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Viral vectors as a novel tool for clinical and neuropsychiatric research applications

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General Psychiatry 2018年第5期31卷 100-108页

作者： Yao Wang zhiwei hu Peijun Ju Shan Yin Fujie Wang Oudong Pan Jinghong Chen Research and development department OBiO Technology (Shanghai) Corp. Ltd. Marketing department OBiO Technology (Shanghai) Corp. Ltd. Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Psychotic Disorders

Background A viral vector is a genetically modified vector produced by genetic engineering. As pathogenic genes in the virus are completely or largely eliminated, it is safe to be widely used in multidisciplinary research fields for expressing genes, such as neuroscience, metabolism, oncology and so on. Neuroscience and psychiatry are the most closely related disciplines in either basic research or clinical research, but the application of viral vectors in neuropsychiatry has not received much attention or not been widely *** This article will focus on the application of viral vectors in basic and clinical neuropsychiatric *** By using viral vectors, scientists can perform neurological labelling, gene expression regulation and physiological manipulation for investigating phenomenon from molecular mechanisms to behaviours. At the same time, to treat mental or neurological disorders, viral vectors can be designed for gene therapy, which alter gene expression levels or repair mutated genes in the brains of *** Viral vectors play an important role in basic research and clinical applications. To further understand brain function and prevent mental and neurological diseases, we hypothesize that viral vectors could be used along with various advanced technologies, such as sequencing and high-throughput expression analysis in the neuroscience research field.

关键词： Methods By using viral vectors Neuroscience and psychiatry

Tackling application limitations of high-safetyγ-butyrolactone electrolytes:Exploring mechanisms and proposing solutions

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Journal of Energy Chemistry 2024年第6期93卷 193-201,I0005页

作者： Haojun Wu Zhangyating Xie Guanjie Li Lei Zheng zhiwei Zhao Jiarong He Yanbin Shen Jiahao hu Zhangquan Peng Guiming Zhong Lidan Xing Weishan Li School of Chemistry South China Normal UniversityGuangzhou 510006GuangdongChina National and Local Joint Engineering Research Center of MPTES in High Energy and Safety LIBs Engineering Research Center of MTEES(Ministry of Education)Research Center of BMET(Guangdong Province)and Key Lab.of ETESPG(GHEI)South China Normal UniversityGuangzhou 510006GuangdongChina Laboratory of Advanced Spectroelectrochemistry and Li-ion Batteries Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina i-Lab CAS Center for Excellence in NanoscienceSuzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of SciencesSuzhou 215123JiangsuChina School of Chemical Engineering Faculty of SciencesEngineering and TechnologyThe University of AdelaideSA 5005Australia

Developing wide-temperature and high-safety lithium-ion batteries(LIBs)presents significant challenges attributed to the absence of suitable solvents possessing broad liquid range and non-flammability properties.γ-Butyrolactone(GBL)has emerged as a promising solvent;however,its incompatibility with graphite anode has hindered its *** limitation necessitates a comprehensive investigation into the underlying mechanisms and potential *** this study,we achieve a molecular-level understanding of the perplexing interphase formation process by employing in-situ spectroelectrochemical techniques and density function *** findings reveal that,even at high salt concentrations,GBL consistently occupies the primary Li^(+)solvation sheath,leading to extensive GBL decomposition and the formation of a high-impedance and inorganic-poor solid-electrolyte interphase(SEI)*** to manipulating solvation structures,our research demonstrates that the utilization of filmforming additives with higher reduction potential facilitates the pre-establishment of a robust SEI film on the graphite *** approach effectively inhibits GBL decomposition and significantly enhances the battery's *** study provides the first reported intrinsic understanding of the unique GBLgraphite incompatibility and offers valuable insights for the development of wide-temperature and high-safety LIBs.

关键词： γ-Butyrolactone/Graphite incompatibility Unique solvation structure SEI film Lithium-ion batteries

A Catalog of ^(13)CO Clumps from the MWISP in l=10°–20°

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Research in Astronomy and Astrophysics 2024年第5期24卷 218-234页

作者： Xiaoyu Luo Sheng Zheng Zhibo Jiang zhiwei Chen Yao huang Shuguang Zeng Xiangyun Zeng Rui Zhang Chen Long Guangrong Zhou Jinbo hu Center for Astronomy and Space Sciences China Three Gorges UniversityYichang 443000China College of Electrical Engineering and New Energy China Three Gorges UniversityYichang 443000China College of Science China Three Gorges UniversityYichang 443000China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China

In this study, we present a catalog of molecular clumps extracted from ^(13)CO(J=1-0) emission data of the Milky Way Imaging Scroll Painting(MWISP) project. The data covers the inner Milky Way within the longitude range10°≤l≤20° and the latitude strip of |b|≤ 5°. 25. The workflow for the extraction of clumps, namely Facet-SS-3DClump, consists of two parts: the identification of clump candidates and their verification. First, Facet-SS-3DClump employs FacetClumps to identify clump candidates. Subsequently, high-confidence clumps are obtained by cross-matching with the clumps detected by other algorithms, such as dendrogram. Second, these high-confidence clumps are used as prior knowledge to train a semi-supervised deep clustering approach, SS-3D-Clump, which is applied to verify clump candidates detected by FacetClumps, providing confidence levels for the molecular clumps. Finally, the catalog comprising 18,757 molecular clumps was obtained using Facet-SS-3D-Clump, and the catalog is 90% complete above 37 K km s^(-1). We observe a significant deviation of the mean Galactic latitude for clumps within |b|≤ 2° from the midplane, with b=-0°.110. We found that 82.3% of the dust clumps correspond to ^(13)CO clumps by matching with Herschel infrared dust clumps. In the future, Facet-SS-3D-Clump will be applied to detect ^(13)CO clumps in the entire MWISP data.

关键词： ISM molecules methods data analysis-stars formation

Single crystal growth and characterization of 166-type magnetic kagome metals

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Chinese Physics B 2024年第9期33卷 145-150页

作者： huangyu Wu Jinjin Liu Yongkai Li Peng Zhu Liu Yang Fuhong Chen Deng hu zhiwei Wang Centre for Quantum Physics Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement(MOE)School of PhysicsBeijing Institute of TechnologyBeijing 100081China Beijing Key Laboratory of Nanophotonics and Ultrafine Optoelectronic Systems Beijing Institute of TechnologyBeijing 100081China Beijing Institute of Technology Zhuhai 519000China Material Science Center Yangtze Delta Region Academy of Beijing Institute of TechnologyJiaxing 314011China

Kagome magnets were predicted to be a good platform to investigate correlated topology band structure,Chern quantum phase,and geometrical frustration due to their unique lattice *** we reported single crystal growth of 166-type kagome magnetic materials,including HfMn_(6)Sn_(6),ZrMn_(6)Sn_(6),GdMn_(6)Sn_(6)and GdV_(6)Sn_(6),by using the flux method with Sn as the *** them,HfMn_(6)Sn_(6)and ZrMn_(6)Sn_(6)single crystals were grown for the first time.X-ray diffraction measurements reveal that all four samples crystallize in HfFe6Ge6-type hexagonal structure with space group P6/*** samples show metallic behavior from temperature dependence of resistivity measurements,and the dominant carrier is hole,except for GdV6Sn6 which is electron *** samples have magnetic order with different transition temperatures,HfMn_(6)Sn_(6),ZrMn_(6)Sn_(6)and GdV_(6)Sn_(6)are antiferromagnetic with TN of 541 K,466 K and 4 K respectively,while GdMn_(6)Sn_(6)is ferrimagnetic with the critical temperature of about 470 *** study will enrich the research platform of magnetic kagome materials and help explore the novel quantum phenomena in these interesting *** dataset of specific crystal structure parameters for HfMn_(6)Sn_(6)are available in Science Data Bank,with the link.

关键词： kagome metal single crystal growth crystal structure physical property

TcPO_(2)changes are more pronounced than SpO_(2)changes during simulated altitude changes in a hypobaric oxygen chamber:a nonrandomized controlled trial

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Emergency and Critical Care Medicine 2024年第3期4卷 105-110页

作者： Yang Li Liang Chen Ziyu Fu zhiwei Wang Shijun Sun Xiaorong Luan Dedong Ma Tianliang hu School of Nursing and Rehabilitation Shandong UniversityJinanShandongChina Department of Emergency and Critical Care Medicine Qilu Hospital of Shandong UniversityJinanShandongChina Department of Pulmonary and Critical Care Medicine Qilu Hospital of Shandong UniversityJinanShandongChina Emergency Management Center of State Grid Shandong Electric Power Company JinanShandongChina School of Nursing and Rehabilitation Cheeloo College of MedicineUniversity of ShandongDepartment of Infection ControlQilu Hospital of Shandong UniversityJinanShandongChina School of Mechanical Engineering Shandong UniversityKey Laboratory of the Ministry of Education for Efficient and Clean Machinery ManufacturingNational Experimental Teaching Demonstration Center for Mechanical EngineeringJinanShandongChina

Background:Hypoxia is a significant risk factor of ***,no studies have used transcutaneous tissue partial pressure of oxygen(TcPO_(2))and partial pressure of carbon dioxide(TcPCO_(2))monitors to measure the respective partial pressures in healthy *** saturation(SpO_(2))is often used for traditional monitoring of vital *** study investigated the changes in TcPO_(2)and SpO_(2)values during rapid changes in *** trial was registered at ***(registration ***06076057).Methods:Healthy adult volunteers were instructed to sit vertically in a hypobaric oxygen chamber,which ascended from 0 m to 2500 m at a uniform speed within 10 *** Danish Radiometer TCM4 was used to measure TcPO_(2)and TcPCO_(2)with the ventral side of the upper arm as the measurement *** Shenzhen Kerokan P0D-1 W pulse oximeter was used to measure heart rate and SpO_(2),with values recorded once every 500 ***:Altogether,49 healthy volunteers were recruited between March 2023 and August *** increasing altitude,TcPO_(2)and SpO_(2)decreased significantly(P500 m,statistical significance was identified between TcPO_(2)in both sexes(P<0.05).Statistical significance in TcPCO_(2)and heart rate was observed at the different elevations(P<0.05).Conclusion:In acutely changing low-pressure hypoxic environments,TcPO_(2)changed more dramatically than SpO_(2).

关键词： Altitude change Low-pressure oxygen chamber Transcutaneous oxygen saturation Transcutaneous partial pressure of oxygen

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美国社区学院课程设置理念及技术流程简析

职业技术教育 2016年第11期37卷 71-76页

作者：胡志伟宁波城市职业技术学院

美国社区学院课程设置的基本理念是:立足社区,面向市场,紧密联系社会实际,多方寻求共赢合作,为各类人群实现各自不同的"美国梦"充当"人生加油站"。其课程设置的程序非常严格、规范,一些比较常见的做法有:将职业技术类课程设置与国家技... 详细信息

美国社区学院课程设置的基本理念是:立足社区,面向市场,紧密联系社会实际,多方寻求共赢合作,为各类人群实现各自不同的"美国梦"充当"人生加油站"。其课程设置的程序非常严格、规范,一些比较常见的做法有:将职业技术类课程设置与国家技能标准对接,以职业群分类为依据构建课程体系,采用DACUM分析法进行课程设置,从一些课程开发机构引进或"购买"相关课程,利用现代信息技术开发远程教育课程和整合学术课程与职业课程等。

关键词：美国社区学院课程设置理念技术流程

无人飞行器Ad Hoc网络中容错节点移动控制算法

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国防科技大学学报 2012年第1期34卷 58-62,71页

作者：陈凌梁加红胡志伟吴冰国防科技大学机电工程与自动化学院湖南长沙410073 防化研究院北京102205

针对无人飞行器Ad Hoc网络的容错设计需求,基于UAV节点的可控移动特性,提出了一种基于强化边启发的节点移动控制算法。首先采用文化基因算法对给定通信网络对应的拓扑图进行搜索,求解使图获取顶点2-连通属性所需新增的最小成本强化边组... 详细信息

针对无人飞行器Ad Hoc网络的容错设计需求,基于UAV节点的可控移动特性,提出了一种基于强化边启发的节点移动控制算法。首先采用文化基因算法对给定通信网络对应的拓扑图进行搜索,求解使图获取顶点2-连通属性所需新增的最小成本强化边组合。以强化边为启发,将连接的节点移动到彼此通信范围内来实现强化边,同时以这些节点为leader,采用基于一致性算法的leader-follower控制算法移动其他关联节点,使变化后的网络为顶点2-连通,从而实现网络容错。仿真实验结果表明算法的可行性与有效性,节点总的移动距离少于用于对比的块移动算法和紧缩算法。

关键词：无人飞行器Ad Hoc网络容错文化基因算法顶点2-连通一致性算法

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采用双重注意力特征金字塔网络检测群养生猪

农业工程学报 2021年第5期37卷 166-174页

作者：胡志伟杨华娄甜田山西农业大学信息科学与工程学院太谷030801 山西大学计算机与信息技术学院(大数据学院) 太原030006 山西农业大学农业经济管理学院太谷030801

为解决复杂环境下,猪只粘连和猪栏遮挡等因素给生猪个体多目标实例检测带来的困难,该研究以群养猪圈场景下8栏(日龄20~105 d)共计45头生猪为研究对象,以视频为数据源,采用平视视角、镜头位置不固定的数据采集方式,共获得标注图像3834张... 详细信息

为解决复杂环境下,猪只粘连和猪栏遮挡等因素给生猪个体多目标实例检测带来的困难,该研究以群养猪圈场景下8栏(日龄20~105 d)共计45头生猪为研究对象,以视频为数据源,采用平视视角、镜头位置不固定的数据采集方式,共获得标注图像3834张,并将其划分为训练集2490张、验证集480张、测试集864张。引入一种融合通道注意力(Channel Attention Unit,CAU)与空间注意力(Position Attention Unit,PAU)的双重注意力单元(Dual Attention Unit,DAU),并将DAU用于特征金字塔网络(Feature Pyramid Network,FPN)结构中,研究基于两大骨干网络ResNet50、ResNet101与4个任务网络Mask R-CNN、Cascade Mask R-CNN、MS R-CNN及HTC(Hybrid Task Cascade)交叉结合模型对群养生猪实例检测性能。结果表明:与CBAM、BAM、SCSE等注意力模块相比,HTC-R101-DAU比HTC-R101-CBAM在IOU阈值为0.5、0.75、0.5~0.95(所有目标)、0.5~0.95(大目标)条件下的4种AP(Average Precision)指标分别提升1.7%、1.7%、2.1%与1.8%;单独加入CAU与PAU以分别探究通道与空间注意力单元对任务网络检测性能影响,试验结果表明,DAU与CAU及PAU相比性能更佳,且加入特定串联数量的PAU效果优于CAU;为获取更为丰富的上下文信息,分别串联1~4个PAU单元以构建不同空间注意力模块,试验结果表明,随着串联PAU单元数量的增加,相同任务网络其预测AP指标值先增加后减小。综合分析,HTC-R101-DAU模型可更为精确、有效地对不同场景生猪进行实例检测,可为后续生猪个体深度研究奠定基础。

关键词：图像处理目标检测算法特征金字塔通道注意力空间注意力

“中国梦”和“美国梦”比较视野下职教发展战略构想

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职业技术教育 2015年第21期36卷 65-69页

作者：胡志伟宁波城市职业技术学院

正确解读美国梦与美国职业教育的关系,有助于我们更好地理解并最终实现中国梦。要从战略高度重新审视并提升职业教育在全民心目中的地位,构建"立交桥"式职业教育体系。要从法律、体制、资金等方面创造有利条件使职业教育"落地生根",全... 详细信息

正确解读美国梦与美国职业教育的关系,有助于我们更好地理解并最终实现中国梦。要从战略高度重新审视并提升职业教育在全民心目中的地位,构建"立交桥"式职业教育体系。要从法律、体制、资金等方面创造有利条件使职业教育"落地生根",全面提升各行业劳动者的自身素质,尤其是当前社会急需的各类不同层次技术型、技能型人才的综合素质。

关键词：中国梦美国梦职业教育发展战略