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Unique Azolyl Acylhydrazonyl Hybridization of Aloe Emodins to Access Potential Antibacterial Agents

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Chinese Journal of Chemistry 2024年第15期42卷 1741-1758页

作者： Yi-Xin Wang Zhao Deng Aisha Bibi Bo Fang Cheng-he zhou Institute of Bioorganic&Medicinal Chemistry Key Laboratory of Applied Chemistry of Chongqing MunicipalitySchool of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China College of Pharmacy National&Local Joint Engineering Research Center of Targeted and Innovative TherapeuticsChongqing Key Laboratory of Kinase Modulators as Innovative MedicineChongqing University of Arts and SciencesChongqing 402160China

A type of unique azole-hybridized acylhydrazonyl aloe emodins(AAEs)were developed as new antibacterial agents for combating bacterial *** target AAEs showed strong antibacterial activities,especially,tetrazolylthioether AAE 27a exhibited broad antibacterial spectrum with 16-256 folds and 8-64 folds more active antibacterial efficacy than the reference drugs aloe emodin and norfloxacin,*** AAE 27a also gave low hemolysis and cytotoxicity,as well as favorable *** mechanism explorations revealed that tetrazolylthioether AAE 27a could cause bacterial membrane depolarization and damage the cell membrane,resulting in nucleic acid ***,compound 27a could intercalate into DNA to impede its replication and form supramolecular 27a-DNA gyrase complex to disturb the function of DNA *** findings would provide valuable insights for the further exploration of azolyl acylhydrazonyl aloe emodins as new potential antibacterial candidates.

关键词： Aloe emodin Hydrazone heterocycle Antibacterial Membrane damage

Wild Gibbon Optimization Algorithm

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Computers, Materials & Continua 2024年第7期80卷 1203-1233页

作者： Jia Guo JinWang Ke Yan Qiankun Zuo Ruiheng Li zhou he Dong Wang Yuji Sato Hubei Key Laboratory of Digital Finance Innovation Hubei University of EconomicsWuhan430205China School of Information Engineering Hubei University of EconomicsWuhan430205China China Construction Third Engineering Bureau Installation Engineering Co. Ltd.Wuhan430074China Hubei Internet Finance Information Engineering Technology Research Center Hubei University of EconomicsWuhan430205China College of Informatics Huazhong Agricultural UniversityWuhan430070China Faculty of Computer and Information Sciences Hosei UniversityTokyo184-8584Japan

Complex optimization problems hold broad significance across numerous fields and ***,as the dimensionality of such problems increases,issues like the curse of dimensionality and local optima trapping also *** address these challenges,this paper proposes a novel Wild Gibbon Optimization Algorithm(WGOA)based on an analysis of wild gibbon population *** two strategies:community search and community *** community search strategy facilitates information exchange between two gibbon families,generating multiple candidate solutions to enhance algorithm ***,the community competition strategy reselects leaders for the population after each iteration,thus enhancing algorithm *** assess the algorithm’s performance,CEC2017 and CEC2022 are chosen as test *** the CEC2017 test suite,WGOA secures first place in 10 *** the CEC2022 benchmark functions,WGOA obtained the first rank in 5 *** ultimate experimental findings demonstrate that theWildGibbonOptimization Algorithm outperforms others in tested *** underscores the strong robustness and stability of the gibbonalgorithm in tackling complex single-objective optimization problems.

关键词： Complex optimization wild gibbon optimization algorithm community search community competition

采用子阵多输入多输出的天基预警雷达强杂波抑制方法

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西安交通大学学报 2024年第4期58卷 170-181页

作者：周贺吴建新张磊中山大学电子与通信工程学院广东深圳518107

针对天基预警雷达因其高速平台运动带来严重的距离模糊和多普勒模糊,导致杂波背景强进而降低雷达目标检测性能的问题,提出一种基于子阵级多输入多输出天基预警雷达强杂波抑制方法。构建基于子阵级多输入多输出天基雷达模型并分析远距离... 详细信息

针对天基预警雷达因其高速平台运动带来严重的距离模糊和多普勒模糊,导致杂波背景强进而降低雷达目标检测性能的问题,提出一种基于子阵级多输入多输出天基预警雷达强杂波抑制方法。构建基于子阵级多输入多输出天基雷达模型并分析远距离机动目标相参性,确定目标出现线性距离徙动和不出现多普勒频率扩散时的最大相参积累时间,以保证长时间相参积累可行性;针对多输入多输出雷达长驻留的特点采用长时间积累提高多普勒分辨率,降低一个距离-多普勒单元的杂波功率,在保证搜索效率的情况下降低该单元杂噪比,并采用3/5准则检测盲区图评估天基雷达检测性能;在强杂波背景下改善了信杂噪比,提高了目标检测概率。实验仿真表明,所提方法相比相控阵雷达可有效降低杂波背景,在单脉冲重复频率下即可达到很好的检测效果,比相控阵雷达检测性能提高约20.48%。

关键词：多输入多输出天基预警雷达目标相参性长时间积累

基于弧面分度凸轮机构的舰炮弹鼓运动规律研究

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舰船科学技术 2024年第8期46卷 169-173页

作者：周银鹤中国船舶集团有限公司第七一三研究所河南郑州450015

某舰炮弹鼓为实现间歇步进运动,采用了余弦加速度运动规律的弧面分度凸轮机构,由于在运动始末处加速度发生突变,运动停止时会产生振动和柔性冲击,导致弹鼓运动平稳性较差,不利于弹鼓与扬弹机交接弹药。基于弧面分度凸轮机构基本运动规... 详细信息

某舰炮弹鼓为实现间歇步进运动,采用了余弦加速度运动规律的弧面分度凸轮机构,由于在运动始末处加速度发生突变,运动停止时会产生振动和柔性冲击,导致弹鼓运动平稳性较差,不利于弹鼓与扬弹机交接弹药。基于弧面分度凸轮机构基本运动规律中速度和加速度相对较小、且连续无突变的改进正弦加速度运动规律,对跃度曲线进行优化,建立数学模型,利用Matlab求解相关系数,得到跃度连续的改进正弦加速度运动规律。通过改进前后凸轮机构运动曲线对比分析,说明改进运动规律的有效性,为提高弹鼓运动平稳性提出一种解决途径。

关键词：弧面分度凸轮机构舰炮弹鼓运动规律凸轮曲线

Effect of negative remodeling of the side branch ostium on the efficacy of a two-stent strategy for distal left main bifurcation lesions:an intravascular ultrasound study

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Journal of Geriatric Cardiology 2024年第5期21卷 506-522页

作者： Yi XU Tian XU Jia-Cong NONG Xiao-Han KONG Meng-Yao ZHAO Zhi-Jing GAO Yi-Fei WANG Wei YOU Pei-Na MENG Yu-he zhou Xiang-Qi WU Zhi-Ming WU Mei-En ZHAN Yan-Qing WANG De-Feng PAN Fei YE Department of Cardiology Nanjing First HospitalNanjing Hospital Affiliated to Nanjing Medical UniversityNanjing Medical UniversityNanjingChina Department of Cardiology Clinical Medicine School of Nanjing UniversityNanjingChina Department of Cardiology Tianchang People’s HospitalTianchangChina Department of Cardiology the Affiliated Hospital of Xuzhou Medical UniversityXuzhouChina

OBJECTIVES To investigate whether negative remodeling(NR) detected by intravascular ultrasound(IVUS) of the side branch ostium(SBO) would affect in-stent neointimal hyperplasia(NIH) at the one-year follow-up and the clinical outcome of target lesion failure(TLF) at the long-term follow-up for patients with left main bifurcation(LMb) lesions treated with a two-stent *** A total of 328 patients with de novo true complex LMb lesions who underwent a 2-stent strategy of percutaneous coronary intervention(PCI) treatment guided by IVUS were enrolled in this study. We divided the study into two phases. Of all the patients, 48 patients who had complete IVUS detection pre-and post-PCI and at the 1-year follow-up were enrolled in phase Ⅰ analysis, which aimed to analyze the correlation between NR and in-stent NIH at SBO at the 1-year follow-up. If the correlation was confirmed, the cutoff value of the remodeling index(RI) for predicting NIH ≥ 50% was analyzed next. The phase Ⅱ analysis focused on the incidence of TLF as the primary endpoint at the 1-to 5-year follow-up for all 328 patients by grouping based on the cutoff value of *** In phase I: according to the results of a binary logistic regression analysis and receiver operating characteristic(ROC) analysis, the RI cutoff value predicting percent NIH ≥ 50% was 0.85 based on the ROC curve analysis, with a sensitivity of 85.7%, a specificity of 88.3%, and an AUC of 0.893(0.778, 1.000), P = 0.002. In phase Ⅱ: the TLR rate(35.8% vs. 5.3%, P her in the several NR(s NR, defined as RI ≤ 0.85) group than in the non-s NR *** The NR of LCx O is associated with more in-stent NIH post-PCI for distal LMb lesions with a 2-stent strategy,and NR with RI ≤ 0.85 is linked to percent NIH area ≥ 50% at the 1-year follow-up and more TLF at the 5-year follow-up.

关键词： lesions remodeling intravascular

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石声汉译著成果的国际传播与影响

上海翻译 2024年第1期 79-84页

作者：张保国周鹤乐山师范学院四川乐山614000 湖南科技大学湖南湘潭411201

石声汉的译著成果在国际农史、科技史学界产生了广泛影响,具体表现为被日、韩、欧美等地汉学家所参照、介评、研究、征引、翻译或转译,为国际中国科技史研究提供了重要借鉴,同时也激发了李约瑟和西山武一的合作意向并间接促成《中国科... 详细信息

石声汉的译著成果在国际农史、科技史学界产生了广泛影响,具体表现为被日、韩、欧美等地汉学家所参照、介评、研究、征引、翻译或转译,为国际中国科技史研究提供了重要借鉴,同时也激发了李约瑟和西山武一的合作意向并间接促成《中国科学技术史》农业卷的诞生,至今仍被白馥兰所参考。其传播之道在于石声汉的开拓精神和科学精神赢得了汉学家的信赖,他的译著成果满足了汉学家的研究需要并引发了学术共同体的协同效应。这给致力于中华学术“走出去”的中国学者提出了三点学术品格要求:要有“人无我有,人有我精”的学术追求、“自我主张”的学术精神和“毛遂自荐”的学术自信。

关键词：石声汉学术外译语内译作国际传播与影响农学典籍

科学传播模式演变与科技创新交互机制的探析和思考

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中国科学院院刊 2024年第2期39卷 358-366页

作者：董纪昌祝魏玮张超贺舟中国科学院大学经济与管理学院北京100190 中国科学院办公厅北京100864 中国科学院科技战略咨询研究院北京100190

在科技发展日新月异的今天,科学传播与科技创新密切相关,是影响国家科技竞争力、争夺全球科技话语权的重要因素。文章分析了科学传播的时代背景及科学传播的理论研究与模式转变,探讨了科学传播与科技创新的相互促进关系,揭示了两者交互... 详细信息

在科技发展日新月异的今天,科学传播与科技创新密切相关,是影响国家科技竞争力、争夺全球科技话语权的重要因素。文章分析了科学传播的时代背景及科学传播的理论研究与模式转变,探讨了科学传播与科技创新的相互促进关系,揭示了两者交互作用的机理。在此基础上,调查了国外一些主要发达国家推动科学传播的典型经验,并结合我国的科学传播现状,尝试提出了促进科学传播事业的对策建议。

关键词：科学传播科学普及科技创新基础研究

Establishment and performance analysis of a new multiplex detection method for influenza an and B virus antigen

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World Journal of Clinical Cases 2024年第23期12卷 5338-5345页

作者： Cheng-Jing Xia Bao-Hua Li Yan-Ni Guo Xiao-he zhou Run-Ling Zhang Ying-No Niu Department of Clinical Laboratory West WingShenzhen Hospital(Guangming)of University of Chinese Academy of SciencesShenzhen 518106Guangdong ProvinceChina Laboratory Nanjing Vazyme Biotech Co.LtdNanjing 210033Jiangsu ProvinceChina

BACKGROUND Influenza A and B virus detection is pivotal in epidemiological surveillance and disease *** and accurate diagnostic techniques are crucial for timely clinical intervention and outbreak *** dot-encoded microspheres have been widely used in *** integration of quantum dot-encoded microspheres with flow cytometry is a well-established technique that enables rapid ***,establishing a multiplex detection method for influenza A and B virus antigens based on flow cytometry quantum dot microspheres will help in disease *** To establish a codetection method of influenza A and B virus antigens based on flow cytometry quantum dot-encoded microsphere technology,which forms the foundation for the assays of multiple respiratory virus *** Different quantum dot-encoded microspheres were used to couple the monoclonal antibodies against influenza A and *** known influenza A and B antigens were detected both separately and simultaneously on a flow cytometer,and the detection conditions were optimized to establish the influenza A and B antigen codetection method,which was utilized for their detection in clinical *** results were compared with the fluorescence quantitative polymerase chain reaction(PCR)method to validate the clinical performance of this *** The limits of detection of this method were 26.1 and 10.7 pg/mL for influenza A and B antigens,respectively,which both ranged from 15.6 to 250000 pg/*** the clinical sample evaluation,the proposed method well correlated with the fluorescent quantitative PCR method,with positive,negative,and overall compliance rates of 57.4%,100%,and 71.6%,*** A multiplex assay for quantitative detection of influenza A and B virus antigens has been established,which is characterized by high sensitivity,good specificity,and a wide detection range and is promising for clinical applications.

关键词： Influenza A Influenza B Quantum dot microspheres Antigen detection Multiplex detection

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带时间窗的多机器人系统复杂任务路径规划

南京邮电大学学报（自然科学版） 2024年第2期44卷 83-90页

作者：何舟刘思羽陕西科技大学电气与控制工程学院陕西西安710021 陕西科技大学机电工程学院陕西西安710021

针对多机器人系统在复杂任务和时间窗双重约束下的路径规划问题,通过改进蚁群算法实现满足以布尔任务给出的轨迹要求及时间窗约束的最短路径规划。首先,根据全局地图信息和布尔任务提出一种基于Dijkstra算法的预处理算法,计算任务区域... 详细信息

针对多机器人系统在复杂任务和时间窗双重约束下的路径规划问题,通过改进蚁群算法实现满足以布尔任务给出的轨迹要求及时间窗约束的最短路径规划。首先,根据全局地图信息和布尔任务提出一种基于Dijkstra算法的预处理算法,计算任务区域之间的最短路径;其次,为了提高求解质量并加快收敛速度,引入基于A∗算法的评估函数改进蚁群算法的启发信息,并结合蚂蚁回退机制,提出一种改进蚁群算法,规划满足任务和时间窗约束的最短路径;最后,通过仿真实验证明所提算法的有效性,并与现有研究进行比较,在求解质量和算法收敛性方面均优于现有方法。

关键词：多机器人系统布尔任务路径规划时间窗