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Mex-3 RNA binding family member A(MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2091-2103页

作者： Ri-Xin Chen Shui-Dan Xu Min-hua Deng Shi-Hui Hao Jie-Wei Chen Xiao-Dan Ma Wei-Tao zhuang jing-hua Cao Yong-Rui Lv jin-Long Lin Si-Yu Li Gui-Bin Qiao Dan Xie Feng-Wei Wang Department of Thoracic Surgery Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China Medical Research Institute Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China Department of Pathology Sun Yat-sen University Cancer CenterGuangzhou 510060China

RNA-binding proteins(RBPs)-RNA networks have contributed to cancer *** RNAs(circRNAs)are considered as protein recruiters;nevertheless,the patterns of circRNA-protein interactions in colorectal cancer(CRC)are still *** bodies(PBs)formed through liquid-liquid phase separation(LLPS)are membrane-less organelles(MLOs)consisting of RBPs and *** evidence suggests a connection between PBs dynamics and cancer *** the increasingly acknowledged crucial role of RBPs and RNA in the accumulation and maintenance of MLOs,there remains a lack of specific research on the interactions between PBs-related RBPs and circRNAs in ***,we identify that MEX-3 RNA binding family member A(MEX3A),frequently upregulated in CRC tissues,predicts poorer patient *** MEX3A accelerates malignance and inhibits autophagy of CRC ***,MEX3A undergoes intrinsically disordered regions(IDRs)-dependent LLPS in the ***,circMPP6 acts as a scaffold to facilitate the interaction between MEX3A and PBs *** MEX3A/circMPP6 complex modulates PBs dynamic and promotes UPF-mediated phosphodiesterase 5A(PDE5A)mRNA degradation,consequently leading to the aggressive properties of CRC ***,CRC patients exhibiting high MEX3A expression and low PDE5A expression have the poorest overall *** findings reveal a collaboration between MEX3A and circMPP6 in the regulation of mRNA decay through triggering the PBs aggregation,which provides prognostic markers and/or therapeutic targets for CRC.

关键词： colorectal inhibiting MPP

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基于灰色模型的沥青混合料低温指标预测

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建筑材料学报 2023年第10期26卷 1104-1110页

作者：朱运鼎银花内蒙古大学交通学院内蒙古呼和浩特010070 内蒙古大学桥梁检测与维修加固工程技术研究中心内蒙古呼和浩特010070

为综合考虑沥青低温性能对沥青混合料低温性能的影响,并实现对混合料低温性能的预测,采用弯曲梁流变试验及常规低温试验测定了5种沥青及其混合料的低温评价指标,并与约束试件温度应力试验结果进行了灰色关联分析,建立了分数阶灰色预测模... 详细信息

为综合考虑沥青低温性能对沥青混合料低温性能的影响,并实现对混合料低温性能的预测,采用弯曲梁流变试验及常规低温试验测定了5种沥青及其混合料的低温评价指标,并与约束试件温度应力试验结果进行了灰色关联分析,建立了分数阶灰色预测模型.结果表明:沥青低温连续分级温度、玻璃态转变温度、脆点、不同温度下的蠕变速率和耗散能比对混合料低温性能影响较大;冻断温度和转折点温度FGM(1,4)模型的误差分别为1.83%和3.71%,精度为优,预测结果合理.

关键词：沥青混合料分数阶灰色预测模型低温性能

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Experimental studies on the Danxia landscape morphogenesis in Mt. Danxiashan, South China

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Journal of Geographical Sciences 2015年第8期25卷 943-966页

作者： zhu Cheng WU Li zhu Tongxin HOU Rongfeng HU Zhinong TAN Yan SUN Wei JIA Tianjiao PENG hua School of Geographic and Oceanographic Sciences Nanjing University Nanjing 210023 China College of Territorial Resources and Tourism Anhui Normal University Wuhu 241002 Anhui China Department of Geography University of Minnesota-Duluth MN 55812 USA Administrative Committee of Danxiashan Scenic Spot Shaoguan 512300 Guangdong China Nanjing Hydraulic Research Institute Nanjing 210029 China School of Geography and Planning Sun Yat-Sen University Guangzhou 510275 China

The formation of Danxia landscapes is too slow to be observed in our life time and the paleoclimates in which Danxia landscapes developed are significantly different from the present. Thus, this study adopted experimental approaches to examine the lithological and paleoclimatic control on the formation of various landscape morphologies in the Mt. Danxiashan, South China. A total of 122 rock samples were collected from a range of Danxia landscape morphologies such as white spots, small and large through caves, honeycomb caves, horizontal grooves, natural bridges, stone pillars, and squama stones. Analyses of the collected samples were conducted in different kinds of experiments, including uniaxial mechanical strength testing; rock resistance against sulfuric acid erosion, freezing, and thawing; X-ray fluorescence spectrometry（XRF） analysis; inductively coupled plasma mass spectrometry（ICP-MS） analysis; and identification analysis under a polarizing microscope. The results indicated that the formation of the various Danxia landscape morphologies could result from one or more of the following processes： differential erosion due to lithological difference, chemical dissolution and recrystallization, freezing and thawing actions, acid corrosion, weathering, lateral erosion of river flows, and tectonic uplifts. Water erosion in humid monsoon climate and the alternations of intensive freezing and thawing actions in the Quaternary glacial stages and the interglacial stages could have had great influences on the formation of Danxia landscape topographies.

关键词： experimental studies rock properties Danxia landform paleoclimates China

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Research on Traditional Herbal Medicine Culture of Guangxi Minorities

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Agricultural Biotechnology 2020年第3期9卷 140-145页

作者： Lin KANG Xinlu YU Zhonghua DAI hua zhu The Art Institute of Guangxi University Nanning 530004China Guangxi University of Chinese Medicine Nanning 530200China

Guangxi Zluang Autoromous HRlegiom is a muli-ethnic area with *** groups including Han Zuang,lao,Mliao,Dong,Mlaoma,Hti,,jing,lYi,Siui,Celao,and *** traditional herbal melicime culure of Guangi ethnic minorties is an important comporent of the trxditional medlicine culture system of ethaie minorities in Guangi,andan exremely inportamt part of Chinas ethaic minoity medicine *** etihmic minorities of Gnamgi have acumulated rich experience in disease prevention andl treatment in the long process of prorluctiomn and life,and formed a unique minority medlical culture.

关键词： Guangxi Ethnic minorities Traditional herbal medicine Medical culture

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Potassium dehydroandrographolide succinate regulates the MyD88/CDH13 signaling pathway to enhance vascular injuryinduced pathological vascular remodeling

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Chinese Journal of Natural Medicines 2024年第1期22卷 62-74页

作者： GUO Qiru LI Jiali WANG Zheng WU Xiao jin Zhong zhu Song LI Hongfei ZHANG Delai HU Wangming XU huan YANG Lan SHI Liangqin WANG Yong College of Basic Medicine Chengdu University of Traditional Chinese MedicineChengdu 610000China Chengdu University of Traditional Chinese Medicine Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610000China

Pathological vascular remodeling is a hallmark of various vascular *** research has established the significance of andrographolide in maintaining gastric vascular homeostasis and its pivotal role in modulating endothelial barrier dysfunction,which leads to pathological vascular *** dehydroandrographolide succinate(PDA),a derivative of andrographolide,has been clinically utilized in the treatment of inflammatory diseases precipitated by viral *** study investigates the potential of PDA in regulating pathological vascular *** effect of PDA on vascular remodeling was assessed through the complete ligation of the carotid artery in C57BL/6 *** approaches,including rat aortic primary smooth muscle cell culture,flow cytometry,bromodeoxyuridine(BrdU)incorporation assay,Boyden chamber cell migration assay,spheroid sprouting assay,and Matrigel-based tube formation assay,were employed to evaluate the influence of PDA on the proliferation and motility of smooth muscle cells(SMCs).Molecular docking simulations and co-immunoprecipitation assays were conducted to examine protein *** results revealed that PDA exacerbates vascular injury-induced pathological remodeling,as evidenced by enhanced neointima *** treatment significantly increased the proliferation and migration of *** mechanistic studies disclosed that PDA upregulated myeloid differentiation factor 88(MyD88)expression in SMCs and interacted with T-cadherin(CDH13).This interaction augmented proliferation,migration,and extracellular matrix deposition,culminating in pathological vascular *** findings underscore the critical role of PDA in the regulation of pathological vascular remodeling,mediated through the MyD88/CDH13 signaling pathway.

关键词： Potassium dehydroandrographolide succinate Smooth muscle cell Myeloid differentiation factor 88 T-cadherin Pathological vascular remodeling

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Thioredoxin-Interacting Protein(TXNIP) Regulates Parkin/PINK1-mediated Mitophagy in Dopaminergic Neurons Under High-glucose Conditions: Implications for Molecular Links Between Parkinson’s Disease and Diabetes

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Neuroscience Bulletin 2020年第4期36卷 346-358页

作者： Cun-jin Su zhu Shen Ru-Xiao Cui Ya huang De-Lai Xu Feng-Lun Zhao Jie Pan Ai-Ming Shi Tong Liu Yun-Li Yu Department of Pharmacy The Second Affiliated Hospital of Soochow UniversitySuzhou 215004China Institute of Neuroscience Soochow UniversitySuzhou 215004China Department of Clinical Pharmacology The Second Affiliated Hospital of Soochow UniversitySuzhou 215004China

Patients with diabetes mellitus have a higher risk of developing Parkinson’s disease(PD). However, the molecular links between PD and diabetes remain *** this study, we investigated the roles of thioredoxininteracting protein(TXNIP) in Parkin/PINK1-mediated mitophagy in dopaminergic(DA) cells under high-glucose(HG) conditions. In streptozotocin-induced diabetic mice,TXNIP was upregulated and autophagy was inhibited in the midbrain, while the loss of DA neurons was accelerated by hyperglycemia. In cultured PC12 cells under HG, TXNIP expression was upregulated and the intracellular reactive oxygen species(ROS) levels increased, leading to cell death. Autophagic flux was further blocked and PINK1 expression was decreased under HG conditions. Parkin expression in the mitochondrial fraction and carbonyl cyanide 3-chlorophenylhydrazone(CCCP)-induced co-localization of COX IV(marker for mitochondria) and LAMP1(marker for lysosomes) were also significantly decreased by HG. Overexpression of TXNIP was sufficient to decrease the expression of both PINK1 and Parkin in PC12 cells, while knockdown of the expression of TXNIP by si RNA decreased intracellular ROS and attenuated cellular injury under HG. Moreover, inhibition of TXNIP improved the CCCP-induced co-localization of COX IV and LAMP1 in PC12 cells under HG. Together, these results suggest that TXNIP regulates Parkin/PINK1-mediated mitophagy under HG conditions, and targeting TXNIP may be a promising therapeutic strategy for reducing the risk of PD under hyperglycemic conditions.

关键词： Diabetes mellitus Parkinson’s disease High glucose TXNIP Mitophagy PC12 cells

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Adaptive fuzzy integral sliding mode pressure control for cutter feeding system of trench cutter

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Journal of Central South University 2016年第12期23卷 3302-3311页

作者：田启岩魏建华方锦辉国凯 State Key Laboratory of Fluid Power Transmission and Control Zhejiang University

A nonlinear pressure controller was presented to track desired feeding pressure for the cutter feeding system(CFS) of trench cutter(TC) in the presence of unknown external *** feeding pressure control of CFS is subjected to unknown load characteristics of rock or soil; in addition,the geological condition is *** to the complex load characteristics of rock or soil,the feeding velocity of TC is related to geological *** is worse,its dynamic model is subjected to uncertainties and its function is *** deal with the particular characteristics of CFS,a novel adaptive fuzzy integral sliding mode control(AFISMC) was designed for feeding pressure control of CFS,which combines the robust characteristics of an integral sliding mode controller and the adaptive adjusting characteristics of an adaptive fuzzy *** AFISMC feeding pressure controller is synthesized using the backstepping *** stability of the overall closed-loop system consisting of the adaptive fuzzy inference system,integral sliding mode controller and the cutter feeding system is proved using Lyapunov *** are conducted on a TC test bench with the AFISMC under different operating *** experimental results demonstrate that the proposed AFISMC feeding pressure controller for CFS gives a superior and robust pressure tracking performance with maximum pressure tracking error within ?0.3 MPa.

关键词： electro-hydraulic system cutter feeding system feeding pressure control adaptive fuzzy integral sliding mode control

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The biogenesis and secretion of exosomes and multivesicular bodies(MVBs):Intercellular shuttles and implications in human diseases

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Genes & Diseases 2023年第5期10卷 1894-1907页

作者： Minxue Xu Jie Ji Dandan jin Yue Wu Tong Wu Renjie Lin Shengze zhu Feng Jiang Yifei Ji Baijun Bao Mei Li Weisong Xu Mingbing Xiao Department of Gastroenterology and Research Center of Clinical Medicine Affiliated Hospital and Medical School of Nantong UniversityNantongJiangsu 226001China Third People's Hospital Affiliated to Nantong University NantongJiangsu 226001China Medical School of Nantong University Oral Medcine192 NantongJiangsu 226001China Department of Medical Oncology Affiliated Hospital of Nantong UniversityNantongJiangsu 226001China Department of Gastroenterology Affiliated Nantong Rehabilitation Hospital of Nantong UniversityNantongJiangsu 226001China

Exosomes carry and transmit signaling molecules used for intercellular *** generation and secretion of exosomes is a multistep interlocking process that allows simultaneous control of multiple regulatory *** molecules,mainly RAB GTPases,cytoskeletal proteins and soluble N-ethylmaleimide-sensitive fusion attachment protein receptor(SNARE),are specifically regulated in response to pathological conditions such as altered cellular microenvironment,stimulation by pathogenic factors,or gene *** interferes with the smooth functioning of endocytosis,translocation,degradation,docking and fusion processes,leading to changes in the secretion of *** numbers of secreted exosomes are disseminated by the flow of body fluids and absorbed by the recipient *** transmitting characteristic functional proteins and genetic information produced under disease conditions,exosomes can change the physiological state of the recipient cells and their *** microenvironment,in turn,affects the occurrence and development of ***,this review will discuss the mechanism by which exosome secretion is regulated in cells following the formation of mature secretory multivesicular bodies(MVBs).The overall aim is to find ways to eliminate disease-derived exosomes at their source,thereby providing an important new basis for the clinical treatment of disease.

关键词： Cellular microenvironment Cytoskeleton Exosome secretion RAB GTPase SNARE

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Facile Modification on Buried Interface for Highly Efficient and Stable FASn_(0.5)Pb_(0.5)I_(3) Perovskite Solar Cells with NiOx Hole-Transport layers

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Chinese Journal of Chemistry 2023年第23期41卷 3197-3204页

作者： Hui Zhang Yuan Zhou Tonghui Guo Xiang Zhang Zhenkun zhu Junjun jin Xiaxia Cui Dan Zhang Zhen Wang Lin Li Nai Wang Guanqi Tang Qidong Tai The Institute of Technological Sciences Wuhan UniversityWuhanHubei430072 China Research Institute of Frontier Science Southwest Jiaotong UniversityChengduSichuan610031 China College of Science Henan University of EngineeringZhengzhouHenan451191 China

Formamidinium(FA)-based Sn-Pb perovskite solar cells(FAPb_(0.5)Sn_(0.5)I_(3) PSCs)with ideal bandgap and impressive thermal stability have caught enormous attention ***,it still suffers from the challenge of realizing high efficiency due to the surface imperfections of the transport materials and the energy-level mismatch between functional ***,it is demonstrated that the modification on buried interface with alkali metal salts is a viable strategy to alleviate these *** systematically investigate the role of three alkali metal bromide salts(NaBr,KBr,CsBr)by burying them between the NiOx hole transport layer(HTL)and the perovskite light-absorbing layer,which can effectively passivate interface defects,improve energy-level matching and release the internal residual strain in perovskite *** device with CsBr buffer layer exhibits the best power conversion efficiency(PCE)approaching 20%,which is one of the highest efficiencies for FA-based Sn-Pb PSCs employing NiO_(x) ***,the long-term storage stability of the unencapsulated device is also greatly *** work provides an efficient strategy to prepare desired FA-based ideal-bandgap Sn-Pb PSCs which could be applied in tandem solar cells.

关键词： Tin-lead perovskite solar cell Formamidinium Alkali metal bromide Efficiency Interfacial modification Stability

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Identification of compound heterozygous mutations in the ITGA2B gene in a Chinese patient with Glanzmann thrombasthenia

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Chinese Medical Journal 2010年第11期123卷 1397-1401页

作者： ZHENG Jia-yong jin Yan-hui zhu Yong-lin jin Pei-pei ZHANG De-ting jin Zi-bing Department of Laboratory Medicine Third People's Hospital ofWenzhou Wenzhou Zhejiang 325000 China Wenzhou Third Clinical Institute of Wenzhou Medical College Wenzhou Zhejiang 325200 China Diagnosis Center of Clinical Laboratory First Affiliated Hospitalof Wenzhou Wenzhou Zhejiang 325000 China Department of Clinical Transfusion Ruijin Hospital MedicalCollege of Shanghai Jiao Tong University Shanghai 200025China Eye Ear Nose and Throat Hospital of Fudan University Shanghai200031 China

Background Glanzmann thrombasthenia （GT） is an autosomal recessive bleeding disorder characterized by the tendency to hemorrhage and the inability of platelets to aggregate in response to agonists. GT is caused by a defect of the platelet glycoprotein lib/Ilia complex. The objective of this study was to describe the clinical features and the genetic cause of GT in a 6-year-old girl from south China. Methods A three-generation family was studied. The proband patient aged 6 years and her parents undertook examinations of platelet counts, blood film, bleeding time, platelet aggregation, and flow cytometry. All coding exons of the ITGA2B and ITGB3 genes were amplified by polymerase chain reaction （PCR）, and direct sequencing was performed for mutational screening on the patient and normal controls consisted of 52 healthy blood donors. Reverse transcription PCR was conducted to test for exon skipping. Results The proposita patient showed dispersing platelets, prolonged bleeding time, and severely reduced platelet aggregation in response to the physiological agonists adenosine diphosphate （ADP）, epinephrine, collagen, and ristocetin. Flow cytometric measurements showed that the contents of allb and 133 were significantly decreased. Sequencing results demonstrated two different types of heterozygous mutations existed in the allb gene （c.2930delG and IVS15-1delG）. The compound mutations were also confirmed in the patient＇s mother and father separately. Conclusions The allbβ3 deficiency of the proband was caused by two compound ITGA2B mutations, which were first reported in Chinese GT patients. The IVS15-1delG was first confirmed to cause an exon skipping.

关键词： Glanzmann thrombasthenia integrin alIIbβ mutation, exon skipping hemorrhage

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