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Cloning of the kininogen gene from Lampetra japonica provides insights into its phylogeny in vertebrates

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Journal of Genetics and Genomics 2009年第2期36卷 109-115页

作者： Liwei zhou Xin liu Ping Jin Qingwei Li College of Life Sciences Liaoning Normal University Dalian 116029 China

Kininogens, the precursors of bradykinins, ubiquitously exist in vertebrates, including mammals, birds, amphibians, and fishes. To elucidate the phylogeny of kininogen genes in early vertebrates, we cloned the full-length cDNA of kininogen gene from the liver of Lampetra japonica. The open reading frame of this sequence contained 546 bp and encoded 181 amino acids, including a cystatin domain without the canonical binding site for cysteine proteinases and a bradykinin domain. Our results suggested that in lampreys and most of other vertebrates, there might be only one kininogen gene, which was fused by certain sequences during vertebrate evolution and encoded proteins with more functions; however, another special kininogen gene, only encoding the bradykinin domain with multiple copies in some species, arose only in amphibians for adapting themselves to the unique environment. Using reverse transcription PCR, kininogen mRNA was also detected in lamprey gut, kidney, and leukocyte, but absent in lamprey buccal gland. Our findings may provide insights into the phylogeny of kininogen genes as well as other gene families in vertebrates.

关键词： kininogen Lampetrajaponica phylogeny bradykinin domain cystatin domain tissue distribution

Application of color structured light pattern to measurement of large out-of-plane deformation

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Acta Mechanica Sinica 2011年第6期27卷 1098-1104页

作者： Xing Lu Jun-Hong zhou Dong-Dong liu Jue Zhang College of Engineering Peking University100871 Beijing China

Measurement of out-of-plane deformation is significant to understanding of the deflection mechanisms of the plate and tube *** this study,a new surface contouring technique with color structured light is applied to measure the out-of-plane deformation of structures with one-shot *** color fringe recognizing,decoding and triangulation processing for the captured images corresponding to each deformation state,the feasibility of the method is testified by the measurement of elastic deflections of a flexible square plate,showing good agreement with those from the calibrated displacement *** plastic deformation of two alloy aluminum rectangular tubes is measured to show the technique application to surface topographic evaluation of the buckling structures with large displacements.

关键词： Out-of-plane deformation Surface contouring Color structured light Plate deflection - Rectangular tube buckling

Validation of Flight Control Law Based on LFT and Structured Singular Value

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Chinese Journal of Aeronautics 2007年第1期20卷 60-65页

作者： zhou Xi liu Lin CHEN Zong-ji DUAN Hai-bin School of Automation Science and Electrical Engineering Beijing University of Aeronautics and Astronautics Beijing 100083 China

The main goal of flight clearance is to use the structured singular value （ μ ） analysis of the flight control system when some parameters in the system vary in a certain range. As the p-analysis can only be done on a linear fractional transformation （LFT） model, the first step of flight clearance is to generate the LFT model of the flight control system. In this paper, based on the introduction of basic theory of LFT and μ-analysis, an X-fighter is chosen as an example to utilize the proposed methods. In order to realize the flight clearance process automatically, a novel soRware package based on MATLAB programming language is developed. The results of simulation experiments validate the feasibility and effectiveness of the novel methods proposed in this paper.

关键词： flight clearance LFT g-analysis robust stability uncertain parameter

Gas marbles: ultra-long-lasting and ultra-robust bubbles formed by particle stabilization

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Frontiers of Chemical Science and Engineering 2022年第11期16卷 1681-1687页

作者： Xuxin Zhao Kunling Yang zhou liu Ho Cheung Shum Tiantian Kong College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518000China Department of Mechanical Engineering University of Hong KongHong KongChina Advanced Biomedical Instrumentation Centre Hong KongChina Department of Biomedical Engineering School of MedicineShenzhen UniversityShenzhen 518000China Department of Urology The Institute of Translational MedicineThe First Affiliated Hospital of Shenzhen UniversityShenzhen Second People’s HospitalShenzhen 518000China

Bubbles and foams are ubiquitous in daily life and industrial *** their dynamic behaviors is of key importance for foam manufacturing processes in food packaging,cosmetics and *** bubbles are inherently fragile and transient;enhancing their robustness and shelf lives is an ongoing *** rupture can be attributed to liquid evaporation,thin film drainage and the nuclei of environmental *** by particle-stabilized interfaces in Pickering emulsions,armored bubbles and liquid marble,bubbles are protected by an enclosed particle-entrapping liquid thin film,and the resultant soft object is termed gas *** gas marble exhibits mechanical strength orders of magnitude higher than that of soap bubbles when subjected to overpressure and underpressure,owing to the compact particle monolayer straddling the surface liquid *** using a water-absorbent glycerol solution,the resulting gas marble can persist for 465 d in normal atmospheric *** particle-stabilizing approach not only has practical implications for foam manufacturing processes but also can inspire the new design and fabrication of functional biomaterials and biomedicines.

关键词： bubble particles interfaces armored bubble liquid marble gas marble Pickering emulsion

Chronic deep brain stimulation of the subthalamic nucleus in a monkey model of hemiparkinsonian Dynamic alterations of extracellular fluid dopamine levels in corpus striatum

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Neural Regeneration Research 2009年第12期4卷 1037-1042页

作者： Yiqun Cao Hanhua liu Xudong Zhao Xiaoping zhou Jianmin liu Dongmei Li Department of Neurosurgery Changhai Hospital Second Military Medical University of Chinese PLA Shanghai 200433 China

BACKGROUND： Although experimental studies have utilized high-frequency stimulation in animal models, few reports have focused on long-term subthalamic nucleus deep brain stimulation （STN DBS） in Parkinson＇s disease （PD） animal models. OBJECTIVE： The present study simulated long-term DBS system and utilized microdialysis technology to study the influence of STN DBS on levels of extracellular dopamine （DA） and its metabolites, homovanillic acid （HVA） and dihydroxy phenyl acetic acid, in the corpus striatum of a hemiparkinsonian monkey model. DESIGN, TIME AND SETTING： A controlled animal study was performed at the Neurosurgery Laboratory, Changhai Hospital of the Second Military Medical University of Chinese PLA between January 2004 and December 2007. MATERIALS： 1-methy-4-phenyl-1, 2, 3, 6-tetrahydropyrindinewas （MPTP） purchased from Sigma, USA. Type-3389 DBS electrode and type-7246 pulse generator were provided by Medtronic, USA. METHODS： Hemiparkinsonism was induced in 2 male, adult Rhesus Macaque monkeys through unilateral internal carotid artery infusion of MPTP. Following model establishment, stimulation electrodes were implanted in the right STN, and chronic high-frequency stimulation （60 μs pulse width, 130 Hz frequency, and 1.5 2.0 V pressure） was performed. MAIN OUTCOME MEASURES： Prior to, and 2 hours, 8 hours, 1 week, 1 month, and 2 months after DBS, samples were collected from the caudate nucleus and putamen using microdialysis technology Extracellular levels of DA and its metabolites were measured using high-performance liquid chromatography and electrochemical detection （HPLC-ECD） methods. RESULTS： At 8 hours, 1 week, 1 month, and 2 months after DBS, DA levels in the putamen and caudate nucleus were increased on the electrode-implanted side by 39%, 91%, 111%, and 114% and 31%, 91%, 106%, and 102%, respectively. The DA turnover rate （HVA/DA） was increased in the putamen and caudate nucleus by 186% and 91%, respectively, at 8 hours after DBS, while there was

关键词： subthalamic nucleus deep brain stimulation Parkinson's disease microdialysis dopamine

甲磺酸伊马替尼联合VDLD方案诱导治疗儿童急性淋巴细胞白血病的临床疗效

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癌症进展 2024年第6期22卷 659-661,666页

作者：吴爱月向金峰周柳南阳市中心医院儿科河南南阳473000 南阳市中心医院儿童血液内科河南南阳473000 南阳市中心医院放射治疗科河南南阳473000

目的探讨甲磺酸伊马替尼联合长春地辛+地塞米松+培门冬酶+去甲氧柔红霉素(VDLD)方案诱导治疗儿童急性淋巴细胞白血病的临床疗效。方法根据化疗方案的不同将104例急性淋巴细胞白血病患儿分为对照组(n=52)和观察组(n=52),对照组患儿给予... 详细信息

目的探讨甲磺酸伊马替尼联合长春地辛+地塞米松+培门冬酶+去甲氧柔红霉素(VDLD)方案诱导治疗儿童急性淋巴细胞白血病的临床疗效。方法根据化疗方案的不同将104例急性淋巴细胞白血病患儿分为对照组(n=52)和观察组(n=52),对照组患儿给予VDLD方案治疗,观察组患儿给予甲磺酸伊马替尼联合VDLD方案治疗。比较两组患儿的临床疗效、肿瘤标志物[血管内皮细胞生长因子(VEGF)、血管内皮细胞生长因子受体(VEGFR)、碱性成纤维细胞生长因子(bFGF)]水平、不良反应发生情况及预后情况。结果观察组患儿的治疗总有效率和5年生存率均高于对照组,5年复发率低于对照组,差异均有统计学意义(P﹤0.05)。治疗后,两组患儿VEGF、VEFGR、bFGF水平均低于本组治疗前,观察组患儿VEGF、VEFGR、bFGF水平均低于对照组,差异均有统计学意义(P﹤0.05)。两组患儿的不良反应总发生率比较,差异无统计学意义(P﹥0.05)。结论甲磺酸伊马替尼联合VDLD方案诱导治疗儿童急性淋巴细胞白血病,能够提高临床疗效,降低复发率,且不会增加不良反应,安全性较高。

关键词：急性淋巴细胞白血病甲磺酸伊马替尼 VDLD方案不良反应

Environmental and biological influences on the stability of silver nanoparticles

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Chinese Science Bulletin 2011年第19期56卷 2009-2015页

作者： liu Wei zhou QunFang liu JiYan FU JianJie liu SiJin JIANG GuiBin State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-environmental Sciences Chinese Academy ofSciences Beijing 100085 China

Silver nanoparticles (Ag NPs) are easily dispersed and stable, and their application has become widespread. Consequently, concern has arisen regarding their potential effects on the environment and human health. However, the current understanding on the stability of Ag NPs is limited. Therefore, in this study the influence of environmental and biological factors, such as ionic strength, valence, biological molecules, pH and temperature, on the properties of Ag NPs was investigated. The absorption spectra, size, zeta potential, and release of silver ions were evaluated. Ionic strength, valence, Dulbecco’s Modified Eagle’s Medium (DMEM), without fetal bovine serum (FBS), reduced the stability of the Ag NPs. However, in DMEM with 10% FBS, the Ag NPs maintained their stability and nanoscale characteristics. These findings provide an essential insight into the environmental and biological factors that should be evaluated in a risk assessment of Ag NPs.

关键词：银纳米粒子生物因素稳定性环境 Zeta电位离子强度胎牛血清 DMEM

Novel On-Line North-Seeking Method Based on a Three-Axis MEMS Gyroscope

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Journal of Beijing Institute of Technology 2018年第4期27卷 623-629页

作者： Yu liu Gaojun Xiang Junqi Guo Min zhou and Hongzhi liu Chongqing Municipal Level Key Laboratory of Photoelectronic Information Sensing and Transmitting Technology Chongqing University of Post and TelecommunicationsChongqing 400065China

A novel on-line north-seeking method based on a three-axis micro-electro-mechanical system(MEMS)gyroscope is *** system processes data by using a Kalman filter to calibrate the installation error of the three-axis MEMS gyroscope in complex *** attitude angle updating for quaternion,based on which the attitude instrument will be rotated in real-time and the true north will be *** experimental platform constitutes the dual-axis electric rotary table and the attitude instrument,which is developed independently by our scientific research *** experimental results show that the accuracy of north-seeking is higher than 1°,while the maximum root mean square error and the maximum mean absolute error are 0.906 7 and 0.910 0,*** accuracy of north-seeking is much higher than the traditional method.

关键词： micro-electro-mechanical system(MEMS)gyroscope quaternion rotating system in realtime north-seeking

Monte Carlo Study of Planar Rotator Model with Weak Dzyaloshinsky-Moriya Interaction

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Communications in Theoretical Physics 2006年第4X期46卷 663-667页

作者： SUN Yun-zhou liu Hui-Ping YI Lin Department of Physics and State Key Laboratory of Laser Technology~ Huazhong University of Science and Technology Wuhan 430074 China

With the help of an improvement Monte Carlo method, the Berezinskii-Kosterlitz-Thouless phase transition arising in two-dimensional planar rotator model with weak Dzyaloshinsky-Moriya （DM） interaction is investigated. The effects of the DM interaction on specific heat, susceptibility, and magnetization are simulated. The critical temperature of transitions is determined by the so-called Binder cumulant and the susceptibility of finite-size scaling. We find that the chiral Z2 symmetry reduced by the DM interactions plays an important role in a two-dimensional XY spin system, typically, the critical temperature is sensitive to weak DM spin couplings.

关键词： Monte Carlo method Berezinskii-Kosterlitz-Thouless phase transition Dzyaloshinsky-Moriya interaction XY model