检索结果-南通市图书馆

Elevated Kallistatin promotes the occurrence and progression of non-alcoholic fatty liver disease

Signal Transduction and Targeted Therapy 2024年第4期9卷 1730-1744页

作者： Zhenzhen Fang Gang Shen Yina Wang Fuyan Hong Xiumei Tang Yongcheng Zeng ting Zhang Huanyi Liu Yanmei Li Jinhong Wang Jing Zhang Anton Gao Weiwei Qi Xia Yang ti zhou Guoquan Gao Department of Biochemistry Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 510080China Department of VIP Medical Center the Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Physical Examination Center the Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Department of Clinical Laboratory Guangzhou First People's HospitalGuangzhou 510080China Guangdong Key Laboratory of Liver Disease Research the Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 51008China Department of Health Sciences College of Health SolutionsArizona State UniversityTempeUSA Guangdong Engineering&Technology Research Center for Gene Manipulation and Biomacromolecular Products Sun Yat-Sen UniversityGuangzhou 510080China Guangdong Province Key Laboratory of Diabetology Guangzhou 510o80China Guangdong Province Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 510080China

Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide,and the development of nonalcoholic steatohepatitis(NASH)might cause irreversible hepatic ***(HLP)is the leading risk factor for *** study aims to illuminate the causative contributor and potential mechanism of Kallistatin(KAL)mediating HLP to NAFLD.221 healthy control and 253 HLP subjects,62 healthy control and 44 NAFLD subjects were *** plasma KAL was significantly elevated in HLP subjects,especially in hypertriglyceridemia(HTG)subjects,and positively correlated with liver ***,KAL levels of NAFLD patients were significantly *** transgenic mice induced hepatic steatosis,inflammation,and fibrosis with time and accelerated inflammation development in high-fat diet(HFD)*** contrast,KAL knockout ameliorated steatosis and inflammation in high-fructose diet(HFruD)and methionine and choline-deficient(MCD)diet-induced NAFLD ***,KAL induced hepatic steatosis and NASH by down-regulating adipose triglyceride lipase(ATGL)and comparative gene identification 58(CGl-58)by LRP6/Gas/PKA/GSK3βpathway through down-regulating peroxisome proliferator-activated receptor(PPARy)and up-regulating kruppel-like factor four(KLF4),***-58 is bound to NF-kB p65 in the cytoplasm,and diminishing CGl-58 facilitated p65 nuclear translocation and TNFa ***,hepatic CGl-58-overexpress reverses NASH in KAL transgenic ***,free fatty acids up-regulated KAL against thyroid hormone in ***,Fenofibrate,one triglyceride-lowering drug,could reverse hepatic steatosis by down-regulating *** results demonstrate that elevated KAL plays a crucial role in the development of HLP to NAFLD and may be served as a potential preventive and therapeutic target.

关键词： GSK3β inflammation elevated

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

高阶矩风险与市场收益:来自中国期权市场的证据

引用

管理科学学报 2024年第5期27卷 122-140页

作者：周倜王云奇南方科技大学商学院金融系深圳518055 深圳证券交易所博士后工作站深圳518038

基于上证50ETF期权隐含的方差和高阶矩的期限结构,本研究使用偏最小二乘回归的降维方法构造了与中国股票市场收益相关的方差-高阶矩风险因子.实证结果显示,在2015年到2020年的样本期内,该风险因子显著地预测未来1个月以及2周至8周的市... 详细信息

基于上证50ETF期权隐含的方差和高阶矩的期限结构,本研究使用偏最小二乘回归的降维方法构造了与中国股票市场收益相关的方差-高阶矩风险因子.实证结果显示,在2015年到2020年的样本期内,该风险因子显著地预测未来1个月以及2周至8周的市场收益,月度样本内和样本外R^(2)分别达到了10.08%和6.55%.在控制了常见的经济预测变量和期权变量后,该因子的预测能力仍然保持显著.这表明我国股市收益中包含了对偏度和峰度风险的补偿,与含时变高阶矩的资产定价模型相一致.在经济价值方面,方差-高阶矩因子的预测能力可为投资者在市场择时交易中带来可观的收益.结果表明,中国期权市场提供了高阶矩风险的独特信息,这为理解我国股市风险与收益的权衡关系提供了新的角度.

关键词：上证50ETF期权风险中性高阶矩股票收益率可预测性偏最小二乘回归时变高阶矩CAPM

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ultra-Thin Layer HTaMoO6 Catalyst for the Upgrading of Carbohydrates into 5-Hydroxymethylfurfural

Ultra-Thin Layer HTaMoO6 Catalyst for the Upgrading of Carbo...

引用

第4届分子科学博士后学术年会

作者： Lei Zhang Bingfeng Chen ti zhou Xiaomeng Cheng Minghua Dong Ye Liu Huizhen Liu Qingling Xu Buxing Han School of Chemistry and Chemical Engineering University of Chinese Academy of Sciences Beijing National Laboratory for Molecular Sciences CAS Laboratory of Colloid and Interface and ThermodynamicsCAS Research/Education Center for Excellence in Molecular SciencesCenter for Carbon Neutral ChemistryInstitute of ChemistryChinese Academy of Sciences Shandong IFT Science & Technology CO LTD.

The conversion of carbohydrates into 5-hydroxymethylfurfural（HMF）, a vital and valuable platform chemical, is sought after in industrial applications but poses significant challenges. In this research, we engineered an ultra-thin layer HTaMoO catalyst using ball-milling/liquid-exfoliation technique, demonstrating its efficiency in catalyzing the transformation of carbohydrates to HMF. In contrast to the conventional method utilizing tetra（n-butylammonium） hydroxide as the intercalation agent, the ball-milling/liquid-exfoliation technique not only reduces catalyst preparation time（within 12 hours） but also enhances the efficient intercalation, leading to the formation of an ultra-thin layer structure. The resulting catalyst exhibits high total acidity, a favorable Br?nsted/Lewis acid ratio, and improved accessibility of active sites due to the thin layer structure post-exfoliation. Compared with bulk LiTaMoO, the ultrathin layer HTaMoO catalyst enables complete fructose dehydration with an HMF yield reaching 89.1% under moderate reaction conditions（120 ℃, 1 hour） and 47.2% yield of HMF is obtained from sucrose at 130 ℃. This work provides a new method to fabricate the solid acid for the transformation of carbohydrates.

关键词： High speed ball-milling Liquid-exfoliation Synergistic catalysis Ultra-thin layer nanosheets 5-hydroxymethylfurfural

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

内皮祖细胞在心血管疾病治疗中的作用机制及临床应用前景

引用

生命的化学 2024年第8期44卷 1449-1457页

作者：钟友斌周倜中山大学中山医学院生物化学与分子生物学系广州510080

心血管疾病(cardiovascular diseases,CVD)是引起死亡的重要因素之一,造成了巨大的经济和医疗负担,探索新的治疗方法和策略显得尤为迫切。在当代医学研究中,内皮祖细胞(endothelial progenitor cells,EPCs)因具有修复受损内皮、促进血... 详细信息

心血管疾病(cardiovascular diseases,CVD)是引起死亡的重要因素之一,造成了巨大的经济和医疗负担,探索新的治疗方法和策略显得尤为迫切。在当代医学研究中,内皮祖细胞(endothelial progenitor cells,EPCs)因具有修复受损内皮、促进血管生成和调节血管功能的能力,作为一种具有潜在治疗价值的细胞类型备受关注。本文首先介绍EPCs的来源、特性和生物学功能,随后重点综述其在CVD治疗中可能的作用机制。此外,本文还总结了EPCs在临床应用中的挑战与机遇,并展望了其在CVD治疗中的潜在应用前景,以期为未来EPCs治疗疾病的相关研究和临床应用提供一定的理论参考。

关键词：内皮祖细胞心血管疾病临床应用

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

新媒体环境下营销人才的能力体系研究——基于广深企业招聘信息的社会网络分析

引用

时代经贸 2024年第5期21卷 113-118页

作者：蒋文锋欧阳峰周倜广州商学院粤港澳大湾区数智商务研究中心广东广州511363

新媒体营销的快速兴起,凸显出新媒体环境下营销人才的供需矛盾,其能力体系不明确,难以适应当前新媒体市场的企业需求。本文运用大数据方法,采集广深两地企业在新媒体营销岗位招聘信息中的文本内容,并采用社会网络分析方法,构建新媒体环... 详细信息

新媒体营销的快速兴起,凸显出新媒体环境下营销人才的供需矛盾,其能力体系不明确,难以适应当前新媒体市场的企业需求。本文运用大数据方法,采集广深两地企业在新媒体营销岗位招聘信息中的文本内容,并采用社会网络分析方法,构建新媒体环境下营销人才的能力体系。研究结果表明,新媒体环境下营销人才的能力体系分为两个层级:一级能力包括数据分析、策划、内容编辑与文案写作、运营与推广等能力,进一步细分得到14个关键的二级能力。相较传统研究方法,大数据社会网络分析方法具有高效率、高代表性和低成本的优势,可以在各专业人才能力体系的构建中广泛使用,其成果为规划专业人才培养方案、建设课程和知识体系、建设实践教学体系提供支持。

关键词：新媒体营销能力体系社会网络分析文本挖掘词频分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influence of varying forms of bionic units on repairing remaining quenching surface of gray cast iron

引用

Journal of Iron and Steel Research International 2021年第2期28卷 201-210页

作者： Hui Li Li Feng Hong zhou Peng Zhang ti zhou Qi Sui Lu-quan Ren Key Laboratory of Automobile Materials(Jilin University) Ministry of EducationChangchun 130025JilinChina School of Material Science and Engineering Jilin UniversityChangchun 130025JilinChina School of Mechanical and Aerospace Engineering Jilin UniversityChangchun 130025JilinChina Key Laboratory of Terrain Machinery Bionics Engineering(Jilin University) Ministry of EducationChangchun 130025JilinChina

In order to repair and reuse remaining quenching surface(RQS)divided into severely worn surface(SWun-S)and mildly worn surface(MWun-S)of abandoned gray cast iron guide rail,inspired by the bionic theory,varying forms of bionic units such as spot(Sp-S),striation(St-S),and reticulation(Re-S)were fabricated on RQS of gray cast iron through laser processing ***,the microstructure,phase composition,and microhardness of bionic units and RQS were analyzed by optical microscopy as well as X-ray diffraction instrument and scanning electron microscopy,***,the oil lubrication wear experiment was performed on homemade line reciprocating wear *** results demonstrated that the bionic units had a significant effect on improving wear resistance of RQS of abandoned guide rail due to the microstructure and higher *** addition,the weight loss ratios of MWun-S,Sp-S,St-S,and Re-S samples were decreased by 36.72%,36.78%,62.26%,and 80.39%,respectively,compared with that of SWun-S *** mechanism of wear resistance enhancement was also discussed.

关键词： Repairing Laser bionic unit Remaining quenching surface Gray cast iron

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

United membrane biological reactor in the treatment of wastewater

引用

Journal of Environmental Sciences 2003年第5期15卷 652-661页

作者： zhou Ji ti YAN Bin DU Cui hong DONG Xiao li Environmental Engineering Institute Dalian University of TechnologyDalian 116012China. Dalian Institute of Light Industry Dalian 116034China

The united membrane biological reactor(UMBR) was studied for the treatment of some simulate and municipal wastewater. The removal efficiency for COD and turbidity are greater than 80% and 99% respectively. Effluent COD is less than 100 mg/L while turbidity less than 5 The removal of LAS in bath wastewater is greater than 70%. In treatment of dinning hall wastewater, removal of fatty oil is greater than 90%, and its concentration in effluent is less than 5 mg/L. The match of biological reactor and the membrane separation component were calculated. The stable performance of wastewater treatment can be maintained by the optimization of operation conditions and the cleanout of membranes.

关键词： membrane biological reactor wastewater treatment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

《口腔修复数字化美学设计流程专家共识》解读

引用

中国实用口腔科杂志 2024年第4期17卷 414-417页

作者：周倜柳忠豪师晓蕊刘峰滨州医学院附属烟台口腔医院山东烟台264000 北京大学口腔医学院第一门诊部北京100034

在口腔美学修复工作中,数字化美学设计能够通过可视化的手段帮助医生预测并呈现未来的治疗效果,促进医患双方对美学目标达到一致的理解与认知,是实现理想美学修复效果的重要支持。然而,许多临床医生在数字化美学设计方面缺少系统的认识... 详细信息

在口腔美学修复工作中,数字化美学设计能够通过可视化的手段帮助医生预测并呈现未来的治疗效果,促进医患双方对美学目标达到一致的理解与认知,是实现理想美学修复效果的重要支持。然而,许多临床医生在数字化美学设计方面缺少系统的认识,相关流程也缺乏明确的诊疗规范和指南。文章旨在通过分析国内外文献和临床实践经验,详细解读《口腔修复数字化美学设计流程专家共识》的制定过程,阐述其主要内容和主要观点,以期为临床医生提供更全面的指导。

关键词：口腔美学修复数字化美学设计专家共识

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Production of Embryogenic Callus and Plant Regeneration from Elite Guizhou Waxy Maize Inbred Lines

引用

Agricultural Sciences in China 2011年第4期10卷 490-498页

作者： ZHONG De-yi ZHU You-yin LIU qian zhou ti ZHAO De-gang Guizhou Key Laboratory ofAgro-Bioengineering Guizhou University Guiyang 550025 P.R. China Laboratory of Green Pesticide and Agricultural Biengineering Ministry of Education/Guizhou University Guiyang 550025 P.R.China College of Life Sciences Guizhou University Guiyang 550025 P.R.China

Immature embryos from three elite Guizhou waxy maize inbred lines （W21019, B7, and QCL5036） were evaluated for their ability of forming callus and regeneration into plants. Immature embryos harvested at different physiological stages were used as explants to initiate callus on N6 basal medium with 0-3.5 mg L-1 of 2,4-dichlorophenoxy acetic acid （2,4-D）. The concentration of 2,4-D, physiological age of immature embryos and genotype had a significant effect （P0.05） on the percentage of embryogenic callus formed. The optimum 2,4-D concentration for the initiation of embryogenic callus was varied among the waxy maize genotypes from 2.0 mg L-1 （B7 and QCL5036） to 3.0 mg L-1 （W21019）. The shoots were generated from embryogenic callus which were transferred into the regeneration medium supplemented with 0-2.5 mg L-1 of 6-benzylaminopurine （6-BA）. 6-BA in the medium significantly promoted the regeneration of embryogenic callus. Embryogenic size was also an important factor that affected regeneration capacity. 0.6-0.7 cm was proved to be the best size for regeneration from embryogenic callus and the mean number of shoots per primary callus in all genotypes achieved the highest number. The ability of the plant regeneration was also affected by genotype. W21019 had the highest number of shoots formed per primary embryogenic callus. With the optimum condition, the highest mean number of shoots per primary callus was up to 12.13, 5.73, and 3.33 in line W21019, B7, and QCL5036, respectively. The successful regeneration of the two inbred lines provides a basis for development of genetic transformation to improve priority traits such as enhanced insects and drought tolerance.

关键词： waxy maize immature embryos embryogenic callus regeneration Zea mays L.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Decolorization of azo dyes with high salt concentration by salt-tolerant mixed cultures under anaerobic conditions

引用

Journal of Environmental Sciences 2005年第6期17卷 984-988页

作者： GUO Jian-bo zhou Ji-ti WANG Dong WANG Jing YU Hui SONG Zhi-yong School of Environmental and Biological Science and Technology Dalian University of Technology Dalian 116023 China

Because the lack of detailed study of biological decolorization in high salt dye wastewater, it is still difficult to evaluate the biological treatment on high-salinity dye wastewater. The experiments were carried out to study the salt-tolerant bacteria, which is useful in the treatment of high-salinity colored wastewater. Simulated wastewater containing 5-150 g/L salt （NaCI） and 50-2000 mg/L Reactive Brilliant Red K-2BP was treated with three salt-tolerant mixed cultures （CAS, TAS, DSAS）, which were under a gradually acclimated procedure. With the increase of concentrations of salt and dye, the decolorization became low. The abilities of decolorization of dyes wastewater by three mixed cultures （CAS, TAS, DSAS） were studied, CAS and DSAS mixed cultures showed more active for the treatment of high-salinity colored wastewater than TAS mixed cultures. The results suggested that there might be a simple process for the high salt wastewater treatment, which could be incorporated into conventional activated sludge plants.

关键词： anaerobic decolorization hyper-salinity salt-tolerant mixed cultures

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：