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MDCFS: few-shot object detection with multilevel decoupled classifiers

Optoelectronics Letters 2025年

作者： LI Chuanhui zhou mian FENG Zhikun SUI Zezhou GAO Zhan School of Computer Science and Engineering， Tianjin University of Technology

Few-shot object detection poses unique challenges as it requires effectively learning novel classes with limited labeled data. Current approaches often suffer from biases towards base classes during fine-tuning， leading to suboptimal performance on detecting novel classes. Additionally， in complex scenes， the confusion between foreground and background objects further affects the accuracy and robustness of the model. To address these issues， we propose the Multilevel Decoupling Classification Few-Shot Algorithm (MDCFS). we decouple the standard classifier into a parallel foreground classifier and a background classifier in the Few-Shot Object Detection (FSOD) setting. This decoupling enables the independent separation of positive samples from noisy negative samples， alleviating the foreground-background confusion problem commonly encountered in few-shot detectors. For Generalized Few-Shot Object Detection (G-FSOD)， where the few-shot dataset contains base classes， we further decouple the foreground classification head into a base class classification head and a novel class classification head. To ensure balance， we assign more weight to the novel class classification head， effectively addressing the bias towards base classes. Furthermore， we optimize the initial weights of the few-shot fine-tuning stage， significantly reducing training time and mitigating catastrophic forgetting in G-FSOD. Additionally， we incorporate metric learning into our model with minimal cost. Experimental results demonstrate the effectiveness of our approach. Compared to state-of-the-art few-shot object detection methods based on fine-tuning， MDCFS achieves performance improvements of up to 6.3% on the PASCAL VOC dataset and 1.5% on the COCO dataset.

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Full-Scale Isogeometric Topology Optimization of Cellular Structures Based on Kirchhoff-Love Shells

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 2479-2505页

作者： Mingzhe Huang Mi Xiao Liang Gao mian zhou Wei Sha Jinhao Zhang State Key Lab of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan430074China

Cellular thin-shell structures are widely applied in ultralightweight designs due to their high bearing capacity and strength-to-weight *** this paper,a full-scale isogeometric topology optimization(ITO)method based on Kirchhoff-Love shells for designing cellular tshin-shell structures with excellent damage tolerance ability is *** method utilizes high-order continuous nonuniform rational B-splines(NURBS)as basis functions for Kirchhoff-Love shell *** geometric and analysis models of thin shells are unified by isogeometric analysis(IGA)to avoid geometric approximation error and improve computational *** topological configurations of thin-shell structures are described by constructing the effective density field on the *** volume constraints are imposed in the proximity of each control point to obtain bone-like cellular *** facilitate numerical implementation,the p-norm function is used to aggregate local volume constraints into an equivalent global *** numerical examples are provided to demonstrate the effectiveness of the proposed *** simulation and comparative analysis,the results indicate that the cellular thin-shell structures optimized by the proposed method exhibit great load-carrying behavior and high damage robustness.

关键词： Cellular thin-shell structures isogeometric analysis full-scale topology optimization Kirchhoff–Love shells

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Extracellular CIRP dysregulates macrophage bacterial phagocytosis in sepsis

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Cellular & Molecular Immunology 2023年第1期20卷 80-93页

作者： mian zhou Monowar Aziz Hao-Ting Yen Gaifeng Ma Atsushi Murao Ping Wang Center for Immunology and Inflammation The Feinstein Institutes for Medical ResearchManhassetNYUSA Departments of Surgery and Molecular Medicine Zucker School of Medicine at Hofstra/NorthwellManhassetNYUSA

In sepsis, macrophage bacterial phagocytosis is impaired, but the mechanism is not well elucidated. Extracellular cold-inducible RNA-binding protein (eCIRP) is a damage-associated molecular pattern that causes inflammation. However, whether eCIRP regulates macrophage bacterial phagocytosis is unknown. Here, we reported that the bacterial loads in the blood and peritoneal fluid were decreased in CIRP^(−/−) mice and anti-eCIRP Ab-treated mice after sepsis. Increased eCIRP levels were correlated with decreased bacterial clearance in septic mice. CIRP−/− mice showed a marked increase in survival after sepsis. Recombinant murine CIRP (rmCIRP) significantly decreased the phagocytosis of bacteria by macrophages in vivo and in vitro. rmCIRP decreased the protein expression of actin-binding proteins, ARP2, and p-cofilin in macrophages. rmCIRP significantly downregulated the protein expression of βPIX, a Rac1 activator. We further demonstrated that STAT3 and βPIX formed a complex following rmCIRP treatment, preventing βPIX from activating Rac1. We also found that eCIRP-induced STAT3 phosphorylation was required for eCIRP’s action in actin remodeling. Inhibition of STAT3 phosphorylation prevented the formation of the STAT3-βPIX complex, restoring ARP2 and p-cofilin expression and membrane protrusion in rmCIRP-treated macrophages. The STAT3 inhibitor stattic rescued the macrophage phagocytic dysfunction induced by rmCIRP. Thus, we identified a novel mechanism of macrophage phagocytic dysfunction caused by eCIRP, which provides a new therapeutic target to ameliorate sepsis.

关键词： βPIX eCIRP Macrophage Phagocytosis Rac1 STAT3

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Enhanced bioproduction of chitin in engineered Pichia pastoris

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Food Bioscience 2022年第3期47卷 1051-1059页

作者： Xue Zhang Chunyue Zhang mian zhou Quanming Xia Liqiang Fan Liming Zhao State Key Laboratory of Bioreactor Engineering School of BiotechnologyEast China University of Science and TechnologyShanghai200237China Shanghai Collaborative Innovation Center for Biomanufacturing Technology (SCICBT) Shanghai200237China

Biopolymer chitin and its derivatives have a wide range of applications in different *** is primarily produced from marine crustacean by strong acid and strong alkali *** reduce the environmental hazardous in the production of chitin,post-fermentation fungal biomass waste like fungi cell walls provides a viable alternative source for *** this study,improved chitin content in yeast cell wall was achieved by overexpressing chitin biosyntheic pathway related *** chitin content was 51.5μg/mg cell wall and 122.9μg/mg cell wall in strain GS-1.10(gfat,uap and chs1 genes overexpression)and strain GS-2.6(gfat,gna1,agm1,uap and chs1 genes overexpression),which were 44.3%and 244.4%higher than that in control strain GS115,*** overexpressing another chitin synthase gene(chs3),the chitin content in strain GS-3.10 was further increased to 136.2μg/mg cell wall,which was 10.8%and 281.6%higher than that in GS-2.6 and in control GS115,***,chitin yield was further improved by various culture conditions optimization,and reached 162.4μg/mg cell wall,which was 4.43 times of that in the starting strain *** final titer of chitin was 2.23 g/L culture broth in 84 h fed-batch fermentation in a 5 L *** our knowledge,this is the first report of chitin production in engineered Pichia pastoris via biosynthetic pathway enhancement.

关键词： Chitin Pichia pastoris Metabolic engineering

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血能铁制剂对哺乳母猪生产性能及生理生化指标的影响

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农业生物技术学报 2025年第1期33卷 116-123页

作者：胡国明黄昌巧周淑棉韦玉衡谢小东胡庭俊胡永浩甘肃农业大学动物医学院广西大学动物科学技术学院贵港市动物疫病预防控制中心

铁作为一种关键的微量元素，对动物的生长具有重大的意义，铁缺乏将会导致发育障碍、繁殖性能不佳、贫血和腹泻等多种不良影响。本研究以产前7 d至产后21 d的哺乳母猪(Sus scrofa domestica)为对象，探讨饲料中添加血能铁制剂对哺乳母... 详细信息

铁作为一种关键的微量元素，对动物的生长具有重大的意义，铁缺乏将会导致发育障碍、繁殖性能不佳、贫血和腹泻等多种不良影响。本研究以产前7 d至产后21 d的哺乳母猪(Sus scrofa domestica)为对象，探讨饲料中添加血能铁制剂对哺乳母猪生产性能、生理生化指标及仔猪相关指标的影响。结果显示，与空白对照组相比，以1 kg/t饲料添加剂量添加血能铁制剂后，连续饲喂28 d能够显著降低母猪助产率、提高断配率，改善母猪产程，增加仔猪初生窝重、仔猪平均体重、断奶窝重，降低仔猪腹泻率、畸形率、死胎率，从而提高母猪生产性能和仔猪生长性能；同时血能铁制剂可以提高第7天哺乳仔猪血清铁和总铁结合力，起到预防仔猪贫血的作用。本研究为兽医临床应用血能铁制剂提高母猪生产性能提供参考和依据。

关键词：血能铁制剂生产性能血液指标

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Structure-specific nucleases in genome dynamics and strategies for targeting cancers

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Journal of Molecular Cell Biology 2024年第5期16卷 3-18页

作者： Haitao Sun Megan Luo mian zhou Li Zheng Hongzhi Li R.Steven Esworthy Binghui Shen Medicinal Plant Resources and Protection Research Center Institute of Medicinal Plant DevelopmentChinese Academy of Medical SciencesPeking Union Medical CollegeBeĳing 100193China Department of Cancer Genetics and Epigenetics Beckman Research Institute of City of HopeDuarteCA 91010USA Department of Molecular and Cell Biology University of CaliforniaBerkeleyBerkeleyCA 94720USA

Nucleases are a super family of enzymes that hydrolyze phosphodiester bonds present in *** widely vary in substrates,causing differentiation in cleavage patterns and having a diversified role in maintaining genetic *** cellular evolution of prokaryotic to eukaryotic,nucleases become structure-specific in recognizing its own or foreign genomic DNA/RNA configurations as its substrates,including flaps,bubbles,and Holliday *** special structural configurations are commonly found as intermediates in processes like DNA replication,repair,and *** structure-specific nature and diversified functions make them essential to maintaining genome integrity and evolution in normal and cancer *** this article,we review their roles in various pathways,including Okazaki fragment maturation during DNA replication,end resection in homology-directed recombination repair of DNA double-strand breaks,DNA excision repair and apoptosis DNA fragmentation in response to exogenous DNA damage,and HIV life *** the nucleases serve as key points for the DNA dynamics,cellular apoptosis,and cancer cell survival pathways,we discuss the efforts in the field in developing the therapeutic regimens,taking advantage of recently available knowledge of their diversified structures and functions.

关键词： structure-specific nucleases DNA replication nuclease inhibitors synthetic lethality

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Inokosterone Is a Potential Drug Target of Estrogen Receptor 1 in Rheumatoid Arthritis Patients:Analysis from Active Ingredient of Cyathula Officinalis

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Chinese Journal of Integrative Medicine 2021年第10期27卷 767-773页

作者： MO Ji-hao XIE Han-kun zhou Ye-mian Ng Sihan-benjamin LI Shao-xia WANG Lei Department of Medical Laboratory Luoyang Orthopedic Hospital of Henan ProvinceOrthopedic Institute of Henan ProvinceLuoyangHenan Province(471002)China Miller School of Medicine University of Miami(33136)MiamiFLUSA Institute of Technical Biology&Agriculture Engineering Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei(230031)China Eatobe Pte.Limited(573969) Singapore

Objective:To elucidate the active compounds and the molecular mechanism of Cyathula Off/c/na//s as a drug treatment for rheumatoid arthritis(RA).Methods:The target genes of active ingredients from Cyathula Officinalis were obtained from bioinformatics analysis tool for the molecular mechanism of traditional Chinese *** protein-protein interaction between the target genes were analyzed using STRING and *** transcriptome of RA patients compared to healthy people(GSE121894)were analyzed using R program package *** relative expression of the target genes was obtained from the RNA-seq *** molecular docking analyses were processed based on the molecular model of estrogen receptor 1(ESR1)binding with estradiol(PDB ID:1A52).The binding details were analyzed by ***:Inokosterone,ecdysterone,and cyaterone were the 3 active ingredients from Cyathula Officinalis that bind to target *** all the significantly changed genes from RA patients,ESR1,ADORA1,and ANXA1 were significantly increased in mRNA samples of RA ***:ESR1,the transcription factor that binds inokosterone in the molecular binding analysis,is the target protein of Cyathula Officinalis.

关键词： rheumatoid arthritis estrogen receptor 1 inokosterone Cyathula Officinalis Chinese medicine

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Isogeometric Analysis for Linear and Nonlinear Cantilever in CAD

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Journal of Mechanics Engineering and Automation 2018年第5期8卷 198-204页

作者： mian zhou Department of Machine and Process Engineering Technical University KaiserslauternKaiserslautern 67655Germany

A novel method for the mechanical simulation of linear and nonlinear Timoshenko-beams has been *** beam strains are based on a kinematic assumption where the shear deformation and rotational are *** the isoparametric concept the kinematic quantities are approximated using NURBS(non-uniform Rational B-spline)*** numerical simulation can be called as isogeometric analysis,which can improve the efficiency in CAD(computer aided design).Furthermore,an efficient Code has been developed and the results for two numerical applications are given in the end.

关键词： Isogeometric analysis NURBS basis functions Timoshenko-beams finite element formulation

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采用臭氧化茂金属乙烯-1-辛烯共聚物(POE)对聚碳酸酯进行改性的研究

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高分子材料科学与工程 2006年第5期22卷 155-158页

作者：周冕高分子材料工程国家重点实验室四川大学高分子研究所四川成都610065

聚碳酸酯(PC)与经臭氧化处理的POE共混后,其力学性能、低温冲击性能、抗溶剂性能以及冲击性能对壁厚的依赖性显著改善。在PC中加入经120 m in臭氧化处理的POE后,PC/POE(90/10)共混物的冲击强度与PC相比从24.6 kJ/m2提高到72.5 kJ/m2,低... 详细信息

聚碳酸酯(PC)与经臭氧化处理的POE共混后,其力学性能、低温冲击性能、抗溶剂性能以及冲击性能对壁厚的依赖性显著改善。在PC中加入经120 m in臭氧化处理的POE后,PC/POE(90/10)共混物的冲击强度与PC相比从24.6 kJ/m2提高到72.5 kJ/m2,低温(-20℃)冲击强度从18.8 kJ/m2提高到68.6 kJ/m2。在丙酮中浸泡4 h后,共混物的冲击强度与PC(降至3.2 kJ/m2)相比仅降至43.7 kJ/m2。未经改性处理的PC冲击强度从67.7 kJ/m2(壁厚3.2 mm)迅速下降到11.5 kJ/m2(壁厚6.4 mm);经120m in臭氧化处理,PC/POE(90/10)共混物的冲击强度从75.5 kJ/m2(壁厚3.2 mm)仅下降到58.0 kJ/m2(壁厚6.4 mm)。PC/POE(90/10)共混体系的加工流变性能与PC相比也得到改善。

关键词：臭氧化茂金属乙烯-1-辛烯共聚物聚碳酸酯

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生物钟与植物免疫互作的研究进展

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植物生理学报 2022年第1期58卷 21-32页

作者：周冕首都师范大学生命科学学院北京100048 植物基因资源与低碳环境生物技术北京市重点实验室北京100048

生物钟作为植物内源的计时系统,参与调控了包括植物免疫反应在内的多种生理生化活动。生物钟帮助植物预测病原体的入侵,主要通过调控抗病基因的表达、免疫激素的合成和信号转导、活性氧分子的稳态以及气孔开闭等多种生理生化过程的节律... 详细信息

生物钟作为植物内源的计时系统,参与调控了包括植物免疫反应在内的多种生理生化活动。生物钟帮助植物预测病原体的入侵,主要通过调控抗病基因的表达、免疫激素的合成和信号转导、活性氧分子的稳态以及气孔开闭等多种生理生化过程的节律性,使植物对于细菌、卵菌、真菌以及病虫侵害的抵抗能力呈现昼夜差异,从而实现资源的优化分配。另一方面,病原体通过分子模式和效应蛋白反馈调控植物的生物钟。作物中关于生物钟与免疫互作的研究尚处于起步阶段,但拟南芥中的研究手段将助力作物中的研究。相关成果也将从时间生物学的角度为提高作物的抗病性提供理论依据。

关键词：生物钟植物免疫病原体免疫激素活性氧分子气孔

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