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母血游离DNA检测对胎儿染色体非整倍体的诊断价值

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中国优生与遗传杂志 2019年第12期27卷 1455-1457页

作者：朱志英丁旭锋汤蕾霞冯茜菡蒋珍珍江苏省宜兴市妇幼保健院围产保健科江苏宜兴214200 江苏省宜兴市妇幼保健院男性生殖科江苏宜兴214200

目的探讨产前外周血游离胎儿DNA检测对胎儿染色体非整倍体的诊断价值。方法选取2018年在我院产前健康检查中接受外周血游离胎儿DNA检测的孕妇983例,根据唐氏综合征血清学筛查结果、孕妇年龄及其他因素分为3组,其中唐氏综合征高危组468例... 详细信息

目的探讨产前外周血游离胎儿DNA检测对胎儿染色体非整倍体的诊断价值。方法选取2018年在我院产前健康检查中接受外周血游离胎儿DNA检测的孕妇983例,根据唐氏综合征血清学筛查结果、孕妇年龄及其他因素分为3组,其中唐氏综合征高危组468例,高龄组312例,其他因素组203例,3组孕妇均采集外周血进行游离胎儿DNA检测,与正常人基因组进行对比分析,检出非整倍体高危者建议行羊膜腔穿刺,取羊水进行染色体核型分析,检验结果为阴性者则对出生胎儿情况进行电话随访。结果983例孕妇均顺利完成游离胎儿DNA检测,结果异常者17例,总异常率为1.73%,其中唐筛高危组检出3例21-三体阳性者,2例18-三体阳性者,2例13-三体阳性者,1例性染色体异常阳性者,异常率为1.71%;高龄组检出21-三体阳性者2例,18-三体阳性者1例,性染色体异常阳性者2例,异常率为1.60%;其他因素组检出21-三体阳性1例,18-三体阳性1例,性染色体异常1例,异常率为1.48%。母血游离胎儿DNA检测染色体非整倍体的灵敏度为100.00%(15/15),特异度为99.79%(966/968)。此外,母血游离胎儿DNA检测未对孕妇及胎儿产生不良反应。结论母体血浆游离胎儿DNA检测能够有效筛查胎儿染色体异常,且准确度及安全性高,对提高优生率有较高的临床价值。

关键词：母血游离胎儿DNA 产前健康检查染色体非整倍体羊水遗传学检测优生价值

Differential Proteomics Analysis on Fluoride-resistant Streptococcus mutans by Label-free Quantitation

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Chemical Research in Chinese Universities 2014年第4期30卷 566-571页

作者： ZHAO Hongyan ZHANG Zhimin zhu Laikuan LI Zhenling LI Penglian LIU Jiabai ZHANG zhiying School of Stomatology Jilin University Changchun 130021 P. R. China Shanghai Key Laboratory of Stomatology The Ninth People's Hospital School of Medicine Shanghai Jiaotong University Shanghai 200011 P. R. China

To figure out the changed biological characteristics of a fluoride-resistant strain compared with those of the parent sensitive strain of Streptococcus mutans（S,mutans） with the help of differential proteomics analysis,sixtyseven proteins with obvious differential expression were identified in fluoride-resistant *** them are the important virulence factors causing caries,including glucosyltransferase-S,glucosyltransferase-I,glucosyltransferase-Si,major cell-surface adhesin Pac,F-ATPase β-subunit,Fth,molecular chaperone DnaK,chaperonin GroEL,and the lactate *** obtained the differential proteomics expression profiles of the fluoride-resistant strain（UA159-FR） and its parental strain（UA159） of *** important virulence factors bringing about caries were identified to have differential expressions,among which the expression of lactate dehydrogenase in fluoride-resistant strain was enhanced compared to that in its parent *** results could provide the basis for analvsing the functions of proteins encoded by caries-related genes from the fluoride-resistant *** strain.

关键词： Fluoride-resistant Streptococcus mutans Differential proteomics Label-free quantitation

Preparation and Characterization of Superparamagnetic Fe_3O_4/CNTs Nanocomposites Dual-drug Carrier

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Journal of Wuhan University of Technology(Materials Science) 2017年第1期32卷 42-46页

作者：张小娟郝凌云 WANG Hehe zhu Xingqun ZHANG zhiying HU Xiaohong JIANG Wei School of Material Engineering Jinling Institute of Technology Nanjing 211169 China National Special Superfine Powder Engineering Research Center Nanjing University of Science and Technology Nanjing 210094 China

Fe3O4/carbon nanotubes（Fe3O4/CNTs） nanocomposites were prepared by polylol hightemperature decomposition of the precursor ferric chloride and CNTs in liquid triethylene *** surface modification with hexanediamine,folate was covalently linked to the amine group of magnetic Fe3O4/CNTs *** products were characterized by Fourier-transform infrared spectroscopy,transmission electron microscopy,and vibrating sample *** Fe3O4/CNTs were used as a dual-drug carrier to co-delivery of the hydrophilic drug epirubicin hydrochloride and hydrophobic drug *** results indicated that the Fe3O4/CNTs had a favorable release property for epirubicin and paclitaxel,and thus had potential application in tumor-targeted combination chemotherapy.

关键词： Fe3O4/CNTs nanocomposites dual-drug carrier epirubicin paclitaxel

管壳式换热器管束有限元模拟合理性研究及失稳分析

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压力容器 2024年第9期41卷 39-47页

作者：朱志颖于洪杰朱国栋钱才富吴志伟北京化工大学机电工程学院北京100029 中国通用机械工程有限公司北京100050 合肥通用机械研究院有限公司合肥230031

针对某DN300 mm、热管长度3 m的浮头式换热器管束失稳的数值模拟问题,首先,不考虑换热管和折流板之间的间隙,采用直接绑定接触将换热管和折流板连接在一起进行非线性失稳分析,结果是由于管束抗失稳,刚度显著增加,在壳程等效轴向压力达到... 详细信息

针对某DN300 mm、热管长度3 m的浮头式换热器管束失稳的数值模拟问题,首先,不考虑换热管和折流板之间的间隙,采用直接绑定接触将换热管和折流板连接在一起进行非线性失稳分析,结果是由于管束抗失稳,刚度显著增加,在壳程等效轴向压力达到42.606 MPa时,管束在轴向载荷作用下发生塑性失效,没有出现失稳;然后,针对换热管和折流板之间存在间隙而出现非线性接触分析难题,提出间隙等效法,即在间隙中填充软材料,从而改变接触形式,实现非线性失稳分析。同时,还针对该浮头换热器,采用间隙等效法成功进行了在壳程等效压力作用下的非线性稳定性分析,结果发现,由于换热器没有筒体支撑,管束会发生整体失稳,失稳变形呈整体偏斜,此时的等效轴向压力为18.6 MPa,小于换热管和折流板直接绑定的结果。另外,由GB/T 151—2014确定的基于欧拉公式计算的单根管临界失稳压力为89790 N,远大于本算例中整体失稳平均每根管承受的轴向压力,这意味着基于欧拉公式的换热器常规设计可能无法保证不会发生管束整体失稳的情况。

关键词：浮头式换热器壳程压力临界压力管束整体失稳

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钩端螺旋体病患者的临床观察及护理

国际医药卫生导报 2005年第24期11卷 85-86页

作者：朱志英曾玉婷石小红温奇观梁瑞花关银华肇庆市第一人民医院广东肇庆526021

笔者通过对28例钩端螺旋体病患者的临床观察及护理,严密观察患者的生命体征及其尿量的变化,及早发现患者的出血倾向、急性肾功能衰竭、肝脏的损害和赫氏反应,提高治愈率与抢救成功率。同时所有的就诊患者都应就地救治,减小对患者(特别... 详细信息

笔者通过对28例钩端螺旋体病患者的临床观察及护理,严密观察患者的生命体征及其尿量的变化,及早发现患者的出血倾向、急性肾功能衰竭、肝脏的损害和赫氏反应,提高治愈率与抢救成功率。同时所有的就诊患者都应就地救治,减小对患者(特别有出血倾向者)的搬运及转院。

关键词：钩端螺旋体病临床观察护理赫氏反应出血倾向

RcSPL1-RcTAF15b regulates the flowering time of rose (Rosa chinensis)

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Horticulture Research 2023年第6期10卷 182-194页

作者： Rui Yu zhiying Xiong Xinhui zhu Panpan Feng Ziyi Hu Rongxiang Fang Yuman Zhang Qinglin Liu Department of Ornamental Horticulture College of HorticultureChina Agricultural UniversityBeijing 100193China National Key Laboratory of Plant Genomics Institute of MicrobiologyChinese Academy of Sciencesand National Plant Gene Research CenterBeijing 100101China University of Chinese Academy of Sciences Beijing 101408China

Rose(Rosa chinensis),which is an economically valuable floral species worldwide,has three types,namely once-flowering(OF),occasional or re-blooming(OR),and recurrent or continuous flowering(CF).However,the mechanism underlying the effect of the age pathway on the duration of the CF or OF juvenile phase is largely *** this study,we observed that the RcSPL1 transcript levels were substantially upregulated during the floral development period in CF and OF ***,accumulation of RcSPL1 protein was controlled by *** ectopic expression of RcSPL1 in Arabidopsis thaliana accelerated the vegetative phase transition and ***,the transient overexpression of RcSPL1 in rose plants accelerated flowering,whereas silencing of RcSPL1 had the opposite ***,the transcription levels of floral meristem identity genes(APETALA1,FRUITFULL,and LEAFY)were significantly affected by the changes in RcSPL1 ***15b protein,which is an autonomous pathway protein,was revealed to interact with *** silencing and overexpression of RcTAF15b in rose plants led to delayed and accelerated flowering,***,the study findings imply that RcSPL1–RcTAF15b modulates the flowering time of rose plants.

关键词： TAF flowering floral

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心脏手术前、后甲状腺功能的变化

天津医药 1999年第2期27卷 84-86页

作者：赵志英朱立王正华李彦芬中国协和医科大学北京协和医院核医学科中国医学科学院 100730

测定心脏病手术前、后血清甲状腺激素及皮质醇浓度。结果显示：与术前相比，术后Ｔ_３、ＦＴ_３明显下降（Ｐ＜０．０１），ｒＴ３和皮质醇明显升高（Ｐ＜０．０１），心脏病术后血清甲状腺激素变化的主要特点为低Ｔ_３综合征，其与内... 详细信息

测定心脏病手术前、后血清甲状腺激素及皮质醇浓度。结果显示：与术前相比，术后Ｔ_３、ＦＴ_３明显下降（Ｐ＜０．０１），ｒＴ３和皮质醇明显升高（Ｐ＜０．０１），心脏病术后血清甲状腺激素变化的主要特点为低Ｔ_３综合征，其与内源性糖皮质激素分泌增多有关。术后有并发症者血清Ｔ_３、Ｔ_４和ＦＴ_３水平明显降低，ｒＴ_３显著升高。Ｔ_３、ＦＴ_３降低的程度与疾病的预后有密切关系。

关键词：心脏外科手术围手术期甲状腺功能

Exogenous melatonin improves cotton yield under drought stress by enhancing root development and reducing root damage

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Journal of Integrative Agriculture 2024年第10期23卷 3387-3405页

作者： Lingxiao zhu Hongchun Sun Ranran Wang Congcong Guo Liantao Liu Yongjiang Zhang Ke Zhang zhiying Bai Anchang Li Jiehua zhu Cundong Li State Key Laboratory of North China Crop Improvement and Regulation/Key Laboratory of Crop Growth Regulation of HebeiProvince/College of Agronomy Hebei Agricultural UniversityBaoding 071000China College of Plant Protection Hebei Agricultural UniversityBaoding 071000China

The exogenous application of melatonin by the root drenching method is an effective way to improve crop drought ***,the optimal concentration of melatonin by root drenching and the physiological mechanisms underlying melatonin-induced drought tolerance in cotton(Gossypium hirsutum L.)roots remain *** study determined the optimal concentration of melatonin by root drenching and explored the protective effects of melatonin on cotton *** results showed that 50μmol L-1 melatonin was optimal and significantly mitigated the inhibitory effect of drought on cotton seedling *** melatonin promoted root development in drought-stressed cotton plants by remarkably increasing the root length,projected area,surface area,volume,diameter,and *** also mitigated the drought-weakened photosynthetic capacity of cotton and regulated the endogenous hormone contents by regulating the relative expression levels of hormone-synthesis genes under drought ***-treated cotton seedlings maintained optimal enzymatic and non-enzymatic antioxidant capacities,and produced relatively lower levels of reactive oxygen species and malondialdehyde,thus reducing the drought stress damage to cotton roots(such as mitochondrial damage).Moreover,melatonin alleviated the yield and fiber length declines caused by drought *** together,these findings show that root drenching with exogenous melatonin increases the cotton yield by enhancing root development and reducing the root damage induced by drought *** summary,these results provide a foundation for the application of melatonin in the field by the root drenching method.

关键词： cotton drought melatonin root morphology root physiology yield

Enhanced methane production in an anaerobic digestion and microbial electrolysis cell coupled system with co-cultivation of Geobacter and Methanosarcina

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Journal of Environmental Sciences 2016年第4期28卷 210-214页

作者： Qi Yin Xiaoyu zhu Guoqiang Zhan Tao Bo Yanfei Yang Yong Tao Xiaohong He Daping Li zhiying Yan Key Laboratory of Environmental and Applied Microbiology Chengdu Institute of Biology Chinese Academy of Sciences Chengdu 610041 China Environmental Microbiology Key Laboratory of Sichuan Province Chengdu 610041 China

The anaerobic digestion（AD）and microbial electrolysis cell（MEC）coupled system has been proved to be a promising process for biomethane *** this paper,it was found that by co-cultivating Geobacter with Methanosarcina in an AD–MEC coupled system,methane yield was further increased by 24.1%,achieving to 360.2 m L/g-COD,which was comparable to the theoretical methane yield of an anaerobic *** the presence of Geobacter,the maximum chemical oxygen demand（COD）removal rate（216.8 mg COD/（L·hr））and current density（304.3 A/m3）were both increased by 1.3 and 1.8 fold compared to the previous study without Geobacter,resulting in overall energy efficiency reaching up to 74.6%.Community analysis demonstrated that Geobacter and Methanosarcina could coexist together in the biofilm,and the electrochemical activities of both were confirmed by cyclic *** study observed that the carbon dioxide content in total gas generated from the AD reactor with Geobacter was only half of that generated from the same reactor without Geobacter,suggesting that Methanosarcina may obtain the electron transferred from Geobacter for the reduction of carbon dioxide to *** together,Geobacter not only can improve the performance of the MEC system,but also can enhance methane production.

关键词： AD–MEC coupled system Geobacter Methanosarcina Co-cultivation Methane production