检索结果-南通市图书馆

PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong Liu Xiaolin Li Xiaowei zhou Wei Chen Aidong Wen Minna Liu Yi Ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidylinositol 3-kinase protein kinase B therapeutics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Low voltage n-type OFET based on double insulators

引用

Optoelectronics Letters 2008年第5期4卷 324-327页

作者： zhou jian-lin ZHANG Fu-jia School of Physics Science and Technology Lanzhou University Lanzhou 730000 China

A top contact n-type organic field-effect transistor with low operating voltage was fabricated by employing Ta2O5/PMMA as the double insulators and PTCDI-Cl2 as the semiconductor active layer. The Ta2O5 layer was prepared by using simple economical anodization technique and the PMMA layer was prepared by using the spin-coating method. Compared with the OFET with single Ta2O5 insulator, the device with double insulators shows obviously better electrical performance. It has a field effect electron mobility of 0.063 cm^2/Vs, an on/off ratio of 1.7 × 10^4 and a threshold voltage of 2.3 V.

关键词：场效应器件电压双绝缘体半导体

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

高碳钢线材组织与性能预报模拟软件的开发

引用

武汉科技大学学报 2006年第2期29卷 112-114,132页

作者：张云祥周家林赵嘉蓉张海鸥王桂兰武汉科技大学湖北武汉430081 华中科技大学湖北武汉430074

为便于研究高速线材轧制过程中的工艺参数与组织、力学性能之间关系,在物理冶金学原理基础上,开发了针对现场生产的模拟软件。该软件可计算轧制过程中轧件温度的变化、微观组织的演变和最终的力学性能。工业应用结果表明,计算结果与实... 详细信息

为便于研究高速线材轧制过程中的工艺参数与组织、力学性能之间关系,在物理冶金学原理基础上,开发了针对现场生产的模拟软件。该软件可计算轧制过程中轧件温度的变化、微观组织的演变和最终的力学性能。工业应用结果表明,计算结果与实测结果吻合较好。

关键词：高碳钢组织演变力学性能软件开发

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

危机情境下领导路径-目标澄清行为对角色绩效的影响

引用

管理工程学报 2025年第1期39卷 95-109页

作者：赵晨周锦来林晨高中华北京邮电大学经济管理学院中国社会科学院工业经济研究所

危机情境下,领导需要澄清团队目标进而提升员工角色绩效。然而,何种路径-目标澄清行为更加有效亟待明确。整合路径目标理论与变革-交易领导框架,本文探究两种竞争性路径-目标澄清行为(愿景阐释行为与积极纠偏行为)对员工角色绩效的影响... 详细信息

危机情境下,领导需要澄清团队目标进而提升员工角色绩效。然而,何种路径-目标澄清行为更加有效亟待明确。整合路径目标理论与变革-交易领导框架,本文探究两种竞争性路径-目标澄清行为(愿景阐释行为与积极纠偏行为)对员工角色绩效的影响。基于某连锁品牌员工的两阶段调查数据发现,愿景阐释行为通过提高团队目标的清晰性增强了员工角色绩效,而积极纠偏行为通过提高团队目标的清晰性对员工角色绩效的影响不显著。团队情绪(团队恐惧与团队自满)调节了路径-目标澄清行为对团队目标清晰性的影响:当团队恐惧情绪水平较高时,愿景阐释行为对团队目标清晰性的积极影响更大;而当团队自满情绪水平较高时,积极纠偏行为对团队目标清晰性的积极影响更大。团队情绪进一步调节了团队目标清晰性在路径-目标澄清行为与员工角色绩效之间的中介机制。本文剖析了团队情绪对于路径-目标澄清行为有效性的影响,对于实现危机情境下的有效领导具有指导意义。

关键词：危机情境路径-目标澄清行为团队目标清晰性角色绩效

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cooling Torsional Nanomechanical Vibration by Spin-Orbit Interactions

引用

Communications in Theoretical Physics 2008年第12期50卷 1457-1460页

作者： ZHAO Nan zhou Duan-Lu ZHU jia-lin Department of Physics Tsinghua University Beijing 100084 China Institute of Physics Chinese Academy of Science Beijing 100080 China

We propose and study a spin-orbit interaction based mechanism to actively cool down the torsional vibrationof a nanomechanical resonator made by semiconductor *** show that the spin-orbit interactions of electronscan induce a coherent coupling between the electron spins and the torsional modes of nanomechanical *** leads to an active cooling for the torsional modes through the dynamical thermalization of the resonator by thespin ensemble.

关键词： nanoelectromeehanical system spin-orbit interaction dynamical thermalization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Rational modulation of fluorophosphate cathode by anionic groups to reduce the polarization behavior for fast-charging sodium-ion batteries

引用

Journal of Energy Chemistry 2025年第1期100卷 509-521页

作者： Xinyuan Wang Fan Zhang Xingyu zhou Qian Wang Changyu Liu Yangyang Liu Hui Wang Xiaojie Liu Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education College of Chemistry & Materials Science Northwest University

Na3V2（PO4）2O2F （VP） is recognized as a promising cathode material for sodium-ion batteries due to its stable structural framework and high specific *** functional theory （DFT） and finite element simulations show that incorporating SO42-into VP decreases its band gap,lowers the migration energy barrier,and ensures a uniform Na+concentration gradient and stress distribution during charge and discharge ***,the average Na+diffusion coefficient of Na3V2（PO4）1.95（SO4）0.05O2F（VPS-1） is roughly double that of VP,leading to enhanced rate capability (80 C,75.5 mAh g-1) and cycling stability (111.0 mAh g-1capacity after 1000 cycles at 10 C current density) for ***-1 exhibits outstanding fast-charging capabilities,achieving an 80%state of charge in just 8.1 *** assembled VPS-1//SbSn/NPC full cell demonstrated stable cycling over 200 cycles at a high 5 C current,maintaining an average coulombic efficiency of 95.35%.

关键词： Anionic group modulation Polarization behavior Fast-charging Sodium-ion battery Fluorophosphate Cathode

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

The inf luence of soil drying- and tillage-induced penetration resistance on maize root growth in a clayey soil

引用

Journal of Integrative Agriculture 2016年第5期15卷 1112-1120页

作者： lin Li-rong HE Yang-bo CHEN jia-zhou Key Laboratory of Arable Land Conservation(Middle and Lower Reaches of Yangtze River) Ministry of Agriculture Huazhong Agricultural University

Soil drying may induce a number of stresses on crops. This paper investigated maize（Zea mays L.） root growth as affected by drought and soil penetration resistance（PR）, which was caused by soil drying and tillage in a clayey red soil. Compared with conventional tillage（C） and deep tillage（D）, soil compaction（P） and no-till（N） significantly increased soil PR in the 0-15 cm layer. The PR increased dramatically as the soil drying increased, particularly in soil with a high bulk density. Increased soil PR reduced the maize root mass density distribution not only in the vertical profile（0-20 cm） but also in the horizontal layer at the same distance（0-5, 5-10, 10-15 cm） from the maize plant. With an increase in soil PR in pots, the maize root length, root surface area and root volume significantly decreased. Specifically, the maize root length declined exponentially from 309 to 64 cm per plant with an increase in soil PR from 491 to 3 370 k Pa; the roots almost stopped elongating when the soil PR was larger than 2 200 k Pa. It appeared that fine roots（〈2.5 mm in diameter） thickened when the soil PR increased, resulting in a larger average root diameter. The average root diameter increased linearly with soil PR, regardless of soil irrigation or drought. The results suggest that differences in soil PR caused by soil drying is most likely responsible for inconsistent root responses to water stress in different soils.

关键词： clayey soil root diameter root elongation soil compaction water stress

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A theoretical model for the estimation of maximum impact force from a rockfall based on contact theory

引用

Journal of Mountain Science 2018年第2期15卷 430-443页

作者： ZHANG Shi-lin YANG Xing-guo zhou jia-wen State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan University College of Water Resource and Hydropower Sichuan University

Rockfall poses a great threat to buildings and personal security. To understand the dynamic characteristics of rockfalls is a prerequisite for disaster prevention and assessment. Models for rockfalls in different forms are established based on the theory of rigid body motion. The equivalent velocity considering the rotational effect is determined by the energy ratio. Besides, considering plastic deformation and nonlinear hardening, the maximum impact force is estimated based on the Hertz contact theory. Then, a case study is carried out to illustrate the applicability of the model and sensitive analyses on some affecting parameters are also made. Calculation results show that the maximum impact force increases with the increasing of incident velocity, angle and slope gradient reflected by the changing of energy ratio. Moreover, the model for the estimation of maximum impact force is validated by two different scales of experiments and compared with other theoretical models. Simulated maximum impact forces agree well with the experiments.

关键词： RockfaU Motion characteristics Contacttheory Maximum impact force

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Text-Image Feature Fine-Grained Learning for Joint Multimodal Aspect-Based Sentiment Analysis

引用

Computers, Materials & Continua 2025年第1期82卷 279-305页

作者： Tianzhi Zhang Gang zhou Shuang Zhang Shunhang Li Yepeng Sun Qiankun Pi Shuo Liu School of Data and Target Engineering Information Engineering UniversityZhengzhou450001China Information Engineering Department Liaoning Provincial College of CommunicationsShenyang110122China School of Computer and Artificial Intelligence Zhengzhou UniversityZhengzhou450000China

Joint Multimodal Aspect-based Sentiment Analysis(JMASA)is a significant task in the research of multimodal fine-grained sentiment analysis,which combines two subtasks:Multimodal Aspect Term Extraction(MATE)and Multimodal Aspect-oriented Sentiment Classification(MASC).Currently,most existing models for JMASA only perform text and image feature encoding from a basic level,but often neglect the in-depth analysis of unimodal intrinsic features,which may lead to the low accuracy of aspect term extraction and the poor ability of sentiment prediction due to the insufficient learning of intra-modal *** this problem,we propose a Text-Image Feature Fine-grained Learning(TIFFL)model for ***,we construct an enhanced adjacency matrix of word dependencies and adopt graph convolutional network to learn the syntactic structure features for text,which addresses the context interference problem of identifying different aspect ***,the adjective-noun pairs extracted from image are introduced to enable the semantic representation of visual features more intuitive,which addresses the ambiguous semantic extraction problem during image feature ***,the model performance of aspect term extraction and sentiment polarity prediction can be further optimized and *** on two Twitter benchmark datasets demonstrate that TIFFL achieves competitive results for JMASA,MATE and MASC,thus validating the effectiveness of our proposed methods.

关键词： Multimodal sentiment analysis aspect-based sentiment analysis feature fine-grained learning graph convolutional network adjective-noun pairs

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrating the environmental factor into the strategy updating rule to promote cooperation in evolutionary games

引用

Chinese Physics B 2012年第1期21卷 529-534页

作者： Zhao lin zhou Xin Liang Zhi Wu jia-Rui Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences University of Science and Technology of ChinaHefei 230026China

Many previous studies have shown that the environment plays an important role for social individuals. In this paper, we integrate the environmental factor, which is defined as the average payoff of all a player＇s neighbours, with the standard Fermi updating rule by introducing a tunable parameter, w. It is found that the level of cooperation increases remarkably, and that the cooperators can better resist the invasion of defection with an increase in w. This interesting phenomenon is then explained from a microscopic view. In addition, the universality of this mechanism is also proved with the help of the small-world network and the random regular graph. This work may be helpful in understanding cooperation behaviour in species from unicellular organisms up to human beings.

关键词： evolutionary game cooperation prisoner's dilemma game

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：