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Micro or nano:Evaluation of biosafety and biopotency of magnesium metal organic framework-74 with different particle sizes

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Nano Research 2020年第2期13卷 511-526页

作者： zhou zhu Shaokang Jiang Yanhua Liu Xiaomeng Gao Shanshan Hu Xin Zhang Chao Huang Qianbing Wan Jian Wang Xibo Pei State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of ProsthodonticsWest China Hospital of StomatologSichuan UniversityChengdu 610041China College of Chemistry Sichuan UniversityChengdu 610064China

In recent years,various particulate materials have played important roles in medical ***,nano-and micron-sized particles of the same material could exhibit distinct properties due to different particle *** finding provided a simple and effective way to improve the biological applications of particulate ***,as a highly promising member,the effect of the particle size change of the magnesium metal organic framework-74(Mg-MOF74)was well worth *** we firsth assessed the in vitro and in vivo toxicity of micron/nanoscale Mg-MOF74(m-Mg-MOF74/n-Mg-MOF74)in *** in vitro study revealed that compared to micron-sized subjects,n-Mg-MOF74 provided a wider range of safe ***,both micron/nanoscale Mg-MOF74 showed good biocompatibility and allowed all the rats under the treatment to survive through the expected experimental periods,with n-Mg-MOF74 still showing lower *** advantages of nanoscale Mg-MOF74might benefit from its sustainable and balanced release of Ma^2+both inside and outside the *** on the biosafety evaluation,advanced bio-functional assessments of m/n-Mg-MOF74 including early osteogenesis and angiogenesis were ***,the suitable dose groups of n-Mg-MOF74 achieved optimal early osteogenic promotion and angiogenic stimulation ***,our combined data delineated the toxicity and biological behaviors of Ma-MOF74 of different scales,and sugqested nanoscale Mg-MOF74 as a better choice for future *** result revealed that particle size reductior might be a viable strategy to improve and expand medical applications of MOFs or other particulate materials.

关键词： magnesium metal organic framework-74 micron/nanoscale biological applications osteogenesis angiogenesis

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Photodegradation of α-naphthaleneacetic acid in aqueous solution

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Journal of Environmental Sciences 2001年第3期13卷 361-364页

作者： LIU Hui jun, zhou zhu fei, LIU Wei ping (Environmental Science Institute, Zhejiang University, Hangzhou 310027, China. Environmental Science Institute Zhejiang University Hangzhou 310027 China.

Kinetic processes of a-naphthaleneacetic acid (NAA) photolysis were studied under different conditions. The results showed that the ultraviolet light was more effective than fluorescent light in promoting degradation, and the degradation of NAA under ultraviolet light followed the first order kinetics with the photolysis rate constant of 1.15 x 10-2 min-1 and half-life time (t1/2) of 60 min. Further, it was proved that the photolysis rate was higher in the presence of oxygen, titanium dioxide (TiO2), and low pH (acidic solution). At last, two photolysis intermediates were identified by GC-MS and possible photolysis pathways were proposed.

关键词： Acids Degradation Fluorescence Photolysis Solutions

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Case Reports:Anesthetic management of emergent critical tracheal stenosis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第7期8卷 522-525页

作者： zhou Yang-feng zhu Shao-jun zhu Sheng-mei AN Xiao-xia Department of Anesthesiology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Two case reports of emergent anesthesia of critical tracheal stenosis are presented. The use of extracorporeal circu-lation may be a lifesaving method for these patients. Two patients both with severe lower tracheal stenosis were admitted with severe inspiratory dyspnea. The first patient had a tracheal tube inserted above the stenosis in the operating room, but ventilation was unsatisfactory, high airway pressure and severe hypercarbia developed, therefore extracorporeal circulation was immediately initiated. For the second patient, we established femoral-femoral cardiopulmonary bypass prior to induction of anaesthesia, and intubated above the tracheal tumor orally under general anesthesia, then adjusted the endotracheal tube to appropriate depth after the tumor had been resected. The patient was gradually weaned from cardiopulmonary bypass. The two patients all recovered very well after surgery. Surgery is lifesaving for patients with critical tracheal stenosis, but how to ensure effective gas exchange is crucial to the anesthetic management. Extracorporeal circulation by the femoral artery and femoral vein cannulation can gain good gas exchange even if the trachea is totally obstructed. Therefore, before the induction of anesthesia, we should assess the site and degree of obstruction carefully and set up cardiopulmonary bypass to avoid exposing the patient to unexpected risks and the anesthesiologist to unexpected challenges.

关键词： Tracheal stenosis Extracorporeal circulation Anesthesia

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基于ODER的节能无线传感器网络覆盖控制

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东南大学学报（自然科学版） 2011年第B09期41卷 139-143页

作者：朱洲朱美琳南京大学工程管理学院南京210093

针对无线传感器网络(WSN)覆盖协议设计中的网络存在冗余节点以及在能耗、计算方面复杂程度较高等的问题,将分组思想引入到节能覆盖研究中,在ODER覆盖协议的基础上,提出一种权衡网络覆盖率和计算能耗的折中方案EB-ODER.利用HEED思想对传... 详细信息

针对无线传感器网络(WSN)覆盖协议设计中的网络存在冗余节点以及在能耗、计算方面复杂程度较高等的问题,将分组思想引入到节能覆盖研究中,在ODER覆盖协议的基础上,提出一种权衡网络覆盖率和计算能耗的折中方案EB-ODER.利用HEED思想对传感器节点进行预处理,选取能量以及位置较优的节点进行覆盖节点的竞争,解决了ODER中冗余覆盖率过大,能耗不均匀等问题.仿真实验结果表明,该方案不仅可以达到了95%以上的覆盖率,工作节点的数量大为减少,网络的寿命更可提高3倍以上,可长时间地保证网络的完整性.

关键词：无线传感器网络覆盖控制休眠调度能耗均匀分簇

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Janus微/纳米颗粒在生物医学中的应用

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中国组织工程研究 2025年第28期29卷 6101-6109页

作者：陈森林朱舟万乾炳四川大学华西口腔医院修复科口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川省成都市610041

背景:Janus微/纳米颗粒因具有形状、结构、功能各向异性被广泛应用于组织工程、药物递送、癌症治疗、生物影像和传感等医学领域。目的:阐述Janus微/纳米颗粒在生物医学的前沿应用。方法:通过计算机检索中国知网、万方、PubMed、Web of S... 详细信息

背景:Janus微/纳米颗粒因具有形状、结构、功能各向异性被广泛应用于组织工程、药物递送、癌症治疗、生物影像和传感等医学领域。目的:阐述Janus微/纳米颗粒在生物医学的前沿应用。方法:通过计算机检索中国知网、万方、PubMed、Web of Science数据库中2010-2024年发表的相关文献,分别以“Janus纳米颗粒,Janus颗粒,双面神颗粒,药物递送,癌症治疗,生物影像,生物传感,组织工程”和“Janus nanoparticle,Janus particle,Drug delivery,Cancer therapy,Biosensing,Bioimaging,Tissue engineering”为中、英文检索词,进行筛选、整理、归纳、总结,最终纳入69篇文献进行综述。结果与结论:Janus微/纳米颗粒可根据基础材料性质分为有机、无机、有机-无机复合三大类,其合成策略有遮蔽、自组装、相分离、微流控和成核生长等。Janus微/纳米颗粒可通过高负载率、门控释放、自主运动等特性进行高效率药物递送。Janus微/纳米颗粒除了增强传统癌症治疗措施(放化疗)的治疗效果外,还可以应用于细胞免疫、蛋白药物、细胞铁死亡等新兴癌症治疗方法;可应用于增强生物影像(CT、MRI、超声)的增敏剂,实现高质量成像,用于指导诊断和治疗;可通过运载生长因子、增强生物支架机械性能和抗菌效果,应用于组织工程。综合目前的研究,研究者们通过集合不同有机聚合物、无机材料的物化特性以不同的合成策略合成功能定制的Janus微/纳米颗粒,应用于复杂的生物医学领域。目前Janus微/纳米颗粒应用于组织再生领域、大规模生产和人体临床试验的报道较少,因此该类材料的开发、合成策略、临床安全评估和转化仍需投入更大的研究力度。

关键词： Janus微/纳米颗粒组织工程药物运输癌症治疗生物影像生物传感工程化材料

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Progress in application of CFD techniques

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Science China(Technological Sciences) 2008年第7期51卷 827-841页

作者： CHEN ZuoBin JIANG Xiong zhou zhu XIAO HanShan HUANG Yong MOU Bin XIAO ZhongYun LIU Gang WANG YunTao Computational Aerodynamics Institute China Aerodynamics Research and Development Center(CARDC)Mianyang 621000China

Computational Fluid Dynamics (CFD) is an important branch of fluid mechanics, and will continue to play great roles on the design of aerospace vehicles, explora- tion of new concept vehicles and new aerodynamic technology. This paper will present the progress of CFD from point of view of engineering application in recent years at CARDC, including the software integration, grid technique, speeding up of convergence, unsteady fluid computation,etc., and also give some engineering application examples of CFD at CARDC.

关键词： computational fluid dynamics aircraft unsteady flow

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Efficient activation of peroxymonosulfate for catalytic degradation of organic pollutants by simultaneously using low-level cobalt ions and calcium carbonate micro-particles

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Journal of Environmental Sciences 2025年第5期151卷 113-124页

作者： Yu zhou Xiaobo Wang Nan Wang Shuangshuang Huang Lihua zhu College of Chemistry and Chemical Engineering Huazhong University of Science and TechnologyWuhan 430074China College of Chemistry and Chemical Engineering Hubei Polytechnic UniversityHuangshi 435003China College of Chemistry and Environmental Engineering Wuhan Polytechnic UniversityWuhan 430023China School of Physics and Technology Center for Electron MicroscopyWuhan UniversityWuhan 430072China

An efficient catalytic system was developed to remove various organic pollutants by simultaneously using low-level cobalt ions,calcium carbonate micro-particles and peroxymonosulfate(PMS).A simple base-induced precipitation was used to successfully loaded Co-centered reactive sites onto the surface of CaCO_(3)*** optimal conditions at 25°C,10 mg/L methylene blue(MB)could be completely degraded within 10 min with 480μg/L Co^(2+),0.4 g/L CaCO_(3)microparticles(or 0.4 g/L Co@CaCO_(3))and 0.1 g/L *** MB degradation followed the pseudo first order kinetics with a rate constant of 0.583 min^(−1),being 8.3,11.5 and 53.0 times that by using Co-OH(0.07 min^(−1)),Co^(2+)(0.044 min^(−1))and CaCO_(3)(0.011 min^(−1))as the catalyst,*** was confirmed that there was a synergistic effect in the catalytic activity between Co species and the CaCO_(3)particles but the major contributor was the highly dispersed Co *** Co^(2+)-containing simulated electroplating wastewater was used as the Co^(2+)source,not only the added MB was also completely degraded within 5 min in this catalytic system,but also the coexisting heavy metal ions were substantially *** presently developed method was applied to simultaneously treat organic wastewater and heavy metals *** present method was also successfully used to efficiently degrade other organic pollutants including bisphenol A,sulfamethoxazole,rhodamine B,tetrabromobisphenol A,ofloxacin and benzoic acid.A catalytic mechanism was proposed for the PMS activation by Co@CaCO_(3).The surface of CaCO_(3)particles favors the adsorption of Co^(2+).More importantly,the surface of CaCO_(3)particles provides plentiful surface-OH and-CO_(3)^(2+),and these surface groups complex with Co^(2+)to producemore catalytically active species such as surface[CoOH]^(−),resulting in rapid Co^(2+)/Co^(3+)cycling and electron *** interactions cause the observed synergistic effect between Co species and Ca

关键词： CaCO3 Low-level cobalt Peroxymonosulfate Oxidative degradation

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Sialic acid-binding immunoglobulin-like lectin 9 as a potential therapeutic target for chronic obstructive pulmonary disease

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Chinese Medical Journal 2021年第7期134卷 757-764页

作者： Zi Chen Shuang-Lan Xu Lin-Yang Ge Jin zhu Tao Zheng zhou zhu Linfu zhou Department of Respiratory and Critical Care Medicine The First Affiliated HospitalNanjing Medical UniversityNanjingJiangsu 210029China Epidemiological Department Huadong Medical Institute of BiotechniquesNanjingJiangsu 210002China Department of Pediatrics and Department of Molecular Microbiology and Immunology Brown University Warren Alpert Medical SchoolProvidenceRI 02912USA.

Chronic obstructive pulmonary disease(COPD)has become the third-leading cause of death worldwide,which is a severe economic burden to the healthcare *** bronchitis is the most common condition that contributes to COPD,both locally and *** inflammation predominates in the COPD airway wall and ***,repression of neutrophilia is an essential fashion to COPD ***,currently available anti-neutrophilic therapies provide little benefit in COPD patients and may have serious side ***,there is an urgent need to explore an effective and safe anti-neutrophilic approach that might delay progression of the *** acid-binding immunoglobulin-like lectin(Siglec)-9 is a member of the Siglec cell surface immunoglobulin *** is noteworthy that Siglec-9 is highly expressed on human neutrophils and *** of Siglec-9 by chemical compounds or synthetic ligands induced apoptosis and autophagic-like cell death in human ***,administration of antibody to Siglec-E,mouse functional ortholog of Siglec-9,restrained recruitment and activation of neutrophils in mouse models of airway inflammation in *** the critical role that neutrophils play in chronic bronchitis and emphysema,targeting Siglec-9 could be beneficial for the treatment of COPD,asthma,fibrosis,and related chronic inflammatory lung diseases.

关键词： Sialic acid-binding immunoglobulin-like lectin-9(Siglec-9) Siglec-E Neutrophils Chronic obstructive pulmonary disease

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EVALUATION OF CIRRHOTIC LIVER WITH PERFUSION-WEIGHTED MAGNETIC RESONANCE IMAGING:A PRELIMINARY EXPERIMENTAL STUDY IN ANIMAL MODELS WITH HALF-LIVER CIRRHOSIS

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Chinese Medical Sciences Journal 2006年第4期21卷 252-257页

作者： Zheng-han Yang Xiao-hua Ye Ye Tan Min Zhang Ming-zhu zhou Jing-xia Xie Min Chen Cheng zhou Department of Radiology Beijing Hospital ＆ the Fifth Clinical Medical School of Peking University Beijing 100730 Department of Radiology the Third Hospital of Peking University Beijing 100083

Objective To investigate the role of peffusion-weighted magnetic resonance imaging （MRI） in evaluation of cirrhotic fiver. Methods With a 4F catheter, 1% diluted carbon tetrachloride （ 1 ml/kg） was selectively injected into fight or left hepatic artery of 12 dogs fortnightly. The half fiver into which carbon tetrachloride was injected was called as study side （SS）, while the other half fiver without carbon tetrachloride injection was called as study control side （SCS）. Conventional and peffusion-weighted MRI were performed in every 4 weeks. Via a 4F catheter, 5ml gadolinium diethylentriamine pentaaceti acid （Gd-DTPA） dilution was injected into superior mesenteric artery at the 5th scan. The signal intensity-thne curves of SS, SCS, and portal vein were completed in MR workstation. The maximal relative signal increase （ MRSI）, peak time （ tp）, and slope of the curves were measured. Results On conventional MR images, no abnormalities of externality and signal intensity were observed in both SS and SCS of fiver at each stage. The mean tp, MP, SI, and slope of intensity-time curves in normal fiver were 10. 56 seconds, 1.01, and 10. 23 arbitrary unit （au）/s, respectively. Three parameters of curves didn＇t show obvious change in SCS of fiver at every stage. Abnormal perfusion curves occurred in SS of fiver at the 12th week after the 1st injection. The abnormality of perfusion curve in SS was more and more serious as the times of injection increased. The mean tp, IVlRSI, and slope intensity-time curves in SS of fiver were 19.45 seconds, 0. 43, and 3. 60 au/s respectively at the 24th week. Conclusion Perfusion-weighted imaging can potentially provide information about portal peffusion of hepatic parenchyma, and to some degree, reflect the severity of cirrhosis.

关键词： liver cirrhosis animal model magnetic resonance imaging perfusion imaging

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Radiomics of rectal cancer for predicting distant metastasis and overall survival

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World Journal of Gastroenterology 2020年第33期26卷 5008-5021页

作者： Mou Li Yu-zhou zhu Yong-Chang Zhang Yu-Feng Yue Hao-Peng Yu Bin Song Department of Radiology West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Gastrointestinal Surgery West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Radiology Chengdu Seventh People’s HospitalChengdu 610213Sichuan ProvinceChina

BACKGROUND Rectal cancer(RC)patient stratification by different factors may yield variable ***,more efficient prognostic biomarkers are needed for improved risk stratification,personalized treatment,and prognostication of RC *** To build a novel model for predicting the presence of distant metastases and 3-year overall survival(OS)in RC *** This was a retrospective analysis of 148 patients(76 males and 72 females)with RC treated with curative resection,without neoadjuvant or postoperative chemoradiotherapy,between October 2012 and December *** patients were allocated to a training or validation set,with a ratio of 7:*** features were extracted from portal venous phase computed tomography(CT)images of *** least absolute shrinkage and selection operator regression analysis was used for feature *** logistic regression analysis was used to develop the radiomics signature(Rad-score)and the clinicoradiologic risk model(the combined model).Receiver operating characteristic curves were constructed to evaluate the diagnostic performance of the models for predicting distant metastasis of *** association of the combined model with 3-year OS was investigated by Kaplan-Meier survival *** A total of 51(34.5%)patients had distant metastases,while 26(17.6%)patients died,and 122(82.4%)patients lived at least 3 years *** values of both the Rad-score(consisted of three selected features)and the combined model were significantly different between the distant metastasis group and the nonmetastasis group(0.46±0.21 vs 0.32±0.24 for the Rad-score,and 0.60±0.23 vs 0.28±0.26 for the combined model;P<0.001 for both models).Predictors contained in the combined model included the Rad-score,pathological N-stage,and *** addition of histologic grade to the model failed to show incremental prognostic *** combined model showed good discrimination,with areas under the curve of 0.842 and

关键词： Radiomics Rectal cancer Overall survival Distant metastasis Computed tomography

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