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Two New Saponins from Lysimachia capillipes Hemsl.

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Journal of Integrative Plant Biology 2005年第10期47卷 1271-1275页

作者： Jing-Kui TIAN zhong-mei zou Li-Zhen XU Shi-Lin YANG Department of Chinese Medicine Sciences and Engineering Zhejiang University Hangzhou 310027 China Institute of Medicinal Plants Development Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100094 China

To investigate the saponins from whole plants of Lysimachia capilUpes Hemsl., two new saponins, named capilliposide E （1） and capilliposide F （2）, were isolated. The structures of the new saponins were elucidated as 3β, 22α-dihydroxy-16α-acetat-28→ 13-lactone-oleanane-3-O- [β-D-glucopyranosyl- （1 →2）-α-L-arabinpyranoyl]-22-O-β-D-glucopyranoside （1） and 3β, 22α-dihydroxy- 16α-acetat-28→ 13-lactone-oleanane-3-O-{ [β-D-glucopyranosyl-（1→2）-β-D-glucopyranosyl-（1→4）]-α-L-arabinpyranoyl}-22-O-β- D-glucopyranoside （2）. The structures of these compounds were determined by 1D- and 2D-NMR, MS techniques, and chemical methods.

关键词： capilliposide E and F, Lysimachia capillipes triterpene saponin.

Two New Polyoxygenated Cyclohexenes from Uvaria kweichowensis

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Chinese Chemical Letters 2005年第10期16卷 1343-1346页

作者： Qiong Ming XU zhong mei zou Li Zhen XU Shi Lin YANG Institute of Medicinal Plant Development Peking Union Medical College and Chinese Academy of Medicinal Sciences Beijing 100094

Two new polyoxygenated cyclohexenes, kweichowenol A and B were isolated from the leaves of Uvaria kweichowensis and their structures were established on the basis of their spectral data.

关键词： Annonaceae Uvaria kweichowensis leaves cyclohexenes kweichowenol A kweichowenol B.

New Cytotoxic Saponins from Lysimachia davurica Ledeb.

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Journal of Integrative Plant Biology 2006年第2期48卷 232-235页

作者： Jing-Kui Tian zhong-mei zou Li-Zhen Xu Shi-Lin Yang Department of Chinese Medicine Sciences and Engineering Zhejiang University Hangzhou 310028 China Institute of Medicinal Plants Development Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100094 China

To investigate the saponins from whole plants of Lysimachia davurica Ledeb., two new saponins named davuricoside I （compound 1） and E （compound 2） were isolated. Their chemical structures were elucidated as 3β, 16α, 28, 29-tetrihydroxy-olean-12-en-3-O-β-D-glucopyranosyl-（1→2）-β-D-glucuronopyranoside （compound 1） and 3β, 16α, 29-trihydroxy-13, 28-epoxy-oleanane-3-O-β-D-glucopyranosyl-（1→2）-β-D-glucuronopyranoside （compound 2） on the basis of their one- and two-dimensional nuclear magnetic resonance and mass spectrometry data, and chemical methods. Compound 1 showed significant cytotoxic activity against human A2780 cells.

关键词： davuricoside I and E Lysimachia davurica triterpene saponin.

Two Novel Saponins from Lysimachia capillipes

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Chinese Chemical Letters 2005年第12期16卷 1607-1610页

作者： Jing Kui TIAN Chen XIE zhong mei zou Li Zhen XU Shi Lin YANG Deptment of Chinese Medicine Science ＆ Engineering Zhejiang University Hangzhou 310028 Institute of Medicinal Plants Development Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100094

Two new saponins named capilliposide C 1 and capilliposide D 2 were isolated from the whole plants of Lysimachia capillipes, their structures were deternuned by 1D and 2D NMR, ESIMS techniques, and chemical *** C show... 详细信息

关键词： Lysimachia capillipes triterpene saponin capilliposide C and D

Fimbrialtols K–M, highly functionalized ent-kaurane diterpenoids from traditional Chinese plant Flickingeria fimbriata(B1.) Hawkes

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Chinese Chemical Letters 2017年第3期28卷 593-596页

作者： Gang Ding Jing Wang Jiao-Dong Fei Rong-Tao Li Hong-mei Jia Tao Zhang Chang-Yuan Yu zhong-mei zou 无 Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100193 China Beijing University of Chemical Technology Beijing 100029 China Hainan Branch of lnstitute of Medicinal Plant Development Chinese Academy of Medical Sdences and Peking Union Medical College Beijing 100193 China

Three new ent-kaurane diterpenoids fimbrialtols K–M（3–5） with highly substituted functionalities were isolated from the extract of Flickingeria fimbriata（B1.） Hawkes. The structures of these new compounds were determined by NMR and HR-ESIMS. The relative configurations of these compounds were determined by analysis of NOESY correlations. The absolute configurations of these new compounds were established by CD methods together with considering the biosynthetic pathway. Compounds 3 and4 contain a cinnamic carboxyl group, whereas compound 5 possesses a benzoic carboxyl group representing the first report in more than known 600 ent-kaurane diterpenoids.

关键词： Flickingeria fimbriata(B1.) Hawkes ent-Kaurane diterpenoids Fimbrialtols NMR CD

Standardized Xin-Ke-Shu Tablets Improves the Disturbances of Lipid, Energy, and Amino Acid Metabolism in a Rabbit Model of Atherosclerosis

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World Journal of Traditional Chinese Medicine 2019年第2期5卷 71-80页

作者： Yong Yang Jing-Bo Peng Meng Yu Hong-mei Jia Hong-Wu Zhang zhong-mei zou Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical College

Objective:Xin-Ke-Shu(XKS),a patent drug,used to treat coronary artery diseases in China for many *** research indicates that XKS has similar therapeutic effect as atorvastatin(AS)against atherosclerotic in ***,biochemical assays demonstrate that XKS could have a different therapeutic mechanism from *** aim of this study is to explore the mechanism of XKS therapeutic effect,especially those different from *** and Methods:~1H nuclear magnetic resonance-based metabonomics were applied to profile the low-molecular-weight polar metabolites in the plasma of rabbits fed a high cholesterol ***:Seven of the eleven pathological biomarkers related to atherosclerosis in rabbits were mediated by XKS treatment,namely low-density lipoprotein/very-low-density lipoprotein LDL/VLDL),lactate,citrate,phosphatidylcholine,glutamine,creatinine,and methionine,as well as two characteristic metabolites of pyruvate and α-*** metabolites involved lipid,energy,and amino acid metabolism,and all could be considered XKS treatment ***,AS only affected the metabolic disorders associated with LDL/VLDL and phosphatidylcholine,which is mainly target lipid ***:This study indicates that the anti-atherosclerosis effects of AS mainly involve reducing blood–lipid levels,but those of XKS involve a multitargeted activity.

关键词： 1^H nuclear magnetic resonance atherosclerosis plasma metabonomics polar small molecules metabolites Xin-Ke-Shu

Stereochemical determination of tetrahydropyran-substituted xanthones from fungus Chaetomium murorum

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Chinese Chemical Letters 2015年第12期26卷 1507-1510页

作者： Meng-Hua Wang Li Li Tao Jiang Xue-Wei Wang Bin-Da Sun Bo Song Qiu-Bo Zhang Hong-mei Jia Gang Ding zhong-mei zou Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of EducationInstitute of Medicinal Plant Development Chinese Academy of Medical Sciences State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences State Key Laboratory of Mycology Institute of Microbiology Chinese Academy of Sciences

Chaetoxanthone D（1）, a new tetrahydropyran-substituted xanthone originated from polyketide pathway, together with the four known natural products chaetoxanthone C（2）, alternariol methyl ether（3）, alternariol（4） and 2,5-dimethyl-7-hydroxychromone（5） was isolated from a strain of Chaetomium murorum. The structures of these compounds were elucidated based on extensive spectroscopic analyses. The absolute configurations of 1 and 2 were determined by using quantum chemical electronic circular dichroism（ECD） calculations.

关键词： substituted elucidated spectroscopic absolute fungus originated pyran circular aromatic planar

The antidepressive mechanism of Chaihu-ShuGan-San（CSGS） based on a tissue targeted metabonomics

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The antidepressive mechanism of Chaihu-ShuGan-San（CSGS） ba...

Serum Metabolic Biomarkers of Liver Failure Patients Caused by Hepatitis B Virus Based upon UPLC-Q-TOF MS System

第十四届全国中药和天然药物学术研讨会

作者： Xing Chang Chao Zhou Ming Wu Hong-mei Jia zhong-mei zou Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical College

Objective:Hippocampus is the main targeted tissue affected by stress and injury.A tissue targeted metabonomic study was used to further explore the antidepressive mechanism of Chaihu-Shu-Gan-San（CSGS） on ***:UPLC-Q-TOF/MS and 1H NMR were applied to study the metabolic profiles of CUMS and CSGS treated *** statistical analysis（PCA and OPLS-DA） and partial least squares regression analysis（PLSR） were used to find out and screen the depression-related ***:CSGS could increase the CUMS rats’ body weight,the number of independent movements and sucrose preference significantly.47 potential biomarkers were identified by OPLS-DA from UPLC-Q-TOF/MS and 1H NMR *** then,22 biomarkers which were considered as depression-related biomarkers were screening out by PLSR through study the relationship between the identified 47 potential biomarkers and sucrose ***:CSGS can regulated the content of the 22 depression-related biomarkers and play the antidepressant effects by improving the disordered metabolic pathways of amino acids metabolism,energy metabolism,neurotransmitter synthesis,glycerophospholipid metabolism,purine *** survey indicates that metabonomics method has a broad prospect,which can be applied to study the mechanism of disease and TCM formula.

关键词： metabonomics hippocampus chronic unpredictable mild stress(CUMS) biomarkers PLSR

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Serum Metabolic Biomarkers of Liver Failure Patients Caused ...