Recent Advances in Surface-Assisted Laser Desorption/Ionization Mass Spectrometry and Its Imaging for Small Molecules

作     者：Huan Huang Dan Ouyang Zi-An Lin Huan Huang;Dan Ouyang;Zi-An Lin

作者机构：Ministry of Education Key Laboratory of Analytical Science for Food Safety and BiologyFujian Provincial Key Laboratory of Analysis and Detection Technology for Food SafetyCollege of ChemistryFuzhou UniversityFuzhou 350108China 

出 版 物：《Journal of Analysis and Testing》 (分析检测（英文）)

年 卷 期：2022年第6卷第3期

页      面：217-234页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 070205[理学-凝聚态物理] 08[工学] 0817[工学-化学工程与技术] 080501[工学-材料物理与化学] 070302[理学-分析化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0702[理学-物理学] 

基　　金：the financial support from the National Natural Science Foundation of China(21974021 91843301 22036001) 

主　　题：Nanomaterials Surface-assisted laser desorption ionization(SALDI) Mass spectrometry imaging(MSI) Small molecules 

摘      要：Mass spectrometry imaging(MSI)has provided a new perspective on acquiring spatial information of multiple molecules in various *** the different ionization methods,matrix-assisted laser desorption/ionization(MALDI)has been widely utilized for detecting macromolecules,with difficulty for small molecules(m/z700 Da)due to the matrix interference or ionization *** the past two decades,surface-assisted laser desorption/ionization mass spectrometry(SALDI-MS)gives rise to lots of attention on account of its unique performances,especially in untargeted analysis of small *** an appropriate substrate is a precondition for SALDI-MS and offers the possibility for SALDI-MS imaging(SALDI-MSI).In the last 5 years,different kinds of nanomaterials have been widely explored as substrates including metal/metal oxide-based,carbon-based,silicon-based,metal-organic frameworks-based,covalent organic frameworksbased substrates,with growing interests on composite materials and nanomaterials with homogeneous film *** review highlights recent advances of various nanomaterials as SALDI substrates,and their emerging imaging applications in botanic,forensic,metabolic and pathological ***,the merits and limitations of SALDI-MS are sketched out and some recommendations of this technique and its imaging are proposed.