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Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology Research 2025年第1期33卷 103-121页

作者： YAN LU KANG WANG YUANHONG PENG MENG CHEN LIN ZHONG LUJI HUANG FU CHENG XINDAN sheng XIN YANG MANZHAO ouyang GEORGE A.CALIN ZHIWEI HE China-America Cancer Research Institute Guangdong Medical UniversityDongguan523808China GCP Center Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China Department of Gastrointestinal Surgery Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou510080China Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Oncology Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors,but the currently used immune checkpoint inhibitors targeting programmed cell death-1(PD-1),programmed cell death ligand-1(PD-L1),and cytotoxic T-lymphocyte antigen-4(CTLA-4)show limited clinical efficacy in many breast cancers.B7H3 has been widely reported as an immunosuppressive molecule,but its immunological function in breast cancer patients remains ***:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program(TCGA)and the Gene Expression Omnibus(GEO)*** were selected using the TarBase,miRTarBase,and miRBase *** regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays,which identified the specific action sites of *** expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR(qPCR).In vitro experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and ***,the regulatory impact of hsa-miR-214-3p on B7H3 was ***-linked immunosorbent assays(ELISA)and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells(PBMCs)on immune cells and associated ***:In breast cancer tissues,the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p,as well as with the regulatory effects on breast cancercell ***-miR-214-3p was found to inhibit breast cancer cell growth by downregulating ***,our research identified,for the first time,two binding sites for hsa-miR-214-3p on the 3’UTR of B7H3,both of which exert similar effects ***-culture experiments revealed that hsamiR-214-3p

关键词： Breast cancer B7H3 Hsa-miR-214-3p Immunotherapy

Modeling dependence based on mixture copulas and its application in risk management

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Applied Mathematics(A Journal of Chinese Universities) 2009年第4期24卷 393-401页

作者： ouyang zi-sheng LIAO Hui YANG Xiang-qun School of Information Hunan University of Commerce Changsha 410205 China School of Mathematics Hunan Normal University Changsha 410081 China

This paper is concerned with the statistical modeling of the dependence structure of multivariate financial data using the copula, and the application of copula functions in VaR valuation. After the introduction of the pure copula method and the maximum and minimum mixture copula method, authors present a new algorithm based on the more generalized mixture copula functions and the dependence measure, and apply the method to the portfolio of Shanghai stock composite index and Shenzhen stock component index. Comparing with the results from various methods, one can find that the mixture copula method is better than the pure Gaussian copula method and the maximum and minimum mixture copula method on different VaR level.

关键词： Gaussian mixture copula value-at-risk dependence back-test Spearman's rho

Attractor for Lattice System of Dissipative Zakharov Equation

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Acta Mathematica Sinica,English Series 2009年第2期25卷 321-342页

作者： Fu Qi YIN sheng Fan ZHOU zi Gen ouyang Cui Hui XIAO School of Mathematics and Computational Science Xiangtan University Xiangtan 411105 P. R. China Mathematics and Science College of Shanghai Normal University Shanghai 200234 P. R. China School of Mathematics and Physics of University of South China Hengyang 421001 P. R. China

We consider the asymptotic behavior of solutions of an infinite lattice dynamical system of dissipative Zakharov equation. By introducing new weight inner product and norm in the space and establishing uniform estimate on ＂Tail End＂ of solutions, we overcome some difficulties caused by the lack of Sobolev compact embedding under infinite lattice system, and prove the existence of the global attractor; then by using element decomposition and the covering property of a polyhedron in the finite-dimensional space, we obtain an upper bound for the Kolmogorov ε-entropy of the global attractor; finally, we present the upper semicontinuity of the global attractor.

关键词： Zakharov Equation global attractor infinite lattice system Kolmogorov ε-entropy uppersemicontinuity

Recent Advances in Surface-Assisted Laser Desorption/Ionization Mass Spectrometry and Its Imaging for Small Molecules

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Journal of Analysis and Testing 2022年第3期6卷 217-234页

作者： Huan Huang Dan ouyang zi-An Lin Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food SafetyCollege of ChemistryFuzhou UniversityFuzhou 350108China

Mass spectrometry imaging(MSI)has provided a new perspective on acquiring spatial information of multiple molecules in various *** the different ionization methods,matrix-assisted laser desorption/ionization(MALDI)has been widely utilized for detecting macromolecules,with difficulty for small molecules(m/z<700 Da)due to the matrix interference or ionization *** the past two decades,surface-assisted laser desorption/ionization mass spectrometry(SALDI-MS)gives rise to lots of attention on account of its unique performances,especially in untargeted analysis of small *** an appropriate substrate is a precondition for SALDI-MS and offers the possibility for SALDI-MS imaging(SALDI-MSI).In the last 5 years,different kinds of nanomaterials have been widely explored as substrates including metal/metal oxide-based,carbon-based,silicon-based,metal-organic frameworks-based,covalent organic frameworksbased substrates,with growing interests on composite materials and nanomaterials with homogeneous film *** review highlights recent advances of various nanomaterials as SALDI substrates,and their emerging imaging applications in botanic,forensic,metabolic and pathological ***,the merits and limitations of SALDI-MS are sketched out and some recommendations of this technique and its imaging are proposed.

关键词： Nanomaterials Surface-assisted laser desorption ionization(SALDI) Mass spectrometry imaging(MSI) Small molecules

Assessment of ecological importance of the Qinghai-Tibet Plateau based on ecosystem service flows

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Journal of Mountain Science 2021年第7期18卷 1725-1736页

作者： LIN zi-yan XIAO Yi ouyang Zhi-yun State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China

Assessments of ecological importance based on static indexes that do not consider service flows frequently underestimate the importance of the Qinghai-Tibet Plateau as a "source".On the basis of natural environmental characteristics,this study selected six type of ecosystem services for evaluation,including water retention,soil retention,carbon sequestration,biodiversity conservation,sandstorm prevention,and *** to the attributes of each ecosystem service flow,we calculated the flow length and traffic accessibility indexes,using Arc GIS hydrological module and kernel functions separately,to comprehensively analyse the ecological importance levels of the Qinghai-Tibet *** showed that after considering the service flows,the ecologically important zone shifted to the core area of the Three River Source Region,such as Zadoi County located in the Tanggula *** area of extreme importance is mainly distributed in the Yarlung Zangbo River basin,Tanggula Mountains,Hengduan Mountains,and Qilian Mountains,which accounts for 31.7% of the Qinghai-Tibet Plateau,providing approximately 60% of the ecosystem services and having extremely high protection efficiency and protection *** introducing ecosystem service flow indexes,this study confirmed the ecological importance of core source areas such as the Tanggula Mountains,weakened the space bias caused by not considering the spatial transfer of ecosystem services,and provided technical support for optimizing ecological protection strategies and coordinating regional development.

关键词： Ecological importance assessment Ecosystem services Ecosystem service flow Qinghai-Tibet Plateau

A precise approach to tracking dim-small targets using spectral fingerprint features

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Frontiers of Computer Science 2012年第5期6卷 527-536页

作者： Hao sheng Chao LI Yuanxin ouyang Zhang XIONG School of Computer Science and Engineering Beihang UniversityBeijing 100191China Research Institute of Beihang University in Shenzhen Shenzhen 518057China State Key Laboratory of Software Development Environment Beihang UniversityBeijing 100191China

A precise method for accurately tracking dim- small targets, based on spectral fingerprint is proposed where traditional full color tracking seems impossible. A fingerprint model is presented to adequately extract spectral features. By creating a multidimensional feature space and extending the limited RGB information to the hyperspectral information, the improved precise tracking model based on a nonparamet- ric kernel density estimator is built using the probability his- togram of spectral features. A layered particle filter algorithm for spectral tracking is presented to avoid the object jumping abruptly. Finally, experiments are conducted that show that the tracking algorithm with spectral fingerprint features is ac- curate, fast, and robust. It meets the needs of dim-small target tracking adequately.

关键词： dim-small target precise tracking spectral fingerprint features LPF algorithm for spectral tracking

Cropland expansion facilitated the outbreak of cereal aphids during 1951–2010 in China

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Science Bulletin 2015年第11期60卷 1036-1037,1062页

作者： zi-Hua Zhao Fang ouyang Feng Ge State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of Zoology Chinese Academy of Sciences Department of Entomology College of Agriculture and Biotechnology China Agricultural University

Landscape-scale pattern could affect ecosystem service such as biocontrol of agricultural pests. Additionally, pest outbreak has been shown to be interwoven with land-use intensity. In the present research, we collected and analysed the 60-year data of cereal aphids and wheat area during 1951–2010 in China. Regression model was applied to analyse the relationship between pest damage and cropland expansion. Results showed that the percentage of cereal aphid outbreak area in wheat area increased rapidly during 1951–2010. It was 9 % during 1951–1960, while it was above 60 % during 2001–2010. In addition, effect of cropland expansion on damage of cereal aphids was significantly positive, which indicated that cropland expansion in agricultural landscape may enhance pest damage ***, we concluded that cropland expansion was one of the most important drivers of increasing pest outbreak,which should be considered in sustainable management of cereal aphids combined with other factor(e.g. climate changes and resistant variety) at large spatiotemporal scale.

关键词： Agricultural intensification Cereal aphids Biocontrol Ecosystem service Scale

Research,application and development of inorganic binder for casting process

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China Foundry 2024年第5期21卷 461-475页

作者： Xiao-long Gong sheng-li Hu zi-tian Fan State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China

Inorganic binder used in casting process has the advantages of low odor,labor-friendly conditions,and relatively low cost,which is one of the main development directions for casting molding materials in the ***,compared to organic binders(such as resin binders),inorganic binders exhibit lower bonding strength and are more sensitive to environmental *** sensitivity poses challenges,particularly in the reclamation of used sand,thus limiting their broader *** this paper,the research and application status of inorganic binders(mainly silicate inorganic binders)and their curing methods are *** addition,the research and application of phosphate inorganic binders and 3D printing inorganic binders that are being developed are ***,a detailed comparative analysis is conducted on the challenging issue of“reclamation for used sand”in the application of inorganic ***,the development direction of inorganic binders is clarified.

关键词： inorganic binder silicate system phosphate system 3D printing used sand reclamation development trend

Modulation of d-orbital to realize enriched electronic cobalt sites in cobalt sulfide for enhanced hydrogen evolution in electrocatalytic water/seawater splitting

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Rare Metals 2024年第2期43卷 511-521页

作者： Jian-Peng Sun Yu Zheng zi-sheng Zhang Xiang-Chao Meng zi-Zhen Li Key Laboratory of Marine Chemistry Theory and Technology(Ministry of Education) College of Chemistry and Chemical EngineeringOcean University of ChinaQingdao266100China Shanxi Institute of Energy Taiyuan030600China Department of Chemical and Biological Engineering Faculty of EngineeringUniversity of OttawaOttawaONK1N6 N5Canada

Herein,a novel single-atomic Pt doping and interface-rich CoS/Co(OH)_(2)(Pt-CoS/Co(OH)_(2)/C)electrocatalyst has been successfully *** from precise regulation of d-orbital electronic structure modulation on Co site,Pt-CoS/Co(OH)_(2)/C exhibited remarkable HER activity and high stability for hydrogen evolution in splitting both water(73 mV@10 mA·cm^(−2)) and seawater(87 mV@10 mA·cm^(−2)).Notably,atomic Pt doping was introduced into CoS/Co(OH)_(2),which could produce local unbalanced Coulombic force and significantly increased the number of S vacancies,and then expose abundant Co ***,Co(OH)_(2) in Pt-CoS/Co(OH)_(2)/C could act as the adsorption sites for H_(2)O in hydrogen evolution reaction *** functional theory results also proved that atomic Pt doping,S vacancies and Co(OH)_(2) coupling could result in the formation of enriched electronic Co sites and optimize d_(z2) orbital electronic structure,and then realize the depth upward shift of d-band center and enhance the adsorption of H*on Co sites.

关键词： Electrocatalysts Hydrogen evolution reaction Pt-CoS/Co(OH)_(2) d-band center Electronic structure Water/seawater electrolysis