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The Experiment Research of Subconjunctival Injections with Etoposide for the Treatment of Retinoblastoma Mice

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Eye Science 2005年第3期21卷 169-174页

作者： Yuxiang Mao zhongyao wu Huasheng Yang Jianliang Zheng Jianfeng He Wei Li Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 China

Purpose: To evaluate the efficacy of subconjunctival injections of Etoposide for retinoblastoma(RB) ***: Twenty-five RB mice were divided into 5 groups for the study(G0～G4). GO for control group received 0.9% sodium chloride injection subconjunctival. G1: 5 RB mice for systemic delivery received 6 systemic administration of Etoposide 150 μg and Cyclosporin A (CSA)1.0mg at 3 days intervals, respectively. G2～G4:5 RB mice in each group received 6 subconjunctival delivery of Etoposide in 50、75、150μg at 3 days intervals, *** observe the changes of the volume of RB in anterior chamber and the part of conjunctiva for injections of chemotherapeutic drugs. All eyes and conjunctiva and scleras of the part for drugs injections were obtained at 6 weeks after experiment for histopathologic examination. The findings under the light microscope were analysed with software to measure the areas of RB in anterior chambers and the tumor inhibition ***:The volume of RB in anterior chambers for G1 and G2 increase quickly and none of the mice exhibited tumor control. The RB volume increase slowly in G3 and exhibit tumor control in G4. The areas of tumors in G0～G4 are 0.710,0.659,0.634,0.515,0.235 mm2, respectively. The rate for tumor inhibition in G0～G4 are 0.0%,7.18%, 10.70% ,27.43% ,66.90%, respectively. There are statistical significant difference between the G1 and G4 for the volumes of tumors and the rate of tumor *** pathologic examination of subconjunctiva and sclera for the injective sites showed no pathologic ***: There are significant effects for the method of subconjunctival delivery of Etoposide in RB control, demonstrating a positive dose-related relationship. Subconjunctival injection of Etoposide reached better efficacy in controlling and inhibiting RB cells than systemic delivery of Etoposide for the same dose. The pathologic results showed the subconjunctival delivery of etoposide were safety for conjunctiva and scle

关键词：医学实验注射剂眼癌小鼠动物实验治疗方法

Features Associated with Recurrence of Idiopathic Orbital Inflammatory Pseudotumor

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眼科学报 2007年第1期23卷 58-64页

作者： Jianhua Yan Zhiqing Lu zhongyao wu Yongping Li Zhicong Chen Yuxiang Mao Siming Ai Huasheng Yang Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 China

Purpose: To explore factors which lead to recurrence of idiopathic orbital inflam-matory pseudotumor (IOIP). Methods: Idiopathic orbital inflammatory pseudotumor in 209 cases between Jan 1, 1978 and Dec 31, 1999 in our hospital was evaluated retrospectively. The comparison of clinical and pathological parameters between patients with at least one episode of recurrence and those with no recurrence at all was performed and analyzed using logistic regression method. Results: Follow-up results (with a mean follow-up time of 3.4 years, ranging from 0.5 year to 21.0 years) showed that the recurrence rate of IOIP was 41%. Sex and proptosis were associated with the recurrence of IOIP. Male gender was more likely to relapse than female counterparts, with the male being 52% and female being 25%. The severer the proptosis is, the higher the rate of recurrence. Among the clinical subtypes of IOIP, the rate of recurrence (17%) in cases with dacryoadinitis was the lowest, followed by anterior local orbital mass (44%), posterior orbital mass (54%), myositis (75%) and diffuse subtype (100%). However, the clinical subtypes did not show significant relationship with the recurrence of IOIP. Conclusions: Male gender and severe proptosis are associated with a higher recurrent rate in patients with IOIP.

关键词：先天性炎性假瘤治疗眼科学复发

Mechanism and Etiology of Primary Chronic Angle Closure Glaucoma

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眼科学报 1994年第3期10卷 186-192页

作者： Ningli Wang , zhongyao wu, Hui LiuZhongshan Opathalmic Center , Sun Yat-sen University of Medical Sciences Guangzhou 510060, China Zhongshan Opathalmic Center Sun Yat-sen University of Medical Sciences Guangzhou China.

The ocular anatomic features, pupil-blocking force, status of angle synechiae closure and positivity of provocative tests were compared between the primary chronic angle closure glaucoma (PCACG) and primary a-cute angle closure glaucoma (PAACG) by using ultrasonic biometry, computerized anterior ocular segment image processing technique, gonioscopy and provocative tests. The studies showed that the anterior chamber depth of PAACG was shallower than that of PCACG; the pupil-blocking force of PAACG was st...

关键词： primary angle closure glaucoma etiology Chinese

A Clinical Analysis of Idiopathic Orbital Inflammatory Pseudotumor

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眼科学报 2000年第3期16卷 208-213页

作者： Jianhua Yan, zhongyao wu, Yongping LiZhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences. Guangzhou 510060 China Zhongshan Ophthalmic Center Sun Yat-sen University of Medical Sciences Guangzhou 510060 China

Purpose: To observe the clinical findings and response to treatment in patients with a diagnosis of idiopathic orbital inflammatory ***: 209 idiopathic orbital inflammatory pseudotumor cases seen between Jan 1, 1978 and Dec 31, 1999 in our hospital were evaluated retrospectively. Results: Of the 209 cases, 118 were male and 91 were female; there were 90 in the right eye, 81 left eye and 38 both eyes. Patients age ranged from 4 to 80 years (mean 44.4). Proptosis (66%), palpable mass (65%), swollen eyelid (55%), increased orbital pressure (55%) and motility restriction (48%) were the five most common presenting signs. According to radiologic and surgical findings, focal mass within orbit was the most frequent subtype (43% ), followed by lacrimal inflammatory pseudotumor (32%), diffuse orbital inflammation (10%), myositis (8%) . Perineuritis (2%), periscleritis(2%), acute inflammation (2%) and eyelid pseudotumor (1%) were rare clinical findings. The response to treatment (with a mean

关键词：炎性假瘤眼眶肿瘤自发性临床分析

Color Doppler Imaging in the Diagnosis and Follow-up of Carotid Cavernous Sinus Fistulas

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眼科学报 1993年第3期9卷 153-157页

作者： zhongyao wu Huasheng Yang Zhongshan Ophthalmic Center,Sun Yat-Sen University of Medical Sciences Guangzhou 510060,China Zhongshan Ophthalmic Center Sun Yat-Sen University of Medical Sciences Guangzhou China.

This report describes color doppler imaging (CDI) in theevaluation and follow-up of nine patients with carotid cavernous *** orbits and carotid arteries were examined with *** allcases,the diagnosis was confirmed by *** clearlydemonstrated the dilated superior ophthalmic veins (SOVs) with retrogradeflow and low resistance arterial doppler waveform in all nine patients (10eyes).After the study of quantitative hemodynamics,we found that directcarotid cavernous sinus fistulas s...

关键词： color doppler imaging carotid cavernous sinus fistulas angiography orbit diagnose

Material-SAM:Adapting SAM for Material XCT

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Computers, Materials & Continua 2024年第3期78卷 3703-3720页

作者： Xuelong wu Junsheng Wang zhongyao Li Yisheng Miao Chengpeng Xue Yuling Lang Decai Kong Xiaoying Ma Haibao Qiao School of Materials Science and Engineering Beijing Institute of TechnologyBeijing100081China Senior Engineer at the Simulation Center Citic Dicastal Co.Ltd.Qinhuangdao066010China

X-ray Computed Tomography(XCT)enables non-destructive acquisition of the internal structure of materials,and image segmentation plays a crucial role in analyzing material XCT *** paper proposes an image segmentation method based on the Segment Anything model(SAM).We constructed a dataset of carbide in nickel-based single crystal superalloys XCT images and preprocessed the images using median filtering,histogram equalization,and gamma ***,SAM was fine-tuned to adapt to the task of material XCT image segmentation,resulting in *** compared the performance of threshold segmentation,SAM,U-Net model,and *** method achieved 88.45%Class Pixel Accuracy(CPA)and 88.77%Dice Similarity Coefficient(DSC)on the test set,outperforming SAM by 5.25%and 8.81%,respectively,and achieving the highest ***-SAM demonstrated lower input requirements compared to SAM,as it only required three reference points for completing the segmentation task,which is one-fifth of the requirement of ***-SAM exhibited promising results,highlighting its potential as a novel method for material XCT image segmentation.

关键词： Segment Anything model X-ray computed tomography U-Net Ni-based superalloys foundation models

Electrophoretic Determination of Aqueous and Serum Neuron-specific Enolase in the Diagnosis of Retinoblastoma

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眼科学报 1997年第1期13卷 12-16页

作者： zhongyao wu, Huasheng Yang, Suhua Pan, Zhicong ChenZhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences , Guangzhou 510060 , China Zhongshan Ophthalmic Center Sun Yat-sen University of Medical Sciences Guangzhou 510060 China.

Purpose: Neuron-specific enolase (NSE) of containing γ-enolase is considered valuable in the diagnosis of tumours of neuroectodermal *** : We used rapid electrophoretic method on cellulose acetate plate to determine the pattern of enolase isoenzymes in 21 aqueous humor and 23 serum specimens from retinoblastoma (Rb) and 21 aqueous and 25 serum specimens from 25 control cases to evaluate NSE in the diagnosis of Rb. The assay allowed assessment of all three major isoenzymes (aa,aγ and γγ),and NSE relative activity and its percentage in the total relative activity of the three enolase isoenzymes were assessed by means of ***: Aqueous from all patients with Rb contained aa,ar and rr isoenzymes and presented strong postitive, the positive rate of NSE being 100% and its relative activity accounting for 45 ± 9% of the total relative activity of the 3 enolase isoenzymes; No enolase was detectable in control aqueous with cataract, glaucoma and Coats's diseases (4 cases),but in two

关键词：眼免疫电泳水状体血清成视网膜细胞瘤神经元性烯醇酶

A Model for Blindness Prevention

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眼科学报 1997年第3期13卷 162-163,147页

作者： Jingjing Xu, Wenshu Mao, Shaozhen Li, Lezheng wu, zhongyao wu Siping Zhu, Qiang Yu, Mingguang HeZhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, China Zhongshan Ophthalmic Center Sun Yat-sen University of Medical Sciences Guangzhou 510060 China

Objective :To introduce the work of the prevention and treatment of blindness of Zhongshan Ophthalmic Center, to find out the effective model of blindness prevention and treatment in ***; 1. To provide high quality clinical service to rural people. 2. To conduct epidemio-logical survey *** train local ophthalmic professionals *** promote international ***:40 000 outpatients cases, 4 500 cataract surgeries have been accomplished. Thousands cataract blind have been rehabilitated. 9 papers concerning epidemiological survey have been published. After the international training courses, 50 local ophthalmic workers have been trained and 4 cataract surgery rehabilitation centers have been founded. Conclusion : An effective model for blindness prevention and treatment should be based on clinical service, population based epidemiological survey and local ophthalmic professionals training. International cooperation is also an important promoter. Eye Science 1997; 13 : 162 -163.

关键词：失明预防方法白内障

Exon-by-exon Screening for RB Germline Mutations Using Heteroduplex-SSCP Analysis

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眼科学报 1997年第1期13卷 5-11页

作者： Qingjiong Zhang, Kensei Minoda, Ruiping Zeng, zhongyao wu Xueshan Xiao, Shiqiang Li, Fengshen ZhangZhongshan Ophthalmic Center Department of Medica GeneticsSun Yat-sen University of Medical Sciences , Guangzhou 510060 , ChinaDepartment of Ophthalmology, Teikyo University Ichihara Hospital, Ichihara , Chiba 299 - 01, Japan. Zhongshan Ophthalmic Center Sun Yat-sen University of Medical Sciences Guangzhou 510060 China.

Objective: To disclose the nature of RBI germline mutations in Chinese and to develop a practical and effective way for mutational screening. Methods: Leukocyte DNA was prepared from 8 Chinese patients with hereditary retinoblastoma. PCR combined with nonisotopic heteroduplex-SSCP analysis was used to screen leukocyte DNA for RBI germline mutations, exon-by-exon, without the use of restriction endonuclease digestion. The mutations were finally identified by sequencing. In order to testify the effectiveness of this method, the same method was used to detect other 17 samples which have been previously analyzed by other methods. Results: Heterozygous germline mutations were detected in the leukocyte DNA of 6 out of 8 Chinese patients;G del/codon 46,T del/codon 131 ,CAGAA del/condon 257 -258, GCAgta→GCAgca/donor of exon 16, C@T/codon 661, and C→T/codon 787. Heteroduplex-SSCP analysis may detect RBI germline mutations in 68% (177 25) unselected patients, which is more effective than SSCP(56%) or

关键词：成视网膜细胞瘤突变 SSCP 遗传因素非遗传因素