TcPO_(2)changes are more pronounced than SpO_(2)changes during simulated altitude changes in a hypobaric oxygen chamber:a nonrandomized controlled trial
作者机构：School of Nursing and RehabilitationShandong UniversityJinanShandongChina Department of Emergency and Critical Care MedicineQilu Hospital of Shandong UniversityJinanShandongChina Department of Pulmonary and Critical Care MedicineQilu Hospital of Shandong UniversityJinanShandongChina Emergency Management Center of State Grid Shandong Electric Power CompanyJinanShandongChina School of Nursing and RehabilitationCheeloo College of MedicineUniversity of ShandongDepartment of Infection ControlQilu Hospital of Shandong UniversityJinanShandongChina School of Mechanical EngineeringShandong UniversityKey Laboratory of the Ministry of Education for Efficient and Clean Machinery ManufacturingNational Experimental Teaching Demonstration Center for Mechanical EngineeringJinanShandongChina
出 版 物：《Emergency and Critical Care Medicine》 (急危重症医学（英文）)
年 卷 期：2024年第4卷第3期
页 面：105-110页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：supported by grants from Shandong Province Key R&D Program(2021CXGC011301)
主 题：Altitude change Low-pressure oxygen chamber Transcutaneous oxygen saturation Transcutaneous partial pressure of oxygen
摘 要：Background:Hypoxia is a significant risk factor of ***,no studies have used transcutaneous tissue partial pressure of oxygen(TcPO_(2))and partial pressure of carbon dioxide(TcPCO_(2))monitors to measure the respective partial pressures in healthy *** saturation(SpO_(2))is often used for traditional monitoring of vital *** study investigated the changes in TcPO_(2)and SpO_(2)values during rapid changes in *** trial was registered at ***(registration ***06076057).Methods:Healthy adult volunteers were instructed to sit vertically in a hypobaric oxygen chamber,which ascended from 0 m to 2500 m at a uniform speed within 10 *** Danish Radiometer TCM4 was used to measure TcPO_(2)and TcPCO_(2)with the ventral side of the upper arm as the measurement *** Shenzhen Kerokan P0D-1 W pulse oximeter was used to measure heart rate and SpO_(2),with values recorded once every 500 ***:Altogether,49 healthy volunteers were recruited between March 2023 and August *** increasing altitude,TcPO_(2)and SpO_(2)decreased significantly(P500 m,statistical significance was identified between TcPO_(2)in both sexes(P0.05).Statistical significance in TcPCO_(2)and heart rate was observed at the different elevations(P0.05).Conclusion:In acutely changing low-pressure hypoxic environments,TcPO_(2)changed more dramatically than SpO_(2).
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