The biogenesis and secretion of exosomes and multivesicular bodies(MVBs):Intercellular shuttles and implications in human diseases
作者机构：Department of Gastroenterology and Research Center of Clinical MedicineAffiliated Hospital and Medical School of Nantong UniversityNantongJiangsu 226001China Third People's Hospital Affiliated to Nantong UniversityNantongJiangsu 226001China Medical School of Nantong University Oral Medcine192NantongJiangsu 226001China Department of Medical OncologyAffiliated Hospital of Nantong UniversityNantongJiangsu 226001China Department of GastroenterologyAffiliated Nantong Rehabilitation Hospital of Nantong UniversityNantongJiangsu 226001China
出 版 物：《Genes & Diseases》 (基因与疾病（英文）)
年 卷 期：2023年第10卷第5期
页 面：1894-1907页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by grants from Natural Science Foundation of Jiangsu Province,China(No.BK20211105) the Key Research and Development Plan of Jiangsu Province,China(No.BE2019692) the Health Project of Jiangsu Province,China(No.H2019072) the Social Development Foundation of Nantong City,China(No.MS22020005,JCZ21061,MSZ20076 and JCZ20065) the Postgraduate Research&Practice Innovation Program of Jiangsu Province,China(No.KYCX20_2673,KYCX20_2681 and KYCX21_3112)
主 题：Cellular microenvironment Cytoskeleton Exosome secretion RAB GTPase SNARE
摘 要：Exosomes carry and transmit signaling molecules used for intercellular *** generation and secretion of exosomes is a multistep interlocking process that allows simultaneous control of multiple regulatory *** molecules,mainly RAB GTPases,cytoskeletal proteins and soluble N-ethylmaleimide-sensitive fusion attachment protein receptor(SNARE),are specifically regulated in response to pathological conditions such as altered cellular microenvironment,stimulation by pathogenic factors,or gene *** interferes with the smooth functioning of endocytosis,translocation,degradation,docking and fusion processes,leading to changes in the secretion of *** numbers of secreted exosomes are disseminated by the flow of body fluids and absorbed by the recipient *** transmitting characteristic functional proteins and genetic information produced under disease conditions,exosomes can change the physiological state of the recipient cells and their *** microenvironment,in turn,affects the occurrence and development of ***,this review will discuss the mechanism by which exosome secretion is regulated in cells following the formation of mature secretory multivesicular bodies(MVBs).The overall aim is to find ways to eliminate disease-derived exosomes at their source,thereby providing an important new basis for the clinical treatment of disease.
维普期刊数据库