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Molecular dynamics simulations for the growth of CH_4-CO_2 mixed hydrate

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Journal of Energy Chemistry 2014年第6期23卷 747-754页

作者： Lizhi Yi Deqing Liang xuebing zhou Dongliang Li Key Laboratory of Renewable Energy and Gas Hydrate Guangzhou Institute of Energy Conversion Chinese Academy of Sciences Guangzhou Center for Gas Hydrate Research Guangzhou Institute of Energy Conversion Chinese Academy of Sciences University of Chinese Academy of Sciences

Molecular dynamics simulations are performed to study the growth mechanism of CH4-CO2 mixed hydrate in xco2 = 75%, xco2 = 50%, and zco2 = 25% systems at T = 250 K, 255 K and 260 K, respectively. Our simulation results show that the growth rate of CH4-CO2 mixed hydrate increases as the CO2 concentration in the initial solution phase increases and the temperature decreases. Via hydrate formation, the composition of CO2 in hydrate phase is higher than that in initial solution phase and the encaging capacity of CO2 in hydrates increases with the decrease in temperature. By analysis of the cage occupancy ratio of CH4 molecules and CO2 molecules in large cages to small cages, we find that CO2 molecules are preferably encaged into the large cages of the hydrate crystal as compared with CH4 molecules. Interestingly, CH4 molecules and CO2 molecules frequently replace with each other in some particular cage sites adjacent to hydrate/solution interface during the crystal growth process. These two species of guest molecules eventually act to stabilize the newly formed hydrates, with CO2 molecules occupying large cages and CH4 molecules occupying small cages in hydrate.

关键词： molecular dynamics simulations methane-carbon dioxide mixed hydrate growth clathrate

基于新工科和美育教育视域的家具设计与工程专业实践教学模式探索——以西南林业大学为例

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创新创业理论研究与实践 2024年第5期7卷 20-22,41页

作者：苏艳炜毛世华周雪冰沈华杰强明礼西南林业大学云南昆明650224 福建理工大学福建福州350118

家具设计与工程专业属多学科交叉专业,兼具科学与艺术的双重属性,契合国家新工科和美育教育的要求。实践教学是人才培养的重要环节,该文以西南林业大学为例,在“三全育人”的引领下,通过挖掘实践教学中蕴含的思政元素和美育资源,利用实... 详细信息

家具设计与工程专业属多学科交叉专业,兼具科学与艺术的双重属性,契合国家新工科和美育教育的要求。实践教学是人才培养的重要环节,该文以西南林业大学为例,在“三全育人”的引领下,通过挖掘实践教学中蕴含的思政元素和美育资源,利用实践教学的全过程,从建构课程体系、优化教学内容、创新教学模式、开展学科竞赛、搭建实践教学平台等方面探索人才培养的新范式,构建“育德+育美+育人”相结合的实践教学体系,为培养多学科复合型设计创新人才奠定基础,达到培养多元化实践型人才的目标。

关键词：实践教学新工科美育教育家具设计与工程创新人才培养课程体系

Crowberry(Empetrum nigrum var. japonicum) inhibits cell proliferation and migration by targeting DEK via the Akt signaling pathway in cholangiocarcinoma cells

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Crowberry(Empetrum nigrum var. japonicum) inhibits cell prol...

Periodontitis exacerbates pulmonary hypertension by promoting IFNγ^(+)T cell infiltration in mice

2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青年科学家论坛

作者： xuebing zhou Xue Wang Ludan Zhang Renbo An Xiangshan Ren YANBIAN University

Background: Cholangiocarcinoma(CCA) is a rare biliary adenocarcinoma related with poor clinical prognosis. Crowberry is used as herbal medicine to control inflammatory diseases and repair cellular antioxidant enzyme activity. Although crowberry has shown significant therapeutic efficacy about the treatment of various tumors and diseases, its anti-cancer results and specific molecular mechanisms in CCA remain poorly *** of the study: The main purpose of this study is to survey the effects of crowberry on the biological behavior of CCA *** and Methods: Chemical profiles of the extract were qualitatively analyzed using highperformance liquid chromatography(HPLC) and HPLC--tandem mass spectrometry. MTT method,colony formation assay and EdU assay were used to measure cell proliferation. The effect of crowberry on CCA cell migration was assessed by wound healing method and migration ***, hochest assays and flow cytometry were used to assessed the cell apoptosis. Western blotting was used to assess the protein expression levels of key factors associated with apoptosis, the Akt signaling pathway, and epithelial-mesenchymal transition. Xenograft model,immunohistochemistry staining and H&E staining were used to assessed the effect of crowberry in ***: Crowberry clearly inhibited the proliferation and migration of CCA cells in a dose-dependent manner and induced apoptosis. Furthermore, crowberry targeted the PI3 K/Akt signaling pathway by obviously altering the expression levels/activation of several key mediators and reducing the expression of the proto-oncogene DEK in vivo and ***: Crowberry inhibits the proliferation and migration of CCA cells by downregulating DEK through the Akt signaling pathway.

关键词： Cholangiocarcinoma Empetrum nigrum var japonicum Proliferation Migration DEK

来源： cnki会议评论

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International Journal of Oral Science 2024年第2期16卷 359-369页

作者： Xiaoqian Meng Linjuan Du Shuo Xu Lujun zhou Boyan Chen Yulin Li Chumao Chen Huilin Ye Jun Zhang Guocai Tian xuebing Bai Ting Dong Wenzhen Lin Mengjun Sun Kecong zhou Yan Liu Wuchang Zhang Shengzhong Duan Department of Endodontics Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghaiChina Laboratory of Oral Microbiota and Systemic Diseases Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghaiChina Hongqiao International Institute of Medicine Shanghai Tongren Hospital/Faculty of Basic MedicineKey Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of EducationShanghai Jiao Tong University School of MedicineShanghaiChina Department of Orthodontics Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghaiChina Department of Periodontology Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghaiChina Stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhouChina

Uncovering the risk factors of pulmonary hypertension and its mechanisms is crucial for the prevention and treatment of the *** the current study,we showed that experimental periodontitis,which was established by ligation of molars followed by orally smearing subgingival plaques from patients with periodontitis,exacerbated hypoxia-induced pulmonary hypertension in ***,periodontitis dysregulated the pulmonary microbiota by promoting ectopic colonization and enrichment of oral bacteria in the lungs,contributing to pulmonary infiltration of interferon gamma positive(IFNγ^(+))T cells and aggravating the progression of pulmonary *** addition,we identified Prevotella zoogleoformans as the critical periodontitis-associated bacterium driving the exacerbation of pulmonary hypertension by periodontitis,and the exacerbation was potently ameliorated by both cervical lymph node excision and IFNγneutralizing *** study suggests a proof of concept that the combined prevention and treatment of periodontitis and pulmonary hypertension are necessary.

关键词： hypertension prevention interferon

X射线衍射分析聚乙烯吡咯烷酮对水合物分解过程的影响

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化工学报 2021年第2期72卷 1125-1131页

作者：唐翠萍周雪冰梁德青中国科学院广州能源研究所广东广州510640 中国科学院天然气水合物重点实验室广东广州510640 广东省新能源和可再生能源研究开发与应用重点实验室广东广州510640 中国科学院广州天然气水合物研究中心广东广州510640 天然气水合物国家重点实验室北京100028

深水油气资源的勘探开发以及开采过程中的环保要求,使得天然气水合物动力学抑制剂使用不可避免,含动力学抑制剂的分解研究对水合物生成后的解堵具有重要的指导意义。本文在高压反应釜内采用甲烷和丙烷混合气,合成天然气水合物,并用X射... 详细信息

深水油气资源的勘探开发以及开采过程中的环保要求,使得天然气水合物动力学抑制剂使用不可避免,含动力学抑制剂的分解研究对水合物生成后的解堵具有重要的指导意义。本文在高压反应釜内采用甲烷和丙烷混合气,合成天然气水合物,并用X射线粉晶衍射仪分析了含动力学抑制剂聚乙烯吡咯烷酮的水合物分解过程。结果显示甲烷和丙烷气体会形成SⅡ型水合物,但伴随有SⅠ型甲烷水合物的生成;添加动力学抑制剂后,水合物的分解速率变慢,在-60℃,添加0.5%的聚乙烯吡咯烷酮后,分解起始的20 min内,无抑制剂体系水合物分解可达69%,而在含抑制剂体系分解约18%;SⅡ型甲烷丙烷混合气水合物分解过程中晶胞各晶面分解速率相同,没有偏好性,水合物笼作为一个整体分解,添加抑制剂不改变这种分解方式,仍以整体分解。

关键词：天然气水合物动力学抑制剂分解 X射线衍射晶体结构

Study on the effects of thrombin on AQP4 mRNA and AQP4 protein expression in rat primary astrocytes

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Journal of Nanjing Medical University 2006年第4期20卷 220-224页

作者： Jinghua zhou xuebing Cao Shenggang Sun Department of Neurology Union Hospital Tongii Medical College Huazhong University of Science and Technology Wuhan 430022 China

Objective： To study the biologic effects of various concentrations of thrombin on aquaporin 4 （AQP4） expression in rat primary cultured astrocytes, and to explore the regulation mechanism of transmembrane water transportation in astrocytes after intracerebral hemorrhage （ICH）. Methods： Primary cultured astrocytes were incubated in culture mediums containing various concentrations of thrombin for 24 h and harvested. AQP4 mRNA and AQP4 protein expression were determined by reverse transcription polymerase chain reaction （RT-PCR） and immunohistochemical technique. Cell apoptosis was detected by TdT- mediated dUTP nick end labeling （TUNEL） technique. Cell morphology was observed by phase contrast microscope, and cell viability was assayed by MTT. Results： AQP4 mRNA and AQP4 protein showed a low expression in normal astrocytes. The expression of AQP4 mRNA and AQP4 protein significantly increased in the astrocytes treated with 100 U/ml or 200 U/ml thrombin （P 〈 0.01 ）,and these astrocytes swelled. The number of TUNEL positive cells significantly increased. On the other hand, AQP4 mRNA and AQP4 protein expression were downegulated in the astrocytes treated with 0.5 U/ml or 1 U/ml thrombin （P 〈 0.05）, and the cell morphology did not change. Few TUNEL positive cells were observed. Conclusion： AQP4 overxpression induced by high concentrations of thrombin causes an increased permeability of water in astrocytic membrane. On the contrary, the decreased AQP4 expression prevents the astrocytes from swelling and apoptosis.

关键词： thrombin astrocytes aquaporin-4 apoptosis

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甲烷水合物分解过程的微尺度测量

化工学报 2019年第3期70卷 1042-1047页

作者：周雪冰刘婵娟罗金琼梁德青中国科学院广州能源研究所广东广州510640 中国科学院天然气水合物重点实验室广东广州510640 广东省新能源和可再生能源研究开发与应用重点实验室广东广州510640 中国科学院广州天然气水合物中心广东广州510640

实验采用激光拉曼和X射线粉末衍射(PXRD)在253 K,常压条件下对甲烷水合物的分解过程分别进行了原位测量。研究发现,位于表层的甲烷水合物在前30～50 min内发生分解并生成Ⅰh冰相,随后表层冰相对内层水合物相的包覆引起了"自保护"效应的... 详细信息

实验采用激光拉曼和X射线粉末衍射(PXRD)在253 K,常压条件下对甲烷水合物的分解过程分别进行了原位测量。研究发现,位于表层的甲烷水合物在前30～50 min内发生分解并生成Ⅰh冰相,随后表层冰相对内层水合物相的包覆引起了"自保护"效应的产生并导致甲烷水合物分解速率显著降低。分解过程中,甲烷在水合物大小笼中的含量之比始终保持在3.2左右,同时水合物晶面特征峰峰面积也按照相同的曲线下降,表明甲烷水合物以晶胞为单位进行整体分解。Ⅰh冰的各个晶面特征峰峰面积差异化的增长曲线表明形成的Ⅰh冰相倾向于片状生长,有助于在水合物表面生成一层冰膜,进而产生"自保护"效应。

关键词：甲烷水合物动力学微尺度

基于smobiler的工商企业信息采集系统的设计与实现

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信息与电脑 2021年第19期33卷 184-186页

作者：周学兵江苏财经职业技术学院江苏淮安223003

工商企业基本信息的采集是工商企业行政管理部门开展一切监管工作的基础。因此,提高工商企业信息采集工作的真实性、便捷性显得尤为重要。随着移动网络技术的发展以及移动开发技术的成熟,使得基于smobiler技术开发移动端采集工商企业信... 详细信息

工商企业基本信息的采集是工商企业行政管理部门开展一切监管工作的基础。因此,提高工商企业信息采集工作的真实性、便捷性显得尤为重要。随着移动网络技术的发展以及移动开发技术的成熟,使得基于smobiler技术开发移动端采集工商企业信息成为现实。本文利用工商企业行政管理部门的服务器实现数据的存储,利用移动网络实现数据的传输,还利用移动端APP实现对工商企业信息的采集录入,真正实现管理部门对企业的高效监管。

关键词： smobiler 工商企业管理系统

水合物法模拟海底封存CO_(2)气体的实验

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化工进展 2021年第6期40卷 3489-3498页

作者：姚远欣周雪冰李栋梁梁德青中国科学院广州能源研究所广东广州510640 中国科学院天然气水合物重点实验室广东广州510640 广东省新能源和可再生能源研究开发与应用重点实验室广东广州510640 中国科学院广州天然气水合物中心广东广州510640 天然气水合物国家重点实验室北京100028 中国科学院大学北京100049

向海底地层和枯竭油气藏中注入CO_(2)气体形成稳定的CO_(2)水合物是一种极具前景的CO_(2)封存技术。为了进一步探究这一技术,本文利用水合物法进行了多组3MPa、5℃天然湿砂的CO_(2)封存实验模拟。初始水饱和度设置为10%、40%、70%,分别... 详细信息

向海底地层和枯竭油气藏中注入CO_(2)气体形成稳定的CO_(2)水合物是一种极具前景的CO_(2)封存技术。为了进一步探究这一技术,本文利用水合物法进行了多组3MPa、5℃天然湿砂的CO_(2)封存实验模拟。初始水饱和度设置为10%、40%、70%,分别进行了纯水封存实验和3.5%(质量分数)NaCl溶液的封存实验,还利用自主研发的反应釜系统探索了3种不同进气方向(顶部进气、横置进气、底部进气)下的CO_(2)封存效果。结果发现横置进气的封存量普遍大于顶部进气的封存量,底部进气的封存量最小,而且横置进气的封存速度最快;初始水饱和度越高,水合物饱和度就越高,但水合物转化率越低,CO_(2)固态封存比例也越低;与纯水实验相比,盐的存在降低了CO_(2)的封存量,固态封存比例也会低于纯水实验,但封存速度更快。本文为实际工程操作时合理控制封存地层水饱和度、盐度以及合适的进气方向提供了依据。

关键词：二氧化碳水合物海洋封存沉积物反应动力学