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Food Bioscience 2023年第1期51卷 1139-1150页

作者： Qi Zhang Yicheng Ding Shiliang Jia lin zhou Xuxia zhou College of Food Science and Technology Zhejiang University of TechnologyHangzhou310014China Key Laboratory of Marine Fishery Resources Exploitment&Utilization of Zhejiang Province Hangzhou310014China National R&D Branch Center for Pelagic Aquatic Products Processing Hangzhou310014China

(E)-4-Hydroxyhexenal(HHE)is receiving widespread attention as a representative reactive carbonyl species(RCS)derived from n-3 polyunsaturated fatty acids peroxidation due to its health ***,few studies have addressed the potential effects of lipid oxidation products on microbial growth in food ***,this study attempted to elucidate the action of HHE on Lactiplantibacillus plantarum(***),the dominant bacteria in dry-cured *** results showed that the minimum inhibitory concentration(MIC)of HHE was 250μg/***-kill curves confirmed the strong inhibitory activity of *** dehydrogenase(LDH)assay indicated that HHE disrupted the integrity of cell *** electron microscopy(SEM)and flow cytometry analysis revealed that HHE induced changes in cell morphology,compromised cell membrane permeability,and thus disrupted intracellular *** on untargeted metabolomic analysis,HHE disrupted multiple metabolic pathways in *** involving amino acid metabolism,lipid metabolism,protein biosynthesis,nucleic acid metabolism and energy *** research provide new insights into the HHE inhibition mechanism and theoretical support for studying the effects of lipid oxidation products on microorganisms in food matrix.

关键词： Reactive carbonyl species(RCS) (E)-4-hydroxyhexenal Lactiplantibacillus plantarum Metabolic profiling Antimicrobial activity

Evapotranspiration estimation considering anthropogenic heat based on remote sensing in urban area

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Science China Earth Sciences 2017年第4期60卷 659-671页

作者： CONG ZhenTao SHEN QiNing zhou lin SUN Ting LIU JiaHong State Key Laboratory of Hydro-Science and Engineering Department of Hydraulic Engineering Tsinghua University Beijing 100084 China Sanjiangyuan Collaborative Innovation Center Tsinghua University Beijing 100084 China China Institute of Water Resources and Hydropower Research Beijing 100038 China

Urbanization influences hydrologic cycle significantly on local,regional even global *** urbanization the water resources demand for dense population sharpened,thus it is a great challenge to ensure water supply for some metropolises such as *** area is traditionally considered as the area with lower evapotranspiration(ET) on account of the impervious surface and the lower wind *** most remote sensing models,the ET,defined as latent heat in energy budget,is estimated as the difference between net radiation and sensible *** sensible heat is generally higher in urban area due to the high surface temperature caused by heat island,therefore the latent heat(*** ET) in urban area is lower than that in other *** estimated water consumption from 2003 to 2012 in Beijing based on water balance method and found that the annual mean ET in urban area was about 654 ***,using Surface Energy Balance System(SEBS) model,the annual mean ET in urban area was only 348 *** attributed this inconsistence to the impact of anthropogenic heat and quantified this impact on the basis of the night-light ***,a new model SEBS-Urban,coupling SEBS model and anthropogenic heat was developed to estimate the ET in urban *** ET in urban area of Beijing estimated by SEBS-Urban showed a good agreement with the ET from water balance *** findings from this study highlighted that anthropogenic heat should be included in the surface energy budget for a highly urbanized area.

关键词： Sponge City Waterlogging Integrated water system approach Opportunities and challenges China

Validation of Flight Control Law Based on LFT and Structured Singular Value

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Chinese Journal of Aeronautics 2007年第1期20卷 60-65页

作者： zhou Xi LIU lin CHEN Zong-ji DUAN Hai-bin School of Automation Science and Electrical Engineering Beijing University of Aeronautics and Astronautics Beijing 100083 China

The main goal of flight clearance is to use the structured singular value （ μ ） analysis of the flight control system when some parameters in the system vary in a certain range. As the p-analysis can only be done on a linear fractional transformation （LFT） model, the first step of flight clearance is to generate the LFT model of the flight control system. In this paper, based on the introduction of basic theory of LFT and μ-analysis, an X-fighter is chosen as an example to utilize the proposed methods. In order to realize the flight clearance process automatically, a novel soRware package based on MATLAB programming language is developed. The results of simulation experiments validate the feasibility and effectiveness of the novel methods proposed in this paper.

关键词： flight clearance LFT g-analysis robust stability uncertain parameter

Low voltage n-type OFET based on double insulators

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Optoelectronics Letters 2008年第5期4卷 324-327页

作者： zhou Jian-lin ZHANG Fu-jia School of Physics Science and Technology Lanzhou University Lanzhou 730000 China

A top contact n-type organic field-effect transistor with low operating voltage was fabricated by employing Ta2O5/PMMA as the double insulators and PTCDI-Cl2 as the semiconductor active layer. The Ta2O5 layer was prepared by using simple economical anodization technique and the PMMA layer was prepared by using the spin-coating method. Compared with the OFET with single Ta2O5 insulator, the device with double insulators shows obviously better electrical performance. It has a field effect electron mobility of 0.063 cm^2/Vs, an on/off ratio of 1.7 × 10^4 and a threshold voltage of 2.3 V.

关键词：场效应器件电压双绝缘体半导体

Reductive transformation and detoxification mechanism of 2,4-dinitrochlorobenzene in combined zero valent iron and anaerobic-aerobic process

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Journal of Environmental Sciences 2012年第11期24卷 1900-1907页

作者： Jinyou Shen Zongyuan zhou Changjin OU Xiuyun Sun Jiansheng Li Weiqing Han lin zhou Lianjun Wang Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse School of Environmental and Biological EngineeringNanjing University of Science and TechnologyNanjing 210094China School of Mechatronical Engineering Beijing Institute of TechnologyBeijing 100081China

A combined zero valent iron （ZVI） and anaerobic-aerobic process was adopted for the treatment of 2,4-dinitrochlorobenzene （DNCB）- containing wastewater. The transformation pathway, reduction of acute toxicity and enhancement of biodegradability were investigated, After pretreatment by ZVI, DNCB in wastewater could be completely converted into 2,4-diaminochlorobenzene （DACB）. The ratio of BODs/COD increased from 0.005±0.001 to 0.168±0.007, while EC50,48hr （V/V） increased from 0.65% to 5.20%, indicating the enhancement of biodegradability and reduction of acute toxicity with the pretreatment by ZVI. DACB was further dechlorinated to m-phenylenediamine during the anaerobic process using methanol as electron donor, with EC50＇ 48 hr increasing from 5.20% to 48.2%. After the subsequent anaerobic-aerobic process, m-phenylenediamine was degraded completely, with effluent COD of 67.5±10.8 mg/L. This effluent of the subsequent anaerobic-aerobic process was not toxic to zebrafish. The combined ZVI and anaerobic-aerobic process offers bright prospects for the treatment of chlorinated nitroaromatic compound-containing wastewater.

关键词： 2,4-dinitrochlorobenzene zero-valent iron toxicity biodegradability

A Brief Analysis of Ambiguity in English Writing

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外语研究 1990年第2期7卷 43-46页

作者： zhou lin

Being teachers,we can hardly deny the fact that we frequently ponder for sometime over a sentence or a phrase written by a student,and still find ourselves un-able to understand what it really *** then do we seem to e... 详细信息

关键词：汽车约翰荷兰商人进口乳酪糖果店店员税款杰出

Clinical management of hepatitis B virus infection correlated with liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2010年第1期9卷 15-21页

作者： Zhang, Jian zhou, lin Zheng, Shu-Sen Zhejiang Univ Sch Med Affiliated Hosp 1Key Lab Organ Transplantat Key Lab Combined Multiorgan TransplantatMinist P Hangzhou 310003 Zhejiang Peoples R China

BACKGROUND: As a radical cure for post-hepatitis B virus (HBV)-related liver cirrhosis and hepatocellular carcinoma, liver transplantation has been applied in many medical centers. Before the use of effective measures, hepatitis B recurrence and the existence of HBsAg(+) donors, patients with hepatitis B-related diseases are contraindicated for liver transplantation. Application of interferon, hepatitis B immunoglobulin (HBIG), and nucleotide analogues (e.g., lamivudine) has made great progress in the clinical care of HBV. However, there are still many shortcomings such as low viral suppression rate, rising expense, and the induction of HBV tyrosine-methionine-aspartate-aspartate (YMDD) mutation. This article systematically reviews the current evidence that immunotherapy, conventional drug combinations, and some special fields of HBV infection correlate with liver transplantation. DATA SOURCES: Studies were identified by searching MEDlinE and PubMed for articles using the keywords 'hepatitis B virus', 'hepatitis B vaccination', 'lamivudine', 'adefovir', 'entecavir', 'tenofovir', 'HBV genotype', and 'liver transplantation' up to October 2009. Additional papers were identified by a manual search of the references from the key articles. RESULTS: Hepatitis B vaccine and human monoclonal antibody have very good clinical prospects. Compared with traditional therapies, the new medical regimens have many benefits such as boosting viral suppression rate and decreasing medical expenses. The triple therapy for YMDD mutation also has an excellent therapeutic effect and a low barrier to resistance. New nucleos(t)ide analogues (entecavir and tenofovir) eliminate virus more effectively with few adverse reactions, and may replace lamivudine or HBIG in future. CONCLUSIONS: Hepatitis B vaccine needs further large-scale and rigorous randomized controlled trials to confirm its effective dose and injection frequency. Monoclonal antibody is still experimental, and the next step is to car

关键词： hepatitis B vaccination hepatitis B immunoglobulin lamivudine liver transplantation adefovir hepatitis B virus genotype

Extracellular matrix and its therapeutic potential for cancer treatment

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Signal Transduction and Targeted Therapy 2021年第5期6卷 1439-1462页

作者： Jiacheng Huang Lele Zhang Dalong Wan lin zhou Shusen Zheng Shengzhang lin Yiting Qiao Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryFirst Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China School of Medicine Zhejiang UniversityHangzhou 310003China NHC Key Laboratory of Combined Multi-Organ Transplantation Hangzhou 310003China Key Laboratory of the Diagnosis and Treatment of Organ Transplantation Research Unit of Collaborative Diagnosis and Treatment For Hepatobiliary and Pancreatic CancerChinese Academy of Medical Sciences(2019RU019)Hangzhou 310003China Key Laboratory of Organ Transplantation Zhejiang ProvinceHangzhou 310003China Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College Hangzhou 310000China

The extracellular matrix(ECM)Is one of the major components of tumors that plays multiple crucial roles,including mechanical support,modulation of the microenvironment,and a source of signaling *** quantity and cross-linking status of ECM components are major factors determining tissue *** tumorigenesis,the interplay between cancer cells and the tumor microenvironment(TME)often results in the stiffness of the ECM,leading to aberrant mechanotransduction and further malignant ***,a comprehensive understanding of ECM dysregulation in the TME would contribute to the discovery of promising therapeutic targets for cancer ***,we summarized the knowledge concerning the following:(1)major ECM constituents and their functions in both normal and malignant conditions;(2)the interplay between cancer cells and the ECM in the TME;(3)key receptors for mechanotransduction and their alteration during carcinogenesis;and(4)the current therapeutic strategies targeting aberrant ECM for cancer treatment.

关键词： therapeutic cancer matrix

Worst-case robust energy harvesting maximization in cellular networks

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Science China(Information Sciences) 2018年第8期61卷 240-242页

作者： Donghua CHEN Yucheng HE lin zhou Rui ZHAO Xiamen Key Laboratory of Mobile Multimedia Communications College of Information Science and EngineeringHuaqiao University

Dear editor,Wireless energy harvesting(EH)is considered as a promising approach to achieve power selfsustainability in energy restricted *** literature,most studies on wireless EH communications focused on the design ... 详细信息

关键词： IR MS CSI Worst-case robust energy harvesting maximization in cellular networks

line-primitive linear Spaces with Fang-Li Parameter gcd（k,r） at Most 12

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Acta Mathematica Sinica,English Series 2011年第4期27卷 657-670页

作者： Sheng lin zhou Yan Bo MA Wei Dong FANG Department of Mathematics South China University of Technology Guangzhou 510641 P. R. China Department of Mathematics and Information Technology Hanshan Normal University Chaozhou 521041 P. R. China

Let G be a subgroup of the automorphism group of a non-trivial finite linear space $. In this paper we prove that if G is line-primitive with Fang-Li parameter gcd（k, r） = 11 and 12, then G is also point-primitive. This extends the results of Fang and Li （1993） and Li and Liu （2001） which combined gives the result for gcd（k,r） ≤ 10.

关键词： Finite linear spaces line-primitive point-imprimitive