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Effect of anesthesia induction with butorphanol on postoperative nausea and vomiting:A randomized controlled trial

World Journal of Clinical Cases 2023年第32期11卷 7806-7813页

作者： Fang Xie De-Feng sun Lin Yang zhong-liang sun Department of Anesthesiology The First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina Department of Neuroelectrophysiology The First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina

BACKGROUND Postoperative nausea and vomiting(PONV)are common complications that affect the recovery and well-being of elderly patients undergoing gastrointestinal laparoscopic *** To investigate the effect of butorphanol on PONV in this patient *** A total of 110 elderly patients(≥65 years old)who underwent gastrointestinal laparoscopic surgery were randomly assigned to receive butorphanol(40μg/kg)or sufentanil(0.3μg/kg)during anesthesia induction in a 1:1 *** measured outcomes included the incidence of PONV at 48 h after surgery,intraoperative dose of propofol and remifentanil,Bruggrmann Comfort Scale score in the postanesthesia care unit(PACU),number of compressions for postoperative patientcontrolled intravenous analgesia(PCIA),and time to first flatulence after *** The results revealed a noteworthy reduction in the occurrence of PONV at 24 h after surgery in the butorphanol group,when compared to the sufentanil group(T1:23.64%vs 5.45%,T2:43.64%vs 20.00%,P0.05).Furthermore,patients in the butorphanol group were more comfortable,when compared to patients in the sufentanil group in the *** The present study revealed that butorphanol can be an efficacious substitute for sufentanil during anesthesia induction to diminish PONV within 24 h following gastrointestinal laparoscopic surgery in the elderly,simultaneously improving patient comfort in the PACU.

关键词： Butorphanol Sufentanil Enhanced recovery after surgery Anesthesiology Gastrointestinal surgery Postoperative nausea and vomiting

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Efficacy and safety of propofol target-controlled infusion combined with butorphanol for sedated colonoscopy

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World Journal of Clinical Cases 2023年第3期11卷 610-620页

作者： Feng Guo De-Feng sun Yan Feng Lin Yang Jing-Lin Li zhong-liang sun Department of Anesthesiology No.967 HospitalJoint Logistics Support Force of Chinese People’s Liberation ArmyDalian 116011Liaoning ProvinceChina Department of Anesthesiology The First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina Department of Neuroelectrophysiology The First Affiliated Hospital of Dalian Medical UniversityDalian 11601Liaoning ProvinceChina

BACKGROUND Propofol is a short-acting,rapid-recovering anesthetic widely used in sedated colonoscopy for the early detection,diagnosis and treatment of colon ***,the use of propofol alone may require high doses to achieve the induction of anesthesia in sedated colonoscopy,which has been associated with anesthesia-related adverse events(AEs),including hypoxemia,sinus bradycardia,and ***,propofol co-administrated with other anesthetics has been proposed to reduce the required dose of propofol,enhance the efficacy,and improve the satisfaction of patients receiving colonoscopy under *** To evaluate the efficacy and safety of propofol target-controlled infusion(TCI)in combination with butorphanol for sedation during *** In this controlled clinical trial,a total of 106 patients,who were scheduled for sedated colonoscopy,were prospectively recruited and assigned into three groups to receive different doses of butorphanol before propofol TCI:Low-dose butorphanol group(5μg/kg,group B1),high-dose butorphanol group(10μg/kg,group B2),and control group(normal saline,group C).Anesthesia was achieved by propofol *** primary outcome was the median effective concentration(EC50)of propofol TCI,which was measured using the up-and-down sequential *** secondary outcomes included AEs in perianesthesia and recovery *** The EC50 of propofol for TCI was 3.03μg/mL[95%confidence interval(CI):2.83-3.23μg/mL]in group B2,3.41μg/mL(95%CI:3.20-3.62μg/mL)in group B1,and 4.05μg/mL(95%CI:3.78-4.34μg/mL)in group *** amount of propofol necessary for anesthesia was 132 mg[interquartile range(IQR),125-144.75 mg]in group B2 and 142 mg(IQR,135-154 mg)in group ***,the awakening concentration was 1.1μg/mL(IQR,0.9-1.2μg/mL)in group B2 and 1.2μg/mL(IQR,1.025-1.5μg/mL)in group ***,the propofol TCI plus butorphanol groups(groups B1 and B2)had a lower incidence of anesthesia AEs,when compared to group ***

关键词： Colonoscopy Sedated colonoscopy Propofol Butorphanol Target-controlled infusion Effective concentration Adverse event

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Paramagnetism and improved upconversion luminescence properties of NaYF4：Yb,Er/NaGdF4 nanocomposites synthesized by a boiling water seed-mediated route

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Frontiers of Materials Science 2016年第1期10卷 38-44页

作者： Chao-Qing YANG Ao-Ju LI Wei GUO Peng-Hua TIAN Xiao-Long YU zhong-Xin LIU Yang CAO zhong-liang sun Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources Hainan University Haikou 570228 China

In a route boiling water served as reaction medium, a stoichiometric amount of rare-earth compound and fluoride are put into this system to form a-NaYF4：Yb, Er nuclei. Then prepared sample is heated at elevated temperature to improve the fluorescence intensity, and next a NaGdF4 shell grows on the surface of NaYF4 nuclei. NaYF4：Yb,ErlNaGdF4 core-shell structured upconversion nanoparticles （CSUCNPs） have been successfully synthesized by above route. The use of boiling water decreases the cubic-to-hexagonal phase transition temperature of NaYF4：Yb,Er to 350℃ and increases its upconversion （UC） luminescence intensity. A heterogeneous NaGdF4 epitaxially growing on the surface of Ln^3＋-doped NaYF4 not only improves UC luminescence, but also creates a paramagnetic shell, which can be used as contrast agents in magnetic resonance imaging （MRI）o The solution of CSUCNPs shows bright green UC fluorescence under the excitation at 980 nm in a power density only about 50 ***-2. A broad spectrum with a dominant resonance at g of about 2 is observed by the electron paramagnetic resonance （EPR） spectrum of CSUCNPs. Above properties suggest that the obtained CSUCNPs could be potential candidates for dual-mode optical/magnetic bioapplications.

关键词： boiling water upconversion nanoparticle fluorescence imaging paramagnetism

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Clinical features and an atypical WT1 mutant site in a child with incomplete Denys-Drash syndrome

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Asian Journal of Andrology 2014年第4期16卷 647-649页

作者： Hai-Yan Wang Zhi-Hui Yue liang-zhong sun Jia-Cong Mo Ying Mo Jun-Jie sun Department of Pediatrics The First Affiliated Hospital Department of Pediatrics Sun Yat-sen Memorial Hospital Department of Pediatric Surgery The First Affiliated Hospital Sun Yat-sen University Guangzhou China.

Dear Editor, Denys-Drash syndrome （DDS） is characterized by the triad of progressive nephropathy, urogenital malformation and Wilms＇ tumor. Incomplete variants present with nephropathy with either intersex disorders or Wilms＇ tumor.1 Most DDS patients carry WTI mutations in exon 8 or 9.1 Here, we report an incomplete DDS child who carried a novel WT1 missense mutation in exon 6 and had unique clinical manifestations.

关键词： @@

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Hemoglobin integrated red blood cell membrane-coated metalorganic framework nano-platform for improving the self-adaptive blood glucose management

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Nano Research 2025年第1期18卷 618-627页

作者： Shuai Wu Li Zhu Sheng Ni Xiong Zhao Meng Yan Yuan zhong Karissa Kusuma Yi liang Kaiwen Bao Kai Qu Xian Qin Kun Zhang Wuquan Deng Da sun Wei Wu Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China Chongqing University Three Gorges Hospital Chongqing Municipality Clinical Research Center for Endocrinology and Metabolic DiseasesChongqing 404000China Institute of Life Sciences&Biomedical Collaborative Innovation Center of Zhejiang Province Wenzhou UniversityWenzhou 325035China Department of Endocrinology School of MedicineChongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400014China

Diabetes,a prevalent chronic metabolic disorder,often leads to severe ***,existing treatment methods may pose life-threatening risks due to poor patient compliance and inaccurate dosing of subcutaneous insulin ***,a biomimetic red blood cell(RBC)membrane-coated glucose-responsive nanoplatform is developed for controlling insulin *** nanoplatforms with RBC membrane can prolong the half-life of nano-formulation in vivo mediated by the biomimetic immune ***,the cascade catalytic effect of glucose oxidase(GOx)encapsulated in metal-organic frameworks(MOFs)and hemoglobin(Hb)in the RBC membrane are able to not only facilitate glucose-responsive insulin release,but also eliminate the detrimental by-product hydrogen peroxide(H_(2)O_(2))resulting from the Hb mediated H_(2)O_(2)*** in vitro and in vivo studies have demonstrated the favorable glucose-responsive performances of this advanced nano-platform with a single intravenous injection maintaining blood glucose balance in Type 1 Diabetes(T1D)mice for an extended duration without the hypoglycemia ***,this biomimetic insulin delivery system is poised to function as a strategy for the intravenous insulin administration,offering a promising drug candidate for the self-adaptive long-term T1D treatment.

关键词： glucose-responsive metal-organic frameworks red blood cell membrane insulin delivery glucose oxidase hemoglobin

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丙烯环氧化制环氧丙烷Fe-Al-P-O催化剂的研究

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燃料化学学报 2004年第6期32卷 740-744页

作者：钟顺和钟亮孙菲菲肖秀芬天津大学化工学院天津300072

用溶胶凝胶法制得了Fe Al P O催化剂,采用IR、XRD、TEM、BET、TPR和微反等技术研究了催化剂的物化性质和反应性能。实验结果表明,Fe1 2Al1 2PO4由10nm左右FePO4和AlPO4微晶组合而成,其晶格氧的活泼性大于单纯FePO4,AlPO4在Fe1 2Al1 2PO... 详细信息

用溶胶凝胶法制得了Fe Al P O催化剂,采用IR、XRD、TEM、BET、TPR和微反等技术研究了催化剂的物化性质和反应性能。实验结果表明,Fe1 2Al1 2PO4由10nm左右FePO4和AlPO4微晶组合而成,其晶格氧的活泼性大于单纯FePO4,AlPO4在Fe1 2Al1 2PO4中起到分散FePO4微晶的作用;Fe1 2Al1 2PO4的反应性能与原料气组成密切相关,丙烯与O2的选择氧化产物主要是丙烯醛,原料气中加入H2后,反应产物以环氧丙烷为主,同时还有部分丙烯醛,原料气中引入水蒸气后,可进一步增加环氧丙烷的选择性及减少丙烯醛的产率;在0.1MPa、200℃、C3H6 O2 H2 H2O N2=1∶1∶1∶1∶6(mol比)和空速1200h-1条件下,丙烯的转化率为8.9%,环氧丙烷的选择性为81.0%。

关键词：溶胶凝胶法 Fe-Al-P-O催化剂丙烯环氧化环氧丙烷

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并网逆变器电流控制器设计

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电力电子技术 2018年第7期52卷 61-63页

作者：李昱刘爱忠孙永亮孙久军山东鲁能智能技术有限公司山东济南250000

提出了一种三相电压型并网逆变器(VSI)在同步旋转坐标系下电流控制器的设计方法。首先,给出同步旋转坐标系下三相VSI的数学模型;然后,介绍了矢量控制策略,提出一种比例积分(PI)电流控制器设计方法,设计方法中考虑了数字控制带来的延迟环... 详细信息

提出了一种三相电压型并网逆变器(VSI)在同步旋转坐标系下电流控制器的设计方法。首先,给出同步旋转坐标系下三相VSI的数学模型;然后,介绍了矢量控制策略,提出一种比例积分(PI)电流控制器设计方法,设计方法中考虑了数字控制带来的延迟环节,并给出了详细的参数计算方法;最后,通过仿真和实验证明了控制器设计方法的正确性。

关键词：并网逆变器矢量控制同步旋转坐标系

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Flexible Graphene Field‑Effect Transistors and Their Application in Flexible Biomedical Sensing

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Nano-Micro Letters 2025年第2期17卷 252-313页

作者： Mingyuan sun Shuai Wang Yanbo liang Chao Wang Yunhong Zhang Hong Liu Yu Zhang Lin Han Institute of Marine Science and Technology Shandong UniversityQingdao 266237ShandongPeople’s Republic of China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongPeople’s Republic of China School of Integrated Circuits Shandong UniversityJinan 250100ShandongPeople’s Republic of China Shandong Engineering Research Center of Biomarker and Artificial Intelligence Application Jinan250100ShandongPeople’s Republic of China

Flexible electronics are transforming our lives by making daily activities more *** to this innovation are field-effect transistors(FETs),valued for their efficient signal processing,nanoscale fabrication,low-power consumption,fast response times,and ***,known for its exceptional mechanical properties,high electron mobility,and biocompatibility,is an ideal material for FET channels and *** combination of graphene and FETs has given rise to flexible graphene field-effect transistors(FGFETs),driving significant advances in flexible electronics and sparked a strong interest in flexible biomedical ***,we first provide a brief overview of the basic structure,operating mechanism,and evaluation parameters of FGFETs,and delve into their material selection and patterning *** ability of FGFETs to sense strains and biomolecular charges opens up diverse application *** specifically analyze the latest strategies for integrating FGFETs into wearable and implantable flexible biomedical sensors,focusing on the key aspects of constructing high-quality flexible biomedical ***,we discuss the current challenges and prospects of FGFETs and their applications in biomedical *** review will provide valuable insights and inspiration for ongoing research to improve the quality of FGFETs and broaden their application prospects in flexible biomedical sensing.

关键词： Flexible Graphene Field-effect transistor Wearable Implantable Biosensor

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Staged dendrite suppression for high safe and stable lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 674-683页

作者： Jun Jiang Zhenjie Lu Yanwen Ding Shujun Liu Zhijie Qi Tian Tang Yunfan Zhang Zhiyuan Ma Jingwen sun liang Xue Wenyao Zhang Pan Xiong Xin Wang Junwu Zhu Yongsheng Fu Key Laboratory for Soft Chemistry and Functional Materials of Ministry of Education Nanjing University of Science and Technology Jiangsu Pylon Battery Co.Ltd

The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur ***,we propose a dual-action strategy to address the lithium dendrite issue in stages by constructing a multifunctional surface-negatively-charged nanodiamond layer with high ductility and robust puncture resistance on polypropylene （PP） *** uniformly loaded compact negative layer can not only significantly enhance electron transmission efficiency and promote uniform lithium deposition,but also reduce the formation of dendrite during early deposition *** importantly,under the strong puncture stress encountered during the deterioration of lithium dendrite growth under limiting current,the high ductility and robust puncture resistance（145.88 MPa） of as-obtained nanodiamond layer can effectively prevent short circuits caused by unavoidable lithium *** Li||Li symmetrical cells assembled with nanodiamond layer modified PP demonstrated a stable cycle of over 1000 h at 2 mA cm-2with a polarization voltage of only 29.3 ***,the negative charged layer serves as a physical barrier blocking lithium polysulfide ions,effectively mitigating capacity *** improved cells achieved a capacity decay of only 0.042%per cycle after 700 cycles at 3 C,demonstrating effective suppression of dendrite growth and capacity attenuation,showing promising prospect.

关键词： Lithium-sulfur batteries Staged dendrite suppression Shuttle effect Surface-negatively-charged nanodiamond

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Nanoparticles for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1665-1680页

作者： Qiwei Yang Di Lu Jiuping Wu Fuming liang Huayi Wang Junjie Yang Ganggang Zhang Chen Wang Yanlian Yang Ling Zhu Xinzhi sun Department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

关键词： antioxidants axon regeneration biocompatible materials drug carriers nanoparticles nerve regeneration neuroinflammatory diseases neuroprotection spinal cord injury stem cells

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