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内侧杏仁核的神经调节素1信号通路调控青春期社会隔离导致的自闭样行为

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Science Bulletin 2024年第10期69卷 1375-1379页

作者：林连虹吴倩云曾恺陈梓瑜王梓萍李伟民张斌高天明刘吉红 Department of Psychiatry Institute of Brain DiseaseNanfang HospitalSouthern Medical UniversityGuangzhou 510515China Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence Southern Medical UniversityGuangzhou 510515China

Autistic spectrum disorder(ASD),characterized by impairments in social interaction and repetitive behaviors,is a complex neurodevelopmental brain disorder that is reportedly increasing in prevalence globally[1].It is ... 详细信息

关键词：社会隔离 impairment prevalence

Self organizing optimization and phase transition in reinforcement learning minority game system

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Frontiers of physics 2024年第4期19卷 297-309页

作者： Si-ping Zhang Jia-Qi Dong Hui-Yu Zhang Yi-Xuan Lü Jue wang zi-Gang Huang Key Laboratory of Biomedical Information Engineering of Ministry of Education Key Laboratory of Neuro-informatics&Rehabilitation Engineering of Ministry of Civil Affairsand Institute of Health and Rehabilitation ScienceSchool of Life Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China Lanzhou Center for Theoretical Physics and Key Laboratory of Theoretical Physics of Gansu Province Lanzhou UniversityLanzhou 730000China

Whether the complex game system composed of a large number of artificial intelligence(AI)agents empowered with reinforcement learning can produce extremely favorable collective behaviors just through the way of agent self-exploration is a matter of practical *** this paper,we address this question by combining the typical theoretical model of resource allocation system,the minority game model,with reinforcement *** individual participating in the game is set to have a certain degree of intelligence based on reinforcement learning *** particular,we demonstrate that as AI agents gradually becomes familiar with the unknown environment and tries to provide optimal actions to maximize payoff,the whole system continues to approach the optimal state under certain parameter combinations,herding is effectively suppressed by an oscillating collective behavior which is a self-organizing pattern without any external *** interesting phenomenon is that a first-order phase transition is revealed based on some numerical results in our multi-agents system with reinforcement *** order to further understand the dynamic behavior of agent learning,we define and analyze the conversion path of belief mode,and find that the self-organizing condensation of belief modes appeared for the given trial and error rates in the AI ***,we provide a detection method for period-two oscillation collective pattern emergence based on the Kullback–Leibler divergence and give the parameter position where the period-two appears.

关键词： oscillatory evolution collective behaviors phase transition reinforcement learning minority game

Study of baryon number transport dynamics and strangeness conservation effects using-hadron correlations

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Nuclear Science and Techniques 2024年第7期35卷 147-156页

作者： Wei-Jie Dong Xiao-Zhou Yu Si-Yuan ping Xia-Tong Wu Gang wang Huan-Zhong Huang zi-Wei Lin Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Fudan UniversityShanghai 200433China Department of Physics and Astronomy University of CaliforniaLos AngelesCA 90095USA Department of Physics East Carolina UniversityGreenvilleNC 27858USA

In nuclear collisions at RHIC energies,an excess ofΩhyperons over n is observed,indicating that几has a net ba ryon number despites and 3 quarks being produced in *** ba ryon number inΩmay have been transported from the incident nuclei and/or produced in the baryon-pair production ofΩ with other types of anti-hyperons such *** investigate these two scenarios,we propose to measure the correlations betweenΩand K and betweenΩand *** use two versions,the default and string-melting,of a multiphase transport(AMPT)modelto illustrate the method for measuring the correlation and to demonstrate the general shape ofthe *** present the S 2-hadron correlations from simulated Au+Au collisions at√SNN=7.7 and 14.6 GeV and discuss the dependence on the cllision energy and on the hadronization scheme in these two AMPT *** correlations can be used to explore the mechanism of baryon number transport and the effects of baryon number and strangeness conservation on nuclear collisions.

关键词： Baryon number transport Strangeness conversation Correlation Gluon junction

Gossypol acetic acid regulates leukemia stem cells by degrading LRPPRC via inhibiting IL-6/JAK1/STAT3 signaling or resulting mitochondrial dysfunction

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World Journal of Stem Cells 2024年第4期16卷 444-458页

作者： Cheng-Jin Ai Ling-Juan Chen Li-Xuan Guo Ya-ping wang zi-Yi Zhao Department of Laboratory Medicine Hospital of Chengdu University of Traditional Chinese MedicineChengdu 641000Sichuan ProvinceChina Department of Ophthalmology Hospital of Chengdu University of Traditional Chinese MedicineChengdu 641000Sichuan ProvinceChina Central Laboratory Hospital of Chengdu University of Traditional Chinese MedicineChengdu 641000Sichuan ProvinceChina Traditional Chinese Medicine Regulating Metabolic Diseases Key Laboratory of Sichuan Province Chengdu University of Traditional Chinese MedicineChengdu 641000Sichuan ProvinceChina

BACKGROUND Leukemia stem cells(LSCs)are found to be one of the main factors contributing to poor therapeutic effects in acute myeloid leukemia(AML),as they are protected by the bone marrow microenvironment(BMM)against conventional *** acetic acid(GAA),which is extracted from the seeds of cotton plants,exerts anti-tumor roles in several types of cancer and has been reported to induce apoptosis of LSCs by inhibiting *** To investigate the exact roles of GAA in regulating LSCs under different microenvironments and the exact *** In this study,LSCs were magnetically sorted from AML cell lines and the CD34+CD38-population was *** expression of leucine-rich pentatricopeptide repeat-containing protein(LRPPRC)and forkhead box M1(FOXM1)was evaluated in LSCs,and the effects of GAA on malignancies and mitochondrial RESULTS LRPPRC was found to be upregulated,and GAA inhibited cell proliferation by degrading *** induced LRPPRC degradation and inhibited the activation of interleukin 6(IL-6)/janus kinase(JAK)1/signal transducer and activator of transcription(STAT)3 signaling,enhancing chemosensitivity in LSCs against conventional chemotherapies,including L-Asparaginase,Dexamethasone,and *** was also found to downregulate FOXM1 indirectly by regulating ***,GAA induced reactive oxygen species accumulation,disturbed mitochondrial homeostasis,and caused mitochondrial *** inhibiting IL-6/JAK1/STAT3 signaling via degrading LRPPRC,GAA resulted in the elimination of ***,GAA induced oxidative stress and subsequent cell damage by causing mitochondrial *** Taken together,the results indicate that GAA might overcome the BMM protective effect and be considered as a novel and effective combination therapy for AML.

关键词： Leukemia stem cells Gossypol acetic acid Reactive oxygen species Mitochondrial dysfunction Interleukin 6/janus kinase 1/signal transducer and activator of transcription 3 signaling

Realizing high initial Coulombic efficiency in manganese-based layered oxide cathodes for sodium-ion batteries via P2/O'3 biphasic structure optimization

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Rare Metals 2024年第5期43卷 2093-2102页

作者： Bo Peng zi-Hao Zhou ping Xuan Jie Xu Lian-Bo Ma School of Materials Science and Engineering Anhui University ofTechnologyMa'anshan 243002China Anhui Product Quality Supervision&Inspection Research Institute Hefei 230051China

Mn-based layered oxides are among the most promising cathode materials for sodium-ion batteries owing to the advantages of abundance,environmenta friendliness,low cost and high specific capacity.P2 and O'3 are two representative structures of Mn-based layered ***,the P2 structure containing insufficien Na generally exhibits low initial charge capacity,while O'3structure with sufficient Na delivers high initial charge capacity but poor cycle *** study prepared a multitude of Na_(x)MnO_(2)(x=0.7,0.8,0.9)cathode materials with varying P2/O'3 ratios and further investigated their electrochemical *** optimized Na_(0.8)MnO_(2) comprising 69.9 wt%O'3 and 30.1 wt%P2 phase,exhibited relatively balanced specific capacity,Coulombic efficiency and cycle ***,it achieved a high specific capacity of 128.9 mAh·g^(-1) with an initia Coulombic efficiency of 98.2%in half-cell configuration The Na_(0.8)MnO_(2)//hard carbon full cell also achieved a high specific capacity of 126.7 mAh·g^(-1) with an initia Coulombic efficiency of 98.9%.Moreover,the capacity fading mechanism was revealed by combining in-situ and ex-situ X-ray *** findings of this study provide theoretical guidance for further modification design of Mnbased layered cathodes.

关键词： Sodium-ion batteries Cathode materials Mn-based layered oxides P2/0'3 composites

Exploring mechanism of hidden,steep obliquely inclined bedding landslides using a 3DEC model:A case study of the Shanyang landslide in Shaanxi Province,China

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China Geology 2024年第2期7卷 303-314,I0001-I0003页

作者： Jia-yun wang zi-long Wu Xiao-ya Shi Long-wei Yang Rui-ping Liu Na Lu Xi’an Center of China Geological Survey/Northwest China Center for Geoscience Innovation Xi’an 710119China Xi’an University of Science and Technology Xi’an 710054China Wuhan Design&Research Institute Co. Ltd.of China Coal Technology&Engineering GroupWuhan 430064China

Catastrophic geological disasters frequently occur on slopes with obliquely inclined bedding structures(also referred to as obliquely inclined bedding slopes),where the apparent dip sliding is not readily *** phenomenon has become a focal point in landslide ***,there is a lack of studies on the failure modes and mechanisms of hidden,steep obliquely inclined bedding *** study investigated the Shanyang landslide in Shaanxi Province,*** field investigations,laboratory tests of geotechnical parameters,and the 3DEC software,this study developed a numerical model of the landslide to analyze the failure process of such *** findings indicate that the Shanyang landslide primarily crept along a weak interlayer under the action of *** landslide,initially following a dip angle with the support of a stable inclined rock mass,shifted direction under the influence of argillization in the weak interlayer,moving towards the apparent dip *** slide resistance effect of the karstic dissolution zone was increasingly significant during this process,with lateral friction being the primary resistance force.A reduction in the lateral friction due to karstic dissolution made the apparent dip sliding characteristics of the Shanyang landslide more ***,deformations such as bending and uplift at the slope’s foot suggest that the main slide resistance shifts from lateral friction within the karstic dissolution zone to the slope foot’s resistance force,leading to the eventual buckling failure of the *** study unveils a novel failure mode of apparent dip creep-buckling in the Shanyang landslide,highlighting the critical role of lateral friction from the karstic dissolution zone in its failure *** insights offer a valuable reference for mitigating risks and preventing disasters related to obliquely inclined bedding landslides.

关键词： Landslide Steep obliquely inclined bedding slope Failure mode Failure mechanism Apparent dip creep-buckling Lateral friction 3DEC model Landslide numerical model Geological hazards survey engineering

Forecast of cosmological constraints with superluminous supernovae from the Chinese Space Station Telescope

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Science China(Physics,Mechanics & Astronomy) 2024年

作者： Xuan-Dong Jia Jian-ping Hu Fa-Yin wang zi-Gao Dai School of Astronomy and Space Science Nanjing University Key Laboratory of Modern Astronomy and Astrophysics (Nanjing University) Ministry of Education Department of Astronomy University of Science and Technology of China

Superluminous supernovae（SLSNe） are a class of intense celestial events that can be standardized for measuring cosmological parameters, bridging the gap between type Ia supernovae and the cosmic microwave background. In this work, we discuss the cosmological applications of SLSNe from the Chinese Space Station Telescope（CSST）. Our estimation suggests that SLSNe rate is biased tracing the cosmic star formation rate, exhibiting a factor of（1 + z）1.2. We futher predict that CSST is poised to observe ～ 360 SLSNe in the 10 square degrees ultra-deep field survey within a span of 2.5 years. A stringent constraint on cosmological parameters can be derived from their peak-color relationship. CSST is anticipated to uncover a substantial number of SLSNe, contributing to a deeper understanding of their central engines and shedding light on the nature of dark energy at high redshifts.

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Association of cardiometabolic multimorbidity with all-cause and cardiovascular disease mortality among Chinese hypertensive patients

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Journal of Geriatric Cardiology 2024年第2期21卷 211-218页

作者： Luo-Xi XIAO zi-Yu wang Jiang-Tao LI Hai-Mei wang Yi-Ming HAO Pan ZHOU Yu-Lin HUANG Qiu-Ju DENG Yong-Chen HAO Na YANG Li-Zhen HAN Zhao YANG ping-ping JIA Yue QI Jing LIU Center for Clinical and Epidemiologic Research Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseasesBeijing Municipal Key Laboratory of Clinical EpidemiologyBeijingChina

BACKGROUND Hypertension usually clusters with multiple ***,the association between cardiometabolic multimorbidity(CMM)and mortality in hypertensive patients is *** study aimed to investigate the association between CMM and all-cause and cardiovascular disease(CVD)mortality in Chinese patients with *** The data used in this study were from the China National Survey for Determinants of Detection and Treatment Status of Hypertensive Patients with Multiple Risk Factors(CONSIDER),which comprised 5006 participants aged 19–91 *** was defined as the presence of one or more of the following morbidities:diabetes mellitus,dyslipidemia,chronic kidney disease,coronary heart disease,and *** proportional hazard models were used to calculate the hazard ratios(HR)with 95%CI to determine the association between the number of CMMs and both all-cause and CVD *** Among 5006 participants[mean age:58.6±10.4 years,50%women(2509 participants)],76.4%of participants had at least one *** mortality rate was 4.57,4.76,8.48,and 16.04 deaths per 1000 person-years in hypertensive patients without any comorbidity and with one,two,and three or more morbidities,*** the fully adjusted model,hypertensive participants with two cardiometabolic diseases(HR=1.52,95%CI:1.09–2.13)and those with three or more cardiometabolic diseases(HR=2.44,95%CI:1.71–3.48)had a significantly elevated risk of all-cause *** findings were similar for CVD mortality but with a greater increase in risk *** In this study,three-fourths of hypertensive patients had *** with two or more comorbidities was associated with a significant increase in the risk of all-cause and cardiovascular mortality among hypertensive patients,suggesting more intensive treatment and control in this high-risk patient group.

关键词： hypertensive patients morbidity

Flotation separation of feldspar from quartz using sodium fluosilicate as a selective depressant

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Rare Metals 2024年第3期43卷 1288-1300页

作者： Xin Hu Xian-ping Luo zi-Shuai Liu Yong-Bing Zhang He-Peng Zhou Zhi-Zhao Yang Xue-Kun Tang Faculty of Resource and Environmental Engineering Jiangxi University of Science and TechnologyGanzhou341000China Yichun Lithium New Energy Industry Research Institute Jiangxi University of Science and TechnologyYichun336000China

The physical and chemical properties of feldspar and quartz are highly similar,thus they cannot be easily separated *** this work,the flotation separation of feldspar from quartz using sodium fluosilicate(Na_(2)SiF_(6);SF)as a selective depressant was ***,the influence mechanism of SF on the selective flotation separation of feldspar and quartz was investigated via flotation tests,chemical analysis of flotation solution,Fourier transform infrared spectroscopy(FTIR),X-ray photoelectron spectroscopy(XPS)and contact angle *** results of the flotation tests show that feld spar and quartz without SF treatment have good *** SF treatment,feldspar still has good floatability,whereas quartz has significantly reduced *** solution chemical analysis shows that the functional group plays an important role in depressing the quartz is[SiF_(6)]^(2-).FTIR,XPS and contact angle analysis results show that[SiF_(6)]^(2-)is adsorbed only on the surface of ***,a thin hydrophilic SiOF layer is generated on the surface,which interferes with the adsorption of the collector on the surface of the *** phenomenon leads to a significant reduction in quartz's ***,SF has a good ability to separate feldspar from quartz by flotation.

关键词： Flotation separation Depressants Sodium fluorosilicate Quartz Feldspar