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Julolidinyl aza-BODIPYs as NIR-Ⅱ fluorophores for the bioimaging of nanocarriers

Acta Pharmaceutica Sinica B 2024年第7期14卷 3155-3168页

作者： Chang Liu Yifan Cai zichen zhang Yi Lu Quangang Zhu Haisheng He Zhongjian Chen Weili Zhao Wei Wu Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China Key Laboratory of Smart Drug Delivery of MOE School of PharmacyFudan UniversityShanghai 201203China Department of MediChinal Chemistry School of PharmacyFudan UniversityShanghai 201203China

The aggregation-caused quenching(ACQ)rationale has been employed to improve the fluorescence imaging accuracy of nanocarriers by precluding free probe-derived ***,its usefulness is undermined by limited penetration and low spatiotemporal resolution of NIR-Ⅰ(700-900 nm)bioimaging owing to absorption and diffraction by biological tissues and tissue-derived *** study aimed to develop ACQ-based NIR-Ⅱ(1000-1700 nm)probes to further improve the imaging resolution and *** strategy employed is to install highly planar and electron-rich julolidine into the 3,5-position of aza-BODIPY based on the larger substituent *** newly developed probes displayed remarkable photophysical properties,with intense absorption centered at approximately 850 nm and bright emission in the 950-1300 nm *** with the NIR-Ⅰ counterpart P2,the NIR-Ⅱ probes demonstrated superior water sensitivity and quenching ***1 and ACQ6 exhibited more promising ACQ effects with absolute fluorescence quenching at water fractions above 40% and higher quenching stability with less than 2.0% fluorescence reillumination in plasma after 24 h of *** calculations verified that molecular planarity is more important than hydrophobicity for ACQ ***,in vivo and ex vivo reillumination studies revealed less than 2.5% signal interference from prequenched ACQ1,in contrast to 15% for P2.

关键词： 3,5-Julolidinyl Aza-BODIPY Nanocarriers Near-infraredⅡ Fluorescence imaging Aggregation-caused quenching Polymeric micelles Polymeric nanoparticles

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Adenosine triphosphate mediates the pain tolerance effect of manual acupuncture at Zusanli(ST36) in mice

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Journal of Traditional Chinese Medicine 2024年第4期44卷 660-669页

作者： LI Zhongzheng ZHAO Yadan Ma Weigang zhang Yonglong XU Zhifang XI Qiang LI Yanqi QIN Siru zhang zichen WANG Songtao ZHAO Xue LIU Yangyang GUO Yi GUO Yongming Research Center of Experimental Acupuncture Science Tianjin University of Traditional Chinese MedicineTianjin 301617China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 301617China Department of Acupuncture and Moxibustion Qingdao Hiser Hospital Affiliated of Qingdao University(Qingdao Traditional Chinese Medicine Hospital)Qingdao 266033China School of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China School of Acupuncture and Moxibustion and Tuina Tianjin University of Traditional Chinese MedicineTianjin 301617China

OBJECTIVE:To investigate the mechanisms behind the effects of acupuncture in Traditional Chinese Medicine,we delved into the adenosine triphosphate/peripheral purinergic P2X receptor 3(ATP/P2X3)receptor signaling system as an indicator of the body's energy state,commonly referred to as"Qi".METHODS:The tail-flick test was utilized to explore the impact of acupuncture on pain tolerance threshold(PTT)in mice,while also assessing adenosine(ADO)levels and adenylate energy charge(EC)at Zusanli(ST36).The study further investigated the dose-dependent effects of acupuncture on PTT and ADO levels at Zusanli(ST36).To shed light on the underlying mechanisms of acupuncture's effects,the study examined the impact of ATP,a P2X3 receptor antagonist,and adenosine disodium on PTT following acupuncture ***:Acupuncture at Zusanli(ST36)led to significant improvements in PTT in mice,with the most effective interventions being twirling for 2 min and needle retention for 28 *** interventions also resulted in significant increases in ATP *** effects of acupuncture were further augmented by administration of different doses of ATP at Zusanli(ST36),and pretreatment with a P2X3 receptor antagonist decreased *** EC peaked at 30 min after intraperitoneal injection of ATP,and pretreatment with various doses of *** 30 min prior to acupuncture increased PTT in a dose-dependent ***,pretreatment with an *** intramuscular injection of adenosine disodium enhanced the effects of ***:This research provides compelling evidence that ATP is involved in the regulation of PTT through acupuncture,revealing new avenues for achieving enhanced clinical outcomes.

关键词： acupuncture point ST36(Zusanli) adenosine triphosphate receptors,purinergic P2X3 energy state

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Syringa pubescens Turcz ethyl acetate extract improves non-alcoholic steatohepatitis by regulating the Nrf2， IκBα and TGF-β1 signaling pathways

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Food Science and Human Wellness 2024年

作者： Weidong Xu Yanfang Wu Jiameng zhang zichen zhang Xinyi Guan Suya zhang Xinsheng Wang Pu Liu Enguo Fan College of Chemistry and Chemical Engineering， Henan University of Science and Technology College of Basic Medical and Forensic Medicine， Henan University of Science and Technology Department of Microbiology and Parasitology， Institute of Basic Medical Sciences， Chinese Academy of Medical Sciences/School of Basic Medicine， Peking Union Medical College

The flower of Syringa pubescens Turcz. （SP）， was used as both medicine and food in China， exhibited a variety of biological activities. However， it remains unknown whether SP has an effect on ameliorative nonalcoholic fatty liver disease （NASH）. In this study， the improvement of SP ethyl acetate extract （SPE） on NASH was evaluated and the potential mechanisms were explored. The glycosides of SPE were determined by an HPLC method. HepG2 cell lines were treated with free fatty acid to clarify the improvement effect and mechanisms of SPE on NASH in vitro. C57BL/6J mice were treated by 60 kcal% high-fat diet （HFD） combined with carbon tetrachloride (CCl4) to establish the NASH model in vivo. The results showed SPE could inhibited the hepatic injury and lipid steatosis by decreasing the levels of ALT， AST， TG and TC in vitro and vivo. The SPE suppressed the oxidative stress and inflammation by restraining the generation of ROS， MDA， IL-1β， IL-6 and TNF-α and enhancing the activity of antioxidant enzymes including SOD， CAT and GSH-Px in NASH model. Moreover， SPE declined the level of fibrosis markers including HYP， Col Ⅰ and α-SMA in HFD combined CCl4（HC）-induced mice. Mechanically， SPE inhibited hepatocellular Keap1 expression and promoted Nrf2 nuclear translocation， which suppressing the phosphorylation of IκBα/NF-κB. In addition， SPE down-regulated the level of TGF-β1 and phosphorylation of Smad2 to mitigate fibrosis. In brief， SPE could significantly alleviate lipid accumulation， oxidative stress， inflammation and fibrosis via regulating Nrf2/HO-1， IκBα/NFκB and TGF-β1/Smad2 pathways in the progression of NASH， which indicated that SPE had the potential to be a novel and effective drug or food supplements for the improvement of NASH.

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氯盐腐蚀环境下波形腹板钢箱组合梁疲劳性能试验研究

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中国铁道科学 2024年第5期45卷 101-109页

作者：张紫辰张豪宁鑫青海大学土木水利学院青海西宁810016 兰州交通大学土木工程学院甘肃兰州730070

为揭示氯盐腐蚀环境下波形腹板钢箱组合梁的疲劳性能,设计制作2片简支组合箱梁缩尺模型,分别进行常幅和分级变幅疲劳试验,研究未腐蚀和腐蚀模型梁的疲劳性能,基于非线性损伤理论进行波形腹板钢箱组合梁的疲劳损伤及疲劳寿命预测。结果表... 详细信息

为揭示氯盐腐蚀环境下波形腹板钢箱组合梁的疲劳性能,设计制作2片简支组合箱梁缩尺模型,分别进行常幅和分级变幅疲劳试验,研究未腐蚀和腐蚀模型梁的疲劳性能,基于非线性损伤理论进行波形腹板钢箱组合梁的疲劳损伤及疲劳寿命预测。结果表明:未腐蚀和腐蚀组合箱梁在经历200万次常幅循环加载后均未发生疲劳破坏,疲劳荷载引起的弯曲附加变形随加载循环次数的增加而增大;弯矩作用下组合梁满足“拟平截面假定”;未腐蚀梁和腐蚀梁分别经历了314.6万次和288万次分级变幅循环加载后发生疲劳破坏,试验梁底板与左右两侧腹板焊缝折角处是该类组合箱梁的疲劳易损部位;考虑多级变幅荷载相互作用影响的改进Corten-Dolan模型能够较好地预测波形腹板钢箱组合梁的疲劳寿命,且多级变幅荷载之间的相互作用对结构疲劳寿命的影响随腐蚀程度的增大而减小。

关键词：波纹腹板钢箱组合梁氯盐腐蚀疲劳性能疲劳损伤疲劳寿命疲劳试验

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极小种群植物川柿叶绿体基因组特征与系统发育分析

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广西植物 2024年第1期44卷 15-29页

作者：杨楠王奥张子晨赵良成北京林业大学生态与自然保护学院北京100083 北京林业大学博物馆北京100083

川柿(Diospyros sutchuensis)为极小种群和国家重点保护野生植物,分布范围狭窄,种群数量极少。目前,川柿基因组信息缺乏,在柿属(Diospyros)中的系统亲缘关系不明确。该研究通过Illumina平台对川柿叶绿体基因组进行测序,应用Getorganelle... 详细信息

川柿(Diospyros sutchuensis)为极小种群和国家重点保护野生植物,分布范围狭窄,种群数量极少。目前,川柿基因组信息缺乏,在柿属(Diospyros)中的系统亲缘关系不明确。该研究通过Illumina平台对川柿叶绿体基因组进行测序,应用Getorganellev1.***.3.4和PGA软件对基因组进行组装和注释,使用DnaSP6.12.03软件进行多序列对比分析,并使用REPuter、Tandem Reapeats Finder和MISA软件进行重复序列分析,使用CodonW1.4和EasyCodemL软件分别进行密码子偏好性和选择压力分析。同时,基于4个不同的叶绿体基因组序列数据集,使用IQtree软件分析川柿与11个柿属物种的系统发育关系。结果表明:(1)川柿叶绿体基因组全长157 917 bp,包含1对26 111 bp的反向重复区、大单拷贝区(87 303 bp)和小单拷贝区(18 392 bp),GC碱基含量为37.4%。(2)川柿叶绿体基因组共注释到113个基因,包括79个蛋白编码基因、30个tRNA基因和4个rRNA基因;共检测到49个长重复序列、27个串联重复序列和34个简单重复序列;蛋白编码基因中高频密码子31个,多数密码子末位碱基为A或U,编码亮氨酸的密码子使用最多;基因组编码区比非编码区更为保守,10个高变热点区域可作为潜在的分子标记;蛋白编码基因中有8个基因(ndhB、ndhG、ndhI、rbcL、rpoB、petB、petD、rps12)受到正选择压力。(3)系统发育分析显示,川柿与老鸦柿(***)和乌柿(***)亲缘关系最为密切,它们与海南柿(***)共同形成一个单系分支。该研究结果既为川柿及柿属种质资源鉴定、遗传多样性保护以及种群恢复等提供了叶绿体基因组资源,也为阐明川柿的系统进化提供了重要的分子信息。

关键词：川柿叶绿体基因组重复序列选择压力系统发育

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波形钢腹板组合箱梁动力特性分析

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山西建筑 2024年第2期50卷 165-168页

作者：吴文杰张紫辰甘肃铁科建设工程咨询有限公司甘肃兰州730000 青海大学土木水利学院青海西宁810016

以哈密顿原理为基础,综合考虑剪力滞、手风琴效应的影响,推导了组合箱梁的控制微分方程及其闭合解,分析了剪力滞、手风琴效应等参数对组合箱梁动力特性的影响。结果表明:计算结果与有限元值吻合良好;剪力滞和手风琴效应对组合箱梁的竖... 详细信息

以哈密顿原理为基础,综合考虑剪力滞、手风琴效应的影响,推导了组合箱梁的控制微分方程及其闭合解,分析了剪力滞、手风琴效应等参数对组合箱梁动力特性的影响。结果表明:计算结果与有限元值吻合良好;剪力滞和手风琴效应对组合箱梁的竖向刚度有减小作用;随箱梁高跨比的增大,频率阶数的升高,手风琴效应和剪力滞的影响表现越明显;不同波纹钢腹板型号对组合箱梁的竖向刚度影响较小。

关键词：公路桥梁动力特性分析组合箱梁波形钢腹板手风琴效应

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Fundamentals of phase-only liquid crystal on silicon (LCOS) devices

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Light(Science & Applications) 2014年第1期3卷 43-52页

作者： zichen zhang Zheng You Daping Chu State Key Laboratory of Precision Measurement Technology and Instruments Collaborative Innovation Center for Micro/Nano FabricationDevice and SystemDepartment of Precision InstrumentTsinghua UniversityBeijing 100084China Electrical Engineering Division Department of EngineeringUniversity of CambridgeCambridge CB30FAUK

This paper describes the fundamentals of phase-only liquid crystal on silicon(LCOS)technology,which have not been previously discussed in *** technology is widely utilized in high efficiency applications for real-time holography and diffractive *** paper begins with a brief introduction on the developmental trajectory of phase-only LCOS technology,followed by the correct selection of liquid crystal(LC)materials and corresponding electro-optic effects in such *** is focused on the essential requirements of the physical aspects of the LC layer as well as the indispensable parameters for the response time of the ***,the basic functionalities embedded in the complementary metal oxide semiconductor(CMOS)silicon backplane for phase-only LCOS devices are illustrated,including two typical addressing ***,the application of phase-only LCOS devices in real-time holography will be introduced in association with the use of cutting-edge computer-generated holograms.

关键词： electro-optic effect liquid crystal material liquid crystal on silicon device real-time holography

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8个人参果品种(系)的果实品质评价

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热带作物学报 2024年第3期45卷 524-532页

作者：张子琛王玉英张晚秋伍全会黄兴龙张青华云南农业大学园林园艺学院云南昆明650201 云南省农业广播电视学校富源县分校云南曲靖655500 石林县经济作物站云南昆明652200

对石林县现有栽培人参果的不同品种(系)开展果实品质检测与评价分析,为人参果产业发展提供指导依据。以石林县大田栽培的大圆果、圆果1号、圆果2号、圆果3号、石优1号、石优2号、石优3号和瑞玉8个主栽的人参果品种(系)为试材,测定可溶... 详细信息

对石林县现有栽培人参果的不同品种(系)开展果实品质检测与评价分析,为人参果产业发展提供指导依据。以石林县大田栽培的大圆果、圆果1号、圆果2号、圆果3号、石优1号、石优2号、石优3号和瑞玉8个主栽的人参果品种(系)为试材,测定可溶性糖、可溶性蛋白、可溶性固形物、矿质元素、维生素C、纤维素和氨基酸7项果实品质指标,并对各项品质指标进行多重比较、相关性和主成分分析。果实品质指标多重比较结果显示:圆果2号的可溶性糖含量最高,大圆果和圆果3号的含量最低;石优2号的可溶性蛋白含量最高,石优1号和瑞玉含量最低;圆果2号的可溶性固形物含量最高,大圆果含量最低;石优3号维生素C含量最高,圆果3号含量最低;圆果2号的粗纤维含量最高,石优1号的含量最低;圆果2号的微量元素含量最高,圆果3号的含量最低;大圆果的氨基酸含量最高,石优2号的氨基酸含量最低。果实品质指标间的相关性分析结果显示:不同品种(系)的各品质指标之间存在相关性,其中可溶性糖和可溶性固形物彼此间存在显著相关性(P<0.05)。果实品质指标主成分分析提取了前3个主成分且累积贡献率达到83.955%,能够反映原品质指标的大部分信息。以提取主成分总的特征值之和中各主成分对应的特征值所占的比例作为权重,最终建立综合评价体系对8个不同品种(系)的人参果进行综合评价。综上,供试8个人参果品种(系)均含有丰富的营养成分,其中圆果2号综合品质最好,可优选作为主栽品种或新种质创制的亲本材料。

关键词：人参果不同品种(系) 品质评价主成分分析

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数字技术驱动下的辽宁制造企业服务化转型分析

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科技创新与生产力 2024年第7期45卷 59-61页

作者：刘成浩张子辰鞍山师范学院人工智能学院辽宁鞍山114007 沈阳航空航天大学经济与管理学院辽宁沈阳110136

本文研究了数字技术驱动下的辽宁制造企业服务化转型问题。首先,介绍了数字技术迅猛发展的背景和辽宁制造企业现状;其次,分析了数字技术驱动辽宁制造企业服务化转型的优势;最后,提出了数字技术驱动辽宁制造企业服务化转型建议。

关键词：制造企业服务化转型数字技术辽宁

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An update on oral drug delivery via intestinal lymphatic transport

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Acta Pharmaceutica Sinica B 2021年第8期11卷 2449-2468页

作者： zichen zhang Yi Lu Jianping Qi Wei Wu Key Laboratory of Smart Drug Delivery of MOE School of PharmacyFudan UniversityShanghai 201203China Center for Medical Research and Innovation Shanghai Pudong HospitalFudan University Pudong Medical CenterShanghai 201399China

Orally administered drug entities have to survive the harsh gastrointestinal environment,penetrate the enteric epithelia and circumvent hepatic metabolism before reaching the systemic *** the gastrointestinal stability can be well maintained by taking proper measures,hepatic metabolism presents as a formidable barrier to drugs suffering from first-pass *** pharmaceutical academia and industries are seeking alternative pathways for drug transport to circumvent problems associated with the portal *** lymphatic transport is emerging as a promising pathway to this *** this review,we intend to provide an updated overview on the rationale,strategies,factors and applications involved in intestinal lymphatic *** are mainly two pathways for peroral lymphatic transportdthe chylomicron and the microfold cell *** underlying mechanisms are being unraveled gradually and nowadays witness increasing research input and applications.

关键词： Drug delivery Oral Lymphatic transport Drug absorption Chylomicron Microfold cell Drug carriers Nanoparticles

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