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Role of 5-hydroxytryptamine type 3 receptors in the regulation of anxiety reactions

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第1期25卷 23-37页

作者： Yinan DU zhiwei LI Yukui ZHAO Jing HAN Weiping hu Zhiqiang LIU MOE Key Laboratory of Modern Teaching Technology Shaanxi Normal UniversityXi’an710062China

5-Hydroxytryptamine(5-HT)type 3 receptor(5-HT_(3)R)is the only type of ligand-gated ion channel in the 5-HT receptor *** the high permeability of Na+,K+,and Ca2+and activation of subsequent voltage-gated calcium channels(VGCCs),5-HT_(3)R induces a rapid increase of neuronal excitability or the release of neurotransmitters from axon terminals in the central nervous system(CNS).5-HT_(3)Rs are widely expressed in the medial prefrontal cortex(mPFC),amygdala(AMYG),hippocampus(HIP),periaqueductal gray(PAG),and other brain regions closely associated with anxiety *** have a bidirectional regulatory effect on anxiety reactions by acting on different types of cells in different brain regions.5-HT_(3)Rs mediate the activation of the cholecystokinin(CCK)system in the AMYG,and theγ-aminobutyric acid(GABA)“disinhibition”mechanism in the prelimbic area of the mPFC promotes anxiety by the activation of GABAergic intermediate inhibitory neurons(IINs).In contrast,a 5-HT_(3)R-induced GABA“disinhibition”mechanism in the infralimbic area of the mPFC and the ventral HIP produces anxiolytic effects.5-HT_(2)R-mediated regulation of anxiety reactions are also activated by 5-HT_(3)R-activated 5-HT release in the HIP and *** provides a theoretical basis for the treatment of anxiety disorders or the production of anxiolytic drugs by targeting 5-HT_(3)***,given the circuit specific modulation of 5-HT_(3)Rs on emotion,systemic use of 5-HT_(3)R agonism or antagonism alone seems unlikely to remedy anxiety,which deeply hinders the current clinical application of 5-HT_(3)R ***,the exploitation of circuit targeting methods or a combined drug strategy might be a useful developmental approach in the future.

关键词： 5-Hydroxytryptamine type 3 receptor(5-HT_(3)R) Anxiety Medial prefrontal cortex Amygdala Hippocampus Periaqueductal gray

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Ultrathin,flexible,and oxidation-resistant MXene/graphene porous films for efficient electromagnetic interference shielding

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Nano Research 2023年第1期16卷 1755-1763页

作者： Xinwei Tang Jiangtao Luo zhiwei hu Shijie Lu Xiaoyi Liu Shuangshuang Li Xu Zhao Zihang Zhang Qianqian Lan Piming Ma Zicheng Wang Tianxi Liu The Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringInternational Joint Research Laboratory for Nano Energy CompositesJiangnan UniversityWuxi 214122China

Designing and fabricating efficient electromagnetic interference(EMI)shielding materials becomes a significant and urgent ***,a novel ultrathin,flexible,and oxidation-resistant MXene-based graphene(M-rGX)porous film is successfully fabricated by electrostatic self-assembly between MXene and graphene oxide(GO)nanosheets,and subsequently thermal annealing under hydrogen-argon *** rapid breakaway of functional groups on GO and MXene sheets induces formation of porous conductive network in film,thereby facilitating efficient shielding for incident electromagnetic *** optimal absolute shielding effectiveness(SSE/t)value of 76,422 dB·cm2·g−1 can be achieved at a thinner thickness of 15μ*** importantly,the effective removal of functional groups on MXene conspicuously improves the oxidation resistance of the film,endowing it with an excellent durability(12 months)in EMI shielding performance.

关键词： MXene graphene porous film oxidation resistance electromagnetic interference shielding

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YN30型残废烟支烟丝回收装置的设计与应用

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机械制造与自动化 2024年第3期53卷 264-268页

作者：肖文平唐军陈然胡智维娄本周冰李焕威云南中烟工业有限责任公司技术中心云南昆明650231 广东中烟工业有限制责任公司广东广州510385

针对传统残废烟支烟丝回收装置存在的烟丝回收率低、纯净度差、整丝率偏低、细支卷烟加工适应性差等问题,研制一种新型残废烟支烟丝回收装置。该装置通过滚筒筛网和搓丝螺杆机构实现了烟丝与卷烟材料的快速分离,通过静电吸附和负压剔除... 详细信息

针对传统残废烟支烟丝回收装置存在的烟丝回收率低、纯净度差、整丝率偏低、细支卷烟加工适应性差等问题,研制一种新型残废烟支烟丝回收装置。该装置通过滚筒筛网和搓丝螺杆机构实现了烟丝与卷烟材料的快速分离,通过静电吸附和负压剔除相结合的除杂技术,实现了分离烟丝精选除杂。以常规卷烟牌号云烟(紫)以及细支卷烟牌号云烟(细支珍品)进行应用测试,常规卷烟加工回收烟丝得率≥80.0%,细支卷烟加工回收烟丝得率≥70.0%;回收烟丝纯净度≥99.0%;回收烟丝整丝率≥60.0%;回收烟丝碎丝率≤6.0%;处理前后烟丝含水率变化≤0.5%。该装置同时可以满足常规卷烟和细支卷烟的残废烟支回收。

关键词：残废烟支回收装置烟丝回收率纯净度

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长三角地区背景大气CO_(2)浓度变化特征

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环境科学学报 2024年第6期44卷 236-248页

作者：胡智伟刘硕臧昆鹏郭娜林溢陈圆圆陈啸鸣兰文港温军潘凤梅陈丽涵李珊鲁嫣冉郭朋方双喜浙江工业大学环境学院杭州310014 浙江工业大学浙江碳中和创新研究院浙江省碳减排与碳监测技术国际科技合作基地杭州310014 南京信息工程大学气象灾害预报预警与评估协调创新中心南京210044

二氧化碳(CO_(2))排放增加是全球变暖的主导因素,其中人为活动排放对全球CO_(2)浓度增长的贡献越来越大,然而当前我国对城市区域的大气CO_(2)监测相对缺乏.本文利用长三角地区背景站点(大明山站,DMS)2020年9月—2022年1月的CO_(2)在线... 详细信息

二氧化碳(CO_(2))排放增加是全球变暖的主导因素,其中人为活动排放对全球CO_(2)浓度增长的贡献越来越大,然而当前我国对城市区域的大气CO_(2)监测相对缺乏.本文利用长三角地区背景站点(大明山站,DMS)2020年9月—2022年1月的CO_(2)在线观测数据,结合地面风的影响,对观测数据进行筛分,采用后向轨迹分析方法,探讨了长江三角洲地区大气CO_(2)季节浓度及源汇特征.结果表明,观测期间DMS大气CO_(2)平均浓度为(421.9±10.2)×10^(-6).CO_(2)浓度在冬季出现峰值(428.7±9.1)×10^(-6),夏季出现谷值(416.7±5.5)×10^(-6).春、夏、秋季,日变化波动分别在01:00、02:00、21:00出现峰值,在14:00、14:00、13:00出现谷值,而冬季呈相反趋势,峰值出现在13:00,谷值出现在00:***的CO_(2)浓度与风速呈显著负相关.春秋季,来自NE-ENE风向的局地风,夏冬季来自SSW-WSW的局地风,携带了较高浓度的CO_(2).白天DMS盛行上升风,不同风向CO_(2)浓度差异较大,浓度和风级呈正相关,夜晚DMS盛行下沉风,不同风向CO_(2)浓度差异不大,和风级呈负相关.此外,基于72 h后向轨迹的聚类分析发现,西南、西北和东南的气团向DMS传输的CO_(2)浓度比较均一,这表明DMS能够充分观测长三角区域混合均匀的大气本底特征.另外,潜在源区分析表明,DMS周边城市是重要的CO_(2)潜在源,人为排放对DMS大气CO_(2)浓度存在重要影响.

关键词：二氧化碳原位监测波动特征季节变化后向轨迹

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腹腔镜胃底折叠术治疗质子泵抑制剂依赖性胃食管反流病10年疗效:单中心160例报道

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中华普通外科杂志 2024年第6期39卷 423-429页

作者：胡志伟吴继敏李萌刘健男邓昌荣战秀岚纪涛王峰田书瑞张玉陈冬中国人民解放军火箭军特色医学中心胃食管外科北京100088

目的探讨腹腔镜胃底折叠术治疗质子泵抑制剂(PPI)依赖性胃食管反流病(GERD)的长期疗效。方法回顾性分析2012年1至6月于中国人民解放军火箭军特色医学中心接受腹腔镜胃底折叠术的PPI依赖性GERD患者的临床资料。研究指标包括GERD症状评分... 详细信息

目的探讨腹腔镜胃底折叠术治疗质子泵抑制剂(PPI)依赖性胃食管反流病(GERD)的长期疗效。方法回顾性分析2012年1至6月于中国人民解放军火箭军特色医学中心接受腹腔镜胃底折叠术的PPI依赖性GERD患者的临床资料。研究指标包括GERD症状评分、症状主观缓解率、PPI停药率和手术满意度,以及复发和并发症等。结果本研究共纳入GERD患者160例,其中64%的患者合并呼吸道症状,行Nissen和Toupet胃底折叠术分别为43和117例,平均随访时间为(127±3)个月。患者术后各GERD相关症状评分均显著低于治疗前(均P<0.001);消化道和呼吸道总体症状主观缓解程度分别为90%(80%,100%)和100%,PPI停药率为86%,疗效总满意率为92%,其中合并呼吸道症状患者的满意率为89%。7%患者出现不同程度的症状复发,4%的患者再次接受内镜下治疗和(或)腹腔镜胃底折叠术,6/7患者再次取得满意疗效。术后长期吞咽困难、腹胀、嗳气、排气增多、腹痛、腹泻和便秘发生率分别为11.3%、16.9%、0、1.3%、0、2.5%和5.6%。结论腹腔镜胃底折叠术治疗GERD具有良好的长期疗效,少数患者术后可出现复发以及吞咽困难和腹胀等并发症,复发患者可通过内镜下治疗或二次手术重新取得满意疗效。

关键词：胃食管反流胃底折叠术质子泵抑制剂疝,食管裂孔食管炎,消化性

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Atomically isolated Pd sites within Pd-S nanocrystals enable trifunctional catalysis for direct,electrocatalytic and photocatalytic syntheses of H_(2)O_(2)

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Nano Research 2022年第3期15卷 1861-1867页

作者： Tang Yang Chengyong Yang Jiabo Le Zhiyong Yu Lingzheng Bu Leigang Li Shuxing Bai Qi Shao zhiwei hu Chih-Wen Pao Jun Cheng Yonggang Feng Xiaoqing huang State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Max-Planck-Institute for Chemical Physics of Solids Nöthnitzer Street 40Dresden 01187Germany “National Synchrotron Radiation Research Center” Hsinchu 30076TaiwanChina

Although high-efficiency production of hydrogen peroxide(H_(2)O_(2))can be realized separately by means of direct,electrochemical,and photocatalytic synthesis,developing versatile catalysts is particularly challenging yet ***,for the first time we reported that palladium-sulphur nanocrystals(Pd-S NCs)can be adopted as robust and universal catalysts,which can realize the efficient O_(2) conversion by three *** a result,Pd-S NCs exhibit an excellent selectivity(89.5%)to H_(2)O_(2)with high productivity(133.6 mol·kgcat^(−1)·h^(−1))in the direct synthesis,along with the significantly enhanced H_(2)O_(2)production activity and stability via electrocatalytic and photocatalytic *** is demonstrated that the isolated Pd sites can enhance the adsorption of O_(2) and inhibit its O–O bond dissociation,improving H_(2)O_(2)selectivity and reducing H_(2)O_(2)*** study confirms that the difference in surface atom composition and arrangement is the key factor for different ORR mechanisms on Pd NCs and Pd-S NCs.

关键词： Pd-S universality direct synthesis of H_(2)O_(2) oxygen reduction photocatalysis

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Effect of cavity flow control on high-speed train pantograph and roof aerodynamic noise

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Railway Engineering Science 2020年第1期28卷 54-74页

作者： Hogun Kim zhiwei hu David Thompson Aerodynamics and Flight Mechanics Research Group University of SouthamptonSouthampton SO171BJUK Institute of Sound and Vibration Research Dynamics Group University of SouthamptonSouthampton SO171BJUK

The pantograph and its recess on the train roof are major aerodynamic noise sources on high-speed *** this noise is particularly important because conventional noise barriers usually do not shield the ***,less attention has been paid to the pantograph recess compared with the *** this paper,the flow features and noise contribution of two types of noise reduction treatments rounded and chamfered edges are studied for a simplified high-speed train pantograph recess,which is represented as a rectangular cavity and numerically investigated at 1/10 *** delayed detached-eddy simulations are performed for the near-field turbulent flow simulation,and the Ffowcs Williams and Hawkings aeroacoustic analogy is used for far-field noise *** highly unsteady flow over the cavity is significantly reduced by the cavity edge modifications,and consequently,the noise radiated from the cavity is ***,effects of the rounded cavity edges on the flow and noise of the pantographs(one raised and one folded)are investigated by comparing the flow features and noise contributions from the cases with and without rounding of the cavity *** train running directions are also *** analysis shows that the highly unsteady flow within the cavity is reduced by rounding the cavity edges and a slightly lower flow speed occurs around the upper parts of the raised pantograph,whereas the flow velocity in the cavity is slightly increased by the *** pressure fluctuations occur on the folded pantograph and the lower parts of the raised pantograph,whereas weaker fluctuations are found on the panhead of the raised *** study shows that by rounding the cavity edges,a reduction in radiated noise at the side and the top receiver positions can be *** reductions in the other directions can also be found.

关键词： High-speed train Aeroacoustics Pantograph Pantograph recess Cavity flow Noise control

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Enhanced H_(2) permeation and CO_(2) tolerance of self-assembled ceramic-metal-ceramic BZCYYb-Ni-CeO_(2) hybrid membrane for hydrogen separation

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Journal of Energy Chemistry 2023年第7期82卷 47-55,I0002页

作者： Jianqiu Zhu Jingzeng Cui Yuxuan Zhang Ze Liu Chuan Zhou Susu Bi Jingyuan Ma Jing Zhou zhiwei hu Tao Liu Zhi Li Xiangyong Zhao Jian-Qiang Wang Linjuan Zhang Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800China Key Laboratory of Optoelectronic Material and Device Department of PhysicsShanghai Normal UniversityShanghai 200234China State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816JiangsuChina Shanghai Synchrotron Radiation Facility Zhangjiang LaboratoryShanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China Max Planck Institute for Chemical Physics of Solids Nöthnitzer Strasse 40Dresden 01187Germany Shandong Energy Group Co. Ltd.Jinan 250014ShandongChina University of Chinese Academy of Sciences Beijing 100049China

Perovskite-type mixed protonic-electronic conducting membranes have attracted attention because of their ability to separate and purify hydrogen from a mixture of gases generated by industrial-scale steam reforming based on an ion diffusion *** cost-effective membrane materials that can achieve both high H_(2) permeability and strong CO_(2)-tolerant chemical stability has been a major challenge for industrial ***,we constructed a triple phase(ceramic-metal-ceramic)membrane composed of a perovskite ceramic phase BaZr_(0.1)Ce_(0.7)Y_(0.1)Yb_(0.1)O_(3-δ)(BZCYYb),Ni metal phase and a fluorite ceramic phase CeO_(2).Under H_(2) atmosphere,Ni metal in-situ exsolved from the oxide grains,and decorated the grain surface and boundary,thus the electronic conductivity and hydrogen separation performance can be *** BZCYYbNi-CeO_(2)hybrid membrane achieved an exceptional hydrogen separation performance of 0.53 mL min^(-1)cm^(-2) at 800℃ under a 10 vol% H_(2) atmosphere,surpassing all other perovskite membranes reported to ***,the CeO_(2) phase incorporated into the BZCYYb-Ni effectively improved the CO_(2)-tolerant chemical *** BZCYYbNi-CeO_(2) membrane exhibited outstanding long-term stability for at least 80 h at 700℃ under 10 vol%CO_(2)-10 vol%H_(2).The success of hybrid membrane construction creates a new direction for simultaneously improving their hydrogen separation performance and CO_(2) resistance stability.

关键词： Hydrogen separation Triple phase hybrid membrane Mixed proton-electron conductor Chemical stability X-ray absorption spectra

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In operando-formed interface between silver and perovskite oxide for efficient electroreduction of carbon dioxide to carbon monoxide

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Carbon Energy 2023年第4期5卷 81-93页

作者： Xinhao Wu Yanan Guo Yuxing Gu Fenghua Xie Mengran Li zhiwei hu Hong-Ji Lin Chih-Wen Pao Yu-Cheng huang Chung-Li Dong Vanessa KPeterson Ran Ran Wei Zhou Zongping Shao State Key Laboratory of Materials‐Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjingJiangsuChina Department of Chemical Engineering Materials for Energy Conversion and Storage(MECS)Faculty of Applied SciencesDelft University of TechnologyHZ DelftThe Netherlands Max Planck Institute for Chemical Physics of Solids DresdenGermany National Synchrotron Radiation Research Center HsinchuTaiwanChina Department of Electrophysics National Yang Ming Chiao Tung UniversityHsinchuTaiwanChina Department of Physics Tamkang UniversityNew Taipei CityTaiwanChina Australian Centre for Neutron Scattering Australian Nuclear Science and Technology OrganisationSydneyNew South WalesAustralia Department of Chemical Engineering Curtin UniversityPerthWestern AustraliaAustralia

Electrochemical carbon dioxide(CO_(2))reduction(ECR)is a promising technology to produce valuable fuels and feedstocks from CO_(2).Despite large efforts to develop ECR catalysts,the investigation of the catalytic performance and electrochemical behavior of complex metal oxides,especially perovskite oxides,is rarely ***,the inorganic perovskite oxide Ag-doped(La_(0.8)Sr_(0.2))_(0.95)Ag_(0.05)MnO_(3-δ)(LSA0.05M)is reported as an efficient electrocatalyst for ECR to CO for the first time,which exhibits a Faradaic efficiency(FE)of 84.3%,a remarkable mass activity of 75Ag^(-1)(normalized to the mass of Ag),and stability of 130 h at a moderate overpotential of 0.79 *** LSA0.05M catalyst experiences structure reconstruction during ECR,creating the in operando-formed interface between the perovskite and the evolved Ag *** evolved Ag is uniformly distributed with a small particle size on the perovskite *** calculations indicate the reconstruction of LSA0.05M during ECR and reveal that the perovskite-Ag interface provides adsorption sites for CO_(2) and accelerates the desorption of the*CO intermediate to enhance *** study presents a novel high-performance perovskite catalyst for ECR andmay inspire the future design of electrocatalysts via the in operando formation of metal-metal oxide interfaces.

关键词： electrochemical CO_(2)reduction faradaic efficiencies interfaces perovskite oxides

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切脉针刺联合下颏抗阻力训练对鼻咽癌放疗后吞咽障碍患者吞咽功能的影响

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上海中医药大学学报 2024年第2期38卷 8-13页

作者：胡志伟谷晓娟王一平蒋玥段腾迟福荣柏丽丽河北省沧州中西医结合医院放化疗三科河北沧州061000 河北省沧州中西医结合医院神经内一科河北沧州061000 河北省沧州中西医结合医院胸外科河北沧州061000 河北省沧州中西医结合医院西药房河北沧州061000

目的:探讨切脉针刺联合下颏抗阻力(CTAR)训练对鼻咽癌(NPC)放疗后吞咽障碍(SD)患者吞咽功能的影响。方法:采用随机对照研究方法,将60例NPC放疗后SD患者随机分为CTAR训练组和联合组,每组各30例。所有患者均给予常规训练,在此基础上,CTAR... 详细信息

目的:探讨切脉针刺联合下颏抗阻力(CTAR)训练对鼻咽癌(NPC)放疗后吞咽障碍(SD)患者吞咽功能的影响。方法:采用随机对照研究方法,将60例NPC放疗后SD患者随机分为CTAR训练组和联合组,每组各30例。所有患者均给予常规训练,在此基础上,CTAR训练组患者给予CTAR训练干预,联合组患者给予切脉针刺联合CTAR训练干预,两组干预周期均为4周。干预前后,评价并比较两组患者的洼田饮水试验(WST)分级情况和吞咽造影检查(VFSS)评分;检测并比较两组患者的白蛋白(ALB)、前白蛋白(PA)水平,评价患者的营养状况;比较两组患者的误吸发生率;采用吞咽障碍特异性生活质量量表(SWAL-QOL)评价两组患者的生活质量。结果:(1)干预后,两组患者的WST分级情况均优于干预前(P<0.05),且联合组患者的WST分级情况优于CTAR训练组(P<0.05)。(2)干预后,两组患者的VFSS评分较干预前均明显升高(P<0.05),且联合组患者的评分高于CTAR训练组(P<0.05)。(3)干预后,两组患者的ALB、PA水平较干预前均明显升高(P<0.05),且联合组患者的ALB、PA水平高于CTAR训练组(P<0.05)。(4)在干预4周内,联合组患者的误吸发生率为3.33%,CTAR训练组患者的误吸发生率为26.67%,联合组患者的误吸发生率明显低于CTAR训练组(P<0.05)。(5)干预后,两组患者的SWAL-QOL评分较干预前均明显升高(P<0.05),且联合组患者的评分高于CTAR训练组(P<0.05)。结论:切脉针刺联合CTAR训练干预NPC放疗后SD患者,可明显改善患者的吞咽功能和营养状况,有效降低误吸发生率,提高患者的生活质量。

关键词：鼻咽癌放疗吞咽障碍切脉针刺下颏抗阻力训练吞咽功能

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