详细信息

共同的理想信念是中国特色社会主义制度的显著优势,研究理想信念的本质特征、优越性和实现方式,对于坚定“四个自信”,克服各种困难,实现中华民族伟大复兴中国梦具有重要的理论价值和现实意义。世界有三大类型理想信念,分别为虚妄邪恶型、矛盾虚伪型和科学友善型,对比其核心要义、采用手段和不同结局,可以判断什么是优越的理想信念。理想信念的重要作用决定于其本质特征、历史依据、现实依据和未来发展趋势。培养坚定的理想信念,需要学习英雄人物和先进理论,更需要创新性的做好本职工作。

关键词：理想信念马克思主义英雄人物中国梦

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静电纺丝技术制备锂离子电池隔膜的研究现状

绝缘材料 2016年第5期49卷 1-6页

作者：张子浩国家知识产权局专利局专利审查协作广东中心广州510530

静电纺丝纳米纤维膜基锂离子电池隔膜由于其优异的纳米特性而得到了广泛的研究。本文从单一聚合物类隔膜以及改性后的多种聚合物类隔膜和有机/无机类复合隔膜3方面对静电纺丝纳米纤维膜基锂离子电池隔膜进行了综述,并提出了静电纺丝纳... 详细信息

静电纺丝纳米纤维膜基锂离子电池隔膜由于其优异的纳米特性而得到了广泛的研究。本文从单一聚合物类隔膜以及改性后的多种聚合物类隔膜和有机/无机类复合隔膜3方面对静电纺丝纳米纤维膜基锂离子电池隔膜进行了综述,并提出了静电纺丝纳米纤维膜基锂电池隔膜在今后的生产中需要解决的问题。

关键词：静电纺丝锂离子电池隔膜研究现状