Fimbrialtols K–M, highly functionalized ent-kaurane diterpenoids from traditional Chinese plant Flickingeria fimbriata(B1.) Hawkes

作     者：Gang Ding Jing Wang Jiao-Dong Fei Rong-Tao Li Hong-Mei Jia Tao Zhang Chang-Yuan Yu Zhong-Mei Zou 无 

作者机构：Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100193 China Beijing University of Chemical Technology Beijing 100029 China Hainan Branch of lnstitute of Medicinal Plant Development Chinese Academy of Medical Sdences and Peking Union Medical College Beijing 100193 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2017年第28卷第3期

页      面：593-596页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：financially supported by the Chinese National S&T Special Project on Major New Drug Innovation(No.2013ZX09508104) the Fundamental Research Funds for the Central Scientific Research Institutes for Public Welfare CAMS Innovation Fund for Medical Sciences(CIFMS,No.2016-I2M-3-015) 

主　　题：Flickingeria fimbriata(B1.) Hawkes ent Kaurane diterpenoids Fimbrialtols NMR CD 

摘      要：Three new ent-kaurane diterpenoids fimbrialtols K–M（3–5） with highly substituted functionalities were isolated from the extract of Flickingeria fimbriata（B1.） Hawkes. The structures of these new compounds were determined by NMR and HR-ESIMS. The relative configurations of these compounds were determined by analysis of NOESY correlations. The absolute configurations of these new compounds were established by CD methods together with considering the biosynthetic pathway. Compounds 3 and4 contain a cinnamic carboxyl group, whereas compound 5 possesses a benzoic carboxyl group representing the first report in more than known 600 ent-kaurane diterpenoids.