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Multidisciplinary and Comprehensive Chinese Medicine for Advanced Non-Small Cell Lung Cancer Patients:A Retrospective Study of 855 Cases

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Chinese Journal of Integrative Medicine 2021年第7期27卷 490-495页

作者： HUANG Xian-ge ZHU Li-hua zhou Lei XU Wei-jie YAO yi-lin zhou zhi-yi LI He-gen The Third Department of Oncology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai200032China

Objective To investigate the effects of multidisciplinary and comprehensive Chinese medicine(CM)treatments on progression-free survival(PFS)and median survival time(MST)in patients with advanced non-small cell lung cancer(NSCLC)and identify factors that influence progression and *** Clinical data of 855 patients with advanced NSCLC who received multidisciplinary and comprehensive CM treatments at Longhua Hospital from January 2009 to December 2018 were retrospectively *** analysis was performed by the Kaplan-Meier method and log-rank sequential *** analysis of significant variables from the univariate analysis was performed with Cox regression *** factors correlated to progression and prognosis were screened out,and a Cox proportional hazard model was established to calculate the prognostic *** The PFS and MST of 855 advanced NSCLC patients were 9.0 and 26.0 months,*** 1-,2-,3-,and 5-year survival rates were 79.2%,54%,36.2%,and 17.1%,***,pathologic type,and clinical stage were independent prognostic risk factors;surgical history,radiotherapy,treatment course of Chinese patent medicine,intravenous drip of Chinese herbal preparation,duration of oral administration of Chinese herbal decoction(CHD),and intervention measures were independent prognostic protective *** was an independent risk factor for progression,while operation history and oral CHD administration duration were independent protective factors(all P<0.05).Women with stage IIIb–IIIc lung adenocarcinoma had the best *** Female patients have lower progression risk and better prognoses than male patients,younger patients have higher progression risk but better long-term prognoses than the elderlys,and patients with lower performance status scores are at lower risk for progression and have better *** CM treatments could significantly reduce progression risk,improve pr

关键词： advanced non-small cell lung cancer prognostic factor progression factor survival analysis Chinese medicine

Rts: learning robustly from time series data with noisy label

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Frontiers of Computer Science 2024年第6期18卷 186332-186332页

作者： zhou zhi JIN yi-Xuan Li Yu-Feng National Key Laboratory for Novel Software Technology Nanjing University

Significant progress has been made in machine learning with large amounts of clean labels and static data. However, in many real-world applications, the data often changes with time and it is difficult to obtain massive clean annotations, that is, noisy labels and time series are faced simultaneously. For example, in product-buyer evaluation, each sample records the daily time behavior of users, but the long transaction period brings difficulties to analysis, and salespeople often erroneously annotate the user’s purchase behavior. Such a novel setting, to our best knowledge, has not been thoroughly studied yet, and there is still a lack of effective machine learning methods. In this paper, we present a systematic approach RTS both theoretically and empirically, consisting of two components, Noise-Tolerant Time Series Representation and Purified Oversampling Learning. Specifically, we propose reducing label noise’s destructive impact to obtain robust feature representations and potential clean samples. Then, a novel learning method based on the purified data and time series oversampling is adopted to train an unbiased model. Theoretical analysis proves that our proposal can improve the quality of the noisy data set. Empirical experiments on diverse tasks, such as the house-buyer evaluation task from real-world applications and various benchmark tasks, clearly demonstrate that our new algorithm robustly outperforms many competitive methods.

关键词： weakly-supervised learning time-series classification class-imbalanced learning

Evolving molecular subtyping of breast cancer advances precision treatment

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Cancer Biology & Medicine 2024年第9期21卷 731-739页

作者： Rui Shan Lei-Jie Dai zhi-Ming Shao yi-zhou Jiang Department of Breast Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China

Breast cancer is the second most prevalent cancer *** 2022,approximately 2.3 million newly diagnosed cases of female breast cancer occurred worldwide,and more than 665 thousand people lost their lives to this disease^... 详细信息

关键词： breast cancer Breast

Learnware:small models do big

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Science China(Information Sciences) 2024年第1期67卷 39-50页

作者： zhi-Hua zhou zhi-Hao TAN National Key Laboratory for Novel Software Technology Nanjing University

There are complaints about current machine learning techniques such as the requirement of a huge amount of training data and proficient training skills,the difficulty of continual learning,the risk of catastrophic forgetting,and the leaking of data privacy/*** research efforts have been focusing on one of those concerned issues separately,paying less attention to the fact that most issues are entangled in *** prevailing big model paradigm,which has achieved impressive results in natural language processing and computer vision applications,has not yet addressed those issues,whereas becoming a serious source of carbon *** article offers an overview of the learnware paradigm,which attempts to enable users not to need to build machine learning models from scratch,with the hope of reusing small models to do things even beyond their original purposes,where the key ingredient is the specification which enables a trained model to be adequately identified to reuse according to the requirement of future users who know nothing about the model in advance.

关键词： artificial intelligence machine learning learnware

一种新型复合溶葡萄球菌酶口腔生物护理液的研究

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中国消毒学杂志 2024年第1期41卷 5-7页

作者：蒋港周怡芝李国栋王薇黄青山上海高科联合生物技术研发有限公司上海201206 复旦大学生命科学学院

目的研究一种新型的复合溶葡萄球菌酶口腔生物护理液及其相关性能。方法通过配方筛选和悬液定量杀菌试验方法,对一种新型复合溶葡萄球菌酶相关性能进行检测与评价。结果该新型复合溶葡萄球菌酶口腔生物护理液主要杀菌成分为重组溶葡萄... 详细信息

目的研究一种新型的复合溶葡萄球菌酶口腔生物护理液及其相关性能。方法通过配方筛选和悬液定量杀菌试验方法,对一种新型复合溶葡萄球菌酶相关性能进行检测与评价。结果该新型复合溶葡萄球菌酶口腔生物护理液主要杀菌成分为重组溶葡萄球菌酶,其含量范围在1000~3000 mg/L。该护理液原液对悬液内金黄色葡萄球菌、大肠埃希菌和白色念珠菌分别作用5 min,杀灭率均>90%。该护理液对金黄地鼠口腔黏膜刺激指数为0,对豚鼠的皮肤致敏率为0%。结论该新型复合溶葡萄球菌酶口腔生物护理液稳定性和成膜性均比较好,对试验菌具有90%以上的杀灭率,对试验动物完整皮肤和黏膜无刺激性。

关键词：复合溶葡萄球菌酶溶菌酶口腔生物护理液杀菌效果

Effects of dietary intervention on human diseases:molecular mechanisms and therapeutic potential

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1389-1422页

作者： Yu-Ling Xiao Yue Gong ying-Jia Qi zhi-Ming Shao yi-zhou Jiang Key Laboratory of Breast Cancer in Shanghai Department of Breast SurgeryFudan University Shanghai Cancer CenterShanghaiChina Department of Oncology Shanghai Medical CollegeFudanUniversityShanghai200032China

Diet,serving as a vital source of nutrients,exerts a profound influence on human health and disease ***,dietary interventions have emerged as promising adjunctive treatment strategies not only for cancer but also for neurodegenerative diseases,autoimmune diseases,cardiovascular diseases,and metabolic *** interventions have demonstrated substantial potential in modulating metabolism,disease trajectory,and therapeutic *** reprogramming is a hallmark of malignant progression,and a deeper understanding of this phenomenon in tumors and its effects on immune regulation is a significant challenge that impedes cancer *** intake,as a key environmental factor,can influence tumor *** evidence indicates that dietary interventions might affect the nutrient availability in tumors,thereby increasing the efficacy of cancer ***,the intricate interplay between dietary interventions and the pathogenesis of cancer and other diseases is *** encouraging results,the mechanisms underlying diet-based therapeutic strategies remain largely unexplored,often resulting in underutilization in disease *** this review,we aim to illuminate the potential effects of various dietary interventions,including calorie restriction,fasting-mimicking diet,ketogenic diet,protein restriction diet,high-salt diet,high-fat diet,and high-fiber diet,on cancer and the aforementioned *** explore the multifaceted impacts of these dietary interventions,encompassing their immunomodulatory effects,other biological impacts,and underlying molecular *** review offers valuable insights into the potential application of these dietary interventions as adjunctive therapies in disease management.

关键词： diseases metabolism potential

TSC prediction and dynamic control of BOF steelmaking with state-of-the-art machine learning and deep learning methods

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Journal of Iron and Steel Research International 2024年第1期31卷 174-194页

作者： Tian-yi Xie Cai-dong Zhang Quan-lin zhou zhi-qiang Tian Shuai Liu Han-jie Guo Material Technology Research Institute Hesteel GroupShijiazhuang050023HebeiChina Tangsteel Company Hesteel GroupTangshan063611HebeiChina School of Artificial Intelligence Beijing Technology and Business UniversityBeijing100048China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China

Mathematical(data-driven)models based on state-of-the-art(SOTA)machine learning and deep learning models and data collected from 12,786 heats were established to predict the values of temperature,sample,and carbon(TSC)test,including temperature of molten steel(TSC-Temp),carbon content(TSC-C)and phosphorus content(TSC-P),which made prepa-ration for eliminating the TSC *** maximize the prediction accuracy of the proposed approach,various models with different inputs were implemented and compared,and the best models were applied to the production process of a Hesteel Group steelmaking plant in China in the *** number of tabular features(hot metal information,scrap,additives,blowing practices,and preset values)was expanded,and time series(off-gas profiles and blowing practice curves)that could reflect the entire steelmaking process were introduced as ***,the latest machine learning models(LightGBM,CatBoost,TabNet,and NODE)were used to make predictions with tabular features,and the best coefficient of determination R^(2)values obtained for TSC-P,TSC-C and TSC-Temp predictions were 0.435(LightGBM),0.857(Cat-Boost)and 0.678(LightGBM),respectively,which were higher than those of classic models(backpropagation and support vector machine).Then,making predictions was performed by using SOTA time series regression models(SCINet,DLinear,Informer,and MLSTM-FCN)with original time series,SOTA image regression models(NesT,CaiT,ResNeXt,and GoogLeNet)with resized time series,and the proposed Concatenate-Model and Parallel-Model with both tabular features and time *** optimization and comparisons,it was finally determined that the Concatenate-Model with MLSTM-FCN,SCINet and Informer as feature extractors performed the best,and its R^(2)values for predicting TSC-P,TSC-C and TSC-Temp reached 0.470,0.858 and 0.710,*** field test accuracies for TSC-P,TSC-C and TSC-Temp were 0.459,0.850 and 0.685,respectively.A related importance analysis was carri

关键词： BOF steelmaking In-blow prediction TSC test Machine learning Deep learning Field application

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杉木林下植物多样性对套种黄精和白及的响应

福建农业科技 2024年第1期55卷 42-47页

作者：叶丽敏叶子豪周肄智陈郑璐许元科景宁畲族自治县生态林业发展中心浙江景宁323500 浙江农林大学环境与资源学院浙江杭州311300

林下套种多花黄精Polygonatum cyrtonema、白及Bletilla striata等中药材是林下经济的主要模式之一,具有良好的社会效益和经济效益,但套种对林下植物多样性影响尚不明确。以浙西南杉木林下套种多花黄精、白及4年后和未套种原生态(CK)林... 详细信息

林下套种多花黄精Polygonatum cyrtonema、白及Bletilla striata等中药材是林下经济的主要模式之一,具有良好的社会效益和经济效益,但套种对林下植物多样性影响尚不明确。以浙西南杉木林下套种多花黄精、白及4年后和未套种原生态(CK)林地为对象,通过标准地法研究林下灌木、草本和藤本植物的组成、种类、数量。结果表明:套种多花黄精和白及4年后,杉木林下草本植物种类显著增加了17.4%~26.1%(P<0.05),而藤本植物种类显著减少了33.3%(P<0.05);物种优势度指数Simpson、多样性指数Shannon-Weiner、均匀度指数Pielou的变化表现为草本植物显著提高了26.4%~36.1%(P<0.05),而藤本植物则显著下降了29.0%~39.3%(P<0.05);林下灌木植物种类和多样性指数对套种的响应不明显;套种后,林下木质型灌木、藤本和株型较高的植物种类减少,而株型较小的植物种类增加。今后需建立长期定位监测,以掌握套种中药材对林下植物多样性的长期影响,为林下种植的效益评估提供基础。

关键词：杉木林下套种多花黄精白及植物多样性

Long-term clinical outcomes and health-related quality of life in patients with isolated methylmalonic acidemia after liver transplantation:experience from the largest cohort study in China

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World Journal of Pediatrics 2024年第8期20卷 809-821页

作者： yi-zhou Jiang Guang-Peng zhou Lin Wei Wei Qu zhi-Gui Zeng ying Liu Yu-Le Tan Jun Wang zhi-Jun Zhu Li-ying Sun Department of Critical Liver Diseases Liver Research CenterBeijing Friendship HospitalCapital Medical UniversityNo.101 Lu Yuan Dong RoadTong-Zhou DistrictBeijing110112China Liver Transplantation Center National Clinical Research Center for Digestive DiseasesBeijing Friendship HospitalCapital Medical UniversityBeijingChina Clinical Center for Pediatric Liver Transplantation No.101 Lu Yuan Dong RoadTong-Zhou DistrictCapital Medical UniversityBeijing110112China

Background Liver transplantation(LT)has been proposed as a viable treatment option for selected methylmalonic acidemia(MMA)***,there are still controversies regarding the therapeutic value of LT for *** systematic assessment of health-related quality of life(HRQoL)-targeted MMA children before and after LT is also *** study aimed to comprehensively assess the long-term impact of LT on MMA,including multiorgan sequelae and HRQoL in children and *** We retrospectively evaluated 15 isolated MMA patients undergoing LT at our institution between June 2013 and March ***-and post-transplant data were compared,including metabolic profiles,neurologic consequences,growth parameters,and *** further assess the characteristics of the HRQoL outcomes in MMA,we compared the results with those of children with biliary atresia(BA).Results All patients had early onset MMA,and underwent LT at a mean age of 4.3 *** 1.3–8.2 years of follow-up,the patient and graft survival rates were 100%.Metabolic stability was achieved in all patients with liberalized dietary protein *** was a significant overall improvement in height Z scores(P=0.0047),and some preexisting neurological complications remained stable or even improved after *** the Pediatric Quality of Life Inventory(PedsQL™)generic core scales,the mean total,physical health,and psychosocial health scores improved significantly posttransplant(P<0.05).In the family impact module,higher mean scores were noted for all subscales post-LT,especially family function and daily activities(P<0.01).However,the total scores on the generic core scales and transplant module were significantly lower(Cohen’s d=0.57–1.17)when compared with BA *** particular,social and school functioning(Cohen’s d=0.86–1.76),treatment anxiety,and communication(Cohen’s d=0.99–1.81)were far behind,with a large effect *** This large single-center study of the mainland of China sh

关键词： Health-related quality of life.Inborn error of metabolism Isolated methylmalonic acidemia Liver transplantation:Outcomes