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Functional protection of pentoxifylline against spinal cord ischemia/reperfusion injury in rabbits： necrosis and apoptosis effects

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Chinese Medical Journal 2008年第23期121卷 2444-2449页

作者： zhu dan-jie xia bing bi qing zhang shui-jun qiu bin-song zhao chen Department of Orthopedics Zhejiang Provincial People's Hospital Hangzhou Zhejiang 310014 China

Background Little is known about neuronal death mechanisms following spinal cord ischemia. The present study aimed to investigate the protective effect of pentoxifylline （PTX） against spinal cord ischemia/reperfusion （I/R） injury. Methods Rabbits sustained spinal cord ischemia following 45 minutes cross-clamping of the infrarenal aorta. Experimental groups were as follows： the first group of animals （sham, n=-8） underwent laparotomy alone and served as the sham group; the second group （I/R, n=20） received carrier （3 ml saline solution） and served as the control group; the third group （PTX-A, n=20） received PTX intravenously 10 minutes prior to ischemia; and the fourth group （PTX-B, n=20） received PTX intravenously at the onset of reperfusion. Rabbits were evaluated for hind-limb motor function with the Tarlov scoring system at 48 hours. Serum was assayed with enzyme-linked immunosorbent assay for tumor necrosis factor α （TNF-α） and spinal cords were harvested for myeloperoxidase （MPO） activity, histopathological analysis, terminal deoxynucleotidyl transferase （TdT）-rnediated dUTP nick end labeling staining, platelet/endothelial ceU adhesion molecule-1 （PECAM-1） and caspase-3 immunohistochemistry, and the number of necrotic and apoptotic neuron were counted and data analyzed at 12, 24, 48 and 72 hours of reperfusion. Spinal cords were studied by electron microscopy. Results Improved Tarlov scores were seen in PTX-treated rabbits as compared with ischemic control rabbits at 48 hours. A significant reduction was found in TNF-α in serum, activity of MPO and immunoreactivity of the PECAM-1 and caspase-3 in PTX-treated rabbits. There were fewer apoptotic neurons than necrotic neurons （P 〈0.05）. A significant decrease in both necrotic and apoptotic neurons was observed in the PTX-treated groups （PTX-A and PTX-B） compared with the I/R group （P 〈0.05）. Both necrotic and apoptotic neurons were found with the electron microscope. Conclusions PTX may induce protection aga

关键词： spinal cord injury pentoxifylline necrosis apoptosis

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Effect of combination therapy with alginate dressing and mouse epidermal growth factor on epidermal stem cells in patients with refractory wounds

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Chinese Medical Journal 2012年第2期125卷 257-261页

作者： bi qing zhang Qiong Ma jun Xu Ming zhang shui-jun qiu bin-song xia bing Gu Hai-feng Hong Jian-fei zhao chen zhu dan-jie Zhejiang Prov Peoples Hosp Dept Orthoped Hangzhou 310014 Zhejiang Peoples R China Zhejiang Prov Peoples Hosp Dept Operating Room Hangzhou 310014 Zhejiang Peoples R China

Background The aim of this research was to determine the efficacy of combination therapy using an alginate dressing and mouse epidermal growth factor （mEGF） on proliferation and differentiation of epidermal stem cells （ESCs） in patients with refractory *** Eighteen patients （12 males and 6 females,aged from 18 to 61 years （mean 36.4 years）） with various skin wounds,were treated by dressing changing for one *** wounds were located in the foot （11）,calf （3）,thigh （2）and forearm （2）.The patients were randomly divided into 3 groups：alginate dressing and mEGF （group A; n=6）,mEGF （group B; n=6） and control （group C; n=6）.Wound closure indexes were measured at 7,14,21 and 28 *** were harvested for pathologic examination,at 7 and 14 days following *** 10 （CK10） and cytokeratin 15 （CK15） positive cells were evaluated using the super-sensitivity （SP） immunohistochemical staining *** Wound healing was promoted in groups A and *** group A,the wound closure index was increased significantly （P 〈0.05）,and in one case the maximum cure area reached 102 *** examination identified a thicker epidermis,active angiogenesis and enhanced granulation in group A compared with groups B and *** the SP immunohistochemical staining technique,we showed that ESCs in group A were bigger in size and larger in number than in groups B and ***,there was a significant difference in ESCs proliferation and differentiation between group A and group B （or C）.Conclusions Combination therapy using an alginate dressing and mEGF shows increased proliferation and differentiation of ESCs in patients with refractory wounds compared with those treated with mEGF alone.

关键词： alginates epidermal growth factor stem cells wound healing

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci xiao-jun bi Yuanjie bi Tianjian bian Fabrizio bianchi Thomas biekotter Michela biglietti Shalva bilanishvili Deng binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che bin chen danping chen Fuqing chen Fusan chen Gang chen Guoming chen Hua-Xing chen Huirun chen Jinhui chen Ji-Yuan chen Kai chen Mali chen Mingjun chen Mingshui chen Ning chen Shanhong chen Shanzhen chen Shao-Long chen Shaomin chen Shiqiang chen Tianlu chen Wei chen xiang chen xiaoyu chen Xin chen Xun chen Xurong chen Ye chen Ying chen Yukai chen Zelin chen Zilin chen Gang chen Boping chen Chunhui chen Hok Chuen cheng Huajie cheng Shan cheng Tongguang cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui xiaohao Cui zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug danhong injection:a randomized trial

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3009-3018页

作者： jun Liu dan-dan Li Wei Dong Yu-Qi Liu Yang Wu Da-Xuan Tang Fu-Chun zhang Meng qiu Qi Hua Jing-Yu He jun Li Bai Du Ting-Hai Du Lin-Lin Niu Xue-jun Jiang Bo Cui Jiang-bin chen Yang-Gan Wang Hai-Rong Wang Qin Yu Jing He Yi-Lin Mao xiao-Fang bin Yue Deng Yu-dan Tian qing-Hua Han Da-Jin Liu Li-Qin Duan Ming-jun zhao Cui-Ying zhang Hai-Ying Dai Ze-Hua Li Ying xiao You-Zhi Hu xiao-Yu Huang Kun Xing Xin Jiang Chao-Feng Liu Jing An Feng-Chun Li Tao Tao Jin-Fa Jiang Ying Yang Yao-Rong Dong Lei zhang Guang Fu Ying Li Shu-Wei Huang Li-Ping Dou Lan-jun Sun Ying-Qiang zhao jie Li Yun xia jun Liu Fan Liu Wen-Jin He Ying Li Jian-Cong Tan Yang Lin Ya-bin Zhou Jian-Fei Yang Guo-qing Ma Hui-jun chen He-Ping Liu Zong-Wu Liu Jian-Xiong Liu xiao-Jia Luo xiao-Hong bin Ya-Nan Yu Hai-xia dang bing Li Fei Teng Wang-Min Qiao xiao-Long zhu bing-Wei chen Qi-Guang chen Chun-Ti Shen Yong-Yan Wang Yun-Dai chen Zhong Wang Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijingChina Department of Cardiology Chinese PLA General HospitalBeijingChina Department of Cardiology Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijingChina Department of Geratology Peking University Third HospitalBeijingChina Department of Cardiology Xuan Wu HospitalCapital Medical UniversityBeijingChina Department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina Department of Cardiology First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouHenanChina Department of Cardiology Wuhan University Renmin HospitalWuhanHubeiChina Department of Cardiology Wuhan University Zhongnan HospitalWuhanHubeiChina Affiliated Zhongshan Hospital of Dalian University DalianLiaoningChina Department of Cardiology Second Affiliated Hospital to Hunan University of Chinese MedicineChangshaHunanChina Department of Cardiology First Affiliated Hospital to Changchun University of Chinese MedicineChangchunJilinChina Department of Cardiology First Affiliated Hospital to Shanxi Medical UniversityTaiyuanShanxiChina Department of Cardiology Affiliated Hospital of Shanxi University of Chinese MedicineXianyangShanxiChina Department of Cardiology Changsha Central HospitalChangshaHunanChina Department of Cardiology Hubei Provincial Hospital of Traditional Chinese MedicineWuhanHubeiChina Department of Cardiology Shanxi Provincial People's HospitalXi'anShanxiChina Department of Cardiology Shanxi Province Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Xi'an City Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Shanghai Tongji HospitalShanghaiChina Department of Cardiology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghaiChina Department of Cardiology The First Hospital of ChangshaChangshaHunanChina Department of Cardiology Xinhua Hospi

It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in thedfferentiated populations with complex diseases,as stable coronary heart ***,in an adaptive,31-center,randomized,double-blind trial invoving 920 patients with moderate symptomatic stable angina treated by 14-day danhong injection(DHI),a kind of polyphamacological drug with high quality control,or placebo(0.9%saline),with 76-day following-up,we firstly confrmed that DHl couldincrease the proportion of patients with clinically significant changes on angina-frequency assessed by Seattle Angina Questionnaire(ASAQ-AF220)(12.78%at Day 30,95%confidence interval[C]5.86-19.71%,P=0.0003,13.82%at Day 6C0,95%CI 6.82-20.82%,P=0.0001and 8.95%at Day 90,95%CI 2.06-15.85%,P=0.01).We also found that there were no significant differences in new-onset major vascularevents(P=0.8502)and serious adverse events(P=0.9105)between DHl and *** performing the RNA sequencing in 62 selectedpatients,we developed a systemic modular approach tp identfy differentilly expressed modules(DEMs)of DHI with the Z_(summay)valueless than 0 compared with the control group,calculated by weighted gene co-expression network analysis(WGCNA),and sketched out thebasic framework on a modular map with 25 functional modules targeted by ***,the effective therapeutic module(ETM),defined as the highest corelation value with the phenotype alteration(SAQ-AF,the change in SAQ-AF at Day 30 from baseline)calculatedby WGCNA,was identifed in the population with the best effect(ASAQ-AF240),which is related to anticoagulation and regulation ofcholesterol *** assessed the modular flexbility of this ETM using the global topological D value based on Euclidean distance,which is corelated with phenotype alteration(r^(2):0.8204,P=0.019)by linear *** study identified the ant-angina therapeuticmodule in the effective population treated by the multi-target

关键词： angina injection sketch

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脂肪抑制三维稳态旋进快速成像FS-3D-FISP序列在诊断踝关节软骨损伤中的应用价值

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中华医学杂志 2010年第25期90卷 1752-1755页

作者：赵晨毕擎夏冰狄幸波朱丹杰郑劼洪剑飞邱斌松章水均顾海峰浙江省人民医院关节外科中心 310014 浙江省人民医院放射科 310014

目的对照不同序列踝关节软骨病损的MRI特点与关节镜表现,评价特殊序列,即脂肪抑制三维稳态旋进快速成像FS-3D-FISP对软骨病变的诊断价值.方法对因踝关节疼痛拟行踝关节镜检查的40例（41踝）患者,术前常规行T2加权快速自旋回波FSE-T2W... 详细信息

目的对照不同序列踝关节软骨病损的MRI特点与关节镜表现,评价特殊序列,即脂肪抑制三维稳态旋进快速成像FS-3D-FISP对软骨病变的诊断价值.方法对因踝关节疼痛拟行踝关节镜检查的40例（41踝）患者,术前常规行T2加权快速自旋回波FSE-T2WI、质子密度加权快速自旋回波FSE-PDWI和FS-3D-FISP 3种MRI序列扫描,分别得到MRI分级结果,并与关节镜分级诊断结果进行比较.结果以关节镜诊断为标准,FS-3D-FISP序列敏感度最高,可达92.9%.在敏感度上FS-3D-1 ISP〉FSE-FDWI〉FSE-T2WI,与关节镜诊断的一致性上：FS-3D-FISP的Kappa值达到0.7590,一致性高,也明显优于FSE-PDWI和FSE-T2WI （P〈0.01）.结论 FS-3D-FISP序列能够准确地反映软骨病变,并且能较真实体现早期的软骨病变,与关节镜诊断结果具有良好的一致性,而且通过三维重建对软骨病变进行立体定位诊断,能更准确地显示病变的部位及程度,并对其进行合理分级,更好地指导临床决策.

关键词：磁共振成像踝关节软骨疾病关节镜检查

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Data release of the LAMOST pilot survey

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Research in Astronomy and Astrophysics 2012年第9期12卷 1243-1246页

作者： A-Li Luo Hao-Tong zhang Yong-Heng zhao Gang zhao xiang-Qun Cui Guo-Ping Li Yao-Quan Chu Jian-Rong Shi Gang Wang Jian-Nan zhang Zhong-Rui Bai xiao-Yan chen Feng-Fei Wang Yan-Xin Guo Jian-jun chen bing Du xiao Kong Ya-Juan Lei Yin-bi Li Yi-Han song Yue Wu Yan-xia zhang Xin-Lin Zhou Fang Zuo Peng Du Lin He Wen Hou Yi-Qiao Dong Jian Li Guang-Wei Li Shuang Li Jing song Yuan Tian Meng-Xin Wang Yong-Hui Hou Zhi-Ying Huo Hong-zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Lei Jia Fang-Hua Jiang xiang Jiang Zi-Bo Jiang Ge Jin Ai-Hua Li Qi Li Yin-Dun Mao Zheng-Hong Tang qing-Sheng Tao Liang-Ping Tu Da-qing Wang dan Wang Jian-Ping Wang Lei Wang Shou-Guan Wang Shu-qing Wang Ya-Nan Wang You Wang Yue-Fei Wang Ming-Zhi Wei xiang-xiang Xue xiao-Zheng Xing Ling-Zhe Xu Xin-Qi Xu Yan Xu De-Hua Yang Shi-Hai Yang Zheng-qiu Yao Yong Yu Hui Yuan Chao Zhai En-Peng zhang Jing zhang Li-Ping zhang Weizhang Yong zhang Zhen-Chao zhang Ming zhao Fang Zhou Yong-Tian zhu jie zhu Si-cheng Zou National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China lal @ lamost o rg Nanjing Institute of Astronomical Optics and Technology National Astronomical ObservatoriesChinese Academy of Sciences Nanjing 210042 China University of Science and Technologyof China Hefei 230026 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Institute of Architecture Design and Research Chinese Academy of Sciences Beijing 100190China

This paper describes the data release of the LAMOST pilot survey, which includes data reduction, calibration, spectral analysis, data products and data access. The accuracy of the released data and the information about the FITS headers of spectra are also introduced. The released data set includes 319 000 spectra and a catalog of these objects.

关键词： techniques: spectroscopic survey — data reduction — data release

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他汀类药物对高胆固醇绝经后妇女骨密度的影响

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中华医学杂志 2013年第29期93卷 2309-2311页

作者：赵晨毕擎胡劲涛夏冰应奇峰朱丹杰章水均顾海峰洪剑飞邱斌松陈宇浙江省人民医院骨科杭州 310014 浙江省人民医院骨密度室杭州 310014 浙江中医药大学杭州 310014

目的观察他汀类药物对高胆固醇血症绝经后妇女骨密度（BMD）及骨代谢标志物的影响及其对骨质疏松症（OP）的治疗机制。方法将2011年1月至2012年8月就诊的100例符合入组标准的骨量减少或骨质疏松合并高胆固醇血症的绝经后妇女随机分为两... 详细信息

目的观察他汀类药物对高胆固醇血症绝经后妇女骨密度（BMD）及骨代谢标志物的影响及其对骨质疏松症（OP）的治疗机制。方法将2011年1月至2012年8月就诊的100例符合入组标准的骨量减少或骨质疏松合并高胆固醇血症的绝经后妇女随机分为两组，即对照组和治疗组（服用阿托伐他汀钙10mgqd）。观察两组患者半年、1年后腰椎BMD、骨吸收标志物Ⅰ型胶原交联C-端肽（CTX）、骨合成标志物I型前胶原N-端肽（PINP）的变化情况，并进行组内及组间比较。结果治疗组的腰椎BMD及PINP在半年及1年后均有上升的趋势。治疗组腰椎BMD与对照组相比差异有统计学意义，（0．68±0．14）比（0．74±0．12），（P〈0．05）。治疗组PINP值在1年后明显改善，（38．8±8．9）比（40．2±8．6），（P〈0．05），该差值高于对照组的差值，两者差异也有统计学意义，（38．4±8．6）比（42．1±8．3），（P〈0．05）。结论他汀类药物对维持或增加高胆固醇血症绝经后妇女骨量有一定帮助，它是通过促进骨合成代谢来实现其抗骨质疏松的作用。

关键词：羟甲基戊二酰基CoA还原酶抑制剂骨质疏松,绝经后骨密度

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The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-Li Luo Yong-Heng zhao Gang zhao Li-Cai Deng xiao-Wei Liu Yi-Peng Jing Gang Wang Hao-Tong zhang Jian-Rong Shi xiang-Qun Cui Yao-Quan Chu Guo-Ping Li Zhong-Rui Bai Yue Wu Yan Cai Shu-Yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-Yuan chen Jian-jun chen Kun-Xin chen Li chen Xue-Lei chen xiao-Yan chen Ying chen Norbert Christlieb Jia-Ru Chu chen-Zhou Cui Yi-Qiao Dong bing Du Dong-Wei Fan Lei Feng Jian-Ning Fu Peng Gao Xue-Fei Gong Bo-Zhong Gu Yan-Xin Guo Zhan-Wen Han Bo-Liang He Jin-Liang Hou Yong-Hui Hou Wen Hou Hong-zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Zhi-Ying Huo Lei Jia Fang-Hua Jiang xiang Jiang Zhi-Bo Jiang Ge Jin xiao Kong Xu Kong Ya-Juan Lei Ai-Hua Li Chang-Hua Li Guang-Wei Li Hai-Ning Li Jian Li Qi Li Shuang Li Sha-Sha Li Xin-Nan Li Yan Li Yin-bi Li Ye-Ping Li Yuan Liang Chien-cheng Lin Chao Liu Gen-Rong Liu Guan-Qun Liu Zhi-Gang Liu Wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg Ji-jun Ni zhao-xiang Qi Yong-jun Qi Shi-Yin Shen Huo-Ming Shi Jing song Yi-Han song Ding-Qiang Su Hong-jun Su Zheng-Hong Tang qing-Sheng Tao Yuan Tian dan Wang Da-Qi Wang Feng-Fei Wang Guo-Min Wang Hai Wang Hong-Chi Wang Jian Wang Jia-Ning Wang Jian-Ling Wang Jian-Ping Wang jun-xian Wang Lei Wang Meng-Xin Wang Shou-Guan Wang Shu-qing Wang xia Wang Ya-Nan Wang You Wang Yue-Fei Wang You-Fen Wang Peng Wei Ming-Zhi Wei Hong Wu Ke-Fei Wu Xue-bing Wu Yu-Zhong Wu xiao-Zheng Xing Ling-Zhe Xu Xin-Qi Xu Yan Xu Tai-Sheng Yan De-Hua Yang Hai-Feng Yang Hui-Qin Yang Ming Yang Zheng-qiu Yao Yong Yu Hui Yuan Hai-Bo Yuan Hai-Long Yuan Wei-Min Yuan Chao Zhai En-Peng zhang Hua-Wei zhang Jian-Nan zhang Li-Pin zhang Wei zhang Yong zhang Yan-xia zhang Zheng-Chao zhang Ming zhao Fang Zhou Xu Zhou jie zhu Yong-Tian zhu Si-cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in june 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in june 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

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